| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maik Grohmann, Paul Hammer, Maria Walther, Nils Paulmann, Andreas Büttner, Wolfgang Eisenmenger, Thomas C Baghai, Cornelius Schüle, Rainer Rupprecht, Michael Bader, Brigitta Bondy, Peter Zill, Josef Priller, Diego J Walthe. Alternative splicing and extensive RNA editing of human TPH2 transcripts. PloS one. vol 5. issue 1. 2010-05-20. PMID:20126463. |
therefore, our results strongly suggest a complex fine-tuning of central nervous system 5-ht biosynthesis by tph2 alternative splicing and rna editing. |
2010-05-20 |
2023-08-12 |
human |
| Scott F Stoltenberg, Joanna M Vandeve. Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19781560. |
because gender moderates the effect of genetic polymorphisms on serotonin function and because there are gender differences in decision-making, the present study examined potential gender moderation of associations between polymorphisms in important serotonin system candidate genes (serotonin transporter [slc6a4] and tryptophan hydroxylase-2 [tph2]) and performance on a decision-making task (iowa gambling task, igt) in healthy, adults (n = 188; 62% women). |
2010-04-13 |
2023-08-12 |
human |
| Guo-Lin Chen, Melinda A Novak, Jerrold S Meyer, Brian J Kelly, Eric J Vallender, Gregory M Mille. The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis. Hormones and behavior. vol 57. issue 2. 2010-04-12. PMID:19900455. |
tryptophan hydroxylase-2 (tph2) synthesizes neuronal serotonin and is closely related to the hypothalamic-pituitary-adrenal (hpa) axis, while early life experience is a critical environmental factor programming the hpa axis response to stress. |
2010-04-12 |
2023-08-12 |
human |
| Kathrin Scheuch, Markus Höltje, Holger Budde, Marion Lautenschlager, Andreas Heinz, Gudrun Ahnert-Hilger, Josef Prille. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain research. vol 1307. 2010-03-08. PMID:19840776. |
using real-time reverse transcriptase polymerase chain reaction and western blotting, we examined the effect of lithium on tryptophan hydroxylase 2 (tph2) expression, the rate-limiting enzyme in brain 5-ht biosynthesis. |
2010-03-08 |
2023-08-12 |
rat |
| Kathrin Scheuch, Markus Höltje, Holger Budde, Marion Lautenschlager, Andreas Heinz, Gudrun Ahnert-Hilger, Josef Prille. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain research. vol 1307. 2010-03-08. PMID:19840776. |
our results suggest that lithium can modify tph2 gene expression and 5-ht release in raphe neurons, providing new insight into the serotonergic mechanisms of action of lithium. |
2010-03-08 |
2023-08-12 |
rat |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
fev (fifth ewing variant) ets transcription factor, tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor were determined at 7-8 levels of the dorsal raphe nucleus with in situ hybridization (ish) using radiolabeled- and digoxygenin-incorporated riboprobes. |
2010-02-12 |
2023-08-12 |
monkey |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
these data suggest that ss monkeys have fewer serotonin (5-ht) neurons than hsr monkeys, and that they have deficient fev expression, which in turn, leads to deficient tph2, sert and 5ht1a expression. |
2010-02-12 |
2023-08-12 |
monkey |
| C G Baehne, A-C Ehlis, M M Plichta, A Conzelmann, P Pauli, C Jacob, L Gutknecht, K-P Lesch, A J Fallgatte. Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals. Molecular psychiatry. vol 14. issue 11. 2010-01-25. PMID:18427560. |
in that respect, several variants of the tryptophan hydroxylase gene (tph2), which codes for the rate-limiting enzyme in the biosynthesis of serotonin (5-ht), have been associated with adhd. |
2010-01-25 |
2023-08-12 |
Not clear |
| Kentaro Mouri, Akitoyo Hishimoto, Masaaki Fukutake, Kyoichi Shiroiwa, Migiwa Asano, Yasushi Nagasaki, Yasuhiro Ueno, Osamu Shirakawa, Naoki Nishiguchi, Kiyoshi Maed. TPH2 is not a susceptibility gene for suicide in Japanese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 8. 2010-01-25. PMID:19748542. |
the newly identified neuronal tryptophan hydroxylase isoform 2 (tph2), the rate-limiting enzyme in serotonin synthesis, represents a prime candidate in numerous genetic association analyses of suicidal behavior; however, the results are still inconclusive. |
2010-01-25 |
2023-08-12 |
human |
| Yi-Mei J Lin, Huei-Chen Ko, Fong-Ming Chang, Tzung-Lieh Yeh, H Sunny Su. Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Archives of women's mental health. vol 12. issue 6. 2010-01-22. PMID:19588223. |
the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase 2 (tph2), is one of the most promising candidate genes for psychiatric disorders. |
2010-01-22 |
2023-08-12 |
Not clear |
| Alexandra Schosser, Siegfried Kaspe. The role of pharmacogenetics in the treatment of depression and anxiety disorders. International clinical psychopharmacology. vol 24. issue 6. 2010-01-07. PMID:19738481. |
two functional polymorphisms of the serotonin transporter gene, 5-httlpr and stin2 have been investigated in a large number of pharmacogenetic studies of depression; other candidate genes include serotonin receptor genes, brain-derived neurotrophic factor, p-glycoprotein (located in the blood-brain barrier), g-proteins, tph1 and tph2, maoa, the noradrenaline transporter gene, fkbp5, or cytochrome p450 (cyp450) genes. |
2010-01-07 |
2023-08-12 |
Not clear |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
all 5-ht neurons express tryptophan hydroxylase-2 (tph2), the brain specific, rate-limiting enzyme for 5-ht synthesis. |
2009-12-14 |
2023-08-12 |
rat |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
therefore, we tested the hypothesis that er beta may contribute to the regulation of gene expression in 5-ht neurons of the dorsal raphe nuclei (drn) by examining the effects of systemic and local application of the selective er beta agonist diarylpropionitrile (dpn) on tph2 mrna expression. |
2009-12-14 |
2023-08-12 |
rat |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
these data indicate that er beta acts at the level of the rat drn to modulate tph2 mrna expression and thereby influence 5-ht synthesis in drn subregions. |
2009-12-14 |
2023-08-12 |
rat |
| Cory D Rice, James H Lois, Ilan A Kerman, Bill J Yate. Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat. Brain research. vol 1279. 2009-09-30. PMID:19433074. |
the present study identified these neurons in cats by combining the transneuronal retrograde transport of rabies virus from the diaphragm with the immunohistochemical detection of the n-terminal region of tryptophan hydroxylase-2 (tph2), the brain-specific isoform of the enzyme responsible for the initial and rate-limiting step in serotonin synthesis. |
2009-09-30 |
2023-08-12 |
cat |
| Ari Illi, Eija Setälä-Soikkeli, Merja Viikki, Outi Poutanen, Heini Huhtala, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampma. 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. vol 20. issue 12. 2009-09-29. PMID:19590397. |
in this study, we evaluated the association of seven serotonin signal transduction-linked single nucleotide polymorphisms [htr1a (rs6295), htr2a (rs6313, rs6311 and rs7997012), htr6 (rs1805054), tph1 (rs1800532) and tph2 (rs1386494)] with major depressive disorder and/or treatment outcome with serotonin reuptake inhibitors. |
2009-09-29 |
2023-08-12 |
Not clear |
| John Jacob, Robert Storm, Diogo S Castro, Christopher Milton, Patrick Pla, François Guillemot, Carmen Birchmeier, James Brisco. Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development (Cambridge, England). vol 136. issue 14. 2009-09-24. PMID:19542360. |
nevertheless, serotonergic precursors begin to differentiate in insm1 mutants, but fail to produce serotonin because of a failure to activate expression of tryptophan hydroxylase 2 (tph2), the key enzyme of serotonin biosynthesis. |
2009-09-24 |
2023-08-12 |
mouse |
| Martin Marziniak, Claudia Kienzler, Gregor Kuhlenbäumer, Claudia Sommer, Rainald Mössne. Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 7. 2009-09-08. PMID:19434366. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in the biosynthesis of 5-ht in the brain and is therefore a major factor in the availability of 5-ht and its rate of production. |
2009-09-08 |
2023-08-12 |
human |
| Ian R Gizer, Courtney Ficks, Irwin D Waldma. Candidate gene studies of ADHD: a meta-analytic review. Human genetics. vol 126. issue 1. 2009-08-25. PMID:19506906. |
further, significant heterogeneity was observed for the associations between adhd and dat1, drd4, drd5, dbh, adra2a, 5htt, tph2, maoa, and snap25, suggesting that future studies should explore potential moderators of these associations (e.g., adhd subtype diagnoses, gender, exposure to environmental risk factors). |
2009-08-25 |
2023-08-12 |
Not clear |
| Yong-Ku Kim, Heon-Jeong Lee, Jong-Chul Yang, Jung-A Hwang, Ho-Kyoung Yoo. A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behavior genetics. vol 39. issue 2. 2009-08-13. PMID:19132526. |
the novel brain-specific serotonin synthesizing enzyme, tryptophan hydroxylase 2 (tph2), which represents the rate-limiting enzyme of serotonin production in the brain, may therefore be of particular importance in pd. |
2009-08-13 |
2023-08-12 |
human |