| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
in particular, nerve growth factor (ngf) plays an important role in the survival and function of cholinergic neurons while brain-derived neurotrophic factor (bdnf) is involved in synaptic plasticity and the maintenance of midbrain dopaminergic and cholinergic neurons. |
2023-08-30 |
2023-09-07 |
Not clear |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
glial cell derived neurotrophic factor (gdnf) promotes the survival of midbrain dopaminergic neurons and neuregulin 1 (nrg-1) contributes to glutamatergic signals regulating the n-methyl-d-aspartate (nmda). |
2023-08-30 |
2023-09-07 |
Not clear |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Natalia Siwecka, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Ireneusz Majstere. Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy. Pharmaceutics. vol 15. issue 8. 2023-08-26. PMID:37631265. |
the most common α-synucleinopathy, parkinson's disease (pd), is caused by abnormal accumulation of α-syn in the dopaminergic neurons of the midbrain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Liqiang Chen, Samuel Daniels, Rachel Dvorak, Hong-Yuan Ch. Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism. Science advances. vol 9. issue 34. 2023-08-23. PMID:37611096. |
degeneration of midbrain dopaminergic (da) neurons alters the connectivity and functionality of the basal ganglia-thalamocortical circuits in parkinson's disease (pd). |
2023-08-23 |
2023-09-07 |
Not clear |
| Christian Altbürger, Jens Holzhauser, Wolfgang Drieve. CRISPR/Cas9-based QF2 knock-in at the Frontiers in neuroanatomy. vol 17. 2023-08-21. PMID:37603776. |
because of their disease relevance, special attention has been paid to mammalian midbrain dopaminergic systems, which have important functions in motor control, reward, motivation, and cognitive function. |
2023-08-21 |
2023-09-07 |
Not clear |
| Christian Altbürger, Jens Holzhauser, Wolfgang Drieve. CRISPR/Cas9-based QF2 knock-in at the Frontiers in neuroanatomy. vol 17. 2023-08-21. PMID:37603776. |
in contrast, midbrain dopaminergic neurons in teleosts were thought to be lost secondarily. |
2023-08-21 |
2023-09-07 |
Not clear |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
in this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. |
2023-08-18 |
2023-09-07 |
Not clear |
| Akiko Terauchi, Patricia Yee, Erin M Johnson-Venkatesh, Mariel P Seiglie, Lisa Kim, Julia C Pitino, Eli Kritzer, Qiyu Zhang, Jie Zhou, Yulong Li, David D Ginty, Wei-Chung A Lee, Hisashi Umemor. The projection-specific signals that establish functionally segregated dopaminergic synapses. Cell. 2023-08-17. PMID:37591240. |
there are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to striatum: nigrostriatal, which controls movement, and mesolimbic, which regulates motivation. |
2023-08-17 |
2023-09-07 |
mouse |
| Ruth Hanssen, Lionel Rigoux, Bojana Kuzmanovic, Sandra Iglesias, Alina C Kretschmer, Marc Schlamann, Kerstin Albus, Sharmili Edwin Thanarajah, Tamara Sitnikow, Corina Melzer, Oliver A Cornely, Jens C Brüning, Marc Tittgemeye. Liraglutide restores impaired associative learning in individuals with obesity. Nature metabolism. 2023-08-17. PMID:37592007. |
the dopaminergic midbrain plays a crucial role in learning adaptive behaviour and is particularly sensitive to peripheral metabolic signals, including intestinal peptides, such as glucagon-like peptide 1 (glp-1). |
2023-08-17 |
2023-09-07 |
human |
| Clayton Hickey, David Acunzo, Jaclyn Del. Suppressive Control of Incentive Salience in Real-World Human Vision. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-10. PMID:37562963. |
reward-related activity in the dopaminergic midbrain is thought to guide animal behaviour, in part by boosting the perceptual and attentional processing of reward-predictive environmental stimuli. |
2023-08-10 |
2023-08-16 |
human |
| Mélanie Lebœuf, Stephanie E Vargas-Abonce, Eugénie Pezé-Hedsieck, Edmond Dupont, Lucia Jimenez-Alonso, Kenneth L Moya, Alain Prochiant. ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons. EMBO reports. vol 24. issue 8. 2023-08-03. PMID:37534581. |
midbrain dopaminergic neurons express engrailed-1 and, similarly to spinal cord α-motoneurons, degenerate in the heterozygote. |
2023-08-03 |
2023-08-14 |
mouse |
| Xiyu Gao, Dewei He, Yanting Liu, Mingchi Cui, Zhe Li, Jie Li, Yuan He, Hefei Wang, Bojian Ye, Shoupeng Fu, Dianfeng Li. Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats. International immunopharmacology. vol 123. 2023-08-03. PMID:37536186. |
the primary characteristic of pd is the degenerative death of midbrain dopaminergic neurons. |
2023-08-03 |
2023-08-14 |
rat |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
it is well established that midbrain dopaminergic neurons support reinforcement learning (rl) in the basal ganglia by transmitting a reward prediction error (rpe) to the striatum. |
2023-08-01 |
2023-08-14 |
Not clear |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
inspired by the recent observations that besides rpe, the firing rates of midbrain dopaminergic neurons correlate with motor and cognitive variables, we propose a model in which dopamine signal in the striatum carries a vector-valued error feedback signal (a loss gradient) instead of a homogeneous scalar error (a loss). |
2023-08-01 |
2023-08-14 |
Not clear |
| Olivia K Swanson, Priscilla E Yevoo, David Richard, Arianna Maffe. Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-01. PMID:37527923. |
our results demonstrate that loss of midbrain dopaminergic neurons alters thalamocortical activation of m1 in both male and female mice, and provide novel insights into circuit mechanisms for motor cortex dysfunction in a mouse model of pd. |
2023-08-01 |
2023-08-14 |
mouse |
| Somayeh Naderi, Zahra Shiri, Masoumeh Zarei-Kheirabadi, Sepideh Mollamohammadi, Parastoo Hosseini, Golnoosh Rahimi, Azadeh Moradmand, Azam Samadian, Amir Shojaei, Meghdad Yeganeh, Seyed Ahmad Mousavi, Motahare Badri, Adeleh Taei, Seyedeh-Nafiseh Hassani, Hossein Baharvan. Cryopreserved clinical-grade human embryonic stem cell-derived dopaminergic progenitors function in Parkinson's disease models. Life sciences. 2023-07-31. PMID:37524159. |
human pluripotent stem cells have emerged as the most promising source of cells for midbrain dopaminergic (mda) neuron replacement in pd. |
2023-07-31 |
2023-08-14 |
human |
| Mitali A Tambe, Aurélie de Rus Jacquet, Katherine E Strathearn, Jennifer A Hensel, Bryce D Colón, Aswathy Chandran, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508001. |
here, we characterized botanical extracts enriched with a mixed profile of polyphenols, as well as a set of purified polyphenolic standards, in terms of their ability to mitigate dopaminergic cell death in midbrain cultures exposed to another pd-related toxicant, paraquat (pq), and we examined underlying neuroprotective mechanisms. |
2023-07-29 |
2023-08-14 |
Not clear |
| Mitali A Tambe, Aurélie de Rus Jacquet, Katherine E Strathearn, Jennifer A Hensel, Bryce D Colón, Aswathy Chandran, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508001. |
several extracts or compounds with the ability to protect against pq neurotoxicity increased the activity of the antioxidant transcription factor nrf2 in cultured astrocytes, and pq-induced dopaminergic cell death was attenuated in nrf2-expressing midbrain cultures. |
2023-07-29 |
2023-08-14 |
Not clear |
| Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-Ichi Ishikawa, Nobutaka Hattor. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-07-28. PMID:37502682. |
a defined method for differentiating human ipscs into midbrain dopaminergic progenitors that safely restore motor deficits in parkinson's disease. |
2023-07-28 |
2023-08-14 |
human |