| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Tikhonova, E L Alperina, T G Tolstikova, D V Bazovkina, V Y Di, G V Idova, A V Kulikov, N K Popov. Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes. Neuroscience and behavioral physiology. vol 40. issue 5. 2011-01-28. PMID:20464512. |
effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1a and 2a serotonin receptors and the tph2 and sert genes. |
2011-01-28 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
brain-specific conditional and time-specific inducible tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
we therefore studied different animal models featuring reduced tph2 expression to investigate the consequences of impaired brain 5-ht synthesis on neuronal development. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
raphe neurons of a brain-specific constitutive tph2 ko were completely devoid of tph2-positive neurons and, consequently, 5-ht in the brain, and also displayed no compensatory up-regulation of tph1 expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
these findings confirm the specificity of tph2 in brain 5-ht synthesis across the lifespan, yet also suggest that neither developmental nor adult 5-ht synthesis is required for the expression of genes specific for serotonergic signalling. |
2010-12-22 |
2023-08-12 |
mouse |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
the aim of this work was to investigat the role of protein gp130 in the regulation of expression of genes, coding the key enzyme of serotonin synthesis--tryptophan hydroxylase 2 (tph2), 5-ht-transporter, 5-ht(1a)- and 5-ht(2a)-receptors of serotonin. |
2010-12-17 |
2023-08-12 |
mouse |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
decreased expression of 5-ht(1a) - 5-ht(2a)-receptor genes in hippocampus midbrain and tph2 gene in midbrain in akr.cba-d13mit76 mice compared with akr mice were shown. |
2010-12-17 |
2023-08-12 |
mouse |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
the results indicate: 1) the participation of gp130 in the regulation of tph2, 5-ht(1a)- and 5-ht(2a)-receptor genes and 2) association of this protein in the genetically determined sensitivity to lps. |
2010-12-17 |
2023-08-12 |
mouse |
| William B Siesser, Xiaodong Zhang, Jacob P R Jacobsen, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice. Neuroscience letters. vol 481. issue 1. 2010-11-08. PMID:20600620. |
tryptophan hydroxylase 2 (tph2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-ht). |
2010-11-08 |
2023-08-12 |
mouse |
| Se-Hoon Shim, Young Hwangbo, Young-Joon Kwon, Hee-Yeon Jeong, Bun-Hee Lee, Jung-A Hwang, Yong-Ku Ki. A case-control association study of serotonin 1A receptor gene and tryptophan hydroxylase 2 gene in attention deficit hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20470849. |
we investigated the association of serotonin the 1a receptor c-1019g single nucleotide polymorphism (htr1a c-1019g snp) and tryptophan hydroxylase 2 gene -703g/t (tph2 -703g/t) snp with adhd. |
2010-11-02 |
2023-08-12 |
human |
| S F Tee, T J Chow, P Y Tang, H C Lo. Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population. Genetics and molecular research : GMR. vol 9. issue 3. 2010-10-19. PMID:20623453. |
association studies have focused on the tryptophan hydroxylase 2 gene (tph2) and the 5-hydroxytryptamine receptor 2a gene (5-htr2a). |
2010-10-19 |
2023-08-12 |
Not clear |
| S Kloiber, M A Kohli, T Brueckl, S Ripke, M Ising, M Uhr, A Menke, P G Unschuld, S Horstmann, D Salyakina, B Muller-Myhsok, E B Binder, F Holsboer, S Luca. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular psychiatry. vol 15. issue 7. 2010-10-18. PMID:19125159. |
this led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (tph2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be predictive for an increased liability for the development of mets in depressed patients. |
2010-10-18 |
2023-08-12 |
Not clear |
| Susann Matthes, Valentina Mosienko, Saleh Bashammakh, Natalia Alenina, Michael Bade. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. vol 85. issue 2. 2010-10-04. PMID:20130443. |
the peripheral and cerebral biosynthesis of 5-ht is initiated by two distinct tryptophan hydroxylases: tph1 and tph2. |
2010-10-04 |
2023-08-12 |
Not clear |
| Stefan Johansson, Anne Halmøy, Thegna Mavroconstanti, Kaya K Jacobsen, Elisabeth T Landaas, Andreas Reif, Christian Jacob, Andrea Boreatti-Hümmer, Susanne Kreiker, Klaus-Peter Lesch, Cornelis C Kan, J J Sandra Kooij, Lambertus A Kiemeney, Jan K Buitelaar, Barbara Franke, Marta Ribasés, Rosa Bosch, Mònica Bayés, Miguel Casas, Josep Antoni Ramos-Quiroga, Bru Cormand, Per Knappskog, Jan Haavi. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 5. 2010-09-29. PMID:20213726. |
the tryptophan hydroxylase 1 and 2 (tph1 and tph2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. |
2010-09-29 |
2023-08-12 |
Not clear |
| Christian P Jacob, Thuy Trang Nguyen, Astrid Dempfle, Monika Heine, Christine Windemuth-Kieselbach, Katarina Baumann, Florian Jacob, Julian Prechtl, Maike Wittlich, Martin J Herrmann, Silke Gross-Lesch, Klaus-Peter Lesch, Andreas Rei. A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder. European archives of psychiatry and clinical neuroscience. vol 260. issue 4. 2010-08-24. PMID:19894072. |
the present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes (coding for the serotonin transporter, 5-htt; the serotonin autoreceptor, htr1a; and the enzyme which synthesizes serotonin in the brain, tph2) with the burden of life events (#le) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit/hyperactivity disorder (aadhd). |
2010-08-24 |
2023-08-12 |
human |
| G-L Chen, M A Novak, J S Meyer, B J Kelly, E J Vallender, G M Mille. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys. Genes, brain, and behavior. vol 9. issue 3. 2010-08-20. PMID:20059554. |
tryptophan hydroxylase-2 (tph2) synthesizes neuronal serotonin and is linked to numerous behavioral traits. |
2010-08-20 |
2023-08-12 |
monkey |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Kyoichi Shiroiwa, Akitoyo Hishimoto, Kentaro Mouri, Masaaki Fukutake, Irwan Supriyanto, Naoki Nishiguchi, Osamu Shirakaw. Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population. Neuroscience letters. vol 472. issue 3. 2010-06-11. PMID:20144688. |
although a genetic association of tryptophan hydroxylase isoform 1 (tph1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform tph2 is more relevant to the central nervous system and the association of tph2 gene with schizophrenia has been much less explored. |
2010-06-11 |
2023-08-12 |
Not clear |
| Simone Becho Campos, Débora Marques Miranda, Bruno Rezende Souza, Patricia Araújo Pereira, Fernando Silva Neves, Maria Aparecida Camargos Bicalho, Paulo Henrique Casadei Melillo, Juliana Tramontina, Flávio Kapczinski, Marco Aurélio Romano-Silva, Humberto Corre. Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. Journal of psychiatric research. vol 44. issue 5. 2010-06-04. PMID:19800079. |
tryptophan hydroxylase 2 (tph2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. |
2010-06-04 |
2023-08-12 |
human |
| Diana Armbruster, Anett Mueller, Alexander Strobel, Clemens Kirschbaum, Klaus-Peter Lesch, Burkhard Brock. Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biological psychology. vol 83. issue 3. 2010-06-02. PMID:20064585. |
allelic variation of tph2 gene expression influences serotonin synthesis in the brain and therefore may modulate emotional processing. |
2010-06-02 |
2023-08-12 |
human |