| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mona Abdollahi, Margaret Fahnestoc. Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons. International journal of molecular sciences. vol 23. issue 12. 2022-06-27. PMID:35743300. |
therefore, in contrast to midbrain dopaminergic neurons and cerebellar granule cells, nurr1 does not regulate bdnf in cortical neurons. |
2022-06-27 |
2024-09-01 |
mouse |
| Krishnan Sriram, Gary X Lin, Amy M Jefferson, Walter McKinney, Mark C Jackson, Jared L Cumpston, James B Cumpston, Howard D Leonard, Michael L Kashon, Jeffrey S Feda. Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression. Toxicology and applied pharmacology. 2022-06-24. PMID:35750205. |
sub-chronic cov exposure caused significant reductions in ne, epi and da in the dopaminergic brain regions, striatum (str) and midbrain (mb), and a large increase in 5-ht in the str. |
2022-06-24 |
2023-08-14 |
rat |
| Wanying Zhu, Mengdan Tao, Yuan Hong, Shanshan Wu, Chu Chu, Zhilong Zheng, Xiao Han, Qian Zhu, Min Xu, Andrew G Ewing, Xing Guo, Yan Li. Dysfunction of vesicular storage in young-onset Parkinson's patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry. Chemical science. vol 13. issue 21. 2022-06-23. PMID:35733907. |
human dopaminergic (da) neurons and midbrain organoids were derived from an induced pluripotent stem cell line from one yopd patient. |
2022-06-23 |
2023-08-14 |
human |
| Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong X. Publisher Correction: A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature neuroscience. 2022-06-21. PMID:35729403. |
publisher correction: a d2 to d1 shift in dopaminergic inputs to midbrain 5-ht neurons causes anorexia in mice. |
2022-06-21 |
2023-08-14 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |
| Taylor Russo, Markus Riesslan. Age-Related Midbrain Inflammation and Senescence in Parkinson's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-20. PMID:35721008. |
we hypothesize that secretion of pro-inflammatory factors by senescent cells in the midbrain triggers neuroinflammation resulting in immune cell-mediated killing of midbrain dopaminergic (da) neurons in pd. |
2022-06-20 |
2023-08-14 |
Not clear |
| Xinguo Zhang, Ruiqi Zhang, Maher Un Nisa Awan, Jie Ba. The Mechanism and Function of Glia in Parkinson's Disease. Frontiers in cellular neuroscience. vol 16. 2022-06-20. PMID:35722618. |
pd is thought to be the loss of midbrain dopaminergic neurons, but it has recently been discovered that glia also affects brain tissue homeostasis, defense, and repair in pd. |
2022-06-20 |
2023-08-14 |
Not clear |
| Mario Bogdanov, Sophia LoParco, A Ross Otto, Madeleine Shar. Dopaminergic medication increases motivation to exert cognitive control by reducing subjective effort costs in Parkinson's patients. Neurobiology of learning and memory. 2022-06-20. PMID:35724812. |
to address this question, we assessed cognitive effort avoidance in patients (n = 38) with parkinson's disease, a condition characterized by loss of midbrain dopaminergic neurons, both on and off dopaminergic medication and compared them to healthy controls (n = 24). |
2022-06-20 |
2023-08-14 |
human |
| Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Che. Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model. The Journal of clinical investigation. 2022-06-14. PMID:35700056. |
human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a parkinson's disease model. |
2022-06-14 |
2023-08-14 |
mouse |
| Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Che. Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model. The Journal of clinical investigation. 2022-06-14. PMID:35700056. |
however, the heterogeneity of hpsc-derived donor cells and the low yield of midbrain dopaminergic (mda) neurons after transplantation hinder its broad clinical application. |
2022-06-14 |
2023-08-14 |
mouse |
| Matthew J Reid, Maria Rogdaki, Lucia Dutan, Bjørn Hanger, Kaarin Sabad, Roland Nagy, Dwaipayan Adhya, Simon Baron-Cohen, Grainne McAlonan, Jack Price, Anthony C Vernon, Oliver D Howes, Deepak P Srivastav. Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity. Schizophrenia research. 2022-06-14. PMID:35701280. |
cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity. |
2022-06-14 |
2023-08-14 |
Not clear |
| Theodora Mourtzi, Ilias Kazani. Endogenous Neural regeneration research. vol 17. issue 12. 2022-06-06. PMID:35662194. |
from the first fetal midbrain intrastriatal graft to the most recent conversion of astrocytes into dopaminergic neurons, we have gained equally, significant insights and questions still looking for an answer. |
2022-06-06 |
2023-08-14 |
Not clear |
| Jinhua Xue, Yanning Li, Yue Qi, Ziwei Zhang, Xiaolu Tan. Exogenous Otx2 protects midbrain dopaminergic neurons from MPP Neurotoxicology. 2022-06-01. PMID:35644505. |
exogenous otx2 protects midbrain dopaminergic neurons from mpp mitochondrial dysfunction is the main pathological mechanism responsible for the death of midbrain dopaminergic (mda) neurons. |
2022-06-01 |
2023-08-13 |
Not clear |
| Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Den. Effects of Risperidone and Prenatal Poly I:C Exposure on GABA Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625659. |
effects of risperidone and prenatal poly i:c exposure on gaba the ventral tegmental area (vta) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. |
2022-05-28 |
2023-08-13 |
Not clear |
| Mayank Patel, Shamsher Sing. Apigenin Attenuates Functional and Structural Alterations via Targeting NF-kB/Nrf2 Signaling Pathway in LPS-Induced Parkinsonism in Experimental Rats : Apigenin Attenuates LPS-Induced Parkinsonism in Experimental Rats. Neurotoxicity research. 2022-05-24. PMID:35608813. |
parkinson's disease (pd) is a progressive hypokinetic movement disorder caused by selective degeneration of dopaminergic neurons in striatum and dopamine deficiency in a region of the midbrain. |
2022-05-24 |
2023-08-13 |
rat |
| Niamh Moriarty, Jessica A Kauhausen, Chiara Pavan, Cameron Pj Hunt, Isabelle R de Luzy, Vanessa Penna, Charlotte M Ermine, Lachlan H Thompson, Clare L Paris. Understanding the influence of target acquisition on survival, integration and phenotypic maturation of dopamine neurons within stem cell-derived neural grafts in a Parkinson's disease model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-24. PMID:35610045. |
midbrain dopaminergic neurons include many subtypes characterised by their location, connectivity and function. |
2022-05-24 |
2023-08-13 |
mouse |
| Iro Boura, Kallol Ray Chaudhur. Coronavirus Disease 2019 and Related Parkinsonism: The Clinical Evidence Thus Far. Movement disorders clinical practice. 2022-05-23. PMID:35601258. |
this theory is further augmented by reports of a pathogenic effect of the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) on the central nervous system with specific impact on the dopaminergic pathway, as well as the possibility of the virus to selectively bind to angiotensin-converting enzyme-2 (ace-2); these molecules are expressed abundantly in the midbrain dopamine neurons and, are likely involved in several cellular mechanisms cited in parkinson's disease (pd) pathophysiology. |
2022-05-23 |
2023-08-13 |
Not clear |
| Francesca Montarolo, Serena Martire, Francesco Chiara, Sarah Allegra, Silvia De Francia, Eriola Hoxha, Filippo Tempia, Marco Alfonso Capobianco, Antonio Bertolott. NURR1-deficient mice have age- and sex-specific behavioral phenotypes. Journal of neuroscience research. 2022-05-20. PMID:35593070. |
the transcription factor nurr1 is essential to the generation and maintenance of midbrain dopaminergic (mda) neurons and its deregulation is involved in the development of dopamine (da)-associated brain disorders, such as parkinson's disease (pd). |
2022-05-20 |
2023-08-13 |
mouse |
| Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Hafiz A Makeen, Mohammed Albratty, Hassan A Alhazmi, Abdulkarim M Meraya, Simona Bunga. Demystifying the Neuroprotective Role of Neuropeptides in Parkinson's Disease: A Newfangled and Eloquent Therapeutic Perspective. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562956. |
parkinson's disease (pd) refers to one of the eminently grievous, preponderant, tortuous nerve-cell-devastating ailments that markedly impacts the dopaminergic (dargic) nerve cells of the midbrain region, namely the substantia nigra pars compacta (sn-pc). |
2022-05-14 |
2023-08-13 |
human |
| Namrata Kumari, Nagarjuna Daram, Md Sabir Alam, Anita Kamra Verm. Rationalizing the Use of Polyphenol Nano-formulations in the Therapy of Neurodegenerative Diseases. CNS & neurological disorders drug targets. 2022-05-13. PMID:35549866. |
dopaminergic neuronal death in the midbrain and accumulation of β- synuclein in the neurons are the hallmark of parkinson's disease. |
2022-05-13 |
2023-08-13 |
Not clear |