| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margus Maksimov, Mariliis Vaht, Carolina Murd, Jaanus Harro, Talis Bachman. Variants of TPH2 interact with fast visual processing as assessed by metacontrast. Neuroreport. vol 28. issue 2. 2018-01-10. PMID:27926628. |
in a sample of normal human individuals, we studied the effects of a single nucleotide polymorphism (rs4570625) in the gene that encodes the rate-limiting enzyme in serotonin synthesis, tph2, on metacontrast masking. |
2018-01-10 |
2023-08-13 |
human |
| Satoshi Ansai, Hiroshi Hosokawa, Shingo Maegawa, Kiyoshi Naruse, Youhei Washio, Kenji Sato, Masato Kinoshit. Deficiency of Serotonin in Raphe Neurons and Altered Behavioral Responses in Tryptophan Hydroxylase 2-Knockout Medaka (Oryzias latipes). Zebrafish. vol 14. issue 6. 2018-01-05. PMID:28933662. |
here, we established a medaka (oryzias latipes) strain with targeted disruption of tryptophan hydroxylase 2 (tph2) gene that is involved in the 5-ht synthesis in the raphe nuclei. |
2018-01-05 |
2023-08-13 |
Not clear |
| Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikso. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27189957. |
here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (tph2) g-703t polymorphism relates to differences in serotonin synthesis assessed with positron emission tomography. |
2017-12-28 |
2023-08-13 |
Not clear |
| Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikso. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27189957. |
in patients, the serotonin synthesis rate in the amygdala and anterior cingulate cortex was significantly elevated in tph2 t carriers in comparison with gg homozygotes. |
2017-12-28 |
2023-08-13 |
Not clear |
| Kasper D Tidemand, Günther H Peters, Pernille Harris, Eva Stensgaard, Hans E M Christense. Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase. Biochemistry. vol 56. issue 46. 2017-12-19. PMID:29035515. |
tph1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while tph2 catalyzes this step in the brain. |
2017-12-19 |
2023-08-13 |
human |
| Kara Kaplan, Ashley E Echert, Ben Massat, Madeleine M Puissant, Oleg Palygin, Aron M Geurts, Matthew R Hodge. Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 9. 2017-12-14. PMID:26869713. |
chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult tph2 knockout rats. |
2017-12-14 |
2023-08-13 |
mouse |
| Kara Kaplan, Ashley E Echert, Ben Massat, Madeleine M Puissant, Oleg Palygin, Aron M Geurts, Matthew R Hodge. Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 9. 2017-12-14. PMID:26869713. |
herein, we generated a mutant rat model with constitutive central nervous system (cns) 5-ht depletion by mutation of the tryptophan hydroxylase 2 (tph2) gene in dark agouti (da(tph2-/-)) rats. |
2017-12-14 |
2023-08-13 |
mouse |
| Scott A Givan, Kevin J Cumming. Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 11. 2017-12-14. PMID:26968026. |
in both groups the expression of the 5-ht transporter and tph2 was increased following ish. |
2017-12-14 |
2023-08-13 |
rat |
| S Neufang, A Akhrif, C G Herrmann, C Drepper, G A Homola, J Nowak, J Waider, A G Schmitt, K-P Lesch, M Romano. Serotonergic modulation of 'waiting impulsivity' is mediated by the impulsivity phenotype in humans. Translational psychiatry. vol 6. issue 11. 2017-12-04. PMID:27824354. |
subjects were genotyped for the tryptophan hydroxylase-2 (tph2; g-703t; rs4570625) variant, an enzyme specific for brain serotonin synthesis. |
2017-12-04 |
2023-08-13 |
human |
| Ning-Ning Song, Qiong Zhang, Ying Huang, Ling Chen, Yu-Qiang Ding, Lei Zhan. Enhanced dendritic morphogenesis of adult hippocampal newborn neurons in central 5-HT-deficient mice. Stem cell research. vol 19. 2017-11-22. PMID:28012347. |
here, we address this question using two central 5-ht-deficient mouse models, tph2 conditional knockout mice (cko) losing central 5-ht from embryonic stage, and pet1-cre;rosa26-dtr (diphtheria toxin receptor) mice lacking central 5-ht neurons exclusively in adulthood. |
2017-11-22 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Daria V Bazovkina, Elizabeth A Kulikova, Dariya V Fursenko, Nikita V Khotskin, Daria V Lichman, Alexander V Kuliko. C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress. Neuroscience letters. vol 640. 2017-10-24. PMID:28069454. |
tryptophan hydroxylase-2 (tph2) is the key enzyme of serotonin (5-ht) synthesis in the brain. |
2017-10-24 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Daria V Bazovkina, Elizabeth A Kulikova, Dariya V Fursenko, Nikita V Khotskin, Daria V Lichman, Alexander V Kuliko. C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress. Neuroscience letters. vol 640. 2017-10-24. PMID:28069454. |
the effect of interaction between c1473g polymorphism and 30min restriction stress on the behavior in the open field test, c-fos gene expression and 5-ht metabolism in the brain in adult male of b6-1473c and b6-1473g congenic mouse lines with high and low tph2 activity was investigated. |
2017-10-24 |
2023-08-13 |
mouse |
| Pei-Tan Hsueh, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Ya-Lei Chen, Jong-Kang Li. Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide. PloS one. vol 12. issue 6. 2017-09-18. PMID:28650979. |
the mrna expression levels of tph2 (5-ht synthesizing enzyme) and slc6a4 (5-ht transporter) were down-regulated in both adolescent (5 weeks of age) and adult (8 weeks of age) brains. |
2017-09-18 |
2023-08-13 |
mouse |
| Pei-Tan Hsueh, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Ya-Lei Chen, Jong-Kang Li. Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide. PloS one. vol 12. issue 6. 2017-09-18. PMID:28650979. |
we concluded that maternal immune activation induced by exposure to a low dose of lps decreased cerebral 5-ht levels in parallel to the down-regulation of the tph2 and slc6a4 genes and in conjunction with anxiety-like behaviors in offspring. |
2017-09-18 |
2023-08-13 |
mouse |
| Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancour. Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase. Biochimie. vol 140. 2017-09-15. PMID:28751217. |
moreover, it is not known if the two tryptophan hydroxylase isoforms (tph1 and tph2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. |
2017-09-15 |
2023-08-13 |
mouse |
| Meredith Sorenson Whitney, Ashley M Shemery, Alexandra M Yaw, Lauren J Donovan, J David Glass, Evan S Deneri. Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656022. |
here, we have developed a genetic approach that reproducibly achieves near-complete elimination of 5-ht synthesis from the adult ascending 5-ht system by stereotaxic injection of an adeno-associated virus expressing cre recombinase (aav-cre) into the midbrain/pons of mice carrying a loxp-conditional tryptophan hydroxylase 2 (tph2) allele. |
2017-08-17 |
2023-08-13 |
mouse |
| Honghai Zhang, Haiting Zhao, Xiaoxuan Yang, Qingsheng Xue, Joseph F Cotten, Hua-Jun Fen. 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. Epilepsia. vol 57. issue 8. 2017-06-20. PMID:27302625. |
the tryptophan hydroxylase-2 (tph2) enzyme converts l-tryptophan to 5-hydroxytryptophan (5-htp), a precursor for central nervous system (cns) serotonin (5-ht) synthesis; and dba/1 mice have a polymorphism that decreases tph2 activity. |
2017-06-20 |
2023-08-13 |
mouse |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:26975194. |
serotonin and the brain's rich club-association between molecular genetic variation on the tph2 gene and the structural connectome. |
2017-04-28 |
2023-08-13 |
Not clear |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:26975194. |
tryptophane hydroxylase 2 (tph2) is a rate-limiting enzyme in the biosynthesis of serotonin and is known to inhibit, in addition to its role as a trans-synaptic messenger, axonal and dendritic growth. |
2017-04-28 |
2023-08-13 |
Not clear |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:26975194. |
the tph2 t-variant has been associated with reduced mrna expression and reduced serotonin levels, which may particularly influence the development of macroscale anatomical connectivity. |
2017-04-28 |
2023-08-13 |
Not clear |