| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Takeshima, K Shimoda, J M Johnston, J W Commission. Standardized methods to bioassay neurotrophic factors for dopaminergic neurons. Journal of neuroscience methods. vol 67. issue 1. 1997-01-06. PMID:8844522. |
the search for specific neurotrophic factors that will eventually be used to reduce or arrest the rate of degeneration of dopaminergic neurons in parkinson's disease is being pursued by first testing the ability of putative compounds to increase the survival of dopaminergic neurons in primary cultures of the fetal, ventral mesencephalon. |
1997-01-06 |
2023-08-12 |
rat |
| T Takeshima, K Shimoda, J M Johnston, J W Commission. Standardized methods to bioassay neurotrophic factors for dopaminergic neurons. Journal of neuroscience methods. vol 67. issue 1. 1997-01-06. PMID:8844522. |
some important experimental variables include the age of the fetal tissue used; the dissection technique used to isolate the ventral mesencephalon; the percentage of dopaminergic neurons present in the culture initially; handling of the tissue during dissection; the technique used to disperse the cells; the use of serum; the technique of plating the cells; the attachment factors used; detachment and loss of cells during the staining procedure; the age of the cultures at the time of analysis; the uneven distribution of cells at the time of analysis and the use of imaging techniques in the analysis. |
1997-01-06 |
2023-08-12 |
rat |
| U Schmidt, C Beyer, A B Oestreicher, I Reisert, K Schilling, C Pilgri. Activation of dopaminergic D1 receptors promotes morphogenesis of developing striatal neurons. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865196. |
the early dopaminergic input from the midbrain may play an important role in the development of the basal ganglia. |
1997-01-06 |
2023-08-12 |
rat |
| C Rouillard, A S Freema. Effects of electrical stimulation of the central nucleus of the amygdala on the in vivo electrophysiological activity of rat nigral dopaminergic neurons. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869165. |
the central nucleus of the amygdala (cea) receives a dopaminergic (da) innervation from the midbrain. |
1997-01-03 |
2023-08-12 |
rat |
| Y Wang, L T Tien, P A Lapchak, B J Hoffe. GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-OHDA-lesioned rats. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854891. |
these results indicate that fetal nigral transplantation and gdnf injection restore the nigrostriatal dopaminergic pathway in parkinsonian animals and support the hypothesis of trophic activity of gdnf on midbrain dopaminergic neurons. |
1996-12-17 |
2023-08-12 |
rat |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
glial cell line-derived neurotrophic factor (gdnf) is a highly selective neurotrophic factor for midbrain dopaminergic neurons and might thus be of potential use in the therapy of parkinson's disease. |
1996-12-17 |
2023-08-12 |
Not clear |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
in serum-free low density cultures of the dissociated embryonic day 15 mesencephalon, dopaminergic neurons undergo constant cell death as evidenced by a 90% reduction in tyrosine hydroxylase-immunoreactive (th-ir) cell numbers between days 1 and 9 of cultivation. |
1996-12-17 |
2023-08-12 |
Not clear |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
taken together, our findings suggest that the action of gdnf on midbrain dopaminergic neurons is modulated by other extracellular signals. |
1996-12-17 |
2023-08-12 |
Not clear |
| H Sawada, S Shimohama, Y Tamura, T Kawamura, A Akaike, J Kimur. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of neuroscience research. vol 43. issue 1. 1996-12-16. PMID:8838574. |
methylphenylpyridium ion (mpp+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. |
1996-12-16 |
2023-08-12 |
rat |
| H Sawada, S Shimohama, Y Tamura, T Kawamura, A Akaike, J Kimur. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of neuroscience research. vol 43. issue 1. 1996-12-16. PMID:8838574. |
using primary culture of the rat mesencephalon, we investigated glutamate-induced cytotoxicity against dopaminergic and non-dopaminergic neurons with or without the pretreatment with mpp+. |
1996-12-16 |
2023-08-12 |
rat |
| C Perrone-Capano, U di Porzi. Epigenetic factors and midbrain dopaminergic neurone development. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 18. issue 10. 1996-12-16. PMID:8885719. |
epigenetic factors and midbrain dopaminergic neurone development. |
1996-12-16 |
2023-08-12 |
Not clear |
| C Perrone-Capano, U di Porzi. Epigenetic factors and midbrain dopaminergic neurone development. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 18. issue 10. 1996-12-16. PMID:8885719. |
in particular we will focus on three major issues: (1) the differentiation of dopaminergic neurones triggered by direct contact with the midbrain floor plate cells through the action of sonic hedgehog; (2) the neurotrophic factors acting on dopaminergic neurones; and (3) the role of target striatal cells on the survival and the axonal growth of developing or grafted dopaminergic neurones. |
1996-12-16 |
2023-08-12 |
Not clear |
| T S Chen, E Koutsilieri, W D Rausc. MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice. Journal of neural transmission. General section. vol 100. issue 2. 1996-12-16. PMID:8962685. |
primary cell cultures of mesencephalon from c57/bl6 mice were used to investigate the effects of various dopaminergic neurotoxins on the intracellular calcium metabolism. |
1996-12-16 |
2023-08-12 |
mouse |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. |
1996-12-13 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
midbrain dopaminergic neurons are known to release dopamine from somata and/or dendrites located in the substantia nigra (sn) and the ventral tegmental area (vta). |
1996-12-13 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
together, these observations support the proposal that dopamine is stored in and may be released from dendritic ssvs and dcvs, but suggest that the ser is the major site of dopamine storage within midbrain dopaminergic neurons. |
1996-12-13 |
2023-08-12 |
rat |
| P G Overton, Z Y Tong, D Clar. A pharmacological analysis of the burst events induced in midbrain dopaminergic neurons by electrical stimulation of the prefrontal cortex in the rat. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 5. 1996-12-10. PMID:8811499. |
a pharmacological analysis of the burst events induced in midbrain dopaminergic neurons by electrical stimulation of the prefrontal cortex in the rat. |
1996-12-10 |
2023-08-12 |
rat |
| P G Overton, Z Y Tong, D Clar. A pharmacological analysis of the burst events induced in midbrain dopaminergic neurons by electrical stimulation of the prefrontal cortex in the rat. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 5. 1996-12-10. PMID:8811499. |
electrical stimulation of the prefrontal cortex produces an inhibition-excitation (ie) activity pattern in the majority of responsive midbrain dopaminergic neurons. |
1996-12-10 |
2023-08-12 |
rat |
| K Krieglstein, C Suter-Crazzolara, K Unsicke. Development of mesencephalic dopaminergic neurons and the transforming growth factor-beta superfamily. Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821057. |
the present review summarizes the evidence concerning their expression in the mammalian midbrain and their functions on developing dopaminergic neurons. |
1996-12-10 |
2023-08-12 |
Not clear |
| W D Rausch, M Abdel-mohsen, E Koutsilieri, W W Chan, G Bringman. Studies of the potentially endogenous toxin TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) in neuronal and glial cell cultures. Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821062. |
for this purpose, primary cell cultures of c57/b16 mouse mesencephalon containing dopaminergic neurons were used. |
1996-12-10 |
2023-08-12 |
mouse |