| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Gacek, Tamlin S Conner, Howard Tennen, Henry R Kranzler, Jonathan Covaul. Tryptophan hydroxylase 2 gene and alcohol use among college students. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18782386. |
tryptophan hydroxylase (tph2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. |
2009-03-05 |
2023-08-12 |
human |
| Eric J Peters, Susan L Slager, Greg D Jenkins, Megan S Reinalda, Holly A Garriock, Stanley I Shyn, Jeffrey B Kraft, Patrick J McGrath, Steven P Hamilto. Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. Pharmacogenetics and genomics. vol 19. issue 1. 2009-03-03. PMID:19077664. |
here, we attempt to expand upon and replicate these results by (i) resequencing the exonic and putatively regulatory regions of five serotonin-related candidate genes (htr1a, htr2a, tph1, tph2, and maoa) in our fluoxetine-treated sample to uncover novel variants; (ii) selecting tagging single nucleotide polymorphisms (snps) for these genes from the resequencing data; and (iii) evaluating these tagging snps for association with response to the selective serotonin reuptake inhibitor citalopram in an independent sample of participants who are enrolled in the sequenced treatment alternatives to relieve depression (star*d) clinical study (n=1953). |
2009-03-03 |
2023-08-12 |
human |
| B-T Lee, B-J Ha. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes, brain, and behavior. vol 7. issue 8. 2009-02-27. PMID:18826444. |
all participants were genotyped with regard to the following polymorphisms: the serotonin transporter-gene-linked polymorphic region (5-httlpr), tryptophan hydroxylase 2 (tph2) g(-703)t, 5-ht(1a) c(-1019)g and 5-ht(2a) single nucleotide polymorphism (snp) rs6311. |
2009-02-27 |
2023-08-12 |
human |
| B-T Lee, B-J Ha. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes, brain, and behavior. vol 7. issue 8. 2009-02-27. PMID:18826444. |
higher activations in response to sad facial stimuli were found in the bilateral amygdala of subjects with the t/t genotype of 5-ht(2a) snp rs6311, compared with c allele carriers, and in subjects with the g/g genotype of tph2 g(-703)t, compared with those with t/t and g/t genotypes. |
2009-02-27 |
2023-08-12 |
human |
| S W Kang, B Leclerc, L J Mauro, M E El Halawan. Serotonergic and catecholaminergic interactions with co-localised dopamine-melatonin neurones in the hypothalamus of the female turkey. Journal of neuroendocrinology. vol 21. issue 1. 2009-02-03. PMID:19094089. |
tph2 mrna expression in serotonin neurones was found in several nuclei, and its most abundant mrna expression was seen in the nucleus locus ceruleus of laying and incubating hens. |
2009-02-03 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
depressed suicide patients have elevated expression of neuronal tryptophan hydroxylase 2 (tph2) mrna and protein in midbrain serotonergic neurons, as well as increases in brain serotonin turnover. |
2009-01-23 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
the mechanisms underlying these changes are uncertain, but increased tph2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. |
2009-01-23 |
2023-08-12 |
Not clear |
| Tomas Furmark, Lieuwe Appel, Susanne Henningsson, Fredrik Ahs, Vanda Faria, Clas Linnman, Anna Pissiota, Orjan Frans, Massimo Bani, Paolo Bettica, Emilio Merlo Pich, Eva Jacobsson, Kurt Wahlstedt, Lars Oreland, Bengt Långström, Elias Eriksson, Mats Fredrikso. A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 49. 2009-01-12. PMID:19052197. |
patients were genotyped with respect to the serotonin transporter-linked polymorphic region (5-httlpr) and the g-703t polymorphism in the tryptophan hydroxylase-2 (tph2) gene promoter. |
2009-01-12 |
2023-08-12 |
human |
| Fumihiro Kaneko, Koji Masuda, Yukari Takeuchi, Yuji Mor. Identifying novel polymorphisms in the canine tryptophan hydroxylase 2 gene. The Journal of veterinary medical science. vol 70. issue 10. 2009-01-08. PMID:18981671. |
tryptophan hydroxylase (tph) serves as the rate-limiting enzyme in the biosynthesis of serotonin, and two forms of tph genes, tph1 and tph2, have been reported with specific nucleotide sequences and expression patterns. |
2009-01-08 |
2023-08-12 |
Not clear |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
the biosynthesis of serotonin is regulated by two rate-limiting enzymes, tryptophan hydroxylase-1 and -2 (tph1 and tph2). |
2008-12-18 |
2023-08-12 |
mouse |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
this resulted in dramatically reduced central 5-ht levels in tph2 knockout (tph2ko) and tph1/tph2 double knockout (dko) mice; and substantially reduced peripheral 5-ht levels in dko, but not tph2ko mice. |
2008-12-18 |
2023-08-12 |
mouse |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
the behavioral effects observed in the tph2 ko and dko mice strongly confirm the role of 5-ht and its synthetic enzymes in the etiology and treatment of affective disorders. |
2008-12-18 |
2023-08-12 |
mouse |
| G-L Chen, G M Mille. Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability. Neuroscience. vol 155. issue 2. 2008-12-03. PMID:18593594. |
tryptophan hydroxylase-2 (tph2) synthesizes neuronal 5-ht and its genetic variance is associated with numerous behavioral traits and psychiatric disorders. |
2008-12-03 |
2023-08-12 |
monkey |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
the present study was designed to assess the effect of mdma on the rate-limiting enzyme in 5-ht biosynthesis, tryptophan hydroxylase (tph), by measuring tph2 protein and mrna levels in rat dorsal raphe (dr) nucleus. |
2008-11-05 |
2023-08-12 |
rat |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
in contrast, tph2 mrna levels were significantly increased by 24% in the mid dr and by 12% in the caudal dr. mdma treatment significantly decreased (125)i-rti-55 labeled sert binding sites in the striatum, nucleus accumbens and cingulate cortex demonstrating a loss of 5-ht terminals. |
2008-11-05 |
2023-08-12 |
rat |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
the increase in tph2 mrna levels in both the mid dr and caudal dr of mdma-treated rats may reflect a compensatory mechanism in the injured 5-ht neurons to increase tph2 protein synthesis. |
2008-11-05 |
2023-08-12 |
rat |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
deficiency of brain 5-ht synthesis but serotonergic neuron formation in tph2 knockout mice. |
2008-10-24 |
2023-08-12 |
mouse |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
to investigate the respective role of tph2 in neuron serotonin (5-ht) synthesis and the role of 5-ht in brain development, mice with a targeted disruption of tph2 were generated. |
2008-10-24 |
2023-08-12 |
mouse |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
the preliminary results indicate that in tph2 knockout mice raphe neurons are completely devoid of 5-ht, whereas no obvious alteration in morphology and fiber distribution are observed. |
2008-10-24 |
2023-08-12 |
mouse |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
the findings confirm the exclusive specificity of tph2 in brain 5-ht synthesis and suggest that tph2-synthesized 5-ht is not required for serotonergic neuron formation. |
2008-10-24 |
2023-08-12 |
mouse |