| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily E Anderson, Carl T Ash, Amy E Moritz, Patricia Dranchak, R Benjamin Free, James Inglese, Joseph P Steiner, David R Sibley, Emmanuel O Akan. Establishing an RNA interference (RNAi) screen for neuroprotection of dopaminergic neurons in Caenorhabditis elegans models of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553997. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the selective death of dopaminergic neurons in the substantia nigra of the midbrain, resulting in bradykinesia, tremors, muscle rigidity, and other motor and non-motor deficits. |
2022-05-13 |
2023-08-13 |
human |
| Amanda Grassel, Carris Borland, Federica Bertolotti, Ryan Osselborn, Tracey Nassuna, Bryce Zabat, Shubhik DebBurma. Insight into Parkinson's Disease From a Yeast Model: How Three Alpha-Synuclein Mutants (A18T, A29S, & A53V) Generate Toxicity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554149. |
parkinson's disease (pd) is a fatal and incurable neurodegenerative disorder linked to the loss of dopaminergic neurons in the midbrain. |
2022-05-13 |
2023-08-13 |
Not clear |
| Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong X. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature neuroscience. 2022-05-02. PMID:35501380. |
a d2 to d1 shift in dopaminergic inputs to midbrain 5-ht neurons causes anorexia in mice. |
2022-05-02 |
2023-08-13 |
mouse |
| Sreekanth Rajan, Hui Ting Toh, Hong Ye, Ziyin Wang, Adeline Henry Basil, Tanvi Parnaik, Jun Yeob Yoo, Kah-Leong Lim, Ho Sup Yoo. Prostaglandin A2 Interacts with Nurr1 and Ameliorates Behavioral Deficits in Parkinson's Disease Fly Model. Neuromolecular medicine. 2022-04-28. PMID:35482177. |
the orphan nuclear receptor nurr1 is critical for the development, maintenance, and protection of midbrain dopaminergic neurons. |
2022-04-28 |
2023-08-13 |
Not clear |
| Ana Chegão, Mariana Guarda, Bruno M Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V Lopes, Pedro R Florindo, Ricardo A Gomes, Patrícia Gomes-Alves, Joana E Coelho, Tiago Fleming Outeiro, Hugo Vicente Mirand. Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-26. PMID:35468899. |
the glycated proteins in the midbrain of mgo-injected thy1-asyn mice strongly correlate with pd and dopaminergic pathways. |
2022-04-26 |
2023-08-13 |
mouse |
| Anurupa A Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Ki. A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457082. |
we also confirmed that the compound treatment reduced the levels of protein aggregation, along with phosphorylated-α-synuclein, in the striatum and ventral midbrain and further dopaminergic neuronal loss. |
2022-04-23 |
2023-08-13 |
mouse |
| Alcmène Chalazonitis, Meenakshi Rao, David Sulze. Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-23. PMID:35459867. |
in addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as parkinson's disease (pd). |
2022-04-23 |
2023-08-13 |
mouse |
| Alcmène Chalazonitis, Meenakshi Rao, David Sulze. Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-23. PMID:35459867. |
although their cellular sources and developmental times of origin differ, midbrain and ens dopaminergic neurons express many transcription factors in common and their respective environments express similar neurotrophic molecules. |
2022-04-23 |
2023-08-13 |
mouse |
| Benjamin M Hiller, David J Marmion, Cayla A Thompson, Nathaniel A Elliott, Howard Federoff, Patrik Brundin, Virginia B Mattis, Christopher W McMahon, Jeffrey H Kordowe. Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson's disease. NPJ Regenerative medicine. vol 7. issue 1. 2022-04-22. PMID:35449132. |
in pursuit of treating parkinson's disease with cell replacement therapy, differentiated induced pluripotent stem cells (ipsc) are an ideal source of midbrain dopaminergic (mda) cells. |
2022-04-22 |
2023-08-13 |
human |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
in the midbrain, dopaminergic neurons are mainly situated in the substantia nigra (sn) and the ventral tegmental area (vta). |
2022-04-22 |
2023-08-13 |
Not clear |
| Silke Nuber, Chee Yeun Chung, Daniel F Tardiff, Pascal A Bechade, Thomas D McCaffery, Kazuma Shimanaka, Jeonghoon Choi, Belle Chang, Waseem Raja, Esther Neve, Christopher Burke, Xin Jiang, Ping Xu, Vikram Khurana, Ulf Dettmer, Saranna Fanning, Kenneth J Rhodes, Dennis J Selkoe, Robert H Scannevi. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-04-21. PMID:35445353. |
increasing evidence has shown that parkinson's disease (pd) impairs midbrain dopaminergic, cortical and other neuronal subtypes in large part due to the build-up of lipid- and vesicle-rich α-synuclein (αsyn) cytotoxic inclusions. |
2022-04-21 |
2023-08-13 |
mouse |
| Nancy Y A Sey, Benxia Hu, Marina Iskhakova, Sool Lee, Huaigu Sun, Neda Shokrian, Gabriella Ben Hutta, Jesse A Marks, Bryan C Quach, Eric O Johnson, Dana B Hancock, Schahram Akbarian, Hyejung Wo. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular psychiatry. 2022-04-15. PMID:35422469. |
to investigate the functional impact of common variants associated with cigarette smoking and alcohol use traits, we applied hi-c coupled magma (h-magma) built upon cortical and newly generated midbrain dopaminergic neuronal hi-c datasets to gwas summary statistics of nicotine dependence, cigarettes per day, problematic alcohol use, and drinks per week. |
2022-04-15 |
2023-08-13 |
Not clear |
| Nancy Y A Sey, Benxia Hu, Marina Iskhakova, Sool Lee, Huaigu Sun, Neda Shokrian, Gabriella Ben Hutta, Jesse A Marks, Bryan C Quach, Eric O Johnson, Dana B Hancock, Schahram Akbarian, Hyejung Wo. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular psychiatry. 2022-04-15. PMID:35422469. |
risk genes were highly expressed in cortical glutamatergic, midbrain dopaminergic, gabaergic, and serotonergic neurons, suggesting them as relevant cell types in understanding the mechanisms by which genetic risk factors influence cigarette smoking and alcohol use. |
2022-04-15 |
2023-08-13 |
Not clear |
| Silvia Arber, Rui M Cost. Networking brainstem and basal ganglia circuits for movement. Nature reviews. Neuroscience. 2022-04-15. PMID:35422525. |
important networking components include broadcasting neurons in the cortex, cerebellar output neurons and midbrain dopaminergic neurons. |
2022-04-15 |
2023-08-13 |
Not clear |
| Amanda R Burmeister, Juozas Gordevicius, Emmanuel N Paul, Christina Houck, Sonia George, Martha L Escobar Galvis, Qiong Sha, Patrik Brundin, J Andrew Pospisilik, Karen Racicot, Lena Brundi. Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. Neurobiology of disease. 2022-04-13. PMID:35417751. |
maternal herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. |
2022-04-13 |
2023-08-13 |
mouse |
| Xin Liu, Zhong Rui Du, Xiong Wang, Xiang Rong Sun, Qing Zhao, Fang Zhao, Wing Tak Wong, Ka Hing Wong, Xiao-Li Don. Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson's disease. Food research international (Ottawa, Ont.). vol 155. 2022-04-11. PMID:35400445. |
our results found oral administration of prebiotic pm or lgg separately or in combination for 5 weeks could prevent dopaminergic neuronal loss via improving reduced walking distance and activity or weakened muscle strength in behavior tests by enhancing tyrosine hydroxylase (th) gene and/or protein expressions in the midbrain and striatum of pd mice. |
2022-04-11 |
2023-08-13 |
mouse |
| Aleksandar Rakovic, Dorothea Voß, Franca Vulinovic, Britta Meier, Ann-Katrin Hellberg, Carla Nau, Christine Klein, Enrico Leipol. Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase. Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401116. |
electrophysiological properties of induced pluripotent stem cell-derived midbrain dopaminergic neurons correlate with expression of tyrosine hydroxylase. |
2022-04-11 |
2023-08-13 |
Not clear |
| F Gubinelli, G Cazzolla, M Negrini, I Kulacz, A Mehrdadian, G Tomasello, C Venuti, L Sarauskyte, F Jacobs, F P Manfredsson, M Davidsson, A Heue. Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioural tests. Behavioural brain research. 2022-04-11. PMID:35405174. |
preclinical rodent models of parkinson's aim to recapitulate some of the hallmarks of the disease as it presents in humans, including the progressive neuronal loss of dopaminergic neurons in the midbrain as well as the development of a behavioural phenotype. |
2022-04-11 |
2023-08-13 |
rat |
| b' Alice Adiletta, Alessandra Pross, Nicol\\xc3\\xb2 Taricco, Paola Sgad\\xc3\\xb. Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic Chicks. Frontiers in integrative neuroscience. vol 16. 2022-04-04. PMID:35369647.' |
we found that vpa affected the rostro-caudal distribution of da neurons, without changing the expression levels of several dopaminergic markers in the mesencephalon. |
2022-04-04 |
2023-08-13 |
chicken |
| Gabriela Novak, Steven Finkbeiner, Gaia Skibinski, Michela Bernini, Cristina Donato, Alexander Skupi. Generation of two human induced pluripotent stem cell lines from fibroblasts of Parkinson's disease patients carrying the ILE368ASN mutation in PINK1 (LCSBi002) and the R275W mutation in Parkin (LCSBI004). Stem cell research. vol 61. 2022-04-04. PMID:35378365. |
the cell lines were successfully used to generate midbrain dopaminergic neurons, the neuron type primarily affected in pd. |
2022-04-04 |
2023-08-13 |
human |