| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Lv, Min Wang, He-Sheng Zheng, Jin-Dong Mao, Fan Yang, Le Yang, Ming-Gao Zhao, Shui-Bing Liu, Kun Zhang, Rui Liu, Yu-Mei W. Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity via Wnt/β-catenin signaling pathway. Brain research bulletin. 2023-08-16. PMID:37586426. |
this was paralleled by correcting abnormal neural plasticity by promoting the expression of psd95 and syn, as well as the number of dendritic spines in the hipp. |
2023-08-16 |
2023-09-07 |
Not clear |
| Yan-Li Jia, Wei Wang, Ning Han, Hong-Liang Sun, Fang-Ming Dong, Ya-Xue Song, Rong-Fang Feng, Jian-Hua Wan. The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating β-amyloid plaque formation and mitochondrial/synaptic deterioration in APP/PS1 mice. Biochemical and biophysical research communications. vol 658. 2023-04-05. PMID:37018887. |
the app/ps1 transgenic mice exhibited elevated expression of aβ40/aβ42 and mitochondrial fission protein dlp1 and reduced expression of synaptophysin (syn) and postsynaptic density protein 95 (psd95) reductions, as well as increased levels of neuronal apoptosis and ros in the hippocampus, and long-term treatment with ss31 reversed these effects. |
2023-04-05 |
2023-08-14 |
mouse |
| Jianping Wang, Yujiao Men, Zeyu Wan. Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model. ACS chemical neuroscience. 2023-02-21. PMID:36802487. |
synaptic function was determined by the levels of brain-derived neurotrophic factor (bdnf), postsynaptic density protein 95 (psd95), and synaptophysin (syn) in the hippocampus and cultured hippocampal neurons. |
2023-02-21 |
2023-08-14 |
mouse |
| Jianping Wang, Yujiao Men, Zeyu Wan. Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model. ACS chemical neuroscience. 2023-02-21. PMID:36802487. |
polydatin increased the number and length of dendrites of cultured hippocampal neurons from mice exposed to cums and alleviated cums-induced synaptic deficits by restoring bdnf, psd95, and syn levels in vivo and in vitro. |
2023-02-21 |
2023-08-14 |
mouse |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
cih accelerated apoptosis of hippocampal neurons and resulted in the synaptic plasticity deficit via downregulated synaptophysin (syn) protein level. |
2023-01-04 |
2023-08-14 |
mouse |
| Cong Lu, Zhen Wei, Yongquan Wang, Shuying Li, Litao Tong, Xinmin Liu, Bei Fan, Fengzhong Wan. Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity. Food & function. 2022-08-22. PMID:35993820. |
additionally, si administration regulated tryptophan (trp) metabolism by increasing 5-hydroxytryptamine (5-ht) levels, inhibiting the release of kynurenine (kyn) in the cortex and hippocampus, and elevating the expressions of synaptic plasticity-related protein markers such as postsynaptic density-95 (psd-95) and synaptophysin (syn). |
2022-08-22 |
2023-08-14 |
mouse |
| Huan Chen, Dan Qiao, Yao Si, Zhen He, Bohan Zhang, Chang Wang, Yizhou Zhang, Xuelin Wang, Yichun Shi, Chengran Cui, Huixian Cui, Sha L. Effects of membrane androgen receptor binding on synaptic plasticity in primary hippocampal neurons. Molecular and cellular endocrinology. 2022-07-08. PMID:35803447. |
while androgens did not cause a short-term increase in dendritic spine density of rat primary hippocampal neurons, they promoted the transformation of dendritic spines from thin to mushroom, promoted dendritic spine maturation, increased dendritic spine surface area, and rapidly increased psd95 and syn expression in the primary hippocampal neurons. |
2022-07-08 |
2023-08-14 |
mouse |
| Kwan-Yu Chan, Wen-Ching Tsai, Chien-Yi Chiang, Meei-Ling Sheu, Chih-Yang Huang, Yi-Ching Tsai, Chia-Yun Tsai, Chia-Jung Lu, Zih-Ping Ho, De-Wei La. Ameliorative Potential of Hot Compress on Sciatic Nerve Pain in Chronic Constriction Injury-Induced Rat Model. Frontiers in synaptic neuroscience. vol 14. 2022-06-10. PMID:35685245. |
synaptophysin (syn) expression in the cci+hot compression group was less than threefold in the cci group at both nerve injury sites and brain (somatosensory cortex and hippocampus). |
2022-06-10 |
2023-08-14 |
rat |
| Weisheng Li, Likui Lu, Dan Zhu, Jingliu Liu, Yajun Shi, Hongtao Zeng, Xi Yu, Jun Guo, Bin Wei, Yongle Cai, Miao Su. Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway. Ecotoxicology and environmental safety. vol 239. 2022-06-01. PMID:35643027. |
it was identified that naf treatment impaired the learning and memory abilities of the male offspring, reduced dendritic spine density, lowered postsynaptic density protein-95 (psd95) and synaptophysin (syn) expression in the male offspring's hippocampus, indicating that synaptic dysfunction may contribute to the cognitive impairment in the naf model. |
2022-06-01 |
2023-08-13 |
mouse |
| Zhu-Qing He, Peng-Fei Huan, Li Wang, Jian-Cheng H. Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling. Metabolic brain disease. 2022-03-01. PMID:35230626. |
additionally, pf improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the ca1 and ca3, and upregulating psd-95 as well as syn protein levels. |
2022-03-01 |
2023-08-13 |
mouse |
| Wenjuan Wang, Caiyun Deng, Fang Chen, Li Zhang, Yi Hu, Qin Lu, Aihua Zhan. Resveratrol attenuates methylmercury-induced neurotoxicity by modulating synaptic homeostasis. Toxicology and applied pharmacology. 2022-03-01. PMID:35231462. |
in the current study, in vivo and in vitro results both indicated that mehg causes a reduction in dendritic length and branching of neurons and decreases the levels of the hippocampal neuronal synaptic protein markers syn and psd-95. |
2022-03-01 |
2023-08-13 |
Not clear |
| Esfandiar Azad Marzabadi, Gholam Hossein Meftahi, Soheila Refah. Pretreatment with combined low-level laser therapy and methylene blue improves learning and memory in sleep-deprived mice. Lasers in medical science. 2022-01-21. PMID:35059872. |
we used the t-maze test, social interaction test (sit), and shuttle box to assess learning and memory and psd-95, gap-43, and synaptophysin (syn) markers to examine synaptic proteins levels in the hippocampus. |
2022-01-21 |
2023-08-13 |
mouse |
| Raghava Jagadeesh Salaka, Kala P Nair, Kiruthiga Annamalai, Bettadapura N Srikumar, Bindu M Kutty, Byrathnahalli S Shankaranarayana Ra. Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats. Journal of neuroscience research. vol 99. issue 6. 2021-11-17. PMID:33713475. |
accordingly, in the current study, we evaluated the effects of ee in chronic epilepsy-induced changes in behavioral hyperexcitability, synaptic transmission, synaptophysin (syn), and calbindin (cb) expression, hippocampal subfield volumes and cell density in male wistar rats. |
2021-11-17 |
2023-08-13 |
rat |
| Lucia E Grijalva, María I Miranda, Raúl G Parede. Differential changes in GAP-43 or synaptophysin during appetitive and aversive taste memory formation. Behavioural brain research. vol 397. 2021-11-15. PMID:32991926. |
previous studies have demonstrated that memory consolidation, in hippocampal dependent paradigms, induces plastic changes like increase in the concentration of proteins considered as markers of neuronal plasticity, such as the growth associated protein 43 (gap-43) and synaptophysin (syn). |
2021-11-15 |
2023-08-13 |
rat |
| D G Coughlin, R Ittyerah, C Peterson, J S Phillips, S Miller, K Rascovsky, D Weintraub, A D Siderowf, J E Duda, H I Hurtig, D A Wolk, C T McMillan, P A Yushkevich, M Grossman, E B Lee, J Q Trojanowski, D J Irwi. Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32892355. |
lewy body diseases (lbd) are characterized by alpha-synuclein (syn) pathology, but comorbid alzheimer's disease (ad) pathology is common and the relationship between these pathologies in microanatomic hippocampal subfields is understudied. |
2021-10-28 |
2023-08-13 |
human |
| D G Coughlin, R Ittyerah, C Peterson, J S Phillips, S Miller, K Rascovsky, D Weintraub, A D Siderowf, J E Duda, H I Hurtig, D A Wolk, C T McMillan, P A Yushkevich, M Grossman, E B Lee, J Q Trojanowski, D J Irwi. Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32892355. |
here we use digital histological methods to test the association between hippocampal syn pathology and the distribution of tau and amyloid-beta (aβ) pathology in lbd and contrast with ad subjects. |
2021-10-28 |
2023-08-13 |
human |
| Dalia A Mandour, M A Bendary, Amira E Alseme. Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin". Journal of molecular histology. vol 52. issue 5. 2021-10-04. PMID:34170456. |
in addition, sections of the hippocampus and prefrontal cortex revealed obvious histopathological changes, overexpression of p-tau protein and glial fibrillary acidic protein (gfap) with a decrease in the expression of synaptophysin (syn). |
2021-10-04 |
2023-08-13 |
rat |
| Martina Canatelli-Mallat, Francisco Lascaray, Maria Entraigues-Abramson, Enrique L Portiansky, Néstor Blamaceda, Gustavo R Morel, Rodolfo G Goy. Cryopreservation of a Human Brain and Its Experimental Correlate in Rats. Rejuvenation research. vol 23. issue 6. 2021-09-14. PMID:32340558. |
confocal microscopy for syn revealed that cryopreservation did not affect the synaptic network in the hippocampus. |
2021-09-14 |
2023-08-13 |
human |
| Justus Baecker, Krista Wartchow, Tina Sehm, Ali Ghoochani, Michael Buchfelder, Andrea Kleindiens. Treatment with the Neurotrophic Protein S100B Increases Synaptogenesis after Traumatic Brain Injury. Journal of neurotrauma. vol 37. issue 8. 2021-08-18. PMID:31597524. |
s100b enhanced significantly the synaptophysin (syn) expression and microglial activation (ectodysplasin [ed1]) in the hippocampus in tbi and uninjured sham animals. |
2021-08-18 |
2023-08-13 |
rat |
| Justus Baecker, Krista Wartchow, Tina Sehm, Ali Ghoochani, Michael Buchfelder, Andrea Kleindiens. Treatment with the Neurotrophic Protein S100B Increases Synaptogenesis after Traumatic Brain Injury. Journal of neurotrauma. vol 37. issue 8. 2021-08-18. PMID:31597524. |
triple-labelling with brdu, neun, and syn confirmed a significant participation of s100b in hippocampal synaptogenesis in tbi and uninjured sham animals. |
2021-08-18 |
2023-08-13 |
rat |