| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huijia Yang, Song Li, Weidong L. Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson's Disease. Aging and disease. vol 13. issue 5. 2022-10-03. PMID:36186124. |
over time, our knowledge of pd has progressed from the detection of midbrain dopaminergic deficits to the identification of a multifaceted disease with a variety of central and peripheral manifestations, with increased attention to the intestinal tract. |
2022-10-03 |
2023-08-14 |
Not clear |
| Yao-Lin Li, Zhong-Xuan Wang, Chang-Zhou Ying, Bao-Rong Zhang, Jia-Li P. Decoding the Role of Familial Parkinson's Disease-Related Genes in DNA Damage and Repair. Aging and disease. vol 13. issue 5. 2022-10-03. PMID:36186134. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the degeneration of midbrain substantia nigra pars compacta dopaminergic neurons and the formation of lewy bodies. |
2022-10-03 |
2023-08-14 |
Not clear |
| Sofía Puvogel, Astrid Alsema, Laura Kracht, Maree J Webster, Cynthia Shannon Weickert, Iris E C Sommer, Bart J L Egge. Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes. Molecular psychiatry. 2022-10-03. PMID:36192459. |
besides the dopaminergic system, the midbrain contains other cell types that may be involved in schizophrenia pathophysiology. |
2022-10-03 |
2023-08-14 |
Not clear |
| Jia Shang, Bin Li, Han Fan, Peidi Liu, Wen Zhao, Tao Chen, Pu Chen, Longqiu Yan. Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids. Frontiers in cell and developmental biology. vol 10. 2022-09-30. PMID:36176283. |
sevoflurane promotes premature differentiation of dopaminergic neurons in hipsc-derived midbrain organoids. |
2022-09-30 |
2023-08-14 |
Not clear |
| Aurore Vuidel, Loïc Cousin, Beatrice Weykopf, Simone Haupt, Zahra Hanifehlou, Nicolas Wiest-Daesslé, Michaela Segschneider, Joohyun Lee, Yong-Jun Kwon, Michael Peitz, Arnaud Ogier, Laurent Brino, Oliver Brüstle, Peter Sommer, Johannes H Wilbert. High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification. Stem cell reports. 2022-09-30. PMID:36179692. |
high-content phenotyping of parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification. |
2022-09-30 |
2023-08-14 |
Not clear |
| Da Woon Lee, Young-Kyoung Ryu, Dong-Ho Chang, Hye-Yeon Park, Jun Go, So-Young Maeng, Dae Youn Hwang, Byoung-Chan Kim, Chul-Ho Lee, Kyoung-Shim Ki. Journal of microbiology and biotechnology. vol 32. issue 9. 2022-09-28. PMID:36168204. |
parkinson's disease (pd) is the second-most prevalent neurodegenerative disease and is characterized by dopaminergic neuronal death in the midbrain. |
2022-09-28 |
2023-08-14 |
Not clear |
| Xi Chen, Zhaofei Yang, Yaping Shao, Kunhyok Kim, Yuanyuan Wang, Ying Wang, Haifeng Wu, Xiaolan Xu, Weidong L. Frontiers in aging neuroscience. vol 14. 2022-09-26. PMID:36158557. |
thus, msns may serve as the emerging targets for pd therapy besides the midbrain dopaminergic neurons. |
2022-09-26 |
2023-08-14 |
Not clear |
| Michal Rafal Zareba, Wiktoria Furman, Marek Binde. Influence of age and cognitive performance on resting-state functional connectivity of dopaminergic and noradrenergic centers. Brain research. 2022-09-17. PMID:36115586. |
in turn, older age was associated with greater local synchronization within vta, its lower fc with caudate, mediodorsal thalamus, and snc, as well as higher fc of both midbrain dopaminergic seeds with red nuclei. |
2022-09-17 |
2023-08-14 |
Not clear |
| Tong Tong, Weixia Duan, Yudong Xu, Huihui Hong, Jia Xu, Guanyan Fu, Xue Wang, Lingling Yang, Ping Deng, Jingjing Zhang, Haotian He, Gaofeng Mao, Yuanqiang Lu, Xiqin Lin, Zhengping Yu, Huifeng Pi, Yong Cheng, Shangcheng Xu, Zhou Zho. Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain. Environment international. vol 169. 2022-09-15. PMID:36108500. |
in summary, we presented initial investigations of pq induced molecular events related to the pd pathogenesis, capturing aspects of disturbed lipid metabolism, neuroinflammation, impairment of dopaminergic neurons in the midbrain, and an intense systemic inflammation. |
2022-09-15 |
2023-08-14 |
mouse |
| Seong Shoon Yoon, Bong Hyo Lee, Seong Ho Lee, Seong Hun Choi, Seon-Ju Jeong, Sang Chan Kim, Chae Ha Yan. Effects of isoflurane anesthesia on addictive behaviors in rats. Psychopharmacology. 2022-09-15. PMID:36109391. |
recently, it has been suggested that isoflurane might reduce dopamine release from rat midbrain dopaminergic neurons, the neurobiological substrate implicated in the reinforcing effects of abused drugs and nondrug rewards. |
2022-09-15 |
2023-08-14 |
rat |
| I R de Luzy, C Pavan, N Moriarty, C P J Hunt, Z Vandenhoven, A Khanna, J C Niclis, C W Gantner, L H Thompson, C L Paris. Identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of Parkinson's disease. Experimental neurology. 2022-09-02. PMID:36055392. |
identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of parkinson's disease. |
2022-09-02 |
2023-08-14 |
human |
| Katharina Pieger, Verena Schmitt, Carina Gauer, Nadja Gießl, Iryna Prots, Beate Winner, Jürgen Winkler, Johann Helmut Brandstätter, Wei Xian. Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation. Biomolecules. vol 12. issue 8. 2022-08-26. PMID:36009004. |
employing nu-asyn-c, we characterized asyn distribution during neuronal differentiation in midbrain dopaminergic neurons (mdans) derived from human-induced pluripotent stem cells (hipscs) and lund human mesencephalic cells, and in primary rat hippocampal neurons. |
2022-08-26 |
2023-08-14 |
human |
| Gunjan Thakur, Vikas Kumar, Keun Woo Lee, Chungkil Wo. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes. vol 13. issue 8. 2022-08-26. PMID:36011337. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. |
2022-08-26 |
2023-08-14 |
Not clear |
| Sara Bagnoli, Baldassare Fronte, Carlo Bibbiani, Eva Terzibasi Tozzini, Alessandro Cellerin. Quantification of noradrenergic-, dopaminergic-, and tectal-neurons during aging in the short-lived killifish Nothobranchius furzeri. Aging cell. 2022-08-20. PMID:35986561. |
parkinson's disease (pd) is characterized by phosphorylation and aggregation of the protein α-synuclein and ensuing neuronal death progressing from the noradrenergic locus coeruleus to midbrain dopaminergic neurons. |
2022-08-20 |
2023-08-14 |
Not clear |
| Deborah Pré, Alexander T Wooten, Steven Biesmans, Sandy Hinckley, Haowen Zhou, Sean P Sherman, Priyanka Kakad, Jeffrey Gearhart, Anne G Ban. Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks. Stem cell reports. 2022-08-19. PMID:35985330. |
here we describe a multi-electrode array (mea)-based assay to investigate chemically induced ltp (cltp) across entire networks of hipsc-derived midbrain dopaminergic (da) and cortical neuronal populations that lasts for days, allowing studies of the late phases of ltp and enabling detection of associated molecular changes. |
2022-08-19 |
2023-08-14 |
human |
| Lydia Hellrung, Matthias Kirschner, James Sulzer, Ronald Sladky, Frank Scharnowski, Marcus Herdener, Philippe N Toble. Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. Communications biology. vol 5. issue 1. 2022-08-19. PMID:35986202. |
analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. |
2022-08-19 |
2023-08-14 |
human |
| Lydia Hellrung, Matthias Kirschner, James Sulzer, Ronald Sladky, Frank Scharnowski, Marcus Herdener, Philippe N Toble. Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. Communications biology. vol 5. issue 1. 2022-08-19. PMID:35986202. |
the dopaminergic midbrain is associated with reinforcement learning, motivation and decision-making - functions often disturbed in neuropsychiatric disorders. |
2022-08-19 |
2023-08-14 |
human |
| Lydia Hellrung, Matthias Kirschner, James Sulzer, Ronald Sladky, Frank Scharnowski, Marcus Herdener, Philippe N Toble. Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. Communications biology. vol 5. issue 1. 2022-08-19. PMID:35986202. |
previous research has shown that dopaminergic midbrain activity can be endogenously modulated via neurofeedback. |
2022-08-19 |
2023-08-14 |
human |
| Yuanxi Li, Bing Zhang, Xiaochuan Pan, Yihong Wang, Xuying Xu, Rubin Wang, Zhiqiang Li. Dopamine-Mediated Major Depressive Disorder in the Neural Circuit of Ventral Tegmental Area-Nucleus Accumbens-Medial Prefrontal Cortex: From Biological Evidence to Computational Models. Frontiers in cellular neuroscience. vol 16. 2022-08-15. PMID:35966208. |
the abnormal dopaminergic pathways of the midbrain cortical and limbic system are the key pathological regions of mdd, particularly the ventral tegmental area- nucleus accumbens- medial prefrontal cortex (vta-nac-mpfc) neural circuit. |
2022-08-15 |
2023-08-14 |
Not clear |
| Lingmin Liang, Yao Tian, Lin Feng, Chaoqun Wang, Guihai Feng, Glyn Nigel Stacey, Ng Shyh-Chang, Jun Wu, Baoyang Hu, Wei Li, Jie Hao, Liu Wang, Yukai Wan. Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. Stem cell research & therapy. vol 13. issue 1. 2022-08-13. PMID:35964138. |
midbrain dopaminergic (da) progenitors derived from human pluripotent stem cells are considered to be a promising treatment for parkinson's disease (pd). |
2022-08-13 |
2023-08-14 |
human |