| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kei-Ichi Ishikawa, Risa Nonaka, Wado Akamats. Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells. Methods in molecular biology (Clifton, N.J.). vol 2322. 2021-08-10. PMID:34043194. |
the midbrain dopaminergic neurons of the substantia nigra are mainly affected in parkinson's disease, but it is impossible to obtain and analyze viable dopaminergic neurons from live patients. |
2021-08-10 |
2023-08-13 |
human |
| Kei-Ichi Ishikawa, Risa Nonaka, Wado Akamats. Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells. Methods in molecular biology (Clifton, N.J.). vol 2322. 2021-08-10. PMID:34043194. |
here, we describe an efficient method for differentiating human ips cells into midbrain dopaminergic neurons. |
2021-08-10 |
2023-08-13 |
human |
| Marianne Amalric, Tommy Pattij, Ioannis Sotiropoulos, Joana M Silva, Nuno Sousa, Samira Ztaou, Cristiano Chiamulera, Lars U Wahlberg, Dwaine F Emerich, Giovanna Paolon. Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders. Frontiers in behavioral neuroscience. vol 15. 2021-08-10. PMID:34366802. |
historically, many investigations into neurodegenerative diseases have focused on alterations in specific neuronal populations such as, for example, the loss of midbrain dopaminergic neurons in parkinson's disease (pd) and loss of cholinergic transmission in alzheimer's disease (ad). |
2021-08-10 |
2023-08-13 |
human |
| Yayoi Shigemune, Iori Kawasaki, Akira Midorikawa, Toru Baba, Atsushi Takeda, Nobuhito Ab. Intrinsic motivation in patients with Parkinson's disease: a neuropsychological investigation of curiosity using dopamine transporter imaging. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 8. 2021-08-09. PMID:33411194. |
although dopaminergic neurons in the midbrain deteriorate in parkinson's disease (pd), it remains unclear whether intrinsic motivation is impaired in pd patients. |
2021-08-09 |
2023-08-13 |
Not clear |
| Shi-Xun Ma, Bo Am Seo, Donghoon Kim, Yulan Xiong, Seung-Hwan Kwon, Saurav Brahmachari, Sangjune Kim, Tae-In Kam, Raja Sekhar Nirujogi, Sang Ho Kwon, Valina L Dawson, Ted M Dawson, Akhilesh Pandey, Chan Hyun Na, Han Seok K. Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease. Journal of proteome research. vol 20. issue 7. 2021-08-09. PMID:34061533. |
notably, a validation study demonstrated that complement component 3 (c3)-positive astrocytes were increased in the ventral midbrain of the intrastriatal α-synuclein pff-injected mice and c3 secreted from astrocytes could induce the degeneration of dopaminergic neurons. |
2021-08-09 |
2023-08-13 |
mouse |
| Maria Argyrofthalmidou, Athanasios D Spathis, Matina Maniati, Amalia Poula, Maira A Katsianou, Evangelos Sotiriou, Maria Manousaki, Celine Perier, Ioanna Papapanagiotou, Zeta Papadopoulou-Daifoti, Pothitos M Pitychoutis, Pavlos Alexakos, Miquel Vila, Leonidas Stefanis, Demetrios K Vassilati. Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice. Human molecular genetics. vol 30. issue 16. 2021-08-06. PMID:33902111. |
as we age, the expression levels of these two genes in midbrain dopaminergic neurons follow opposite directions and asyn expression increases while the expression of nurr1 decreases. |
2021-08-06 |
2023-08-13 |
mouse |
| Xiaoyi Xu, Xin He, Shanshan Ma, Mingtao Li, Qiaoying Huan. Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model. Neuroscience letters. vol 759. 2021-08-06. PMID:34119603. |
nurr1 (nr4a2), a nuclear receptor essential for the maintenance of midbrain dopaminergic neurons, is transcriptionally downregulated in both patients with pd and animal models and has been considered as a promising therapeutic target for neuroprotection in pd. |
2021-08-06 |
2023-08-13 |
mouse |
| Razvan-Marius Brazdis, Julian E Alecu, Daniel Marsch, Annika Dahms, Katrin Simmnacher, Sandra Lörentz, Anna Brendler, Yanni Schneider, Franz Marxreiter, Laurent Roybon, Beate Winner, Wei Xiang, Iryna Prot. Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease. Human molecular genetics. vol 29. issue 7. 2021-08-04. PMID:32160287. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by protein inclusions mostly composed of aggregated forms of α-synuclein (α-syn) and by the progressive degeneration of midbrain dopaminergic neurons (mdans), resulting in motor symptoms. |
2021-08-04 |
2023-08-13 |
human |
| Longping Yao, Jiayu Wu, Sumeyye Koc, Guohui L. Genetic Imaging of Neuroinflammation in Parkinson's Disease: Recent Advancements. Frontiers in cell and developmental biology. vol 9. 2021-08-03. PMID:34336822. |
parkinson's disease (pd) is one of the most prevalent neurodegenerative aging disorders characterized by motor and non-motor symptoms due to the selective loss of midbrain dopaminergic (da) neurons. |
2021-08-03 |
2023-08-13 |
mouse |
| Derya Cansız, Unsal Veli Ustundag, Ismail Unal, A Ata Alturfan, Ebru Emekli-Alturfa. Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity. Drug and chemical toxicology. 2021-08-03. PMID:34340603. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases due to the loss of dopaminergic neurons in the midbrain in the substantia nigra. |
2021-08-03 |
2023-08-13 |
zebrafish |
| Caroline I Jahn, Chiara Varazzani, Jérôme Sallet, Mark E Walton, Sébastien Boure. Noradrenergic But Not Dopaminergic Neurons Signal Task State Changes and Predict Reengagement After a Failure. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 9. 2021-07-31. PMID:32390051. |
we therefore examined the activity of putative noradrenergic neurons in the locus coeruleus and putative midbrain dopaminergic neurons in monkeys cued to perform effortful actions for rewards. |
2021-07-31 |
2023-08-13 |
monkey |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (sn) in the midbrain due to loss of dopaminergic neurons. |
2021-07-26 |
2023-08-13 |
rat |
| Yi Han Ng, Soham Chanda, Justyna A Janas, Nan Yang, Yuko Kokubu, Thomas C Südhof, Marius Werni. Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics. Stem cell reports. vol 16. issue 7. 2021-07-23. PMID:34171286. |
efficient generation of dopaminergic induced neuronal cells with midbrain characteristics. |
2021-07-23 |
2023-08-13 |
mouse |
| Yi Han Ng, Soham Chanda, Justyna A Janas, Nan Yang, Yuko Kokubu, Thomas C Südhof, Marius Werni. Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics. Stem cell reports. vol 16. issue 7. 2021-07-23. PMID:34171286. |
co-delivery of additional midbrain transcription factors en1, foxa2, and pitx3 resulted in facile and robust generation of functional dopaminergic neurons of midbrain character. |
2021-07-23 |
2023-08-13 |
mouse |
| Scott Bell, Vincent McCarty, Huashan Peng, Malvin Jefri, Nuwan Hettige, Lilit Antonyan, Liam Crapper, Liam A O'Leary, Xin Zhang, Ying Zhang, Hanrong Wu, Diane Sutcliffe, Ilaria Kolobova, Thad A Rosenberger, Luc Moquin, Alain Gratton, Jelena Popic, Ilse Gantois, Patrick S Stumpf, Andreas A Schuppert, Naguib Mechawar, Nahum Sonenberg, Michel L Tremblay, Hyder A Jinnah, Carl Erns. Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells. Stem cell reports. vol 16. issue 7. 2021-07-23. PMID:34214487. |
lesch-nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells. |
2021-07-23 |
2023-08-13 |
Not clear |
| Toni S Pearson, Nalin Gupta, Waldy San Sebastian, Jill Imamura-Ching, Amy Viehoever, Ana Grijalvo-Perez, Alex J Fay, Neha Seth, Shannon M Lundy, Youngho Seo, Miguel Pampaloni, Keith Hyland, Erin Smith, Gardenia de Oliveira Barbosa, Jill C Heathcock, Amy Minnema, Russell Lonser, J Bradley Elder, Jeffrey Leonard, Paul Larson, Krystof S Bankiewic. Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons. Nature communications. vol 12. issue 1. 2021-07-21. PMID:34253733. |
gene therapy for aromatic l-amino acid decarboxylase deficiency by mr-guided direct delivery of aav2-aadc to midbrain dopaminergic neurons. |
2021-07-21 |
2023-08-13 |
Not clear |
| Hyo In Kim, Seungbeom Lee, Juhee Lim, Sungkyun Chung, Tae-Sung Koo, Yu-Geun Ji, Young-Ger Suh, Woo Sung Son, Seok-Ho Kim, Hyun Jin Cho. ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. Pharmacological research. vol 165. 2021-07-16. PMID:33434621. |
brain derived neurotrophic factor (bdnf) promotes maturation of dopaminergic (daergic) neurons in the midbrain and positively regulates their maintenance and outgrowth. |
2021-07-16 |
2023-08-13 |
Not clear |
| Lily Sarrafha, Gustavo M Parfitt, Ricardo Reyes, Camille Goldman, Elena Coccia, Tatyana Kareva, Tim Ahfeld. High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells. STAR protocols. vol 2. issue 2. 2021-07-13. PMID:33997803. |
here, we describe a high-throughput 3d differentiation protocol for deriving midbrain dopaminergic neurons from human pluripotent stem cells. |
2021-07-13 |
2023-08-13 |
human |
| Lily Sarrafha, Gustavo M Parfitt, Ricardo Reyes, Camille Goldman, Elena Coccia, Tatyana Kareva, Tim Ahfeld. High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells. STAR protocols. vol 2. issue 2. 2021-07-13. PMID:33997803. |
our approach is advantageous for large-scale production of uniform midbrain organoids that can be maintained in diverse formats, and our reporters allow for sorting of dopaminergic neurons. |
2021-07-13 |
2023-08-13 |
human |
| Rolando Lara-Rodarte, Daniel Cortés, Karla Soriano, Francia Carmona, Luisa Rocha, Enrique Estudillo, Adolfo López-Ornelas, Iván Velasc. Mouse Embryonic Stem Cells Expressing GDNF Show Enhanced Dopaminergic Differentiation and Promote Behavioral Recovery After Grafting in Parkinsonian Rats. Frontiers in cell and developmental biology. vol 9. 2021-07-10. PMID:34239871. |
parkinson's disease (pd) is characterized by the progressive loss of midbrain dopaminergic neurons (dans) of the |
2021-07-10 |
2023-08-13 |
mouse |