| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huihui Hong, Jingdian Li, Tong Tong, Ting Yang, Hui Wang, Yudong Xu, Xiqin Lin, Jinxian Lin, Sicheng Liu, Kun Luo, Zhengping Yu, Wei Yuan, Huifeng Pi, Zhou Zho. Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin. The Science of the total environment. vol 934. 2024-05-18. PMID:38750743. |
results showed that pq-induced motor deficits and midbrain dopaminergic neuronal damage in c57bl/6 j mice were protected by melatonin pretreatment. |
2024-05-18 |
2024-05-27 |
mouse |
| Pedro Rifes, Janko Kajtez, Josefine Rågård Christiansen, Alrik Schörling, Gaurav Singh Rathore, Daniel A Wolf, Andreas Heuer, Agnete Kirkeb. Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons. Stem cell reports. 2024-05-17. PMID:38759646. |
forced lmx1a expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons. |
2024-05-17 |
2024-05-27 |
human |
| Saba Afsheen, Ahmed Shaney Rehman, Azfar Jamal, Nazia Khan, Suhel Parve. Understanding Role of Pesticides in Development of Parkinson's Disease: Insights from Drosophila and Rodent Models. Ageing research reviews. 2024-05-17. PMID:38759892. |
parkinson's disease is a neurodegenerative illness linked to ageing, marked by the gradual decline of dopaminergic neurons in the midbrain. |
2024-05-17 |
2024-05-27 |
drosophila_melanogaster |
| Guoyi Tang, Yuan Guo, Ruotong Li, Yixuan Wang, Jie Yang, Shasha Gao, Jian Li. Lateral habenula 5-HT Neurochemistry international. 2024-05-16. PMID:38750961. |
lateral habenula 5-ht although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not clear the role of lhb 5-ht |
2024-05-16 |
2024-05-27 |
Not clear |
| Katarina Mihajlović, Gaia Ceddia, Noël Malod-Dognin, Gabriela Novak, Dimitrios Kyriakis, Alexander Skupin, Nataša Pržul. Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-05-14. PMID:38744869. |
the onset of pd symptoms corresponds to 50% loss of midbrain dopaminergic (mda) neurons, limiting early-stage understanding of pd. |
2024-05-14 |
2024-05-27 |
Not clear |
| Blake L Elliott, Raana A Mohyee, Ian C Ballard, Ingrid R Olson, Lauren M Ellman, Vishnu P Murt. In vivo structural connectivity of the reward system along the hippocampal long axis. Hippocampus. 2024-05-03. PMID:38700259. |
while the dopaminergic midbrain (ventral tegmental area) showed stronger connectivity with the anterior versus posterior hippocampus, the ventromedial prefrontal cortex showed stronger connectivity with the posterior hippocampus. |
2024-05-03 |
2024-05-05 |
human |
| Brian L Edlow, Mark Olchanyi, Holly J Freeman, Jian Li, Chiara Maffei, Samuel B Snider, Lilla Zöllei, J Eugenio Iglesias, Jean Augustinack, Yelena G Bodien, Robin L Haynes, Douglas N Greve, Bram R Diamond, Allison Stevens, Joseph T Giacino, Christophe Destrieux, Andre van der Kouwe, Emery N Brown, Rebecca D Folkerth, Bruce Fischl, Hannah C Kinne. Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness. Science translational medicine. vol 16. issue 745. 2024-05-01. PMID:38691619. |
complementary analyses of in vivo 7-tesla resting-state functional mri data from the human connectome project identified the dopaminergic ventral tegmental area in the midbrain as a widely connected hub node at the nexus of the subcortical arousal and cortical awareness networks. |
2024-05-01 |
2024-05-04 |
human |
| Vasily Vorobyov, Alexander Deev, Kirill Chaprov, Natalia Ninkin. Disruption of Electroencephalogram Coherence between Cortex/Striatum and Midbrain Dopaminergic Regions in the Knock-Out Mice with Combined Loss of Alpha, Beta, and Gamma Synucleins. Biomedicines. vol 12. issue 4. 2024-04-27. PMID:38672235. |
disruption of electroencephalogram coherence between cortex/striatum and midbrain dopaminergic regions in the knock-out mice with combined loss of alpha, beta, and gamma synucleins. |
2024-04-27 |
2024-04-29 |
mouse |
| Magdalena Tyczyńska, Marta Gędek, Adam Brachet, Wojciech Stręk, Jolanta Flieger, Grzegorz Teresiński, Jacek Ba. Trace Elements in Alzheimer's Disease and Dementia: The Current State of Knowledge. Journal of clinical medicine. vol 13. issue 8. 2024-04-27. PMID:38673657. |
parkinson's disease is caused by the accumulation of fe in the midbrain dopaminergic nucleus, and the pathogenesis of multiple sclerosis derives from zn deficiency, leading to an imbalance between t cell functions. |
2024-04-27 |
2024-04-29 |
Not clear |
| Suraj Cherian, Gabriel Simms, Liqiang Chen, Hong-Yuan Ch. Loss of Midbrain Dopamine Neurons Does Not Alter GABAergic Inhibition Mediated by Parvalbumin-Expressing Interneurons in Mouse Primary Motor Cortex. eNeuro. 2024-04-24. PMID:38658137. |
however, how degeneration of the midbrain dopaminergic neurons affects the anatomy, microcircuit connectivity, and function of the m1 network remains poorly understood. |
2024-04-24 |
2024-04-28 |
mouse |
| Meng Yu, Fengjiao Sun, Guo Xiang, Yuhan Zhang, Xuejun Wang, Xia Liu, Bin Huang, Xingang Li, Di Zhan. Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation. Frontiers in molecular neuroscience. vol 17. 2024-04-22. PMID:38646099. |
the dopaminergic system, originating from the midbrain ventral tegmental area (vta), is a key modulator of cognitive function. |
2024-04-22 |
2024-04-24 |
mouse |
| Sang Hui Yong, Sang-Mi Kim, Gyeong Woon Kong, Seung Hwan Ko, Eun-Hye Lee, Yohan Oh, Sang Hui Yon. ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy. BMB reports. 2024-04-22. PMID:38649147. |
ascl1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for parkinson's disease therapy. |
2024-04-22 |
2024-04-26 |
Not clear |
| Hye-Yeon Park, Ga Seul Lee, Jun Go, Young-Kyoung Ryu, Chul-Ho Lee, Jeong Hee Moon, Kyoung-Shim Ki. Angiotensin-converting enzyme inhibition prevents L-dopa-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease. European journal of pharmacology. 2024-04-20. PMID:38642669. |
parkinson's disease (pd) is characterised by severe movement defects and the degeneration of dopaminergic neurones in the midbrain. |
2024-04-20 |
2024-04-23 |
mouse |
| In-Beom Jin, Nam-Heon Kim, Jung-Soo Ha. Emerging role of the lateral habenula in conditioned inhibition and depression. Behavioral neuroscience. 2024-04-18. PMID:38635178. |
recent research has shed light on the lateral habenula (lhb) engagement in conditioned inhibition, along with the midbrain dopaminergic neurons. |
2024-04-18 |
2024-04-20 |
Not clear |
| Adrian Romero, Armando Sanchez, Jocelyn D Jones, Kristel Ledesma, Medhat S El-Halawany, Ayman K Hamouda, Brent R Bil. Optimization of Zebrafish Larvae 6-OHDA Exposure for Neurotoxin Induced Dopaminergic Marker Reduction. Zebrafish. 2024-04-12. PMID:38608227. |
parkinson's disease (pd) is a neurodegenerative disorder that is clinically assessed by motor symptoms associated with the loss of midbrain dopaminergic neurons affecting the quality of life for over 8.5 million people worldwide. |
2024-04-12 |
2024-04-15 |
zebrafish |
| Chiara Prodani, Elaine E Irvine, Alessandro Sardini, Hannah J Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J Withers, Mark A Ungless, Matthias Merkenschlager, Amanda G Fishe. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific reports. vol 14. issue 1. 2024-04-12. PMID:38609446. |
exposure to lpd in utero resulted in significantly more tyrosine hydroxylase positive (dopaminergic) neurons in the midbrain of adult offspring as compared to age-matched, control-diet equivalents. |
2024-04-12 |
2024-04-15 |
mouse |
| Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill, Paul D Dodso. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons. Cell reports. vol 43. issue 4. 2024-04-06. PMID:38581677. |
here, we investigated the organizational logic of dopaminergic signaling by recording and labeling individual midbrain dopamine neurons during associative behavior. |
2024-04-06 |
2024-04-10 |
Not clear |
| Jean-Louis A Parmasad, Konrad M Ricke, Benjamin Nguyen, Morgan G Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M Geertsma, Eric Lian, Nathalie A Lengacher, Steve M Callaghan, Alvin Joselin, Julianna J Tomlinson, Michael G Schlossmacher, William L Stanford, Jiyan Ma, Patrik Brundin, Scott D Ryan, Maxime W C Rousseau. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell death & disease. vol 15. issue 4. 2024-04-04. PMID:38575601. |
parkinson's disease (pd) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (dans) and the abnormal accumulation of α-synuclein (α-syn) protein. |
2024-04-04 |
2024-04-07 |
mouse |
| Malú Gámez Tansey, Jake Boles, Jenny Holt, Cassandra Cole, Noelle Neighbarger, Nikhil Urs, Oihane Uriarte-Huart. Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis. Research square. 2024-04-01. PMID:38559083. |
in all, this study supports the growing appreciation for the lc as neuroprotective against inflammation-induced brain injury and draws attention to the potential for neergic interventions to exert disease-modifying effects under conditions where peripheral inflammation may compromise ventral midbrain dopaminergic neurons and increase the risk for development of pd. |
2024-04-01 |
2024-04-04 |
mouse |
| Aggeliki Dimopoulou, Vasiliki Panagiotakopoulou, Theodora Mourtzi, Ilias Kazanis, Fevronia Angelato. Alpha-synuclein pathology in the "weaver" mouse, a genetic model of dopaminergic denervation. microPublication biology. vol 2024. 2024-03-29. PMID:38550606. |
our results revealed increased serine 129 phosphorylation in the midbrain, striatum, and cortex at a phase of established dopaminergic degeneration on postnatal day 100. |
2024-03-29 |
2024-03-31 |
mouse |