| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Y Tong, P G Overton, D Clar. Antagonism of NMDA receptors but not AMPA/kainate receptors blocks bursting in dopaminergic neurons induced by electrical stimulation of the prefrontal cortex. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 8-9. 1997-05-12. PMID:9013383. |
evidence suggests that the prefrontal cortex (pfc) plays an important role in the burst activity of midbrain dopaminergic (da) neurons. |
1997-05-12 |
2023-08-12 |
Not clear |
| Z Y Tong, P G Overton, D Clar. Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132987. |
stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. |
1997-04-29 |
2023-08-12 |
rat |
| Z Y Tong, P G Overton, D Clar. Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132987. |
evidence suggests that excitatory amino acid-containing afferents from the prefrontal cortex (pfc) play an important role in the induction of burst firing in midbrain dopaminergic (da) neurons. |
1997-04-29 |
2023-08-12 |
rat |
| R H Zetterström, L Solomin, L Jansson, B J Hoffer, L Olson, T Perlman. Dopamine neuron agenesis in Nurr1-deficient mice. Science (New York, N.Y.). vol 276. issue 5310. 1997-04-28. PMID:9092472. |
mice lacking nurr1 failed to generate midbrain dopaminergic neurons, were hypoactive, and died soon after birth. |
1997-04-28 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
the purpose of the present study was to determine whether mptp also causes degeneration of midbrain dopaminergic neurons in nuclei a8 and a10 in the mouse, as occurs in humans with parkinson's disease. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
seven days later, dopamine concentrations were measured in the striatum using high performance liquid chromatography, and midbrain dopaminergic neurons were identified using an antibody against tyrosine hydroxylase. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
although the highest dose (300 mg/kg) caused an 86% reduction in striatal dopamine concentrations, there was only a moderate and non-significant loss of midbrain dopaminergic neurons. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
in the c57bl/6 strain, however, a high dose of mptp (240 mg/kg) caused a significant reduction in both striatal dopamine concentrations (95%), and midbrain dopaminergic cells; 69% loss of nucleus a8 cells, 75% loss of nucleus a9 cells, and in nucleus a10 subnuclei there was 42% loss of ventral tegmental area cells, 55% loss of interfascicular nucleus cells, and no loss of cells in the central linear nucleus. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
these data (1) provide further evidence for differential susceptibility to mptp toxicity among different mouse strains, (2) indicate that a significant depletion of striatal dopamine is not necessarily due to degeneration of midbrain dopaminergic neurons, (3) provide the precise locations of midbrain dopaminergic cells that are vulnerable to mptp, which will aid future studies that seek to determine the mechanism/s by which-mptp selectively destroys only certain midbrain dopaminergic neurons, and (4) indicate that mptp produces midbrain dopaminergic neuronal degeneration in the same nuclei in the c57bl16 mouse that degenerate in humans with parkinson's disease. |
1997-04-24 |
2023-08-12 |
mouse |
| C L Liang, C M Sinton, P K Sonsalla, D C Germa. Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117542. |
midbrain dopaminergic neurons in the mouse that contain calbindin-d28k exhibit reduced vulnerability to mptp-induced neurodegeneration. |
1997-04-24 |
2023-08-12 |
mouse |
| C L Liang, C M Sinton, P K Sonsalla, D C Germa. Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117542. |
the calcium-binding protein calbindin-d28k (cb) is located in midbrain dopaminergic (da) neurons that are less vulnerable to degeneration in parkinson's disease and in an animal model of the disorder, the mptp-treated monkey. |
1997-04-24 |
2023-08-12 |
mouse |
| V Kostic, M E Gurney, H X Deng, T Siddique, C J Epstein, S Przedborsk. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124807. |
midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. |
1997-04-24 |
2023-08-12 |
mouse |
| V Kostic, M E Gurney, H X Deng, T Siddique, C J Epstein, S Przedborsk. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124807. |
we used a transgenic mouse model of familial amyotrophic lateral sclerosis (transgenic g1h mice) based on expression of mutant human cu/zn-sod to examine the influence of the transgene expression on midbrain dopaminergic neurons, cells that contain conspicuous amounts of this enzyme. |
1997-04-24 |
2023-08-12 |
mouse |
| V Kostic, M E Gurney, H X Deng, T Siddique, C J Epstein, S Przedborsk. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124807. |
these findings indicate that overexpression of the mutated cu/zn-sod protein caused a significant loss of midbrain dopaminergic neurons in addition to the loss of spinal motor neurons. |
1997-04-24 |
2023-08-12 |
mouse |
| M Rufer, S B Wirth, A Hofer, R Dermietzel, A Pastor, H Kettenmann, K Unsicke. Regulation of connexin-43, GFAP, and FGF-2 is not accompanied by changes in astroglial coupling in MPTP-lesioned, FGF-2-treated parkinsonian mice. Journal of neuroscience research. vol 46. issue 5. 1997-04-14. PMID:8951672. |
basic fibroblast growth factor (bfgf; fgf-2) has potent trophic effects on developing and toxically impaired midbrain dopaminergic (daergic) neurons which are crucially affected in parkinson's disease. |
1997-04-14 |
2023-08-12 |
mouse |
| B A Morrow, R H Rot. Serotonergic lesions alter cocaine-induced locomotor behavior and stress-activation of the mesocorticolimbic dopamine system. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807745. |
the aim of this study was to examine the effects of serotonergic lesions to the dorsal raphe on midbrain dopaminergic systems. |
1997-03-24 |
2023-08-12 |
rat |
| R H Zetterström, L Solomin, T Mitsiadis, L Olson, T Perlman. Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Molecular endocrinology (Baltimore, Md.). vol 10. issue 12. 1997-03-20. PMID:8961274. |
notably, nurr1 is expressed in the prenatal ventral midbrain in a region that gives rise to dopaminergic neurons. |
1997-03-20 |
2023-08-12 |
mouse |
| W J Smeets, J R Alonso, A Gonzále. Distribution of NADPH-diaphorase and nitric oxide synthase in relation to catecholaminergic neuronal structures in the brain of the lizard Gekko gecko. The Journal of comparative neurology. vol 377. issue 1. 1997-03-19. PMID:8986877. |
from the present evidence, it is concluded that extensive colocalization of nadphd/nos with catecholamines occurs in the midbrain dopaminergic cell groups of reptiles and birds, but not (or only sparsely) in the corresponding cell groups of amphibians and mammals. |
1997-03-19 |
2023-08-12 |
Not clear |
| N Le Novère, M Zoli, J P Changeu. Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. The European journal of neuroscience. vol 8. issue 11. 1997-03-17. PMID:8950106. |
the present results show that alpha 6 is the major nicotinic acetylcholine receptor alpha subunit expressed in dopaminergic cell groups of the mesencephalon and noradrenergic cells of the locus coeruleus. |
1997-03-17 |
2023-08-12 |
rat |
| A C Granholm, N Srivastava, J L Mott, S Henry, M Henry, H Westphal, J G Pichel, L Shen, B J Hoffe. Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994069. |
glial cell line-derived neurotrophic factor (gdnf) is a member of the tgf-beta superfamily of growth factors with neurotrophic activity on midbrain dopaminergic neurons and on developing and mature motoneurons of the brainstem and spinal cord. |
1997-03-17 |
2023-08-12 |
mouse |