| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nafisa R Komilova, Plamena R Angelova, Alexey V Berezhnov, Olga A Stelmashchuk, Ulugbek Z Mirkhodjaev, Henry Houlden, Alexander V Gourine, Noemi Esteras, Andrey Y Abramo. Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease. The FEBS journal. 2021-09-25. PMID:34528385. |
parkinson's disease (pd) is a progressive neurodegenerative disorder induced by the loss of dopaminergic neurons in midbrain. |
2021-09-25 |
2023-08-13 |
mouse |
| Shamma Qarin, Sarah K Howlett, Joanne L Jones, Roger A Barke. The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease. Neuronal signaling. vol 5. issue 3. 2021-09-25. PMID:34552761. |
the immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in parkinson's disease. |
2021-09-25 |
2023-08-13 |
human |
| Yun Jung Bae, Jong-Min Kim, Chul-Ho Sohn, Ji-Hyun Choi, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se Jin Cho, Beomseok Jeon, Jae Hyoung Ki. Imaging the Substantia Nigra in Parkinson Disease and Other Parkinsonian Syndromes. Radiology. vol 300. issue 2. 2021-09-24. PMID:34100679. |
parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. |
2021-09-24 |
2023-08-13 |
Not clear |
| James D Howard, Thorsten Kahn. To be specific: The role of orbitofrontal cortex in signaling reward identity. Behavioral neuroscience. vol 135. issue 2. 2021-09-20. PMID:33734730. |
moreover, we summarize recent findings suggesting that specific reward expectations in ofc are learned and updated by means of identity errors in the dopaminergic midbrain. |
2021-09-20 |
2023-08-13 |
Not clear |
| Francois Singh, Ian G Ganle. Parkinson's disease and mitophagy: an emerging role for LRRK2. Biochemical Society transactions. vol 49. issue 2. 2021-09-20. PMID:33769432. |
it is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, which is thought to account for the major clinical symptoms such as tremor, slowness of movement and muscle stiffness. |
2021-09-20 |
2023-08-13 |
Not clear |
| Adaze Bijou Enogieru, William Haylett, Donavon Hiss, Okobi Ekp. Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP Metabolic brain disease. vol 36. issue 7. 2021-09-20. PMID:33978902. |
parkinson's disease (pd) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neurotoxic activity of 1-methyl-4-phenylpyridinium (mpp |
2021-09-20 |
2023-08-13 |
Not clear |
| Henrik Renner, Hans R Schöler, Jan M Brude. Combining Automated Organoid Workflows With Artificial Intelligence-Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High-Throughput Screens for Parkinson's Disease and Beyond. Movement disorders : official journal of the Movement Disorder Society. 2021-09-20. PMID:34498298. |
parkinson's disease (pd) is the second most common neurodegenerative disease and primarily characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2021-09-20 |
2023-08-13 |
human |
| Barbara Calamini, Nathalie Geyer, Nathalie Huss-Braun, Annie Bernhardt, Véronique Harsany, Pierrick Rival, May Cindhuchao, Dietmar Hoffmann, Sabine Gratze. Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease. Disease models & mechanisms. vol 14. issue 6. 2021-09-18. PMID:34114604. |
parkinson's disease (pd) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. |
2021-09-18 |
2023-08-13 |
human |
| Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K Ushna S Islam, Gabriela O Bodea, Ece Öztürk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen M J van Loo, Stefan Britsch, Pengtao Liu, Walid T Khaled, Emmanouil Metzakopian, Stephan L Baader, Donato A Di Monte, Sandra Blaes. The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell reports. vol 36. issue 11. 2021-09-15. PMID:34525371. |
the transcription factor bcl11a defines distinct subsets of midbrain dopaminergic neurons. |
2021-09-15 |
2023-08-13 |
human |
| Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K Ushna S Islam, Gabriela O Bodea, Ece Öztürk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen M J van Loo, Stefan Britsch, Pengtao Liu, Walid T Khaled, Emmanouil Metzakopian, Stephan L Baader, Donato A Di Monte, Sandra Blaes. The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell reports. vol 36. issue 11. 2021-09-15. PMID:34525371. |
midbrain dopaminergic (mda) neurons are diverse in their projection targets, effect on behavior, and susceptibility to neurodegeneration. |
2021-09-15 |
2023-08-13 |
human |
| Cheng Qian, Bryan Dong, Xu-Yang Wang, Feng-Quan Zho. In vivo glial trans-differentiation for neuronal replacement and functional recovery in central nervous system. The FEBS journal. vol 288. issue 16. 2021-09-07. PMID:33351267. |
next, we discuss emerging evidence from mouse studies, in which the in vivo glia-to-neuron conversion could be achieved with sequential or one-step genetic manipulations, such as the conversions from retinal mgs to interneurons, photoreceptors, or retinal ganglion cells (rgcs), as well as the conversions from midbrain astrocytes to dopaminergic or gabaergic neurons. |
2021-09-07 |
2023-08-13 |
mouse |
| Abeer Dagra, Douglas R Miller, Min Lin, Adithya Gopinath, Fatemeh Shaerzadeh, Sharonda Harris, Zachary A Sorrentino, Jonatan Fullerton Støier, Sophia Velasco, Janelle Azar, Adetola R Alonge, Joseph J Lebowitz, Brittany Ulm, Mengfei Bu, Carissa A Hansen, Nikhil Urs, Benoit I Giasson, Habibeh Khoshboue. α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. NPJ Parkinson's disease. vol 7. issue 1. 2021-09-04. PMID:34408150. |
the presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of the cardinal features of parkinson's disease. |
2021-09-04 |
2023-08-13 |
mouse |
| Diana M Hendrickx, Pierre Garcia, Amer Ashrafi, Alessia Sciortino, Kristopher J Schmit, Heike Kollmus, Nathalie Nicot, Tony Kaoma, Laurent Vallar, Manuel Buttini, Enrico Glaa. A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32997293. |
it is tempting to speculate that molecular changes similar to those changes observed in our model happen in midbrain dopaminergic neurons before they start to degenerate. |
2021-09-01 |
2023-08-13 |
mouse |
| Jiali Pu, Ting Gao, Ran Zheng, Yi Fang, Yang Ruan, Chongyao Jin, Ting Shen, Jun Tian, Baorong Zhan. Parkin mutation decreases neurite complexity and maturation in neurons derived from human fibroblasts. Brain research bulletin. vol 159. 2021-08-31. PMID:32156628. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders, and mainly characterized by the progressive degeneration of dopaminergic (da) neurons in the midbrain substantia nigra and non-da neurons in many other parts of the brain. |
2021-08-31 |
2023-08-13 |
mouse |
| Luca Magistrelli, Elena Contaldi, Cristoforo Com. The Impact of Life (Basel, Switzerland). vol 11. issue 8. 2021-08-31. PMID:34440548. |
the impact of parkinson's disease (pd) is a common and progressive neurodegenerative disease, caused by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain, which is clinically characterized by a constellation of motor and non-motor manifestations. |
2021-08-31 |
2023-08-13 |
Not clear |
| Stefano Cattaneo, Maria Regoni, Jenny Sassone, Stefano Tavern. Cell-attached and Whole-cell Patch-clamp Recordings of Dopamine Neurons in the Substantia Nigra Pars Compacta of Mouse Brain Slices. Bio-protocol. vol 11. issue 15. 2021-08-31. PMID:34458403. |
the substantia nigra pars compacta (snc) is a midbrain dopaminergic nucleus that plays a key role in modulating motor and cognitive functions. |
2021-08-31 |
2023-08-13 |
mouse |
| Yi-Fan Ma, Yi-An Lin, Chin-Lin Huang, Chih-Chieh Hsu, Sabrina Wang, Shih-Rung Yeh, Ying-Chieh Tsa. Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson's Disease. Probiotics and antimicrobial proteins. 2021-08-27. PMID:34449056. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. |
2021-08-27 |
2023-08-13 |
rat |
| Blake L Elliott, Kimberlee D'Ardenne, Prerona Mukherjee, Julie B Schweitzer, Samuel M McClur. Limbic and Executive Meso- and Nigrostriatal Tracts Predict Impulsivity Differences in Attention-Deficit/Hyperactivity Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-08-26. PMID:34051394. |
we tested whether human midbrain pathways (where dopaminergic cell bodies originate) between the substantia nigra (sn) and ventral tegmental area (vta) and the striatum differed between participants with adhd and typically developing adolescent and young adult participants. |
2021-08-26 |
2023-08-13 |
human |
| Denis Pavăl, Ioana Valentina Micluți. The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects. Developmental neuroscience. vol 43. issue 2. 2021-08-25. PMID:34010842. |
in 2017, we provided a theoretical framework for a "dopamine hypothesis of asd" which proposed that autistic behavior arises from a dysfunctional midbrain dopaminergic system. |
2021-08-25 |
2023-08-13 |
Not clear |
| Denis Pavăl, Ioana Valentina Micluți. The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects. Developmental neuroscience. vol 43. issue 2. 2021-08-25. PMID:34010842. |
furthermore, in the light of these new insights, we further refine and reconceptualize our model, debating on the possibility that various etiologies of asd converge upon a dysfunctional midbrain dopaminergic system. |
2021-08-25 |
2023-08-13 |
Not clear |