| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
overall, syns deletion in mice leads to a reduction in drn 5-ht firing activity and hippocampal 5-ht levels along with behavioral alterations reminiscent of human neuropsychiatric conditions associated with syn dysfunction. |
2021-07-19 |
2023-08-13 |
mouse |
| Sunan Gao, Siyu Zhang, Hongmei Zhou, Xiaoyan Tao, Yunjian Ni, Daqing Pei, Shuai Kang, Weiwei Yan, Jian L. Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice. Frontiers in aging neuroscience. vol 13. 2021-05-04. PMID:33935683. |
the levels of synaptophysin (syn) and postsynaptic density protein 95 (psd-95) in the hippocampus were also examined by western blotting. |
2021-05-04 |
2023-08-13 |
mouse |
| Sunan Gao, Siyu Zhang, Hongmei Zhou, Xiaoyan Tao, Yunjian Ni, Daqing Pei, Shuai Kang, Weiwei Yan, Jian L. Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice. Frontiers in aging neuroscience. vol 13. 2021-05-04. PMID:33935683. |
in conclusion, anesthesia/surgery induced mtor hyperactivation and autophagy impairments, and then reduced the levels of syn and psd-95 in the hippocampus. |
2021-05-04 |
2023-08-13 |
mouse |
| Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong L. The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats. Frontiers in psychiatry. vol 12. 2021-03-23. PMID:33746787. |
synaptophysin (syn), postsynaptic density-95 (psd-95), and growth-associated protein-43 (gap-43) expressions in the hippocampus were detected by western blot. |
2021-03-23 |
2023-08-13 |
rat |
| Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong L. The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats. Frontiers in psychiatry. vol 12. 2021-03-23. PMID:33746787. |
expression of the hippocampus syn protein was further detected by immunohistochemistry. |
2021-03-23 |
2023-08-13 |
rat |
| Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong L. The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats. Frontiers in psychiatry. vol 12. 2021-03-23. PMID:33746787. |
also, few nissl bodies in the hippocampus ca1 and dg regions, less percentage of syn-positive cells, and downregulated expressions of syn, psd-95, and gap43 were found in the hippocampus of rats in ms+cums group. |
2021-03-23 |
2023-08-13 |
rat |
| Hui Zhao, Bingyu Liang, Linjie Yu, Yun X. Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress. Experimental and therapeutic medicine. vol 14. issue 2. 2020-09-30. PMID:28810562. |
in addition, synaptic density in the hippocampus was evaluated and western blot and immunostaining were used to analyze hippocampal expression of postsynaptic density protein-95 (psd95), synaptophysin (syn), cyclic adenosine monophosphate response element binding protein (creb), brain-derived neurotrophic factor (bdnf), akt and glycogen synthase kinase (gsk)-3β as well as their phosphorylated (p) versions. |
2020-09-30 |
2023-08-13 |
mouse |
| Hui Zhao, Bingyu Liang, Linjie Yu, Yun X. Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress. Experimental and therapeutic medicine. vol 14. issue 2. 2020-09-30. PMID:28810562. |
moreover, jycf upregulated the expression of psd95, syn and bdnf and increased phosphorylated akt, creb and gsk-3β in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Christian Griñán-Ferré, Vanesa Izquierdo, Eduard Otero, Dolors Puigoriol-Illamola, Rubén Corpas, Coral Sanfeliu, Daniel Ortuño-Sahagún, Mercè Pallà. Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30158856. |
neurodegenerative markers as β-ctf and tau hyperphosphorylation, reduced protein levels whiles appα, postsynaptic density 95 (psd95) and synaptophysin (syn) protein levels increased protein levels in the hippocampus of 5xfad-ee mice group. |
2020-09-29 |
2023-08-13 |
mouse |
| Chao-Chao Yu, Jia Wang, Si-Si Ye, Shan Gao, Jia Li, Li Wang, Tao Jiang, Xue-Song Wang, Bo-Cun Li, Qing Shu, Wei Lu, Yan-Jun Du, Li-Hong Kon. Preventive Electroacupuncture Ameliorates D-Galactose-Induced Alzheimer's Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3 Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32382276. |
we found that preventive electroacupuncture at gv20-bl23 acupoints during aging attenuated the hippocampal loss of dendritic spines, ameliorated neuronal microtubule injuries, and increased the expressions of postsynaptic psd95 and presynaptic syn, two important synapse-associated proteins involved in synaptic plasticity. |
2020-09-28 |
2023-08-13 |
rat |
| Shanyan Hong, Honghong Huang, Meili Yang, Haining Wu, Lingxing Wan. Enriched Environment Decreases Cognitive Impairment in Elderly Rats With Prenatal Mobile Phone Exposure. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32581772. |
the results demonstrated that prenatal long-term but not short-term exposure to mobile phone lead to cognitive impairment, morphological changes in the hippocampal cells, reduced synaptic number, decreased syn, psd-95, and bdnf expression in elderly offspring, which were alleviated by postnatal ee housing. |
2020-09-28 |
2023-08-13 |
rat |
| Lanfen Lin, Xuan Chen, Qiuping Zhou, Peixian Huang, Shuqi Jiang, Huifang Wang, Yiyu Den. Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide. Neuroscience letters. vol 709. 2020-09-24. PMID:31288048. |
expression of synaptophysin (syn), synaptosomal associated protein of 25 kd (snap-25), and n-methyl d-aspartate receptor (nmdar) in the hippocampus in septic brain were significantly reduced. |
2020-09-24 |
2023-08-13 |
rat |
| Bin Liu, Jinxia Liu, Jinxia Zhang, Wenjing Mao, Shiying L. Effects of autophagy on synaptic-plasticity-related protein expression in the hippocampus CA1 of a rat model of vascular dementia. Neuroscience letters. vol 707. 2020-03-11. PMID:31163225. |
the expression of lc3-ii, synaptophysin (syn), and postsynaptic density protein 95 (psd-95) in the ca1 area of the rat hippocampus were detected using western blotting. |
2020-03-11 |
2023-08-13 |
rat |
| Fen Xue, Shan-Shan Xue, Ling Liu, Han-Fei Sang, Quan-Rui Ma, Qing-Rong Tan, Hua-Ning Wang, Cui-Hong Zhou, Zheng-Wu Pen. Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30946940. |
in the present study, we used an enhanced single prolonged stress (esps) model to access the effects of early ea intervention on the prevention of anxiety-like and fear learning behaviors, as well as the influence of the expression of post-synaptic density protein 95 (psd95), synaptophysin (syn), brain derived neurotrophic factor (bdnf), diacylglycerol lipase alpha (daglα) and cannabinoid type 1 receptor (cb1r) in the hippocampus with or without daglα or cb1r knockdown by a short hairpin rna (shrna) in the hippocampus. |
2020-02-14 |
2023-08-13 |
rat |
| Raffaella Barbieri, Andrea Contestabile, Maria Grazia Ciardo, Nicola Forte, Antonella Marte, Pietro Baldelli, Fabio Benfenati, Franco Onofr. Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice. Oncotarget. vol 9. issue 27. 2019-11-20. PMID:29721159. |
we performed a systematic evaluation of the distinct stages of neurogenesis in the hippocampal dentate gyrus of syn i and syn ii knockout (ko) mice, before (2-months-old) and after (6-months-old) the appearance of the epileptic phenotype. |
2019-11-20 |
2023-08-13 |
mouse |
| Francesca Longhena, Gaia Faustini, Tatiana Varanita, Michela Zaltieri, Vanessa Porrini, Isabella Tessari, Pietro Luigi Poliani, Cristina Missale, Barbara Borroni, Alessandro Padovani, Luigi Bubacco, Marina Pizzi, PierFranco Spano, Arianna Bellucc. Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains. Brain pathology (Zurich, Switzerland). vol 28. issue 6. 2019-05-28. PMID:29330884. |
here, we observed that lb and ln, in the substantia nigra of pd patients and hippocampus of one subject with dlb, displayed a marked immunopositivity for syn iii. |
2019-05-28 |
2023-08-13 |
human |
| Jingwen Chen, Qiang Niu, Tao Xia, Guoyu Zhou, Pei Li, Qian Zhao, Chunyan Xu, Lixin Dong, Shun Zhang, Aiguo Wan. ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity. Toxicology. vol 410. 2019-05-01. PMID:30130557. |
using sprague-dawley rats developmentally exposed to sodium fluoride (naf) from pregnancy until 6 months of delivery as in vivo model, we showed that fluoride impaired the cognitive abilities of offspring rats, decreased the density of dendritic spines and the expression of synapse proteins synaptophysin (syn) and postsynaptic density protein-95 (psd-95) in hippocampus, suggesting fluoride-induced cognitive deficit associates with synaptic impairment. |
2019-05-01 |
2023-08-13 |
human |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
exposure of the hippocampal neurons to high glucose (75 mm for 72 h) resulted in cell apoptosis, decreased mrna and protein expression levels of three synaptic plasticity‑related proteins (syn, arc and cyclic amp response element‑binding protein), and changes in the cellular distribution of syn, indicating loss of synaptic density. |
2019-03-05 |
2023-08-13 |
rat |
| Jing-Xue Gu, Xiao-Jing Cheng, Xuan Luo, Xia Yang, Yi-Peng Pang, Xiao-Fei Zhang, Yu-Yun Zhang, Yi Li. Luteolin Ameliorates Cognitive Impairments by Suppressing the Expression of Inflammatory Cytokines and Enhancing Synapse-Associated Proteins GAP-43 and SYN Levels in Streptozotocin-Induced Diabetic Rats. Neurochemical research. vol 43. issue 10. 2019-01-14. PMID:30088237. |
furthermore, luteolin treatment upregulated the expressions of gap-43 and syn in the hippocampus. |
2019-01-14 |
2023-08-13 |
rat |
| Xin-Chen Wang, Yu-Min Xu, Hong-Ying Li, Chun-Ying Wu, Ting-Ting Xu, Na-Chuan Luo, Shi-Jie Zhang, Qi Wang, Shi-Jian Qua. Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice. BioMed research international. vol 2018. 2019-01-08. PMID:30050927. |
furthermore, jtw promotes the expressions of neurotrophic factors including postsynaptic density protein 95 (psd95) and synaptophysin (syn) and brain-derived neurotrophic factor (bdnf) in both hippocampus and cortex. |
2019-01-08 |
2023-08-13 |
mouse |