| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Kulikov, M A Tikhonova, E A Kulikova, T M Khomenko, D V Korchagina, K P Volcho, H F Salachutdinov, N K Popov. [Effect of new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, on the expression of serotonin-related genes in mouse brain]. Molekuliarnaia biologiia. vol 45. issue 2. 2011-07-08. PMID:21634115. |
the expression of genes encoding 1) the key enzyme of serotonin synthesis, tryptophan hydroxylase 2 (tph2), 2) main enzyme of serotonin degradation, monoamine oxydase a (maoa), 3) 5-ht transporter (sert) and 4) 5-ht(1a) receptor was studied using quantitative rt-pcr. |
2011-07-08 |
2023-08-12 |
mouse |
| K Raghuveer, C C Sudhakumari, B Senthilkumaran, H Kagawa, A Dutta-Gupta, Y Nagaham. Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation. General and comparative endocrinology. vol 171. issue 1. 2011-07-05. PMID:21156177. |
differential expression of tph2 was observed at mrna and protein levels in the poa-hyp and oct regions of male and female brains during development that further correlate with the 5-hydroxytryptophan (5-htp) and 5-ht levels measured using hplc method in these regions of male and female brains. |
2011-07-05 |
2023-08-12 |
Not clear |
| K Raghuveer, C C Sudhakumari, B Senthilkumaran, H Kagawa, A Dutta-Gupta, Y Nagaham. Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation. General and comparative endocrinology. vol 171. issue 1. 2011-07-05. PMID:21156177. |
changes in tph2 mrna expression, 5-htp, and 5-ht levels in the poa-hyp+oct region of brains of methyltestosterone and para-chlorophenylalanine treated fishes during development further endorse our results. |
2011-07-05 |
2023-08-12 |
Not clear |
| Catherina E M van Beijsterveldt, Christel M Middeldorp, Margarita C T Slof-Op't Landt, Meike Bartels, Jouke-Jan Hottenga, H Eka D Suchiman, P Eline Slagboom, Dorret I Boomsm. Influence of candidate genes on attention problems in children: a longitudinal study. Behavior genetics. vol 41. issue 1. 2011-06-28. PMID:21049304. |
this study investigated the effect of 26 single nucleotide polymorphisms (snps) in genes encoding for serotonin receptors 2a (htr2a), catechol-o-methyltransferase (comt), tryptophane hydroxylase type 2 (tph2), and brain derived neurotrophic factor (bdnf). |
2011-06-28 |
2023-08-12 |
Not clear |
| Jonas Waider, Naozumi Araragi, Lise Gutknecht, Klaus-Peter Lesc. Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective. Psychoneuroendocrinology. vol 36. issue 3. 2011-06-21. PMID:21257271. |
based on genetic variation, there is accumulating evidence that altered function of tryptophan hydroxylase-2 (tph2), the enzyme critical for synthesis of serotonin (5-ht) in the brain, plays a role in anxiety-, aggression- and depression-related personality traits and in the pathogenesis of disorders featuring deficits in cognitive control and emotion regulation. |
2011-06-21 |
2023-08-12 |
mouse |
| Jonas Waider, Naozumi Araragi, Lise Gutknecht, Klaus-Peter Lesc. Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective. Psychoneuroendocrinology. vol 36. issue 3. 2011-06-21. PMID:21257271. |
mouse models in conjunction with cognitive neuroscience approaches in humans are providing unexpected results and it may well be that future research on tph2 will provide an entirely new view of 5-ht in brain development and function related to neuropsychiatric disorders. |
2011-06-21 |
2023-08-12 |
mouse |
| S Jun, R Kohen, K C Cain, M E Jarrett, M M Heitkempe. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21073637. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: tph1 and tph2. |
2011-05-31 |
2023-08-12 |
Not clear |
| M Camiller. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21159063. |
lx-1031 appears promising for chronic diarrhea associated with increased 5-ht expression including ibs-d. optimal doses, efficacy and safety in ibs clinical trials need to be fully elucidated; low systemic exposure, selectivity for tph1 over tph2, and lack of effect on brain 5-ht in several species suggest that lx-1031 is unlikely to cause affective disorders. |
2011-05-31 |
2023-08-12 |
human |
| Yan Liu, Yun'ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen, Yi Ra. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. vol 472. issue 7341. 2011-05-31. PMID:21441904. |
a role for 5-ht was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (tph2), which is required for the first step of 5-ht synthesis in the brain. |
2011-05-31 |
2023-08-12 |
mouse |
| Yan Liu, Yun'ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen, Yi Ra. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. vol 472. issue 7341. 2011-05-31. PMID:21441904. |
thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-htp), which circumvented tph2 to restore 5-ht to the wild-type level, adult tph2 knockout mice also preferred females over males. |
2011-05-31 |
2023-08-12 |
mouse |
| Jasminka Stefulj, Gordana Mokrovic, Dubravka Hranilovic, Tatjana Bordukalo-Niksic, Mirko Bakula, Milovan Kubat, Branimir Jerne. Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide. Psychiatry research. vol 186. issue 2-3. 2011-05-12. PMID:20869124. |
the association between suicide and g-703t polymorphism of the tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of croatian origin. |
2011-05-12 |
2023-08-12 |
human |
| Caroline A Browne, Gerard Clarke, Timothy G Dinan, John F Crya. Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains. Neuropharmacology. vol 60. issue 4. 2011-05-12. PMID:21130784. |
the balb/c strain is stress-sensitive, highly anxious and possess a single nucleotide polymorphism in their tryptophan hydroxylase (tph) 2 gene (tph2), resulting in reduced levels of central serotonin compared to c57bl/6j mice, which harbour the wild-type allele. |
2011-05-12 |
2023-08-12 |
mouse |
| Kirsten X Jacobsen, Margaret Czesak, Mariam Deria, Brice Le François, Paul R Alber. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21182526. |
in the raphe nuclei of pet-1-/- mice tryptophan hydroxylase 2 (tph2) rna, and 5-ht and tph immunostaining were greatly reduced, indicating a deficit in 5-ht production. |
2011-04-15 |
2023-08-12 |
mouse |
| Alexander Jung, Andreas Huge, Gregor Kuhlenbäumer, Steffi Kempt, Tanja Seehafer, Stefan Evers, Klaus Berger, Martin Marzinia. Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 11. 2011-03-21. PMID:20740293. |
the tph2 isoform is responsible for the cerebral serotonin biosynthesis. |
2011-03-21 |
2023-08-12 |
Not clear |
| Alessia Omenetti, Liu Yang, Raul R Gainetdinov, Cynthia D Guy, Steve S Choi, Wei Chen, Marc G Caron, Anna Mae Dieh. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 2. 2011-03-15. PMID:21071507. |
results in the cell culture models confirm that cholangiocytes have serotonin receptors and demonstrate for the first time that these cells express tph2 and produce serotonin, which autoinhibits their growth but stimulates mf production of tgf-β(1). |
2011-03-15 |
2023-08-12 |
mouse |
| Alessia Omenetti, Liu Yang, Raul R Gainetdinov, Cynthia D Guy, Steve S Choi, Wei Chen, Marc G Caron, Anna Mae Dieh. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 2. 2011-03-15. PMID:21071507. |
studies of tph2ki mice confirm that tph2-mediated production of serotonin plays an important role in remodeling damaged bile ducts because mice with decreased tph2 function have reduced biliary serotonin levels and exhibit excessive cholangiocyte proliferation, accumulation of aberrant ductules and liver progenitors, and increased liver fibrosis after bile duct ligation. |
2011-03-15 |
2023-08-12 |
mouse |
| Donald M Kuhn, Catherine E Sykes, Timothy J Geddes, Karen L Eskow Jaunarajs, Christopher Bisho. Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of neurochemistry. vol 116. issue 3. 2011-02-17. PMID:21105877. |
therefore, the oxidative processes that prevail in pd could cause tph2 misfolding and modify serotonin neuronal function much as is seen in dopamine neurons. |
2011-02-17 |
2023-08-12 |
Not clear |
| Donald M Kuhn, Catherine E Sykes, Timothy J Geddes, Karen L Eskow Jaunarajs, Christopher Bisho. Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of neurochemistry. vol 116. issue 3. 2011-02-17. PMID:21105877. |
the propensity of tph2 to misfold upon oxidation of its cysteine residues is responsible for its catalytic lability and may be related to loss of serotonin neuronal function in pd and the emergence of non-motor (psychiatric) symptoms. |
2011-02-17 |
2023-08-12 |
Not clear |
| C M Middeldorp, M C T Slof-Op 't Landt, S E Medland, C E M van Beijsterveldt, M Bartels, G Willemsen, J-J Hottenga, E J C de Geus, H E D Suchiman, C V Dolan, M C Neale, P E Slagboom, D I Boomsm. Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? Genes, brain, and behavior. vol 9. issue 7. 2011-02-08. PMID:20633049. |
this study investigated the effect of 45 single nucleotide polymorphisms (snps) in genes encoding for serotonin receptors 1a, 1d, 2a, catechol-o-methyltransferase (comt), tryptophane hydroxylase type 2 (tph2), brain derived neurotrophic factor (bdnf), plexina2 and regulators of g-protein-coupled signaling (rgs) 2, 4, 16. |
2011-02-08 |
2023-08-12 |
human |
| Nina K Popova, Alexander V Kuliko. Targeting tryptophan hydroxylase 2 in affective disorder. Expert opinion on therapeutic targets. vol 14. issue 11. 2011-02-07. PMID:20874521. |
the key and rate limiting enzyme of 5-ht synthesis is tryptophan hydroxylase 2 (tph2). |
2011-02-07 |
2023-08-12 |
Not clear |