| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Subcortical encoding of agent-relevant associative signals for adaptive social behavior in the macaque. Neuroscience and biobehavioral reviews. vol 125. 2021-06-28. PMID:33609569. |
here, we review the literature supporting the hypothesis that behavioral variables important for decision-making, i.e., stimulus, action, and outcome, are associated with agent information (self and other) in subcortical regions, such as the amygdala, striatum, lateral hypothalamus, and dopaminergic midbrain nuclei. |
2021-06-28 |
2023-08-13 |
monkey |
| Diego Sucunza, Alberto J Rico, Elvira Roda, María Collantes, Gloria González-Aseguinolaza, Ana I Rodríguez-Pérez, Iván Peñuelas, Alfonso Vázquez, José L Labandeira-García, Vania Broccoli, José L Lancieg. Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques. International journal of molecular sciences. vol 22. issue 9. 2021-06-28. PMID:34062940. |
glucocerebrosidase gene therapy induces alpha-synuclein clearance and neuroprotection of midbrain dopaminergic neurons in mice and macaques. |
2021-06-28 |
2023-08-13 |
mouse |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Alberto F Cintrón-Colón, Gabriel Almeida-Alves, Alicia M Boynton, John M Spitsberge. GDNF synthesis, signaling, and retrograde transport in motor neurons. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32897420. |
gdnf was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons. |
2021-06-23 |
2023-08-13 |
rat |
| Rupinder Kaur Sodhi, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Baldeep Kumar, Anurag Kuha. IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease. Neurotoxicology. vol 84. 2021-06-22. PMID:33774066. |
parkinson's disease (pd), a common neurodegenerative motor disorder characterized by striatal dopaminergic neuronal loss and localized neuroinflammation in the midbrain region. |
2021-06-22 |
2023-08-13 |
Not clear |
| Hidefumi Suzuki, Naohiro Egawa, Takayuki Kondo, Keiko Imamura, Takako Enami, Kayoko Tsukita, Mika Suga, Ran Shibukawa, Yasue Okanishi, Tsuyoshi Uchiyama, Haruhisa Inoue, Ryosuke Takahash. Generation of a human induced pluripotent stem cell line derived from a Parkinson's disease patient carrying SNCA duplication. Stem cell research. vol 45. 2021-06-21. PMID:32413791. |
the ipsc line displayed a capacity to differentiate into midbrain dopaminergic neurons affected in pd. |
2021-06-21 |
2023-08-13 |
human |
| Silvia Cerri, Fabio Blandin. In vivo modeling of prodromal stage of Parkinson's disease. Journal of neuroscience methods. vol 342. 2021-06-21. PMID:32512030. |
prodromal animal models of pd represent an important tool for testing new therapeutic strategies and shedding light on the early pathogenic steps that set the ground for the extensive dopaminergic cell death observed in the midbrain. |
2021-06-21 |
2023-08-13 |
Not clear |
| Qiankun Lv, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Wei Huan. MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33448372. |
parkinson disease (pd) is a neurodegenerative disease characterized by selective loss of dopaminergic (da) neurons in the midbrain. |
2021-06-21 |
2023-08-13 |
mouse |
| Jonathan R Reinwald, Alexander Sartorius, Wolfgang Weber-Fahr, Markus Sack, Robert Becker, Michael Didriksen, Tine B Stensbøl, Adam J Schwarz, Andreas Meyer-Lindenberg, Natalia Gas. Separable neural mechanisms for the pleiotropic association of copy number variants with neuropsychiatric traits. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32170065. |
the combination of cortical hypoconnectivity and dopaminergic hyperconnectivity and reduced cerebellum in 22q11.2 deletion mirrors key neurodevelopmental features of schizophrenia, whereas changes in midbrain and auditory/striatal morphology and topology in 1q21.1 and 15q13.3 rather indicate focal processes possibly linked to the emergence of abnormal salience perception and hallucinations. |
2021-06-18 |
2023-08-13 |
mouse |
| Jérémy Cousineau, Léa Lescouzères, Anne Taupignon, Lorena Delgado-Zabalza, Emmanuel Valjent, Jérôme Baufreton, Morgane Le Bon-Jég. Dopamine D2-Like Receptors Modulate Intrinsic Properties and Synaptic Transmission of Parvalbumin Interneurons in the Mouse Primary Motor Cortex. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32321772. |
the primary motor cortex (m1), which is essential for motor control and the acquisition of motor skills, receives dopaminergic inputs in its superficial and deep layers from the midbrain. |
2021-06-18 |
2023-08-13 |
mouse |
| Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. |
whereas most studies on nrg1-erbb4 signaling have focused on gabaergic interneurons, erbb4 is also expressed by midbrain dopaminergic neurons where it modulates extracellular dopamine (da) levels. |
2021-06-18 |
2023-08-13 |
mouse |
| Bianca Marchett. Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease. Redox biology. vol 36. 2021-06-18. PMID:32863224. |
oxidative stress and inflammation have long been recognized to contribute to parkinson's disease (pd), a common movement disorder characterized by the selective loss of midbrain dopaminergic neurons (mdan) of the substantia nigra pars compacta (snpc). |
2021-06-18 |
2023-08-13 |
mouse |
| Francesca Morello, Vootele Voikar, Pihla Parkkinen, Anne Panhelainen, Marko Rosenholm, Aki Makkonen, Tomi Rantamäki, Petteri Piepponen, Teemu Aitta-Aho, Juha Partane. ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33087695. |
the neural circuits regulating motivation and movement include midbrain dopaminergic neurons and associated inhibitory gabaergic and excitatory glutamatergic neurons in the anterior brainstem. |
2021-06-18 |
2023-08-13 |
mouse |
| Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitn. Effects of L-DOPA on Gene Expression in the Frontal Cortex of Rats with Unilateral Lesions of Midbrain Dopaminergic Neurons. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33257528. |
effects of l-dopa on gene expression in the frontal cortex of rats with unilateral lesions of midbrain dopaminergic neurons. |
2021-06-18 |
2023-08-13 |
rat |
| Yun Tang, Xiao-Ke Yang, Xin-Wei Zhang, Wen-Tao Wu, Fu-Li Zhang, Hong Jiang, Yan-Ling Liu, Christian Amatore, Wei-Hua Huan. Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry. Chemical science. vol 11. issue 3. 2021-06-15. PMID:34123052. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (daergic) neurons and low level of dopamine (da) in the midbrain. |
2021-06-15 |
2023-08-13 |
Not clear |
| S A Antonov, E V Novosadov. Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson's Disease Drug Development. International journal of molecular sciences. vol 22. issue 7. 2021-06-11. PMID:33806103. |
as a unique source of midbrain dopaminergic (da) neurons, ips cells provide unparalleled capabilities for investigating the pathogenesis of pd, the development of novel anti-parkinsonian drugs, and personalized therapy design. |
2021-06-11 |
2023-08-13 |
human |
| Shaun Martin, Stefanie Smolders, Chris Van den Haute, Bavo Heeman, Sarah van Veen, David Crosiers, Igor Beletchi, Aline Verstraeten, Helena Gossye, Géraldine Gelders, Philippe Pals, Norin Nabil Hamouda, Sebastiaan Engelborghs, Jean-Jacques Martin, Jan Eggermont, Peter Paul De Deyn, Patrick Cras, Veerle Baekelandt, Peter Vangheluwe, Christine Van Broeckhove. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta neuropathologica. vol 139. issue 6. 2021-06-08. PMID:32172343. |
parkinson's disease (pd) is a progressive neurodegenerative brain disease presenting with a variety of motor and non-motor symptoms, loss of midbrain dopaminergic neurons in the substantia nigra pars compacta and the occurrence of α-synuclein-positive lewy bodies in surviving neurons. |
2021-06-08 |
2023-08-13 |
Not clear |
| Juhee Lim, Hyo In Kim, Hyun Jin Cho. Regulation of dopaminergic neuronal phenotypes by the estrogen-related receptor gamma ligand GSK4716 via the activation of CREB signaling. Neurochemistry international. vol 136. 2021-06-07. PMID:32173553. |
midbrain dopaminergic (daergic) neurotransmission plays a crucial role in regulating motor, cognitive, and emotional functions. |
2021-06-07 |
2023-08-13 |
Not clear |
| Enrique M Toledo, Shanzheng Yang, Daniel Gyllborg, Kim E van Wijk, Indranil Sinha, Manuel Varas-Godoy, Christopher L Grigsby, Peter Lönnerberg, Saiful Islam, Knut R Steffensen, Sten Linnarsson, Ernest Arena. Srebf1 Controls Midbrain Dopaminergic Neurogenesis. Cell reports. vol 31. issue 5. 2021-06-03. PMID:32375051. |
srebf1 controls midbrain dopaminergic neurogenesis. |
2021-06-03 |
2023-08-13 |
Not clear |
| Enrique M Toledo, Shanzheng Yang, Daniel Gyllborg, Kim E van Wijk, Indranil Sinha, Manuel Varas-Godoy, Christopher L Grigsby, Peter Lönnerberg, Saiful Islam, Knut R Steffensen, Sten Linnarsson, Ernest Arena. Srebf1 Controls Midbrain Dopaminergic Neurogenesis. Cell reports. vol 31. issue 5. 2021-06-03. PMID:32375051. |
liver x receptors (lxrs) and their ligands are potent regulators of midbrain dopaminergic (mda) neurogenesis and differentiation. |
2021-06-03 |
2023-08-13 |
Not clear |