| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Coyle, Justin M Murphy, Brian Doyle, Anne Marie O'Donnell, John Gillick, Prem Pur. Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis. World journal of gastroenterology. vol 22. issue 19. 2017-04-10. PMID:27217698. |
to determine if expression of colonic tryptophan hydroxylase-2 (tph2), a surrogate marker of neuronal 5-hydroxytryptamine, is altered in hirschsprung's-associated enterocolitis. |
2017-04-10 |
2023-08-13 |
Not clear |
| Yan Fei, Xin Wang, Songsong Chen, Qiangqiang Zhou, Chao Zhang, Ying Li, Lihong Sun, Licai Zhan. Role of the RVM in Descending Pain Regulation Originating from the Cerebrospinal Fluid-Contacting Nucleus. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26961890. |
a significant downregulation of 5-ht-labeled neurons and tryptophan hydroxylase 2 (tph2) as the marker of 5-ht cells in the rvm, and 5-ht expression in spinal dorsal horn in both normal and chronic constriction injury (cci) rats after i.c.v. |
2017-03-03 |
2023-08-13 |
rat |
| Kanu Megha, Pravin S Deshmukh, Alok K Ravi, Ashok K Tripathi, Mahesh P Abegaonkar, Basu D Banerje. Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain. Cell biochemistry and biophysics. vol 73. issue 1. 2017-01-18. PMID:25672490. |
tyrosine hydroxylase (th) (for da, ne and e) and tryptophan hydroxylase (tph1 and tph2) (for serotonin) was also estimated. |
2017-01-18 |
2023-08-13 |
human |
| Kaitlyn M Harding, Joseph S Lonstei. Extensive juvenile "babysitting" facilitates later adult maternal responsiveness, decreases anxiety, and increases dorsal raphe tryptophan hydroxylase-2 expression in female laboratory rats. Developmental psychobiology. vol 58. issue 4. 2017-01-17. PMID:26806471. |
we examined the effect of chronic exposure to pups during post-weaning juvenile life (days 22-36) on adult maternal responsiveness, anxiety-related behaviors, and dorsal raphe tryptophan hydroxylase-2 (tph2) and serotonin transporter (sert) levels in nulliparous rats. |
2017-01-17 |
2023-08-13 |
rat |
| Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. European archives of psychiatry and clinical neuroscience. vol 266. issue 3. 2016-12-21. PMID:26100147. |
using a highly sensitive enzyme-linked immunosorbent assay, we studied bdnf concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (tph)2-deficient (tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (sert)-deficient (sert(-/-)) mice lacking serotonin re-uptake. |
2016-12-21 |
2023-08-13 |
mouse |
| Jin Gao, Mingrui Jia, Dongdong Qiao, Huimin Qiu, Jeremy Sokolove, Jingxuan Zhang, Zhenglun Pa. TPH2 gene polymorphisms and bipolar disorder: A meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 171B. issue 2. 2016-12-13. PMID:26365518. |
tryptophan hydroxylase-2 (tph2) is an important rate-limiting enzyme in the synthetic pathway for brain serotonin and has been suggested to play a role in bd. |
2016-12-13 |
2023-08-13 |
Not clear |
| R Hiroi, D L Carbone, D G Zuloaga, H A Bimonte-Nelson, R J Hand. Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood. Neuroscience. vol 320. 2016-12-13. PMID:26844389. |
tph2 is the rate-limiting enzyme for serotonin (5-ht) synthesis and has been implicated in the etiology of human affective disorders. |
2016-12-13 |
2023-08-13 |
human |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of tph2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. |
2016-10-19 |
2023-08-13 |
rat |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
crhr2 blockade prevented stress-induced increases of tph2 activity within the drd/drc, while blockade of crhr1 potentiated stress-induced tph2 activity in the entire dr. stress-induced tph2 activity in the drd/drc furthermore predicted tph2 activity in the amygdala and in the caudal pontine reticular nucleus (pnc), while serotonin synthesis in the pnc was strongly correlated with the maximum startle response. |
2016-10-19 |
2023-08-13 |
rat |
| Jodi L Lukkes, Kevin J Norman, Shirisha Meda, Susan L Anderse. Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area. Synapse (New York, N.Y.). vol 70. issue 3. 2016-10-17. PMID:26696011. |
the serotonin and catecholamine enzymes in the dr and vta, tryptophan hydroxylase 2 (tph2) and tyrosine hydroxylase, respectively, were also analyzed for maturational differences. |
2016-10-17 |
2023-08-13 |
rat |
| Christina M Ragan, Kaitlyn M Harding, Joseph S Lonstei. Associations among within-litter differences in early mothering received and later emotional behaviors, mothering, and cortical tryptophan hydroxylase-2 expression in female laboratory rats. Hormones and behavior. vol 77. 2016-09-15. PMID:26219576. |
medial prefrontal cortex expression of tryptophan hydroxylase-2 (tph2; enzyme necessary for serotonin synthesis) was negatively associated with early maternal licking received. |
2016-09-15 |
2023-08-13 |
rat |
| Alexander V Kulikov, Nina K Popov. Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives? Reviews in the neurosciences. vol 26. issue 6. 2016-09-09. PMID:26167977. |
tryptophan hydroxylase 2 (tph2) is the key and rate-limiting enzyme in 5-ht synthesis in the brain. |
2016-09-09 |
2023-08-13 |
human |
| Alexander V Kulikov, Nina K Popov. Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives? Reviews in the neurosciences. vol 26. issue 6. 2016-09-09. PMID:26167977. |
the main conclusions of this review are as follows: (i) the brain 5-ht deficiency contributes to the mechanism underlying sad, (ii) tph2 is involved in the regulation of some kinds of genetically defined affective disorders and (iii) the activation of 5-ht synthesis with exogenous l-tryptophan alone or in combination with light therapy could be effective in sad treatment. |
2016-09-09 |
2023-08-13 |
human |
| Rani K Vasudeva, Alexander R Hobby, Lynn G Kirb. Ethanol consumption in the Sprague-Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine. Behavioural brain research. vol 295. 2016-09-05. PMID:26073764. |
quantification of 5-ht depletion in the dorsal raphe nucleus (drn) using tryptophan hydroxylase-2 (tph2) immunohistochemistry resulted in a 76% decrease in staining with 5,7-dht treatment. |
2016-09-05 |
2023-08-13 |
rat |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
cellular resilience: 5-ht neurons in tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-ht. |
2016-08-26 |
2023-08-13 |
mouse |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
we report that the active properties of dorsal raphe nucleus (drn) 5-ht neurons in vivo (firing rate magnitude and variability; the presence of spike doublets) and in vitro (firing in response to depolarizing current pulses; action potential shape) as well as the resting membrane potential remained essentially unchanged across tph2 genotypes. |
2016-08-26 |
2023-08-13 |
mouse |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
this difference may at least in part be a consequence of slightly bigger size of the drn 5-ht neurons in tph2(-/-) mice (approximately 10%, p<0.0001). |
2016-08-26 |
2023-08-13 |
mouse |
| Michael M Havranek, Matthias Vonmoos, Christian P Müller, Jessica R Büetiger, Eve Tasiudi, Lea M Hulka, Katrin H Preller, Rainald Mössner, Edna Grünblatt, Erich Seifritz, Boris B Quedno. Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 13. 2016-08-25. PMID:26013962. |
several significant gene × environment interactions between 5-ht genotypes and cocaine use on wm emerged: in cocaine users, the long/long (5-httlpr), 9+10/9+10 (vntr in2) and c/c (tph2 rs1386497) genotypes were risk alleles for wm impairments, whereas in healthy controls these polymorphisms were associated with improved wm performance. |
2016-08-25 |
2023-08-13 |
human |
| Rui Weng, Sensen Shen, Yonglu Tian, Casey Burton, Xinyuan Xu, Yi Liu, Cuilan Chang, Yu Bai, Huwei Li. Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific reports. vol 5. 2016-08-10. PMID:26154191. |
serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (tph) using p-chlorophenylalanine (pcpa) or genetic knockout of the neuronal specific tph2 isoform. |
2016-08-10 |
2023-08-13 |
mouse |
| Rui Weng, Sensen Shen, Yonglu Tian, Casey Burton, Xinyuan Xu, Yi Liu, Cuilan Chang, Yu Bai, Huwei Li. Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific reports. vol 5. 2016-08-10. PMID:26154191. |
this dual approach improved specificity for the serotonin deficiency-associated biomarkers while minimizing nonspecific effects of pcpa treatment or tph2 knockout (tph2-/-). |
2016-08-10 |
2023-08-13 |
mouse |