| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gokul Krishna, Rahul Agrawal, Yumei Zhuang, Zhe Ying, Afshin Paydar, Neil G Harris, Luiz Fernando F Royes, Fernando Gomez-Pinill. 7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-27. PMID:28315455. |
compared to sham-injured controls, tbi resulted in reduced hippocampal activation of the bdnf receptor trkb and associated creb, reduced levels of plasticity markers gap-43 and syn i, as well as impaired memory as indicated by the barnes maze task. |
2018-11-27 |
2023-08-13 |
Not clear |
| Hong-Ying Li, Xin-Chen Wang, Yu-Min Xu, Na-Chuan Luo, Si Luo, Xu-Yi Hao, Shu-Yi Cheng, Jian-Song Fang, Qi Wang, Shi-Jie Zhang, Yun-Bo Che. Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. Rejuvenation research. vol 21. issue 3. 2018-11-15. PMID:28782427. |
moreover, western blot analysis revealed that bbr increased the synapse- and nerve-related protein expression (psd95, syn, and ngf) and decreased the protein expression of inflammatory factors (tnf-α and nf-κb) in the hippocampus of db/db mice. |
2018-11-15 |
2023-08-13 |
mouse |
| Karen L G Farizatto, Sara A McEwan, Vinogran Naidoo, Spyros P Nikas, Vidyanand G Shukla, Michael F Almeida, Aaron Byrd, Heather Romine, David A Karanian, Alexandros Makriyannis, Ben A Bah. Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28803438. |
in rat hippocampal slice cultures, high-dose pxn was applied resulting in a presynaptic vulnerability evidenced by a 64% reduction in synapsin iib (syn iib) levels, whereas the postsynaptic protein glur1 was unchanged. |
2018-06-27 |
2023-08-13 |
rat |
| Karen L G Farizatto, Sara A McEwan, Vinogran Naidoo, Spyros P Nikas, Vidyanand G Shukla, Michael F Almeida, Aaron Byrd, Heather Romine, David A Karanian, Alexandros Makriyannis, Ben A Bah. Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28803438. |
as observed in hippocampal slices, the faah inhibitor also prevented the pxn-induced loss of syn iib in vivo. |
2018-06-27 |
2023-08-13 |
rat |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
in addition, western blot results (bcl-2, bax and caspase-3) and tunel staining show that bsyz prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (ngf), postsynapticdensity 95 (psd95) and synaptophysin (syn), in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Zhaohua Xiao, Jing Peng, Liwen Wu, Ahmed Arafat, Fei Yi. The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy. Neurological research. vol 39. issue 7. 2018-03-26. PMID:28372486. |
phosphatidylinositol 3-kinase (pi3k)/akt/ mammalian target of rapamycin (mtor) signaling pathway may play a critical role in regulating syn expression and electrophysiology of hippocampal neurons. |
2018-03-26 |
2023-08-13 |
rat |
| Yanan Li, Xinran Li, Cen Guo, Lina Li, Yuxin Wang, Yiming Zhang, Yu Chen, Wenhan Liu, Li Ga. Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28415680. |
the hippocampal protein levels of nerve growth factor (ngf), extracellular signal-regulated kinase (erk), phosphorylated-erk (p-erk), cyclic adenosine monophosphate response element-binding (creb), p-creb, synaptophysin (syp), synapsin (syn), and postsynaptic density-95 (psd95) were measured via western blot. |
2018-03-26 |
2023-08-13 |
rat |
| Yanan Li, Xinran Li, Cen Guo, Lina Li, Yuxin Wang, Yiming Zhang, Yu Chen, Wenhan Liu, Li Ga. Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28415680. |
we found that ketamine caused long-term neurocognitive dysfunction, reduced the density of the dendritic spin, caused neuronal loss, and down-regulated the expression of ngf, erk, p-erk, mitogen, and stress-activated protein kinase (msk), creb, p-creb, syp, syn, and psd95 in the hippocampus. |
2018-03-26 |
2023-08-13 |
rat |
| Divya Pathak, Amandine Berthet, Jacob T Bendor, Katharine Yu, Rhyomi C Sellnow, Adam L Orr, Mai K Nguyen, Robert H Edwards, Fredric P Manfredsson, Ken Nakamur. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. eNeuro. vol 4. issue 2. 2018-03-08. PMID:28462393. |
we found that αsyn knockout (ko) does not affect the respiration of cultured hippocampal neurons or cortical and dopaminergic synaptosomes, and that neither loss of αsyn nor all three (α, β and γ) syn isoforms decreased mitochondria-derived atp levels at the synapse. |
2018-03-08 |
2023-08-13 |
Not clear |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
high fat diet (hfd)-induced obesity has been shown to reduce the levels of neuronal plasticity-related proteins, specifically brain-derived neurotrophic factor (bdnf) and synaptophysin (syn), in the hippocampus. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
one goal of this study was to determine whether hyperglycemia and hyperlipidemia could cause hippocampal ers in hfd-induced obese sd rats, and explore the potential mechanisms of ers regulating hippocampal bdnf and syn proteins production. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
additionally, although regular aerobic exercise could reduce central inflammation and elevate hippocampal bdnf and syn levels in obese rats, the regulated mechanisms are poorly understood. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
therefore, the other goal of this study was to determine whether aerobic exercise could activate nrf2-ho-1 in hippocampus to alleviate obesity-induced hippocampal ers, which would lead to increased bdnf and syn levels. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
these results suggest that dietary obesity could induce hippocampal ers in male sd rats, and excessive hippocampal ers plays a critical role in decreasing the levels of bdnf and syn. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
moreover, aerobic exercise could activate hippocampal nrf2 and ho-1 to relieve ers and heighten bdnf and syn production in obese rats. |
2018-01-11 |
2023-08-13 |
mouse |
| YuanBo Cui, ShanShan Ma, ChunYan Zhang, Wei Cao, Min Liu, DongPeng Li, PengJu Lv, Qu Xing, RuiNa Qu, Ning Yao, Bo Yang, FangXia Gua. Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer's disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis. Behavioural brain research. vol 320. 2017-12-27. PMID:28007537. |
the mechanisms underlying the improved cognitive function may be linked to hippocampal neurogenesis and an up-regulation of neuronal synaptic plasticity related proteins levels including silent information regulator 1 (sirt1), brain-derived neurotrophic factor (bdnf) and synaptophysin (syn). |
2017-12-27 |
2023-08-13 |
mouse |
| Ming-Rui Zhang, Chao Qu, Jia Sun, Cui Wang, Hong-Yan Li, Ye-Jun Zhang, Bing-Qiang Zhang, Wei Zo. [Different subtypes of estrogen receptor α and related signal molecules in the hippocampus are associated with spatial cognitive impairment of diabetic mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 3. 2017-10-03. PMID:28638916. |
meanwhile, using western blot, we detected the protein expressions of er-α36, er-α66, caveolin-1, pkcα, camp-response element binding protein 2 (creb2), and synaptophysin (syn) in the hippocampus of the mice. |
2017-10-03 |
2023-08-13 |
mouse |
| Xia Tian, Yanlin Liu, Guangwei Ren, Ling Yin, Xiaoyan Liang, Tao Geng, Heqin Dang, Rufeng A. Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity. Brain research. vol 1650. 2017-08-21. PMID:27566063. |
our results showed that the cognitive performances in diabetic group were markedly deteriorated, accompanied by noticeable alterations in oxidative as well as inflammation parameters, syn and gap-43 expression were reduced in the hippocampus. |
2017-08-21 |
2023-08-13 |
rat |
| Wen-Guang Xia, Chan-Juan Zheng, Xuan Zhang, Juan Wan. Effects of "nourishing liver and kidney" acupuncture therapy on expression of brain derived neurotrophic factor and synaptophysin after cerebral ischemia reperfusion in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 2. 2017-06-13. PMID:28397041. |
the aim of the present study was to investigate the effect of "nourishing liver and kidney" acupuncture therapy on motor and cognitive deficits, and the underlying mechanism following cerebral ischemia-reperfusion (i/r) via increasing the expression of brain derived neurotrophic factor (bdnf) and synaptophysin (syn) in the hippocampus. |
2017-06-13 |
2023-08-13 |
rat |
| Wen-Guang Xia, Chan-Juan Zheng, Xuan Zhang, Juan Wan. Effects of "nourishing liver and kidney" acupuncture therapy on expression of brain derived neurotrophic factor and synaptophysin after cerebral ischemia reperfusion in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 2. 2017-06-13. PMID:28397041. |
the expression of bdnf and syn in the hippocampus was detected by immunohistochemical sp method and the synaptic structure in hippocampus area was assessed morphologically and quantitatively at the 3rd, 7th and 14th day. |
2017-06-13 |
2023-08-13 |
rat |