| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander V Kulikov, Maria A Tikhonova, Daria V Osipova, Victor A Kulikov, Nina K Popov. Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21726574. |
here, the influence of the 1473g allele on the antidepressant effect of selective serotonin reuptake inhibitors (ssris), citalopram (2.5 or 5.0mg/kg) and paroxetine (5.0 or 10.0mg/kg), in the forced swim test was studied using b6-1473g and b6-1473c congenic mouse lines with the 1473g (decreased tph2 activity) or 1473c (normal tph2 activity) alleles, respectively, transferred to the genome of c57bl/6 mouse strain. |
2011-12-09 |
2023-08-12 |
mouse |
| Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sor. Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886586. |
we analyzed the association between the variations in the brain tryptophan hydroxylase 2 (tph2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (meth) dependence/psychosis in a japanese population. |
2011-11-10 |
2023-08-12 |
Not clear |
| Kyung-Won Hong, Alexander Weiss, Naruki Morimura, Toshifumi Udono, Ikuo Hayasaka, Tatyana Humle, Yuichi Murayama, Shin'ichi Ito, Miho Inoue-Murayam. Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism. PloS one. vol 6. issue 7. 2011-11-09. PMID:21765945. |
in the brain, serotonin production is controlled by tryptophan hydroxylase 2 (tph2), a genotype. |
2011-11-09 |
2023-08-12 |
mouse |
| Kyung Bong Koh, Eun Hee Choi, Young-Joon Lee, Mooyoung Ha. Serotonin-related gene pathways associated with undifferentiated somatoform disorder. Psychiatry research. vol 189. issue 2. 2011-11-08. PMID:21531467. |
the genotype and allele frequencies of tryptophan hydroxylase (tph)1 a218c, tph2 rs1386494, serotonin receptor 2a-t102c (5-htr 2a-t102c), 5-htr 2a-g1438a and serotonin transporter (5httlpr) gene were compared between the groups. |
2011-11-08 |
2023-08-12 |
human |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
balb/c is an inbred stress-sensitive mouse strain exhibiting low brain serotonin (5-ht) content and a 5-ht biosynthetic enzyme tryptophan hydroxylase (tph2) variant reported to have lower catalytic activity compared with other inbred base strains. |
2011-11-01 |
2023-08-12 |
mouse |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
to evaluate other mechanisms that may explain low 5-ht, we compared balb/cj mice and a control inbred strain c57bl/6j mice, for expression of tph2 mrna, tph2 protein and regional levels of 5-ht and its metabolite 5-hydroxyindoleacetic acid. |
2011-11-01 |
2023-08-12 |
mouse |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
the behavioral differences in balb/cj mice relative to the c57bl/6j strain may be due in part, to fewer 5-ht neurons and lower tph2 gene expression resulting in less 5-ht neurotransmission. |
2011-11-01 |
2023-08-12 |
mouse |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
here we examine both the spatial and temporal profile of 5-ht related gene expression, including 5ht1a, 2a, 2c receptors, the 5-ht transporter (5htt), and tryptophan hydroxylase 2 (tph2) during early development (postnatal day [p]14, p17, p21, p28) in mice challenged with lipopolysaccharide (lps) during the first postnatal week. |
2011-10-31 |
2023-08-12 |
mouse |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
increased tph2 and 5htt expression in the ventrolateral region of the dr of lps-mice accompanied decreased expression of ventral dr 5ht1a and dorsal dr 5htt. |
2011-10-31 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
availability of 5-ht depends on the expression of the enzyme tryptophan hydroxylase (tph), and the recent discovery of a dual system for 5-ht synthesis in the brain (tph2) and periphery (tph1) has renewed interest in studying the potential functions played by 5-ht in nonnervous tissues. |
2011-10-18 |
2023-08-12 |
mouse |
| Thibault Renoir, Michelle S Zajac, Xin Du, Terence Y Pang, Leah Leang, Caroline Chevarin, Laurence Lanfumey, Anthony J Hanna. Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PloS one. vol 6. issue 7. 2011-10-13. PMID:21760962. |
while tissue levels of serotonin were reduced in both male and female hd mice, we found that serotonin concentration and hydroxylase-2 (tph2) mrna levels were higher in the hippocampus of males compared to female animals. |
2011-10-13 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
5-ht biosynthesis depends on tryptophan hydroxylase 1 (tph1) in ec cells and on tph2 in neurons; therefore, mice lacking tph1 and/or tph2 distinguish ec-derived from neuronal 5-ht. |
2011-08-22 |
2023-08-12 |
mouse |
| Elisabeth M Dykens, Elizabeth Roof, Douglas Bittel, Merlin G Butle. TPH2 G/T polymorphism is associated with hyperphagia, IQ, and internalizing problems in Prader-Willi syndrome. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 5. 2011-08-18. PMID:21418060. |
as aberrant serotonergic functioning is strongly implicated in pws, we examined associations between the pws phenotype and polymorphisms in tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in the biosynthesis of serotonin in the brain. |
2011-08-18 |
2023-08-12 |
Not clear |
| Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Din. Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21246047. |
after administration of tamoxifen, the level of 5-ht in the brain of lmx1b icko mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (tph2), serotonin transporter (sert) and vesicular monoamine transporter 2 (vmat2) was greatly down-regulated. |
2011-08-02 |
2023-08-12 |
mouse |
| Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Din. Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21246047. |
our results reveal that lmx1b is required for the biosynthesis of 5-ht in adult mouse brain, and it may be involved in maintaining normal functions of central 5-htergic neurons by regulating the expression of tph2, sert and vmat2. |
2011-08-02 |
2023-08-12 |
mouse |
| Chen Zhang, Zezhi Li, Yang Shao, Bin Xie, Yasong Du, Yiru Fang, Shunying Y. Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. Journal of molecular neuroscience : MN. vol 43. issue 3. 2011-07-21. PMID:20938755. |
tryptophan hydroxylase 2 (tph2), a newly identified isoform of tryptophan hydroxylase (the rate limiting enzyme in the biosynthesis of serotonin), regulates the brain-specific serotonin synthesis. |
2011-07-21 |
2023-08-12 |
human |
| Nurgul Carkaci-Salli, Ugur Salli, Kara L Kuntz-Melcavage, Michael M Pennock, Hande Ozgen, Izel Tekin, Willard M Freeman, Kent E Vran. TPH2 in the ventral tegmental area of the male rat brain. Brain research bulletin. vol 84. issue 6. 2011-07-18. PMID:21272616. |
tph2 is the genetic isoform of tph that catalyzes the rate-limiting step in serotonin biosynthesis within the central nervous system. |
2011-07-18 |
2023-08-12 |
rat |
| Laurent Nexon, Dominique Sage, Paul Pévet, Sylvie Raiso. Glucocorticoid-mediated nycthemeral and photoperiodic regulation of tph2 expression. The European journal of neuroscience. vol 33. issue 7. 2011-07-18. PMID:21299657. |
in the syrian hamster dorsal and median raphé nuclei, the tryptophan hydroxylase 2 gene (tph2), which codes the rate-limiting enzyme of serotonin synthesis, displays daily variations in its expression in animals entrained to a long but not to a short photoperiod. |
2011-07-18 |
2023-08-12 |
Not clear |
| Prisila Dulcy Charles, Ganesh Ambigapathy, Pitchairaj Geraldine, Mohammad Abdulkadar Akbarsha, Koilmani Emmanuvel Raja. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. Journal of ethnopharmacology. vol 134. issue 1. 2011-07-14. PMID:21129470. |
bacopa monniera leaf extract up-regulates tryptophan hydroxylase (tph2) and serotonin transporter (sert) expression: implications in memory formation. |
2011-07-14 |
2023-08-12 |
rat |
| Massimo Cocchi, Lucio Tonello, Fabio Gabrielli, Massimo Pregnolat. Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology. Annals of general psychiatry. vol 10. 2011-07-14. PMID:21450092. |
moreover, it is believed that the hereditary or acquired involvement of tryptophan hydroxylase 2 (tph2) or 5-hydroxytryptamine transporter (5-htt) is responsible for the reduced concentration of serotonin in the central nervous system, causing depression and affective disorders. |
2011-07-14 |
2023-08-12 |
human |