| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyu Pan, Anqi Guo, Kaiyu Guan, Congcong Chen, Shengnan Xu, Yali Tang, Xi Li, Zhengwei Huan. Lactobacillus rhamnosus GG attenuates depression-like behaviour and cognitive deficits in chronic ethanol exposure mice by down-regulating systemic inflammatory factors. Addiction biology. vol 29. issue 11. 2024-11-25. PMID:39585236. |
the use of lgg and antibiotics alleviated the depression-like behaviour and cognitive impairment of cee-induced mice, reduced expression of inflammatory factors such as interleukin (il)-6, il-1β and tumour necrosis factor (tnf)-α in the ileum, serum and brain and increased the expression of synaptophysin (syn), postsynaptic density protein-95 (psd-95) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2024-11-25 |
2024-11-27 |
mouse |
| Qin Lyu, Liu-Qing Shi, Hai-Yang Chen, Mei Lu, Xi-Cai Liang, Xian-De Ma, Xin Zhou, Lu Re. Electroacupuncture combined with NSCs-Exo alters the response of hippocampal neurons in a chronic unpredictable mild stress paradigm in ovx rats. Life sciences. vol 359. 2024-11-13. PMID:39528081. |
this was evidenced by reductions in hippocampal synaptic plasticity proteins psd95, syn, and gap43, as well as decreased expression of energy metabolism pathway proteins ampk, nrf1, pgc1α, and tfam. |
2024-11-13 |
2024-11-17 |
rat |
| Paola C Bello-Medina, Mauricio Díaz-Muñoz, Sandra Teresita Martín Del Campo, Fermín Paul Pacheco-Moisés, Claudia Flores Miguel, Raquel Cobián Cervantes, Perla Belén García Solano, Mónica Navarro-Mez. A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats. Journal of nutritional science. vol 13. 2024-10-29. PMID:39469193. |
hence, in the present study, we assess whether an isocaloric low-protein diet (ilpd) affects the fatty acid profile in breast milk, the hippocampal synaptophysin (syn) ratio, and the oxidative stress markers in the neonatal stage of male and female offspring. |
2024-10-29 |
2024-10-31 |
rat |
| Paola C Bello-Medina, Mauricio Díaz-Muñoz, Sandra Teresita Martín Del Campo, Fermín Paul Pacheco-Moisés, Claudia Flores Miguel, Raquel Cobián Cervantes, Perla Belén García Solano, Mónica Navarro-Mez. A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats. Journal of nutritional science. vol 13. 2024-10-29. PMID:39469193. |
the aim of this work was to assess the effect of an ilpd on the fatty acid profile in breast milk, quantified the hippocampal synaptophysin (syn) ratio and oxidative stress markers in neonatal stage of male and female offspring. |
2024-10-29 |
2024-10-31 |
rat |
| Paola C Bello-Medina, Mauricio Díaz-Muñoz, Sandra Teresita Martín Del Campo, Fermín Paul Pacheco-Moisés, Claudia Flores Miguel, Raquel Cobián Cervantes, Perla Belén García Solano, Mónica Navarro-Mez. A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats. Journal of nutritional science. vol 13. 2024-10-29. PMID:39469193. |
significant decreases of hippocampal syn ratio in male offspring (decreases of 98% in hippocampal ca1 pyramidal and ca1 oriens, 83%, stratum pyramidal in ca3, 80%, stratum lucidum in ca3, and 81% stratum oriens in ca3). |
2024-10-29 |
2024-10-31 |
rat |
| Jing Cheng, Yihan Yang, Jincheng Chen, Ting Rao, Yijing Jiang, Shanli Yan. [Effects of electroacupuncture on learning-memory function and synaptic plasticity in rats with cerebral ischemia-reperfusion injury based on the BDNF/TrkB pathway]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 44. issue 9. 2024-09-25. PMID:39318295. |
to observe the effects of electroacupuncture (ea) at "baihui" (gv 20) and "sishencong" (ex-hn 1) on the expression of brain-derived neurotrophic factor (bdnf)/tyrosine kinase receptor b (trkb) pathway, synaptophysin (syn), and the levels of interleukin-1β (il-1β) and interleukin-18 (il-18) in the hippocampus of the ischemic side in rats with cerebral ischemia-reperfusion injury (ciri), and to explore the effects and action mechanism of ea on post-ciri learning-memory function. |
2024-09-25 |
2024-09-27 |
rat |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
the protein expressions of cd300f, tlr4, synaptophysin(syn), and postsynaptic density protein 95(psd-95) in microglial cells of the hippocampus were detected by immunofluorescence and western blot. |
2024-09-22 |
2024-09-26 |
rat |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
moreover, the expression of synapse-related proteins syn and psd-95 in hippocampal neurons decreased, and the synaptic ultrastructure of hippocampal neurons was significantly damaged. |
2024-09-22 |
2024-09-26 |
rat |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
they could up-regulate the protein expression of presyna-ptic membrane syn and postsynaptic membrane psd-95 in hippocampal neurons and finally improve the damage to the hippocampal synaptic microenvironment. |
2024-09-22 |
2024-09-26 |
rat |
| Wenyan Zhao, Wei Zhang, Yingying Hu, Yuliang Zhou, Jinying Zhao, Yahong Li, Zhipeng X. AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice. Neurochemical research. vol 49. issue 8. 2024-07-09. PMID:38819697. |
in addition, adiporon treatment up-regulated synaptic proteins (psd95, syn, gap43, and syp), increased the number of hippocampal synapses and attenuated synaptic damage, including the length, the number and the density of dendritic spines in ca1 and dg regions. |
2024-07-09 |
2024-07-12 |
mouse |
| Xi Yu, Jun Guo, Yueyang Song, Bin Wei, Yajun Shi, Yan Zhao, Zejun Zhao, Qinqin Gao, Bin Wang, Miao Su. HDAC1/2/3-mediated downregulation of neurogranin is involved in cognitive impairment in offspring exposed to maternal subclinical hypothyroidism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 12. 2024-06-12. PMID:38865202. |
chip analysis revealed that h3k9ac on the neurogranin (ng) promoter was reduced in the hippocampus of the offspring of sch, with a significant reduction in ng protein, leading to reduced expression levels of synaptic plasticity markers psd95 (a membrane-associated protein in the postsynaptic density) and syn (synaptophysin, a specific marker for presynaptic terminals), and impaired synaptic plasticity. |
2024-06-12 |
2024-06-15 |
mouse |
| Jiena Hong, Jiemei Chen, Chao Li, Fei Zhao, Jiantao Zhang, Yilong Shan, Hongmei We. High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia. Behavioural brain research. vol 467. 2024-04-28. PMID:38678971. |
the underlying mechanism might be modulating the synaptic plasticity and up-regulating the expression psd95, syn, and bdnf in the hippocampus. |
2024-04-28 |
2024-05-01 |
rat |
| Sarawut Lapmanee, Nattapon Supkamonseni, Sakkarin Bhubhanil, Nattakan Treesaksrisakul, Chaiyos Sirithanakorn, Mattaka Khongkow, Katawut Namdee, Piyaporn Surinlert, Chittipong Tipbunjong, Prapimpun Wongchitra. Stress-induced changes in cognitive function and intestinal barrier integrity can be ameliorated by venlafaxine and synbiotic supplementations. PeerJ. vol 12. 2024-03-04. PMID:38435986. |
hippocampal dentate gyrus showed stress-induced neuronal cell death, which was attenuated by syn and/or vlx treatment. |
2024-03-04 |
2024-03-06 |
rat |
| Sarawut Lapmanee, Nattapon Supkamonseni, Sakkarin Bhubhanil, Nattakan Treesaksrisakul, Chaiyos Sirithanakorn, Mattaka Khongkow, Katawut Namdee, Piyaporn Surinlert, Chittipong Tipbunjong, Prapimpun Wongchitra. Stress-induced changes in cognitive function and intestinal barrier integrity can be ameliorated by venlafaxine and synbiotic supplementations. PeerJ. vol 12. 2024-03-04. PMID:38435986. |
in addition, syn and vlx partly contributed to affecting the expression of the glial cell-derived neurotrophic factor in the hippocampus and intestines of stressed rats, suggesting particularly protective effects on both the gut barrier and the brain. |
2024-03-04 |
2024-03-06 |
rat |
| Mengdie Wang, Namin Feng, Jia Qin, Shengqiang Wang, Jiabao Chen, Shaojie Qian, Yulin Liu, Foquan Lu. Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats. Neurotoxicology. 2024-02-12. PMID:38346645. |
accordingly, the activity of histone deacetylases increased, the protein levels of nedd9, bdnf, p-trkb, syn and psd-95 decreased, and the density of dendritic spines reduced in the hippocampus of the offspring of the surgery group, and such effects were not seen in the offspring of the ketamine group, neither in the offspring of control group. |
2024-02-12 |
2024-02-15 |
rat |
| Yuhan Wu, Zhanpeng Zhu, Tian Lan, Shuhan Li, Ye Li, Changmin Wang, Yabo Feng, Xueqin Mao, Shuyan Y. Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway. Molecular neurobiology. 2023-12-06. PMID:38057644. |
levomilnacipran increased the expression of postsynaptic dense 95 (psd-95) and synaptophysin (syn) and reversed the imbalance between pro- and anti-inflammatory cytokines within hippocampus of depressed rats. |
2023-12-06 |
2023-12-10 |
rat |
| Εvgenia Dandi, Paschalis Theotokis, Maria Christina Petri, Vaia Sideropoulou, Evangelia Spandou, Despina A Tat. Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex-specific manner. Developmental psychobiology. vol 65. issue 7. 2023-10-05. PMID:37796476. |
to this end, we studied possible alterations in hippocampal glial fibrillary acidic protein (gfap) and synaptophysin (syn) in cus rats previously housed in ee. |
2023-10-05 |
2023-10-07 |
rat |
| Εvgenia Dandi, Paschalis Theotokis, Maria Christina Petri, Vaia Sideropoulou, Evangelia Spandou, Despina A Tat. Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex-specific manner. Developmental psychobiology. vol 65. issue 7. 2023-10-05. PMID:37796476. |
cus reduced the expression of syn in all hippocampal areas, whereas lower gfap expression was evident only in ca1 and ca3. |
2023-10-05 |
2023-10-07 |
rat |
| Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Y. N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype. European journal of pharmacology. 2023-09-06. PMID:37673363. |
the results showed that pea ameliorated the depression-like phenotype in rats induced by ucms, prevented the ucms-induced reduction in the number of brdu-positive cells, and increased brdu/neun co-localization in the hippocampus, and upregulated the levels of synapse associated protein ncam, map2, syn and psd95 in the hippocampus. |
2023-09-06 |
2023-10-07 |
rat |
| Tao Lv, Min Wang, He-Sheng Zheng, Jin-Dong Mao, Fan Yang, Le Yang, Ming-Gao Zhao, Shui-Bing Liu, Kun Zhang, Rui Liu, Yu-Mei W. Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity via Wnt/β-catenin signaling pathway. Brain research bulletin. 2023-08-16. PMID:37586426. |
in this study, we found that enhanced single prolonged stress (esps)-induced ptsd led to abnormal neural plasticity, characterized by the decline of dendritic spines, the expression of postsynaptic density 95 (psd95), and synaptophysin (syn) in the stressed hipp along with the reduction of wnt3a and β-catenin, and increased gsk-3β. |
2023-08-16 |
2023-09-07 |
Not clear |