| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajasree Odumpatta, Mohanapriya Arumuga. Integrative Analysis of Gene Expression and Regulatory Network Interaction Data Reveals the Protein Kinase C Family of Serine/Threonine Receptors as a Significant Druggable Target for Parkinson's Disease. Journal of molecular neuroscience : MN. vol 71. issue 3. 2021-10-04. PMID:32728898. |
parkinson's disease (pd) is a progressive neurodegenerative disease affecting the ventral midbrain dopaminergic neurons, resulting in motor defects mainly tremor, rigidity, and bradykinesia along with a wide array of non-motor symptoms. |
2021-10-04 |
2023-08-13 |
Not clear |
| Massimiliano Zanin, Bruno F R Santos, Paul M A Antony, Clara Berenguer-Escuder, Simone B Larsen, Zoé Hanss, Peter A Barbuti, Aidos S Baumuratov, Dajana Grossmann, Christophe M Capelle, Joseph Weber, Rudi Balling, Markus Ollert, Rejko Krüger, Nico J Diederich, Feng Q H. Mitochondria interaction networks show altered topological patterns in Parkinson's disease. NPJ systems biology and applications. vol 6. issue 1. 2021-10-04. PMID:33173039. |
the mins of midbrain dopaminergic neurons (mdans) derived from several genetic pd patients also displayed specific changes. |
2021-10-04 |
2023-08-13 |
Not clear |
| Panpan Wang, Xi Chen, Yuanyuan Wang, Congcong Jia, Xinyao Liu, Ying Wang, Haifeng Wu, Huaibin Cai, Han-Ming Shen, Weidong L. Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration. Cell death & disease. vol 12. issue 1. 2021-10-04. PMID:33483473. |
to study the impact of vmp1-deficiency on midbrain dopaminergic (mdaergic) neurons, we selectively deleted vmp1 in the mdaergic neurons of vmp1 |
2021-10-04 |
2023-08-13 |
Not clear |
| Yaxin Yang, Jian Liu, Yixuan Wang, Xiang Wu, Libo Li, Guanyun Bian, Wenjuan Li, Haifeng Yuan, Qiaojun Zhan. Blockade of pre-synaptic and post-synaptic GABA Neuropharmacology. vol 196. 2021-10-01. PMID:34246684. |
blockade of pre-synaptic and post-synaptic gaba although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not known how blockade of gaba |
2021-10-01 |
2023-08-13 |
Not clear |
| Xiaohong Huang, Shihuan Kuang, Todd J Applegate, Tsang-Long Lin, Heng-Wei Chen. Prenatal Serotonin Fluctuation Affects Serotoninergic Development and Related Neural Circuits in Chicken Embryos. Neuroscience. vol 473. 2021-10-01. PMID:34425158. |
5-ht exposure mainly affected the neural development in the pons and midbrain, altered the serotoninergic and dopaminergic (daergic) neuronal morphology, nucleus distribution, and their metabolisms and related gene expressions. |
2021-10-01 |
2023-08-13 |
chicken |
| Barbara J Knowlton, Alan D Caste. Memory and Reward-Based Learning: A Value-Directed Remembering Perspective. Annual review of psychology. 2021-09-30. PMID:34587778. |
these different mechanisms are subserved by different neural substrates, with left-hemisphere semantic processing regions active during the strategic encoding of high-value items, and automatic enhancement of encoding of high-value items may be supported by activation of midbrain dopaminergic projections to the hippocampal region. |
2021-09-30 |
2023-08-13 |
Not clear |
| Rong Yin, Jie Xue, Yanfeng Tan, Chuantao Fang, Chunchun Hu, Qian Yang, Xinyu Mei, Dashi Q. The Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2021. 2021-09-29. PMID:34567415. |
parkinson's disease (pd) is a complex neurodegenerative disease, manifested by the progressive functional impairment of the midbrain nigral dopaminergic neurons. |
2021-09-29 |
2023-08-13 |
Not clear |
| Nafisa R Komilova, Plamena R Angelova, Alexey V Berezhnov, Olga A Stelmashchuk, Ulugbek Z Mirkhodjaev, Henry Houlden, Alexander V Gourine, Noemi Esteras, Andrey Y Abramo. Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease. The FEBS journal. 2021-09-25. PMID:34528385. |
parkinson's disease (pd) is a progressive neurodegenerative disorder induced by the loss of dopaminergic neurons in midbrain. |
2021-09-25 |
2023-08-13 |
mouse |
| Shamma Qarin, Sarah K Howlett, Joanne L Jones, Roger A Barke. The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease. Neuronal signaling. vol 5. issue 3. 2021-09-25. PMID:34552761. |
the immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in parkinson's disease. |
2021-09-25 |
2023-08-13 |
human |
| Yun Jung Bae, Jong-Min Kim, Chul-Ho Sohn, Ji-Hyun Choi, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se Jin Cho, Beomseok Jeon, Jae Hyoung Ki. Imaging the Substantia Nigra in Parkinson Disease and Other Parkinsonian Syndromes. Radiology. vol 300. issue 2. 2021-09-24. PMID:34100679. |
parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. |
2021-09-24 |
2023-08-13 |
Not clear |
| James D Howard, Thorsten Kahn. To be specific: The role of orbitofrontal cortex in signaling reward identity. Behavioral neuroscience. vol 135. issue 2. 2021-09-20. PMID:33734730. |
moreover, we summarize recent findings suggesting that specific reward expectations in ofc are learned and updated by means of identity errors in the dopaminergic midbrain. |
2021-09-20 |
2023-08-13 |
Not clear |
| Francois Singh, Ian G Ganle. Parkinson's disease and mitophagy: an emerging role for LRRK2. Biochemical Society transactions. vol 49. issue 2. 2021-09-20. PMID:33769432. |
it is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, which is thought to account for the major clinical symptoms such as tremor, slowness of movement and muscle stiffness. |
2021-09-20 |
2023-08-13 |
Not clear |
| Adaze Bijou Enogieru, William Haylett, Donavon Hiss, Okobi Ekp. Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP Metabolic brain disease. vol 36. issue 7. 2021-09-20. PMID:33978902. |
parkinson's disease (pd) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neurotoxic activity of 1-methyl-4-phenylpyridinium (mpp |
2021-09-20 |
2023-08-13 |
Not clear |
| Henrik Renner, Hans R Schöler, Jan M Brude. Combining Automated Organoid Workflows With Artificial Intelligence-Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High-Throughput Screens for Parkinson's Disease and Beyond. Movement disorders : official journal of the Movement Disorder Society. 2021-09-20. PMID:34498298. |
parkinson's disease (pd) is the second most common neurodegenerative disease and primarily characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2021-09-20 |
2023-08-13 |
human |
| Barbara Calamini, Nathalie Geyer, Nathalie Huss-Braun, Annie Bernhardt, Véronique Harsany, Pierrick Rival, May Cindhuchao, Dietmar Hoffmann, Sabine Gratze. Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease. Disease models & mechanisms. vol 14. issue 6. 2021-09-18. PMID:34114604. |
parkinson's disease (pd) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. |
2021-09-18 |
2023-08-13 |
human |
| Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K Ushna S Islam, Gabriela O Bodea, Ece Öztürk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen M J van Loo, Stefan Britsch, Pengtao Liu, Walid T Khaled, Emmanouil Metzakopian, Stephan L Baader, Donato A Di Monte, Sandra Blaes. The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell reports. vol 36. issue 11. 2021-09-15. PMID:34525371. |
the transcription factor bcl11a defines distinct subsets of midbrain dopaminergic neurons. |
2021-09-15 |
2023-08-13 |
human |
| Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K Ushna S Islam, Gabriela O Bodea, Ece Öztürk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen M J van Loo, Stefan Britsch, Pengtao Liu, Walid T Khaled, Emmanouil Metzakopian, Stephan L Baader, Donato A Di Monte, Sandra Blaes. The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell reports. vol 36. issue 11. 2021-09-15. PMID:34525371. |
midbrain dopaminergic (mda) neurons are diverse in their projection targets, effect on behavior, and susceptibility to neurodegeneration. |
2021-09-15 |
2023-08-13 |
human |
| Cheng Qian, Bryan Dong, Xu-Yang Wang, Feng-Quan Zho. In vivo glial trans-differentiation for neuronal replacement and functional recovery in central nervous system. The FEBS journal. vol 288. issue 16. 2021-09-07. PMID:33351267. |
next, we discuss emerging evidence from mouse studies, in which the in vivo glia-to-neuron conversion could be achieved with sequential or one-step genetic manipulations, such as the conversions from retinal mgs to interneurons, photoreceptors, or retinal ganglion cells (rgcs), as well as the conversions from midbrain astrocytes to dopaminergic or gabaergic neurons. |
2021-09-07 |
2023-08-13 |
mouse |
| Abeer Dagra, Douglas R Miller, Min Lin, Adithya Gopinath, Fatemeh Shaerzadeh, Sharonda Harris, Zachary A Sorrentino, Jonatan Fullerton Støier, Sophia Velasco, Janelle Azar, Adetola R Alonge, Joseph J Lebowitz, Brittany Ulm, Mengfei Bu, Carissa A Hansen, Nikhil Urs, Benoit I Giasson, Habibeh Khoshboue. α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. NPJ Parkinson's disease. vol 7. issue 1. 2021-09-04. PMID:34408150. |
the presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of the cardinal features of parkinson's disease. |
2021-09-04 |
2023-08-13 |
mouse |
| Diana M Hendrickx, Pierre Garcia, Amer Ashrafi, Alessia Sciortino, Kristopher J Schmit, Heike Kollmus, Nathalie Nicot, Tony Kaoma, Laurent Vallar, Manuel Buttini, Enrico Glaa. A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32997293. |
it is tempting to speculate that molecular changes similar to those changes observed in our model happen in midbrain dopaminergic neurons before they start to degenerate. |
2021-09-01 |
2023-08-13 |
mouse |