| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Liu, Yang Su, Xiaolong Ma, Yao Wei, Rui Qia. How close are we to a breakthrough? The hunt for blood biomarkers in Parkinson's disease diagnosis. The European journal of neuroscience. 2024-02-21. PMID:38379501. |
by the time clinical diagnosis becomes possible, more than 60% of dopamine neurons in the substantia nigra (sn) of patients have already degenerated. |
2024-02-21 |
2024-02-23 |
Not clear |
| Erind Alushaj, Nicholas Handfield-Jones, Alan Kuurstra, Anisa Morava, Ravi S Menon, Adrian M Owen, Manas Sharma, Ali R Khan, Penny A MacDonal. Increased iron in the substantia nigra pars compacta identifies patients with early Parkinson'sdisease: A 3T and 7T MRI study. NeuroImage. Clinical. vol 41. 2024-02-20. PMID:38377722. |
degeneration in the substantia nigra (sn) pars compacta (snc) underlies motor symptoms in parkinson's disease (pd). |
2024-02-20 |
2024-02-23 |
Not clear |
| G-L Liu, H-W Zhang, C-B Zha, T-W Fan, S-T Chen, T-T Shen, K H. Magnetic resonance imaging assessment of substantia nigral iron deposition in Parkinson's disease: a meta-analysis. European review for medical and pharmacological sciences. vol 28. issue 3. 2024-02-20. PMID:38375696. |
magnetic resonance imaging (mri) studies have shown that patients with parkinson's disease have an increased amount of iron in their substantia nigra (sn). |
2024-02-20 |
2024-02-22 |
Not clear |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |
| Areej Turkistani, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Athanasios Alexiou, Marios Papadakis, Mohamed M Elfiky, Hebatallah M Saad, Gaber El-Saber Batih. Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue. Molecular neurobiology. 2024-02-17. PMID:38367137. |
parkinson's disease (pd) is a progressive neurodegenerative disease of the brain due to degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-02-17 |
2024-02-20 |
Not clear |
| Xiaomin Fu, Le Qu, Huamin Xu, Junxia Xi. Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease. Experimental neurology. 2024-02-16. PMID:38365133. |
here, our results showed that the expression of ndfip1 decreased in the substantia nigra (sn) of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced pd mouse model. |
2024-02-16 |
2024-02-19 |
mouse |
| Solmaz Alizadehmoghaddam, Fereshteh Pourabdolhossein, Hossein Najafzadehvarzi, Maryam Sarbishegi, Kiarash Saleki, Hamid Reza Nour. Crocin attenuates the lipopolysaccharide-induced neuroinflammation via expression of AIM2 and NLRP1 inflammasome in an experimental model of Parkinson's disease. Heliyon. vol 10. issue 3. 2024-02-15. PMID:38356604. |
furthermore, hematoxylin and eosin (h&e) and immunostaining were performed on whole brain tissue, while dissected substantia nigra (sn) was used for immunoblotting and real-time pcr to evaluate compartments involved in pd. |
2024-02-15 |
2024-02-17 |
rat |
| Isabel Soto, Robert McManus, Walter Navarrete-Barahona, Ella A Kasanga, Kirby Doshier, Vicki A Nejtek, Michael F Salvator. Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352365. |
young adult pink1 ko rats exhibited hyperkinetic behavior associated with elevated da and th in the substantia nigra (sn), which decreased therein, but not striatum, in the aged ko rats. |
2024-02-14 |
2024-02-16 |
human |
| David Zarate-Lopez, Andrea P Garzón-Partida, Oscar Gonzalez-Perez, Alma Y Gálvez-Contrera. Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. Developmental psychobiology. vol 66. issue 2. 2024-02-13. PMID:38351305. |
these abnormal patterns may be due to alterations in dopamine synthesis in the ventral tegmental area (vta) and substantia nigra (sn). |
2024-02-13 |
2024-02-16 |
mouse |
| Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Pol Andrés-Benito, Angelique di Domenico, Yvonne Richaud-Patin, Valentina Baruffi, Laura Marruecos, Lluís Espinosa, Alicia Garrido, Eduardo Tolosa, Michael J Edel, Manel Juan Otero, José Luis Mosquera, Isidre Ferrer, Angel Raya, Antonella Consigli. Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson's disease. JCI insight. vol 9. issue 3. 2024-02-08. PMID:38329129. |
parkinson's disease (pd) is a neurodegenerative disease associated with progressive death of midbrain dopamine (dan) neurons in the substantia nigra (sn). |
2024-02-08 |
2024-02-10 |
human |
| Qiuyu Lv, Xuanyi Wang, Pan Lin, Xiang Wan. Neuromelanin-sensitive magnetic resonance imaging in the study of mental disorder: A systematic review. Psychiatry research. Neuroimaging. vol 339. 2024-02-07. PMID:38325165. |
recent research suggests that neuromelanin-sensitive magnetic resonance imaging (nm-mri) techniques may overcome this limitation by enabling the non-invasive imaging of the substantia nigra (sn)/ ventral tegmental area (vta) dopaminergic and locus coeruleus (lc) noradrenergic systems. |
2024-02-07 |
2024-02-10 |
Not clear |
| Rongsha Chen, Ke Li, Yinying Wang, Liyun Song, Ruohua Wang, Wenhui Fan, Ninghui Zhao, Wei Zou, Zhongshan Yang, Jinyuan Ya. Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model. Journal of drug targeting. 2024-02-05. PMID:38315456. |
the present study demonstrated that cos increased dopaminergic neurons in the substantia nigra (sn) and ameliorated dyskinesia in a pd mouse model. |
2024-02-05 |
2024-02-09 |
mouse |
| Himanshi Varshney, Yasir Hasan Siddiqu. Effect of Flavonoids against Parkinson's Disease. Central nervous system agents in medicinal chemistry. 2024-02-02. PMID:38305395. |
it is characterized by the depletion of striatal dopamine content and aggregation of alphasynuclein in the substantia nigra (sn). |
2024-02-02 |
2024-02-04 |
Not clear |
| Xi Chen, Zhao Wang, Weihua Yang, Yuejun F. Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra. Journal of integrative neuroscience. vol 23. issue 1. 2024-01-30. PMID:38287845. |
this study aims to probe the action of l-dopa on nlr pyrin domain containing 3 (nlrp3) inflammasome activation and tyrosine hydroxylase (th) levels in the striatum (str) and substantia nigra (sn) of mice with pd symptoms. |
2024-01-30 |
2024-02-01 |
mouse |
| Giansalvo Gusinu, Claudia Frau, Giuseppe A Trunfio, Paolo Solla, Leonardo Antonio Sech. Segmentation of Substantia Nigra in Brain Parenchyma Sonographic Images Using Deep Learning. Journal of imaging. vol 10. issue 1. 2024-01-26. PMID:38276318. |
among them, brain parenchyma sonography (bps) is used to evaluate the hyperechogenicity of substantia nigra (sn), found in more than 90% of pd patients. |
2024-01-26 |
2024-01-28 |
Not clear |
| Junming Huang, Bowen Li, Huangwei Wei, Chengxin Li, Chao Liu, Hua Mi, Shaohua Che. Integrative analysis of gene expression profiles of substantia nigra identifies potential diagnosis biomarkers in Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-01-25. PMID:38272954. |
parkinson's disease (pd) is a progressive neurodegenerative disease whose etiology is attributed to development of lewy bodies and degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-01-25 |
2024-01-28 |
human |
| Michael F Salvator. Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function-Not a New Concept, but Neglected Reality. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256204. |
although da release in substantia nigra (sn) was first reported almost 50 years ago, assessment of nigral da signaling changes in relation to motor function is rarely considered. |
2024-01-23 |
2024-01-25 |
human |
| Ramasamy Thangavel, Harleen Kaur, Iuliia Dubova, Govindhasamy Pushphavathi Selvakumar, Mohammad Ejaz Ahmed, Sudhanshu P Raikwar, Raghav Govindarajan, Duraisamy Kempura. Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256254. |
we analyzed the expression pattern of the gmf protein in conjunction with amyloid plaques (aps) and neurofibrillary tangles (nfts) in the substantia nigra (sn) and striatum of pdd brains using immunostaining. |
2024-01-23 |
2024-01-25 |
human |
| Haruka Takeshige-Amano, Taku Hatano, Koji Kamagata, Christina Andica, Takashi Ogawa, Atsuhiko Shindo, Wataru Uchida, Wataru Sako, Shinji Saiki, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattor. Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease. Journal of the neurological sciences. vol 457. 2024-01-21. PMID:38246127. |
the aim of this study is to elucidate white matter and substantia nigra (sn) microstructural differences between patients with parkinson's disease with and without selegiline treatment by two independently recruited cohorts. |
2024-01-21 |
2024-01-24 |
Not clear |
| Xiao-Lei Zhang, Meng-Ni Hu, Zhen Rong, Ya-Nan Li, Yao Wang, Jun M. Effect of electroacupuncture on Nrf2/NLRP3/Caspase-1 pathway mediated-pyroptosis in mice with Parkinson's disease. Zhen ci yan jiu = Acupuncture research. vol 49. issue 1. 2024-01-19. PMID:38239134. |
to observe the effect of electroacupuncture (ea) on nuclear transcription factor e2 related factor 2 (nrf2)/nod-like receptor family pyrin domain-containing protein 3 (nlrp3)/cysteine aspartic acid specific protease-1 (caspase-1) pathway in the substantia nigra (sn) of mice with parkinson's disease (pd), so as to explore the neuroprotective mechanism of ea. |
2024-01-19 |
2024-01-21 |
mouse |