| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberto Laureano-Melo, Janaina Sena de Souza, Rodrigo Rodrigues da Conceição, Josie Marcelle Lira Albuquerque, Nayana Coutinho Rodrigues, Bruno Guimarães Marinho, Emerson Lopes Olivares, Gisele Giannocco, Wellington da Silva Côrte. Prenatal thyroxine treatment promotes anxiolysis in male Swiss mice offspring. Hormones and behavior. vol 108. 2020-01-22. PMID:30576638. |
in the hippocampus, t4 offspring had a higher expression of tryptophan hydroxylase 2 (tph2), serotonin transporter (sert) and glutamate decarboxylase 67 (gad 67) in comparison to controls. |
2020-01-22 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Dariya V Fursenko, Elizabeth A Kulikova, Nikita V Khotskin, Nadezhda A Sinyakova, Alexander A Kuliko. Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity. Neuroscience letters. vol 699. 2019-12-17. PMID:30685409. |
tryptophan hydroxylase-2 (tph2) is the key enzyme of 5-ht synthesis in the brain. |
2019-12-17 |
2023-08-13 |
mouse |
| Kasper D Tidemand, Hans E M Christensen, Niclas Hoeck, Pernille Harris, Jane Boesen, Günther H Peter. Stabilization of tryptophan hydroxylase 2 by l-phenylalanine-induced dimerization. FEBS open bio. vol 6. issue 10. 2019-11-20. PMID:27761358. |
tryptophan hydroxylase 2 (tph2) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. |
2019-11-20 |
2023-08-13 |
human |
| Yukino Nawa, Hanae Kaneko, Masayuki Oda, Masaaki Tsubonoya, Tomoko Hiroi, Maria Teresa Gentile, Luca Colucci-D'Amato, Ryoya Takahashi, Hiroaki Matsu. Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression. Journal of neurochemistry. vol 142. issue 6. 2019-11-20. PMID:28464229. |
tryptophan hydroxylase 2 (tph2) is the key enzyme in the synthesis of neuronal serotonin. |
2019-11-20 |
2023-08-13 |
human |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
depletion of brain 5-ht in tph2 mutant mice resulted in reduced behavioural despair, reduced anxiety, marked aggression and lower habituation in novel environments, reminiscent of bipolar-associated manic behaviour. |
2019-11-18 |
2023-08-13 |
mouse |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
role of the allelic variation in the 5-hydroxytryptamine receptor 1a (htr1a) and the tryptophan hydroxylase 2 (tph2) genes in the development of ptsd. |
2019-09-16 |
2023-08-13 |
Not clear |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
the aim of this study was to investigate the potential role of single nucleotide polymorphisms (snps) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1a (htr1a) and tryptophan hydroxylase 2 (tph2) in the pathogenesis of ptsd and comorbid psychopathology. |
2019-09-16 |
2023-08-13 |
Not clear |
| Narek Israelyan, Andrew Del Colle, Zhishan Li, Yeji Park, Albert Xing, Jacob P R Jacobsen, Ruth Ann Luna, Dane D Jensen, Moneek Madra, Virginia Saurman, Ray Rahim, Rocco Latorre, Kimberly Law, William Carson, Nigel W Bunnett, Marc G Caron, Kara G Margoli. Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression. Gastroenterology. vol 157. issue 2. 2019-08-26. PMID:31071306. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in 5-ht biosynthesis. |
2019-08-26 |
2023-08-13 |
mouse |
| V M Pokrovskii, Yu V Kashina, O V Kiek, O V Gumerova, V Yu Gorbunova, V G Abushkevich, A G Penzhoyan, N V Zabolotskik. Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism. Bulletin of experimental biology and medicine. vol 166. issue 4. 2019-07-15. PMID:30783842. |
we performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase tph1 (a218c polymorphism) and tph2 (g703t polymorphism), and serotonin receptors (htr2c and htr2a genes). |
2019-07-15 |
2023-08-13 |
human |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Shi-Feng Chu, Zheng Mou, Nai-Hong Che. The effects of glucocorticoids on depressive and anxiety-like behaviors, mineralocorticoid receptor-dependent cell proliferation regulates anxiety-like behaviors. Behavioural brain research. vol 362. 2019-07-11. PMID:30654121. |
it was interesting to find that the level of serotonin (5-ht) and the expression of tryptophan hydroxylase-2 (tph2) were decreased after cus in the hippocampus in sham rats, while adrenalectomy (adx) prevented such decreases. |
2019-07-11 |
2023-08-13 |
rat |
| Marta Pratelli, Massimo Pasqualett. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models. Biochimie. vol 161. 2019-07-08. PMID:30513372. |
in 2003 it became evident that two distinct isoforms of tryptophan hydroxylase (tph), the rate-limiting enzyme for the synthesis of serotonin, are selectively expressed in peripheral tissues and in the cns, with tph2 as the brain specific isoform. |
2019-07-08 |
2023-08-13 |
human |
| Marta Pratelli, Massimo Pasqualett. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models. Biochimie. vol 161. 2019-07-08. PMID:30513372. |
we mainly focus on the analysis of animal models generated by genetic manipulation of tph2, in which the synthesis of brain serotonin was either reduced or disrupted. |
2019-07-08 |
2023-08-13 |
human |
| Jianying Yu, Zaiquan Dong, Tao Yu, Xirong Li, Xueli Su. [Association of TPH2 gene polymorphism with response to antidepressant treatment among ethnic Han Chinese population]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 35. issue 4. 2019-06-24. PMID:30098258. |
to assess the association of tph2 gene polymorphisms with the response or remission to selective serotonin reuptake inhibitors (ssris) drugs during treatment of major depressive disorder. |
2019-06-24 |
2023-08-13 |
Not clear |
| Charlotte S Auth, Magdalena T Weidner, Sandy Popp, Tatyana Strekalova, Angelika G Schmitt-Böhrer, Daniel LA van den Hove, Klaus-Peter Lesch, Jonas Waide. Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 11. 2019-05-29. PMID:30146458. |
in order to further elucidate the interaction of genetic predisposition and adversity in early, developmental stages on anxiety-related behaviours, the current study employed tryptophan hydroxylase 2 (tph2)-deficient female mice, as a model for lifelong brain 5-ht synthesis deficiency. |
2019-05-29 |
2023-08-13 |
mouse |
| b' Guillemette Fouquet, Tereza Coman, Olivier Hermine, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin, hematopoiesis and stem cells. Pharmacological research. vol 140. 2019-05-13. PMID:30107202.' |
since the generation of tryptophan hydroxylase (tph1 and tph2) knockout mice, unsuspected roles have been identified for serotonin synthesized outside the brain. |
2019-05-13 |
2023-08-13 |
mouse |
| Huan Liu, Qingyi Huang, Hanzhi Sun, Jieming Li, Qianwen Lin, Haoming Wu, Chunhong Li. Effects of separate or combined exposure of nonylphenol and octylphenol on central 5-HT system and related learning and memory in the rats. Ecotoxicology and environmental safety. vol 172. 2019-04-29. PMID:30743168. |
levels of estrogen receptor β (erβ), 5-ht, tryptophan hydroxylase 2 (tph2), monoamine oxidase (maoa) enzyme, serotonin transporter (sert), the vesicular monoamine transporter 2 (vmat2), 5-hydroxytryptamine 1 a (5-ht |
2019-04-29 |
2023-08-13 |
rat |
| Anoosha Attaran, Arash Salahinejad, Adam L Crane, Som Niyogi, Douglas P Chiver. Chronic exposure to dietary selenomethionine dysregulates the genes involved in serotonergic neurotransmission and alters social and antipredator behaviours in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). vol 246. 2019-04-09. PMID:30623840. |
in the zebrafish brain, we found significant upregulation in the mrna expression of serotonin receptors (htr1aa and htr1b), a transporter (slc6a4a), and tryptophan hydroxylase-2 (tph2), whereas there was a downregulation of the monoamine oxidase (mao) gene. |
2019-04-09 |
2023-08-13 |
zebrafish |
| Adrian M Russo, Adam J Lawther, Benjamin M Prior, Luke Isbel, W Gregory Somers, John A Lesku, Amanda L Richdale, Cheryl Dissanayake, Stephen Kent, Christopher A Lowry, Matthew W Hal. Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice. Behavioural brain research. vol 359. 2019-04-03. PMID:29935278. |
for example, balb/c mice carry a loss-of-function single nucleotide polymorphism (snp; c1473 g) in tryptophan hydroxylase 2 (tph2), which encodes the brain-specific isoform of the rate-limiting enzyme for serotonin synthesis, and these mice frequently have been used to model symptoms of asd. |
2019-04-03 |
2023-08-13 |
mouse |
| Claudia Schoenichen, Christoph Bode, Daniel Duerschmie. Role of platelet serotonin in innate immune cell recruitment. Frontiers in bioscience (Landmark edition). vol 24. 2019-04-01. PMID:30468670. |
peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (tph), which exists in two different isoforms: tph2 being responsible for serotonin synthesis in neurons and tph1 for generation of serotonin in peripheral organs. |
2019-04-01 |
2023-08-13 |
Not clear |
| Hailong Shi, Yaya Cui, Yifei Qi. Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug. Chemical biology & drug design. vol 91. issue 1. 2019-02-20. PMID:28719094. |
two distinct tryptophan hydroxylases (tph), tph1 and tph2, are the rate-limiting enzymes in the 5-ht biosynthesis process. |
2019-02-20 |
2023-08-13 |
rat |