| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Smitha Bhaskar, Jeevan Gowda, Jyothi Prasanna, Anujith Kuma. Does altering proteasomal activity and trafficking reduce the arborization mediated specific vulnerability of SNpc dopaminergic neurons of Parkinson's disease? Medical hypotheses. vol 143. 2021-05-14. PMID:32652429. |
the disease originates majorly due to compromised function of the dopaminergic (da) neurons in the substantia nigra pars compacta (snpc), but not the ventral tegmental area (vta) region of the midbrain. |
2021-05-14 |
2023-08-13 |
Not clear |
| Bo-Ryoung Choi, Dong-Hee Kim, Michela Gallagher, Jung-Soo Ha. Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus. Neuroscience. vol 444. 2021-05-14. PMID:32717296. |
neurons in the lateral habenula (lhb) are activated by reward omission and inhibited by reward delivery-reward processing functions opposite those of midbrain dopaminergic neurons. |
2021-05-14 |
2023-08-13 |
rat |
| Bo-Ryoung Choi, Dong-Hee Kim, Michela Gallagher, Jung-Soo Ha. Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus. Neuroscience. vol 444. 2021-05-14. PMID:32717296. |
the number of c-fos-positive signals in lhb neurons projecting to dopaminergic midbrain neurons was higher in the unpaired group than in the paired group. |
2021-05-14 |
2023-08-13 |
rat |
| Afia Asif, Silvia García-López, Arto Heiskanen, Alberto Martínez-Serrano, Stephan S Keller, Marta P Pereira, Jenny Emnéu. Pyrolytic Carbon Nanograss Enhances Neurogenesis and Dopaminergic Differentiation of Human Midbrain Neural Stem Cells. Advanced healthcare materials. vol 9. issue 20. 2021-05-14. PMID:32902188. |
pyrolytic carbon nanograss enhances neurogenesis and dopaminergic differentiation of human midbrain neural stem cells. |
2021-05-14 |
2023-08-13 |
human |
| Gianpaolo Antonio Basile, Alessia Bramanti, Salvatore Bertino, Giuseppina Cutroneo, Antonio Bruno, Adriana Tisano, Giuseppe Paladina, Demetrio Milardi, Giuseppe Anastas. Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients. Medicina (Kaunas, Lithuania). vol 56. issue 12. 2021-05-14. PMID:33322072. |
structural connectivity-based parcellation of the dopaminergic midbrain in healthy subjects and schizophrenic patients. |
2021-05-14 |
2023-08-13 |
human |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Luca Magistrelli, Marco Ferrari, Alessia Furgiuele, Anna Vera Milner, Elena Contaldi, Cristoforo Comi, Marco Cosentino, Franca Marin. Polymorphisms of Dopamine Receptor Genes and Parkinson's Disease: Clinical Relevance and Future Perspectives. International journal of molecular sciences. vol 22. issue 7. 2021-05-12. PMID:33917417. |
parkinson's disease (pd) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. |
2021-05-12 |
2023-08-13 |
Not clear |
| Tae Hwan Kwak, Ji Hyun Kang, Sai Hali, Jonghun Kim, Kee-Pyo Kim, Chanhyeok Park, Ju-Hyun Lee, Ha Kyun Ryu, Ji Eun Na, Junghyun Jo, Hyunsoo Shawn Je, Huck-Hui Ng, Jeongwoo Kwon, Nam-Hyung Kim, Kwon Ho Hong, Woong Sun, Chi Hye Chung, Im Joo Rhyu, Dong Wook Ha. Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling. Stem cells (Dayton, Ohio). vol 38. issue 6. 2021-05-07. PMID:32083763. |
here we describe the robust generation of mos with homogeneous distribution of midbrain dopaminergic (mda) neurons. |
2021-05-07 |
2023-08-13 |
human |
| Shermaine Huiping Tay, Winanto, Zi Jian Khong, Yong Hui Koh, Shi Yan N. Generation of Cortical, Dopaminergic, Motor, and Sensory Neurons from Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). 2021-05-07. PMID:33959917. |
in this chapter, we provide details of the differentiation protocols to reliably derive four currently relevant neuronal subtypes, i.e., cortical neurons, midbrain dopaminergic neurons, spinal motor neurons, and sensory neurons. |
2021-05-07 |
2023-08-13 |
human |
| Aaron Lerne. The intestinal luminal sources of α-synuclein: a gastroenterologist perspective. Nutrition reviews. 2021-05-04. PMID:33942062. |
parkinson's disease is characterized by nonmotor/motor dysfunction, midbrain dopaminergic neuronal death, and α-synuclein (asn) deposits. |
2021-05-04 |
2023-08-13 |
Not clear |
| Xin Liu, Zhong-Rui Du, Xiong Wang, Kar-Him Luk, Cheuk-Hin Chan, Xu Cao, Qing Zhao, Fang Zhao, Wing-Tak Wong, Ka-Hing Wong, Xiao-Li Don. Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson's Disease Mice Model. Frontiers in aging neuroscience. vol 13. 2021-04-30. PMID:33912026. |
colonic dopaminergic neurons changed reversely with those in the midbrain via gut microbiota-mediated autophagy in a chronic parkinson's disease mice model. |
2021-04-30 |
2023-08-13 |
mouse |
| Xin Liu, Zhong-Rui Du, Xiong Wang, Kar-Him Luk, Cheuk-Hin Chan, Xu Cao, Qing Zhao, Fang Zhao, Wing-Tak Wong, Ka-Hing Wong, Xiao-Li Don. Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson's Disease Mice Model. Frontiers in aging neuroscience. vol 13. 2021-04-30. PMID:33912026. |
our study employed a classical pd mice model achieved by chronic mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) injection to study concurrent changes of dopaminergic neurons in the midbrain and the colon of mice. |
2021-04-30 |
2023-08-13 |
mouse |
| Nora N Esmaiel, Engy A Ashaat, Rehab Mosaad, Alaaeldin Fayez, Mona Ibrahim, Zeinab Y Abdallah, Mahmoud Y Issa, Sohair Salem, Abeer Ramadan, Maged A El Wakeel, Neveen A Ashaat, Maha S Zaki, Samira Ismai. The potential impact of COMT gene variants on dopamine regulation and phenotypic traits of ASD patients. Behavioural brain research. vol 378. 2021-04-29. PMID:31586564. |
the pathogenesis of autism may be related to dysfunction in the midbrain dopaminergic system. |
2021-04-29 |
2023-08-13 |
human |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Shameema Bano, Shubha Shukl. Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease. Behavioural brain research. vol 378. 2021-04-29. PMID:31626851. |
the depletion of da in midbrain due to degeneration of nigral dopaminergic (daergic) neurons leads to parkinson's disease (pd). |
2021-04-29 |
2023-08-13 |
rat |
| Lingling Zhang, Hao Yan. Promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons. Neuroscience letters. vol 742. 2021-04-29. PMID:33246026. |
promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons. |
2021-04-29 |
2023-08-13 |
mouse |
| Lingling Zhang, Hao Yan. Promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons. Neuroscience letters. vol 742. 2021-04-29. PMID:33246026. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of midbrain dopaminergic (da) neurons. |
2021-04-29 |
2023-08-13 |
mouse |
| Tsukika Sato, Kent Imaizumi, Hirotaka Watanabe, Mitsuru Ishikawa, Hideyuki Okan. Generation of region-specific and high-purity neurons from human feeder-free iPSCs. Neuroscience letters. vol 746. 2021-04-29. PMID:33516803. |
this system is the best optimized approach for feeder-free ipsc culture and generates specific neuronal subtypes with high purity and functionality, including forebrain cortical neurons, forebrain interneurons, midbrain dopaminergic neurons, and spinal motor neurons. |
2021-04-29 |
2023-08-13 |
human |
| Lukas Meyerolbersleben, Christine Winter, Nadine Bernhard. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. Behavioural brain research. vol 378. 2021-04-28. PMID:31629834. |
the predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. |
2021-04-28 |
2023-08-13 |
rat |
| Guozhen Qiu, Chunyan Xu, Qiwen Guo, Fei-Qi Zh. SORL1 mutations are associated with parkinsonian and psychiatric features in Alzheimer disease: Case reports. Medicine. vol 100. issue 16. 2021-04-26. PMID:33879716. |
sorla also mediates a trophic pathway that acts through glial cell line-derived neurotrophic factor (gdnf), a critical survival factor for the midbrain dopaminergic (da) neurons. |
2021-04-26 |
2023-08-13 |
Not clear |
| Dvijen C Purohit, Atulya D Mandyam, Michael J Terranova, Chitra D Mandya. Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats. Behavioural brain research. vol 377. 2021-04-23. PMID:31521739. |
adult female rats show greater running output compared with age-matched male rats, and the midbrain dopaminergic system may account for behavioral differences in running output. |
2021-04-23 |
2023-08-13 |
rat |