| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Haduch, Przemysław J Danek, Wojciech Kuban, Renata Pukło, Natalia Alenina, Joanna Gołębiowska, Piotr Popik, Michael Bader, Władysława A Danie. Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats. Neurochemistry international. vol 152. 2021-12-11. PMID:34780807. |
in summary, the aging process and tph2 deficit affect the cyp2d activity and protein level in female rats, which may have a negative impact on the compensatory capacity of cyp2d in the synthesis of serotonin and dopamine in cerebral structures involved in cognitive and emotional functions. |
2021-12-11 |
2023-08-13 |
rat |
| Valentina S Evsiukova, Daria Bazovkina, Ekaterina Bazhenova, Elizabeth A Kulikova, Alexander V Kuliko. Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish ( International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884655. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in 5-ht synthesis in the brain. |
2021-12-10 |
2023-08-13 |
zebrafish |
| Kento Igarashi, Toshiko Kuchiiwa, Satoshi Kuchiiwa, Haruki Iwai, Kazuo Tomita, Tomoaki Sat. Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels. Brain research. vol 1768. 2021-12-09. PMID:34260963. |
furthermore, gene expression of tryptophan hydroxylase (tph) 1 and tph2 were increased and 5-ht immunofluorescence was slightly increased in the dorsal raphe nucleus (drn) of isolation-reared mice administered with kss. |
2021-12-09 |
2023-08-13 |
mouse |
| Tianle Zhu, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhan. The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor. Andrology. 2021-12-07. PMID:34874128. |
although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (pe), tryptophan hydroxylase-2 (tph2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-ht) and few studies have reported that brain tph2 is involved in the regulation of ejaculation. |
2021-12-07 |
2023-08-13 |
Not clear |
| B Aboagye, T Weber, H L Merdian, D Bartsch, K P Lesch, J Waide. Serotonin deficiency induced after brain maturation rescues consequences of early life adversity. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686115. |
tamoxifen (tam)-induced cre/loxp-mediated inactivation of the tryptophan hydroxylase-2 gene (tph2) was used to investigate the effects of provoked 5-ht deficiency in adult mice (tph2 icko) previously subjected to maternal separation (ms). |
2021-11-22 |
2023-08-13 |
mouse |
| B Aboagye, T Weber, H L Merdian, D Bartsch, K P Lesch, J Waide. Serotonin deficiency induced after brain maturation rescues consequences of early life adversity. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686115. |
the impact of tph2 icko in interaction with ms stress (tph2 icko × ms) on physiological parameters, emotional behavior and expression of 5-ht system-related marker genes were assessed. |
2021-11-22 |
2023-08-13 |
mouse |
| B Aboagye, T Weber, H L Merdian, D Bartsch, K P Lesch, J Waide. Serotonin deficiency induced after brain maturation rescues consequences of early life adversity. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686115. |
tph2 icko mice displayed a significant reduction in 5-ht immunoreactive cells and 5-ht concentrations in the rostral raphe region within four weeks following tam treatment. |
2021-11-22 |
2023-08-13 |
mouse |
| Ross A McDevitt, Rosa Anna M Marino, Hugo A Tejeda, Antonello Bonc. Serotonergic inhibition of responding for conditioned but not primary reinforcers. Pharmacology, biochemistry, and behavior. vol 205. 2021-11-22. PMID:33836219. |
we next performed region-specific knock out of tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme in serotonin synthesis. |
2021-11-22 |
2023-08-13 |
mouse |
| Jessica Romero-Reyes, Edgar Ricardo Vázquez-Martínez, Daniel Bahena-Alvarez, Jessica López-Jiménez, Anayansi Molina-Hernández, Ignacio Camacho-Arroyo, Néstor Fabián Día. Differential localization of serotoninergic system elements in human amniotic epithelial cells†. Biology of reproduction. vol 105. issue 2. 2021-11-18. PMID:34057176. |
we found the expression of tryptophan hydroxylase type 1 (tph1), type 2 (tph2), serotonin transporter (sert), monoamine oxidase-a (maoa), as well as htr1d and htr7 receptors at mrna level in amnion tissue as well in haec. |
2021-11-18 |
2023-08-13 |
human |
| Gary C Mouradian, Madeline Kilby, Santiago Alvarez, Kara Kaplan, Matthew R Hodge. Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex. Physiological reports. vol 9. issue 13. 2021-11-10. PMID:34228894. |
infants that succumb to sudden infant death syndrome (sids) have reduced brainstem 5-ht levels and tryptophan hydroxylase 2 (tph2). |
2021-11-10 |
2023-08-13 |
rat |
| Luoyang Ding, Shane K Maloney, Mengzhi Wang, Jennifer Rodger, Lianmin Chen, Dominique Blach. Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep. Genes, brain, and behavior. vol 20. issue 3. 2021-11-09. PMID:33161622. |
variations like single nucleotide polymorphisms (snps) in the genes for tryptophan 5-hydroxylase (tph2), the serotonin transporter (slc6a4), the serotonin receptor (htr2a), and the oxytocin receptor (oxtr) are associated with behavioral phenotype in humans. |
2021-11-09 |
2023-08-13 |
Not clear |
| Chunyan Yao, Zhiyuan Wang, Huiyong Jiang, Ren Yan, Qianfei Huang, Yin Wang, Hui Xie, Ying Zou, Ying Yu, Longxian L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34211003. |
glaa administration increased the levels of the sleep-promoting neurotransmitter 5-hydroxytryptamine and the tph2, iptr3 and gng13 transcripts in the sleep-regulating serotonergic synapse pathway in the hypothalamus during this process. |
2021-11-08 |
2023-08-13 |
mouse |
| Chen Li, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun L. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31980728. |
here we show that adiponectin receptor 1 (adipor1) is expressed in the dorsal raphe nucleus (drn) and colocalized with tryptophan hydroxylase 2 (tph2), a marker of serotonin (5-ht) neurons. |
2021-11-02 |
2023-08-13 |
mouse |
| Chen Li, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun L. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31980728. |
the expression levels of tph2 were downregulated with a concurrent reduction of 5-ht-immunoreactivity in the drn and its two major projection regions, the hippocampus and medial prefrontal cortex (mpfc), in male but not female mice lacking adipor1 in 5-ht neurons. |
2021-11-02 |
2023-08-13 |
mouse |
| Manuel A Giannoni-Guzmán, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Douglas G McMaho. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. Journal of pineal research. vol 70. issue 2. 2021-11-01. PMID:33210730. |
we found that long photoperiod significantly reduced levels of kcnk2 in serotonin neurons co-expressing tph2, and pet-1. |
2021-11-01 |
2023-08-13 |
mouse |
| Weam Fageera, Sarojini M Sengupta, Marie-Ève Fortier, Natalie Grizenko, Svetlana Babienco, Aurelie Labbe, Ridha Joobe. Sex-dependent complex association of TPH2 with multiple dimensions of ADHD. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33677046. |
tryptophan hydroxylase 2 (tph2) is a key enzyme in the biosynthesis of serotonin in the brain. |
2021-11-01 |
2023-08-13 |
Not clear |
| Lu Xiao, Junyan Yan, Ting Yang, Jiang Zhu, Tingyu Li, Hong Wei, Jie Che. Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice. mSystems. vol 6. issue 2. 2021-10-28. PMID:33824200. |
western blotting detected the protein expression levels of tryptophan hydroxylase 1 (tph1), serotonin transporter (sert), and serotonin 1a receptor (5-ht1ar) in the colon and tph2, sert, and 5-ht1ar in the prefrontal cortex of mice. |
2021-10-28 |
2023-08-13 |
mouse |
| Chao-Jin Xu, Peng-Zhang, Ting-Li Dai, Xue-Yuan Niu, Jun-Ling Wang, Ming-Shun Jin, Min-Lia. Evaluation of blood-brain barrier permeability in tryptophan hydroxylase 2-knockout mice. Experimental and therapeutic medicine. vol 8. issue 5. 2021-10-21. PMID:25289042. |
tryptophan hydroxylase 2 (tph2) is a unique genetic enzyme isoform that catalyzes the rate-limiting step in the biosynthesis of 5-ht in the cns; however, its role in the permeability changes of the bbb remains unclear. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
tryptophan hydroxylase type 2 (tph2) is the rate-limiting enzyme for serotonin (5-ht) biosynthesis in the brain. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
dysfunctional tph2 alters 5-ht biosynthesis, leading to a deficiency of 5-ht, which could have repercussions on human behavior. |
2021-10-21 |
2023-08-13 |
mouse |