| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer Sally Samson, Anuradha Ramesh, Venkatachalam Deepa Parvath. Development of midbrain dopaminergic neurons and the advantage of using hiPSCs as a model system to study Parkinson's disease. Neuroscience. 2024-03-24. PMID:38522661. |
development of midbrain dopaminergic neurons and the advantage of using hipscs as a model system to study parkinson's disease. |
2024-03-24 |
2024-03-27 |
Not clear |
| Jennifer Sally Samson, Anuradha Ramesh, Venkatachalam Deepa Parvath. Development of midbrain dopaminergic neurons and the advantage of using hiPSCs as a model system to study Parkinson's disease. Neuroscience. 2024-03-24. PMID:38522661. |
midbrain dopaminergic (mda) neurons are significantly impaired in patients inflicted with parkinson's disease (pd), subsequently affecting a variety of motor functions. |
2024-03-24 |
2024-03-27 |
Not clear |
| Lizett Ortiz de Ora, Julia M Balsamo, Kylie S Uyeda, Elizabeth N Bes. Discovery of a Gut Bacterial Metabolic Pathway that Drives α-Synuclein Aggregation. ACS chemical biology. 2024-03-22. PMID:38517270. |
parkinson's disease (pd) etiology is associated with aggregation and accumulation of α-synuclein (α-syn) proteins in midbrain dopaminergic neurons. |
2024-03-22 |
2024-03-24 |
Not clear |
| Y Li, J Xu, C Jiang, Z Chen, Y Chen, M Ying, A Wang, C Ma, C Wang, Y Guo, C Li. [Rho kinase inhibitor Y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 44. issue 2. 2024-03-19. PMID:38501408. |
[rho kinase inhibitor y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in to improve the efficiency of induced differentiation of primitive neural epithelial cells derived from human induced pluripotent stem cells (hipscs-necs) into functional midbrain dopaminergic progenitor cells (daps). |
2024-03-19 |
2024-03-21 |
human |
| Ana Araújo, Isabel Catarina Duarte, Teresa Sousa, Joana Oliveira, Ana Telma Pereira, António Macedo, Miguel Castelo-Branc. Neural inhibition as implemented by an actor-critic model involves the human dorsal striatum and ventral tegmental area. Scientific reports. vol 14. issue 1. 2024-03-17. PMID:38493169. |
rodent and computational studies show that midbrain regions play crucial roles during errors by sending dopaminergic learning signals to the basal ganglia for behavioural adjustment. |
2024-03-17 |
2024-03-19 |
human |
| Fuyuki Karube, Yang Yang, Kenta Kobayashi, Fumino Fujiyam. Anterograde trans-neuronal labeling of striatal interneurons in relation to dopamine neurons in the substantia nigra pars compacta. Frontiers in neuroanatomy. vol 18. 2024-03-14. PMID:38482378. |
dopaminergic (da) neurons in the midbrain are highly heterogeneous in terms of gene and protein expression and axonal projections. |
2024-03-14 |
2024-03-16 |
Not clear |
| Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui L. LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease. Journal of cellular physiology. 2024-03-13. PMID:38477420. |
neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (da) neurons in the midbrain are its primary pathological manifestations. |
2024-03-13 |
2024-03-15 |
mouse |
| Liqing Lin, Jie Deng, Junhui Peng, Jing Cui, Lei Wang, Min Zhang, Jia Gao, Fudong Li, Yunyu Shi, Mengqi L. Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain. The FEBS journal. 2024-03-11. PMID:38465368. |
lim homeodomain transcription factor 1-alpha (lmx1a) is a neuronal lineage-specific transcription activator that plays an essential role during the development of midbrain dopaminergic (mda) neurons. |
2024-03-11 |
2024-03-14 |
Not clear |
| Ruotong Li, Guoyi Tang, Jie Yang, Shasha Gao, Yixuan Wang, Xiang Wu, Yihua Bai, Jian Li. The avBNST Neurochemistry international. 2024-03-08. PMID:38458538. |
the vta and drn contain dopaminergic and serotonergic cell groups in the midbrain which regulate anxiety-like behaviors. |
2024-03-08 |
2024-03-11 |
rat |
| Min Seong Kim, Subeen Yoon, Jiwoo Choi, Yong Jun Kim, Gabsang Le. Stem Cell-Based Approaches in Parkinson's Disease Research. International journal of stem cells. 2024-03-07. PMID:38449089. |
parkinson's disease (pd) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. |
2024-03-07 |
2024-03-09 |
Not clear |
| Annie J Zalon, Drew J Quiriconi, Caleb Pitcairn, Joseph R Mazzull. α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson's disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-02-29. PMID:38420922. |
parkinson's disease (pd) is a common age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. |
2024-02-29 |
2024-03-02 |
Not clear |
| Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arathi Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selko. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease. vol 10. issue 1. 2024-02-29. PMID:38424059. |
both 1d and 3d mice undergo loss of striatal th+ fibers and midbrain dopaminergic neurons by 12 mos and a bradykinesia responsive to l-dopa. |
2024-02-29 |
2024-03-03 |
mouse |
| Ankul Singh S, Aarita Sood, Chitra Vellapandia. The Role of Ocimene in Decreasing α-Synuclein Aggregation using Rotenone-induced Rat Model. Central nervous system agents in medicinal chemistry. 2024-02-27. PMID:38409725. |
parkinson's disease is defined by the loss of dopaminergic neurons in the midbrain of substantia nigra associated with lewy bodies. |
2024-02-27 |
2024-03-02 |
rat |
| Jake Sondag Boles, Jenny Holt, Cassandra L Cole, Noelle K Neighbarger, Nikhil M Urs, Oihane Uriarte Huarte, Malú Gámez Tanse. Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405709. |
in all, this study supports the growing appreciation for the lc as neuroprotective against inflammation-induced brain injury and draws attention to the potential for neergic interventions to exert disease-modifying effects under conditions where peripheral inflammation may compromise ventral midbrain dopaminergic neurons and increase the risk for development of pd. |
2024-02-26 |
2024-02-28 |
mouse |
| Fatema Currim, Shatakshi Shukla, Jyoti Singh, Dhruv Gohel, Minal Mane, Anjali Shinde, Milton Roy, Shani Goyani, Hitesh Vasiyani, Aswathy Chandran, Jean-Christophe Rochet, Jason Cannon, Rajesh Sing. Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions. Neurotoxicology. 2024-02-24. PMID:38401688. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra part of the brain. |
2024-02-24 |
2024-02-27 |
Not clear |
| Qingfang Liu, Yao Zhao, Sumedha Attanti, Joel L Voss, Geoffrey Schoenbaum, Thorsten Kahn. Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks. Nature communications. vol 15. issue 1. 2024-02-24. PMID:38402210. |
previous work across species has shown that the dopaminergic midbrain responds to violations in expected reward identity and that the lateral orbitofrontal cortex (ofc) represents reward identity expectations. |
2024-02-24 |
2024-02-27 |
Not clear |
| Qingfang Liu, Yao Zhao, Sumedha Attanti, Joel L Voss, Geoffrey Schoenbaum, Thorsten Kahn. Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks. Nature communications. vol 15. issue 1. 2024-02-24. PMID:38402210. |
these results support the idea that ipe signals in the dopaminergic midbrain are computed based on outcome expectations represented in the lateral ofc. |
2024-02-24 |
2024-02-27 |
Not clear |
| Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wan. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398662. |
in vivo experiments further corroborated these findings, demonstrating that la mitigated the death of th-positive dopaminergic neurons and reduced microglia activation in the ventral snpc brain region of the midbrain and the striatum. |
2024-02-24 |
2024-02-26 |
Not clear |
| Lingling Zhang, Hao Yan. Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson's disease. Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400887. |
parkinson's disease (pd) is a neurodegenerative disease, the most characteristic pathological feature is the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compactus (snpc) of the mesencephalon, along with reduced dopamine content in the striatum. |
2024-02-24 |
2024-02-27 |
Not clear |
| Emad Albadawi, Ahmed El-Tokhy, Muayad Albadrani, Mohammed Adel, Randa El-Gamal, Wael Zaarina, Mosaab Salah El-Din El-Agawy, Hassan Reda Hassan Elsaye. The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Tissue & cell. vol 87. 2024-02-22. PMID:38387425. |
the results showed that nettle caused recovery of midbrain dopaminergic neurons, by inhibiting apoptosis, inflammation, and oxidative stress and by restoring the autophagic machinery with clearance of α-synuclein deposits. |
2024-02-22 |
2024-02-25 |
rat |