| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I D Smith, A A Grac. Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity. Synapse (New York, N.Y.). vol 12. issue 4. 1993-01-19. PMID:1465742. |
the influence of subthalamic nucleus (stn) afferents on dopaminergic (da) neurons of the rat substantia nigra (sn) was investigated. |
1993-01-19 |
2023-08-11 |
rat |
| H Wachtel, M Kunow, P A Löschman. NBQX (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and CPP (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats. Neuroscience letters. vol 142. issue 2. 1993-01-06. PMID:1280793. |
the selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) antagonist 6-nitro-sulfamoyl-benzo-quinoxaline-dione (nbqx) and the competitive n-methyl-d-aspartate (nmda) antagonist 3-carboxy-piperazin-propyl phosphonic acid (cpp) ameliorate parkinsonian symptomatology when co-administered with threshold doses of l-dopa in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated common marmosets and induce rotations in rats with unilateral 6-hydroxydopamine (6-ohda) lesions of the substantia nigra (sn). |
1993-01-06 |
2023-08-11 |
rat |
| A Pasini, A Tortorella, K Gal. Anticonvulsant effect of intranigral fluoxetine. Brain research. vol 593. issue 2. 1993-01-06. PMID:1450936. |
bilateral focal injections of the serotonin uptake inhibitor, fluoxetine (1.75-7.0 nmol) into substantia nigra (sn) protected against convulsive seizures evoked by the focal injection of bicuculline methiodide into area tempestas, an epileptogenic site within the deep prepiriform cortex. |
1993-01-06 |
2023-08-11 |
Not clear |
| S H Appel, W D Le, J Tajti, L J Haverkamp, J I Engelhard. Nigral damage and dopaminergic hypofunction in mesencephalon-immunized guinea pigs. Annals of neurology. vol 32. issue 4. 1992-12-31. PMID:1360786. |
to support a potential role for immune mechanisms in the destruction of substantia nigra (sn) neurons, guinea pigs were immunized with bovine mesencephalon containing sn neurons. |
1992-12-31 |
2023-08-11 |
human |
| T Shirao, M J Evinger, L Iacovitti, D J Rei. Lesions of nigrostriatal pathway reduce expression of tyrosine hydroxylase gene in residual dopaminergic neurons of substantia nigra. Neuroscience letters. vol 141. issue 2. 1992-12-11. PMID:1359468. |
the effects of unilateral mechanical transection of the nigrostriatal bundle of rat brain on the level of tyrosine hydroxylase (th) mrna and on the activity of th enzyme in the substantia nigra (sn) were examined. |
1992-12-11 |
2023-08-11 |
rat |
| A Mølle. Mean volume of pigmented neurons in the substantia nigra in Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 137. 1992-11-04. PMID:1414260. |
a new unbiased stereological estimator, the rotator, was used to estimate the mean volume of pigmented substantia nigra (sn) neurons in three parkinson's disease (pd) brains and age-matched controls. |
1992-11-04 |
2023-08-11 |
Not clear |
| M P Carrera, R Mattioli, C Toma. Preoperative operant circling training facilitates recovery following unilateral substantia nigra lesion in rats. Behavioral and neural biology. vol 58. issue 1. 1992-11-04. PMID:1417669. |
this study was undertaken to examine (1) whether pre- and/or postoperative training, using water reinforcement, to turn in circles (rotation) affects the behavioral symptoms induced by unilateral 6-hydroxydopamine (6-ohda)-induced da denervation of the rat substantia nigra (sn); (2) whether there was any influence of this training on the temporal pattern of recovery; and (3) whether the rotational training influences turning induced by systemic injection of dopaminergic drugs. |
1992-11-04 |
2023-08-11 |
rat |
| E Pileblad, T Magnusso. Increase in rat brain glutathione following intracerebroventricular administration of gamma-glutamylcysteine. Biochemical pharmacology. vol 44. issue 5. 1992-10-22. PMID:1530658. |
a dose-dependent increase in the gsh concentration (145-170% of controls) was found in the substantia nigra (sn) and in the rest of the brain stem after injection of gamma-gc, whereas no significant alterations in gsh were observed in the striatum and in the cerebral cortex. |
1992-10-22 |
2023-08-11 |
rat |
| K Ostergaard, I E Holm, J Zimme. Tyrosine hydroxylase and acetylcholinesterase in the domestic pig mesencephalon: an immunocytochemical and histochemical study. The Journal of comparative neurology. vol 322. issue 2. 1992-10-14. PMID:1355778. |
the mesencephalon of the young domestic pig was studied by tyrosine hydroxylase (th) immunocytochemistry and acetylcholinesterase (ache) histochemistry with focus on the substantia nigra (sn), the ventral tegmental area (vta), and related areas. |
1992-10-14 |
2023-08-11 |
Not clear |
| M F Hawkins, B Cubic, A A Baumeister, C Barto. Microinjection of opioid antagonists into the substantia nigra reduces stress-induced eating in rats. Brain research. vol 584. issue 1-2. 1992-10-07. PMID:1515944. |
in order to test the possibility that the substantia nigra (sn) might be involved, the amount of food intake and gnawing produced by mild tail pinch were assessed following bilateral microinjections of opioid antagonists into the sn. |
1992-10-07 |
2023-08-11 |
rat |
| K F Greif, N J Tillakaratne, M G Erlander, S Feldblum, A J Tobi. Transient increase in expression of a glutamate decarboxylase (GAD) mRNA during the postnatal development of the rat striatum. Developmental biology. vol 153. issue 1. 1992-10-07. PMID:1516745. |
using in situ hybridization to the two gad mrnas, we observed a selective increase in gad65 mrna during the second postnatal week, at the time when striatal matrix neurons innervate the substantia nigra (sn). |
1992-10-07 |
2023-08-11 |
human |
| T Ogawa, W R Matson, M F Beal, R H Myers, E D Bird, P Milbury, S Sas. Kynurenine pathway abnormalities in Parkinson's disease. Neurology. vol 42. issue 9. 1992-10-01. PMID:1513457. |
we measured metabolites of tyrosine and tryptophan (trp) in the frontal cortex, putamen (pt), and pars compacta of the substantia nigra (sn) of control and parkinson's disease (pd) brain tissues. |
1992-10-01 |
2023-08-11 |
Not clear |
| Y Yasui, K Nakano, Y Nakagawa, T Kayahara, T Shiroyama, N Mizun. Non-dopaminergic neurons in the substantia nigra project to the reticular formation around the trigeminal motor nucleus in the rat. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1380874. |
the dorsolateral part of the substantia nigra (sn) of the rat was observed to send projection fibers to the reticular formation (rf) around the trigeminal motor nucleus (vm), bilaterally with a clear-cut ipsilateral dominance, by the anterograde and retrograde tracing techniques with pha-l and wga-hrp. |
1992-09-29 |
2023-08-11 |
rat |
| D Ben-Shachar, G Eshel, P Riederer, M B Youdi. Role of iron and iron chelation in dopaminergic-induced neurodegeneration: implication for Parkinson's disease. Annals of neurology. vol 32 Suppl. 1992-09-18. PMID:1510367. |
recent studies in parkinson's disease suggest that the degeneration of the nigrostriatal melanin-containing dopaminergic neurons results from toxic effects of free radicals, which are generated during dopamine metabolism in the substantia nigra (sn). |
1992-09-18 |
2023-08-11 |
rat |
| D T Dexter, P Jenner, A H Schapira, C D Marsde. Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group. Annals of neurology. vol 32 Suppl. 1992-09-18. PMID:1510387. |
previously we have shown that cell death in the substantia nigra (sn) in parkinson's disease (pd) is associated with an increase in iron content but a decrease in the level of the iron-binding protein ferritin. |
1992-09-18 |
2023-08-11 |
human |
| E K O'Malley, B A Sieber, I B Black, C F Dreyfu. Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture. Brain research. vol 582. issue 1. 1992-09-14. PMID:1379874. |
we previously demonstrated that substantia nigra (sn) support cells selectively increase sn dopamine (da) neuron survival in dissociated primary culture. |
1992-09-14 |
2023-08-11 |
rat |
| T Yamada, P L McGeer, E G McGee. Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins. Acta neuropathologica. vol 84. issue 1. 1992-09-14. PMID:1502878. |
the substantia nigra (sn) in 11 parkinson's disease (pd) patients and 5 neurologically normal controls was examined immunohistochemically using antibodies to various proteins of the complement system. |
1992-09-14 |
2023-08-11 |
Not clear |
| A Kastner, E C Hirsch, O Lejeune, F Javoy-Agid, O Rascol, Y Agi. Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494900. |
in control brains, the distribution of melanized neurons in the nigral complex showed a high proportion of lightly melanized neurons in the ventral tegmental area and the pars alpha and gamma of the substantia nigra (sn), whereas heavily melanized neurons were mostly located in the pars beta and lateralis of the sn. |
1992-09-09 |
2023-08-11 |
human |
| F Moriwaka, K Tashiro, K Itoh, T Hamada, K Miyasak. [Magnetic resonance imaging in Parkinson's disease--the evaluation of the width of pars compacta on T2 weighted image]. Rinsho shinkeigaku = Clinical neurology. vol 32. issue 1. 1992-08-14. PMID:1628441. |
the width of substantia nigra (sn) in 59 cases with idiopathic parkinson's disease as well as 21 normal controls was analyzed by t2 weighted image (t2wi) of 1.5 tesla high-field magnetic resonance image (mri). |
1992-08-14 |
2023-08-11 |
Not clear |
| B Deleplanque, P J Neveu, S Vitiello, M Le Moa. Early effects of unilateral lesions of substantia nigra on immune reactivity. Neuroscience letters. vol 135. issue 2. 1992-08-07. PMID:1625797. |
mitogen-induced proliferation of t lymphocytes was shown to be enhanced 4-6 weeks after right lesion of the substantia nigra (sn) in mice, when compared to left lesioned and control animals. |
1992-08-07 |
2023-08-11 |
mouse |