| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Petese, Franca L Fries, Bianca Broske, Ralf Stumm, Sandra Blaes. Lineage analysis of eNeuro. 2022-08-12. PMID:35961772. |
lineage analysis of midbrain dopaminergic (mda) neurons are generated from a ventral midbrain progenitor zone over a time span of several days (embryonic day (e)10.0-e14.5 in mouse). |
2022-08-12 |
2023-08-14 |
mouse |
| Walaa F Alsanie, Sherin Abdelrahman, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Charlotte A E Hauser, Hossam H Tayeb, Abdulhakeem S Alamri, Bassem M Raafat, Sirajudheen Anwar, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. Prenatal Exposure to Gabapentin Alters the Development of Ventral Midbrain Dopaminergic Neurons. Frontiers in pharmacology. vol 13. 2022-08-09. PMID:35942222. |
prenatal exposure to gabapentin alters the development of ventral midbrain dopaminergic neurons. |
2022-08-09 |
2023-08-14 |
Not clear |
| May Hui, Kevin T Beie. Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain. Frontiers in molecular neuroscience. vol 15. 2022-08-08. PMID:35935333. |
though dopaminergic cells themselves are spatially restricted to the midbrain and constitute a relatively small proportion of all neurons, their projections influence many brain regions. |
2022-08-08 |
2023-08-14 |
Not clear |
| Lukas Leupold, Veronika Sigutova, Elizaveta Gerasimova, Martin Regensburger, Sebastian Zundler, Friederike Zunke, Wei Xiang, Beate Winner, Iryna Prot. The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis. Frontiers in neurology. vol 13. 2022-08-01. PMID:35911883. |
we further utilize our workflow to demonstrate the ability of the 2a7 antibody to distinguish between physiological differences in asyn expression in neuronal and non-neuronal cells from the cortical organoids, and in neural progenitors and midbrain dopaminergic neurons from healthy controls and in patients with parkinson's disease who have asyn gene locus duplication. |
2022-08-01 |
2023-08-14 |
human |
| Tianyi Dou, Dmitry Kurousk. Phosphatidylcholine and Phosphatidylserine Uniquely Modify the Secondary Structure of α-Synuclein Oligomers Formed in Their Presence at the Early Stages of Protein Aggregation. ACS chemical neuroscience. 2022-07-29. PMID:35904551. |
these aggregates are the underlying molecular cause of an onset of the irreversible degeneration of dopaminergic neurons in midbrain, hypothalamus, and thalamus, a pathology known as parkinson's disease. |
2022-07-29 |
2023-08-14 |
Not clear |
| Jesus Alarcon-Gil, Ana Sierra-Magro, Jose A Morales-Garcia, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Marta Cortes-Canteli, Mireia Niso-Santano, Guadalupe Martínez-Chacón, Jose M Fuentes, Angel Santos, Ana Perez-Castill. Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy. Cells. vol 11. issue 15. 2022-07-27. PMID:35892594. |
the principal pathological feature of pd is the progressive loss of dopaminergic neurons in the ventral midbrain. |
2022-07-27 |
2023-08-14 |
mouse |
| Jordan D Prahl, Steven E Pierce, Edwin J C Schans, Gerhard A Coetzee, Trevor Tyso. The Parkinson's Disease Variant rs356182 Regulates Neuronal Differentiation Independently from Alpha-Synuclein. Human molecular genetics. 2022-07-22. PMID:35866299. |
we use crispr-cas9 in luhmes cells, a model for dopaminergic midbrain neurons, to generate precise hemizygous lesions at rs356182. |
2022-07-22 |
2023-08-14 |
Not clear |
| Jaron T Colas, Neil M Dundon, Raphael T Gerraty, Natalie M Saragosa-Harris, Karol P Szymula, Koranis Tanwisuth, J Michael Tyszka, Camilla van Geen, Harang Ju, Arthur W Toga, Joshua I Gold, Dani S Bassett, Catherine A Hartley, Daphna Shohamy, Scott T Grafton, John P O'Dohert. Reinforcement learning with associative or discriminative generalization across states and actions: fMRI at 3 T and 7 T. Human brain mapping. 2022-07-21. PMID:35860954. |
with high-resolution high-field fmri targeting the dopaminergic midbrain, the grl model's rpe signals (alongside value and decision signals) were localized within not only the striatum but also the substantia nigra and the ventral tegmental area, including specific effects of generalization that also extend to the hippocampus. |
2022-07-21 |
2023-08-14 |
human |
| Rayan Fakih, Véronique Sauvé, Kalle Gehrin. Feedforward activation of PRKN/parkin. Autophagy. 2022-07-15. PMID:35838500. |
parkinson disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. |
2022-07-15 |
2023-08-14 |
Not clear |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
level of motivation, responsiveness to rewards and punishment, invigoration of exploratory behaviours, and motor performance are subject to daily fluctuations that emerge from circadian rhythms in neuronal activity of the midbrain's dopaminergic system. |
2022-07-11 |
2023-08-14 |
human |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
these processes cause dopamine levels released in structures innervated by midbrain dopaminergic neurons (e.g., the striatum) to oscillate in a circadian fashion. |
2022-07-11 |
2023-08-14 |
human |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
previous studies have shown that the information about the value and salience of stimuli perceived by the animal is encoded in the neuronal activity of brain structures innervating midbrain dopaminergic centres. |
2022-07-11 |
2023-08-14 |
human |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellench. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35805964. |
the development of midbrain dopaminergic (da) neurons requires a fine temporal and spatial regulation of a very specific gene expression program. |
2022-07-09 |
2023-08-14 |
mouse |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellench. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35805964. |
using published transcriptomic data, we found a significant enrichment of mir-204/211 target genes in midbrain dopaminergic neurons where lmx1a was selectively deleted at embryonic stages. |
2022-07-09 |
2023-08-14 |
mouse |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellench. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35805964. |
thus, our data indicate the lmx1a-mir-204/211-nurr1 axis as a key component in the cascade of events that ultimately lead to mature midbrain dopaminergic neurons differentiation and point to mir-204/211 as the molecular switch regulating the timing of nurr1 expression. |
2022-07-09 |
2023-08-14 |
mouse |
| Jiwei Liu, Li Yang, Han Li, Yichuan Cai, Jiali Feng, Zelan H. Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size. Journal of chemical neuroanatomy. 2022-07-06. PMID:35792205. |
conditional ablation of protein tyrosine phosphatase receptor u in midbrain dopaminergic neurons results in reduced neuronal size. |
2022-07-06 |
2023-08-14 |
mouse |
| Jiwei Liu, Li Yang, Han Li, Yichuan Cai, Jiali Feng, Zelan H. Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size. Journal of chemical neuroanatomy. 2022-07-06. PMID:35792205. |
protein tyrosine phosphatase receptor u (ptpru) is involved in midbrain patterning during early stages of development and is continuously expressed in the adult midbrain areas where dopaminergic neurons reside in. |
2022-07-06 |
2023-08-14 |
mouse |
| Jiwei Liu, Li Yang, Han Li, Yichuan Cai, Jiali Feng, Zelan H. Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size. Journal of chemical neuroanatomy. 2022-07-06. PMID:35792205. |
however, whether ptpru is also involved in the maintenance and survival of midbrain dopaminergic (mda) neurons during the late stages of development or in the adult midbrain still remains unknown. |
2022-07-06 |
2023-08-14 |
mouse |
| Haley M Geertsma, Konrad M Ricke, Maxime W C Rousseau. Assessment of Dopaminergic Neurodegeneration in Mice. Methods in molecular biology (Clifton, N.J.). vol 2515. 2022-07-01. PMID:35776351. |
in addition, we outline the protocol for the analysis of the dopaminergic terminals in the striatum, the projection area of midbrain dopaminergic neurons, as a readout for the integrity of the nigrostriatal projections. |
2022-07-01 |
2023-08-14 |
mouse |
| Mona Abdollahi, Margaret Fahnestoc. Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons. International journal of molecular sciences. vol 23. issue 12. 2022-06-27. PMID:35743300. |
nurr1 regulates bdnf in midbrain dopaminergic neurons and cerebellar granule cells. |
2022-06-27 |
2024-09-01 |
mouse |