| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A G Galyamina, I L Kovalenko, D A Smagin, N N Kudryavtsev. [Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 67. issue 1. 2019-02-19. PMID:30695556. |
'we found that genes, related with serotonin (tph2, maob, sic6a4, htr4, htr1a) were upregulated but expression of htr3a gene was downregulated in the ventral tegmental area of depressive mice in comparison with the control. |
2019-02-19 |
2023-08-13 |
mouse |
| Mihye Ko, Smi Choi-Kwon, Sang-Eun Jun, Ju Han Kim, Kyung-Hee Cho, Hyun-Wook Nah, Hasup Song, Jong S Ki. Poststroke emotional disturbances and a tryptophan hydroxylase 2 gene polymorphism. Brain and behavior. vol 8. issue 2. 2019-02-11. PMID:29484259. |
despite reports on serotonergic involvement in the etiology of poststroke emotional dysfunction (psed), the role of serotonin synthesizing tryptophan hydroxylase 2 (tph2) genes in the development of psed remains unclear. |
2019-02-11 |
2023-08-13 |
Not clear |
| Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booi. TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 92. 2019-02-11. PMID:29775696. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in brain serotonin synthesis. |
2019-02-11 |
2023-08-13 |
Not clear |
| Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booi. TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 92. 2019-02-11. PMID:29775696. |
characterizing how exactly the different tph2 variants influence the serotonergic neurotransmission is a next necessary step in understanding the psychiatric disorders where serotonin is implicated. |
2019-02-11 |
2023-08-13 |
Not clear |
| Yi Zhang, Cuiyuan Jin, Xiaoyu Wang, Manlu Shen, Jiajie Zhou, Sisheng Wu, Zhengwei Fu, Yuanxiang Ji. Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice. Environmental toxicology. vol 34. issue 1. 2019-01-28. PMID:30251769. |
it was observed that acute or chronic exposure to pm changed the levels of serotonin (5-ht) and dopamine in the serum and colon and the transcription of tph2 and drd2 in the colons of mice. |
2019-01-28 |
2023-08-13 |
mouse |
| Alexander V Kulikov, Raul R Gainetdinov, Evgeni Ponimaskin, Allan V Kalueff, Vladimir S Naumenko, Nina K Popov. Interplay between the key proteins of serotonin system in SSRI antidepressants efficacy. Expert opinion on therapeutic targets. vol 22. issue 4. 2019-01-03. PMID:29542343. |
specifically, it discusses: (1) the data on the association between antidepressant drug efficacy and genetically defined characteristics of key proteins in the 5-ht signaling (tph2, maoa, sert and 5-ht |
2019-01-03 |
2023-08-13 |
Not clear |
| Melanie Y Vincent, Nina C Donner, David G Smith, Christopher A Lowry, Lauren Jacobso. Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice. Neuroscience letters. vol 665. 2018-11-13. PMID:29174640. |
drn gr deletion increased tph2 mrna levels in the dorsal, lateral wing, and caudal parts of the drn without altering tissue concentrations of 5-ht, 5-hiaa, or the 5-hiaa/5-ht ratio in limbic forebrain regions. |
2018-11-13 |
2023-08-13 |
mouse |
| Melanie Y Vincent, Nina C Donner, David G Smith, Christopher A Lowry, Lauren Jacobso. Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice. Neuroscience letters. vol 665. 2018-11-13. PMID:29174640. |
we conclude that drn gr inhibit drn tph2 gene expression in mice without marked effects on serotonin metabolism, at least under basal conditions at the circadian nadir. |
2018-11-13 |
2023-08-13 |
mouse |
| Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielse. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric genetics. vol 27. issue 5. 2018-07-27. PMID:28590957. |
genetic moderation of cocaine subjective effects by variation in the tph1, tph2, and slc6a4 serotonin genes. |
2018-07-27 |
2023-08-13 |
Not clear |
| Wei-Yang Xiao, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Li. Tributyltin impaired reproductive success in female zebrafish through disrupting oogenesis, reproductive behaviors and serotonin synthesis. Aquatic toxicology (Amsterdam, Netherlands). vol 200. 2018-07-25. PMID:29775928. |
in addition, tbt significantly suppressed the expressions of serotonin-related genes, such as tph2 (encoding serotonin synthase), pet1 (marker of serotonin neuron) and kiss 1 (the modulator of serotonin synthesis), suggesting that tbt might disrupt the non-reproductive behaviors of zebrafish. |
2018-07-25 |
2023-08-13 |
zebrafish |
| J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell, M R Arnold, B Aboagye, A Schmitt-Böhrer, C A Lowry, H C Pape, K P Lesc. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Translational psychiatry. vol 7. issue 10. 2018-06-14. PMID:28972592. |
here we investigate the influence of constitutively deficient 5-ht synthesis on stressor-related anxiety-like behaviors using tryptophan hydroxylase 2 (tph2) mutant mice. |
2018-06-14 |
2023-08-13 |
mouse |
| J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell, M R Arnold, B Aboagye, A Schmitt-Böhrer, C A Lowry, H C Pape, K P Lesc. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Translational psychiatry. vol 7. issue 10. 2018-06-14. PMID:28972592. |
our findings indicate that constitutive tph2 inactivation and consequential lack of 5-ht synthesis in tph2 null mutant mice (tph2 |
2018-06-14 |
2023-08-13 |
mouse |
| Feng Wang, Mingliang Fang, David E Hinton, Melissa Chernick, Shenglan Jia, Yingdan Zhang, Lingtian Xie, Wenjing Dong, Wu Don. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere. vol 198. 2018-05-29. PMID:29421749. |
moreover, exposure to 100 nm 6-oh-bde-47 significantly reduced the number of hypothalamic 5-hydroxytryptamine (5-ht, serotonin)-immunoreactive (5-ht-ir) neurons and the mrna expression of tryptophan hydroxylase 2 (tph2). |
2018-05-29 |
2023-08-13 |
zebrafish |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
the interaction between sert and the key enzyme of 5-ht synthesis in the brain, tryptophan hydroxylase 2 (tph2), is essential to maintain the brain 5-ht level. |
2018-04-27 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
the polymorphism did not affect the levels of 5-ht, its metabolite, 5-hydroxyindoleacetic acid (5-hiaa) and tph2 gene mrna in the brain. |
2018-04-27 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
fluoxetine significantly attenuated 5-ht levels in the cortex and striatum, 5-hiaa concentrations in the cortex, hippocampus, striatum and midbrain, and tph2 gene expression in the midbrain. |
2018-04-27 |
2023-08-13 |
mouse |
| D A Nikishin, N M Alyoshina, Y B Shmukle. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Doklady. Biochemistry and biophysics. vol 478. issue 1. 2018-04-09. PMID:29536299. |
using rt-pcr, we showed the presence of tph1 mrna in follicular cells and tph2 mrna in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle. |
2018-04-09 |
2023-08-13 |
mouse |
| Maurizio Pompili, Giovanna Gentile, Catia Scassellati, Cristian Bonvicini, Marco Innamorati, Denise Erbuto, Franco Montebovi, Giuseppe Ducci, Alberto Forte, Eleonora De Pisa, Stefano Ferracuti, Gianluca Serafini, Vincenzo De Luca, Mario Amore, Maurizio Simmaco, Paolo Girard. Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients. Neuroscience letters. vol 656. 2018-04-05. PMID:28716530. |
we aimed to investigate functional polymorphisms in eight genes (serotonin transporter, slc6a4; receptors, 5htr1a, 1b, 5htr2a; tryptophan hydroxylase, tph1, tph2; monoamine oxidase, maoa and g protein subunit beta 3, gnb3) to investigate their predictive value for suicide. |
2018-04-05 |
2023-08-13 |
Not clear |
| Patricia Gassó, Natalia Rodríguez, Daniel Boloc, Ana Blázquez, Teresa Torres, Ana Gortat, Maria Teresa Plana, Amalia Lafuente, Sergi Mas, Joan Albert Arnaiz, Luisa Lázar. Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28456685. |
tph2 is one of the most important serotonergic candidate genes in selective serotonin reuptake inhibitors (ssris) pharmacogenetic studies. |
2018-03-05 |
2023-08-13 |
human |
| Helene Bach, Victoria Arango, Suham A Kassir, Andrew J Dwork, J John Mann, Mark D Underwoo. Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides. Archives of suicide research : official journal of the International Academy for Suicide Research. vol 20. issue 3. 2018-01-24. PMID:26954509. |
tryptophan hydroxylase (tph2) synthesizes serotonin and is over-expressed in suicides. |
2018-01-24 |
2023-08-13 |
Not clear |