| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting-Li Dai, Chan Zhang, Fang Peng, Xue-Yuan Niu, Ling Hu, Qiong Zhang, Ying Huang, Ling Chen, Lei Zhang, Weidong Zhu, Yu-Qiang Ding, Ning-Ning Song, Min Lia. Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009587. |
depletion of canonical wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an mptp-induced mouse model of parkinson's disease. |
2021-10-21 |
2023-08-13 |
mouse |
| Ting-Li Dai, Chan Zhang, Fang Peng, Xue-Yuan Niu, Ling Hu, Qiong Zhang, Ying Huang, Ling Chen, Lei Zhang, Weidong Zhu, Yu-Qiang Ding, Ning-Ning Song, Min Lia. Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009587. |
the canonical wnt signaling pathway is critical for the development of midbrain dopaminergic (da) neurons, and recent studies have suggested that disruption of this signaling cascade may underlie the pathogenesis of parkinson's disease (pd). |
2021-10-21 |
2023-08-13 |
mouse |
| Yuria Hori, Reiho Tsutsumi, Kento Nasu, Alex Boateng, Yasuhiko Ashikari, Masaharu Sugiura, Makoto Nakajima, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, Takahiro Sek. Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities. Cells. vol 10. issue 5. 2021-10-21. PMID:34063571. |
aromatic-turmerone analogs protect dopaminergic neurons in midbrain slice cultures through their neuroprotective activities. |
2021-10-21 |
2023-08-13 |
Not clear |
| Ayla Aksoy-Aksel, Andrea Gall, Anna Seewald, Francesco Ferraguti, Ingrid Ehrlic. Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice. eLife. vol 10. 2021-10-18. PMID:34028352. |
midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice. |
2021-10-18 |
2023-08-13 |
mouse |
| Ayla Aksoy-Aksel, Andrea Gall, Anna Seewald, Francesco Ferraguti, Ingrid Ehrlic. Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice. eLife. vol 10. 2021-10-18. PMID:34028352. |
dopaminergic midbrain neurons encode prediction error-like signals when threats differ from expectations. |
2021-10-18 |
2023-08-13 |
mouse |
| Sebastian Keller, Witold Henryk Polanski, Christoph Enzensperger, Heinz Reichmann, Andreas Hermann, Gabriele Gill. 9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 7. 2021-10-15. PMID:32285253. |
in this study, the role of astrocytes in neurostimulative, neuroregenerative and neuroprotective properties of 9-me-bc was further explored.9-me-bc exerted anti-proliferative effects without toxic properties in dopaminergic midbrain and cortical astrocyte cultures. |
2021-10-15 |
2023-08-13 |
Not clear |
| Icnelia Huerta-Ocampo, Daniel Dautan, Nadine K Gut, Bakhtawer Khan, Juan Mena-Segovi. Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33907215. |
cholinergic neurons of the pedunculopontine (ppn) and laterodorsal tegmental nucleus (ldt) send long-ranging axonal projections that target sensorimotor and limbic areas in the thalamus, the dopaminergic midbrain and the striatal complex following a topographical gradient, where they influence a range of functions including attention, reinforcement learning and action-selection. |
2021-10-14 |
2023-08-13 |
rat |
| Kevin Jehasse, Laurent Massotte, Sebastian Hartmann, Romain Vitello, Sofian Ringlet, Marie Vitello, Han Chow Chua, Stephan A Pless, Dominique Engel, Jean-François Liégeois, Bernard Lakaye, Jochen Roeper, Vincent Seuti. The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology. vol 197. 2021-10-14. PMID:34273387. |
the gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. |
2021-10-14 |
2023-08-13 |
Not clear |
| Lei Xiao, Todd F Robert. What Is the Role of Thalamostriatal Circuits in Learning Vocal Sequences? Frontiers in neural circuits. vol 15. 2021-10-12. PMID:34630047. |
area x receives inputs from cortical-like pallial song circuits and midbrain dopaminergic circuits and sends projections to the thalamus. |
2021-10-12 |
2023-08-13 |
Not clear |
| Muhammad Zubair, Sjoerd R Murris, Kaoru Isa, Hirotaka Onoe, Yoshinori Koshimizu, Kenta Kobayashi, Wim Vanduffel, Tadashi Is. Divergent Whole Brain Projections from the Ventral Midbrain in Macaques. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 6. 2021-10-11. PMID:33558867. |
to understand the connectome of the axonal arborizations of dopaminergic midbrain neurons, we investigated the anterograde spread of highly sensitive viral tracers injected into the ventral tegmental area (vta) and adjacent areas in 3 macaques. |
2021-10-11 |
2023-08-13 |
monkey |
| Muhammad Zubair, Sjoerd R Murris, Kaoru Isa, Hirotaka Onoe, Yoshinori Koshimizu, Kenta Kobayashi, Wim Vanduffel, Tadashi Is. Divergent Whole Brain Projections from the Ventral Midbrain in Macaques. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 6. 2021-10-11. PMID:33558867. |
double-labeling with antibodies against transduced fluorescent proteins (fps) and tyrosine hydroxylase indicated that substantial portions of transduced midbrain neurons were dopaminergic. |
2021-10-11 |
2023-08-13 |
monkey |
| Muhammad Zubair, Sjoerd R Murris, Kaoru Isa, Hirotaka Onoe, Yoshinori Koshimizu, Kenta Kobayashi, Wim Vanduffel, Tadashi Is. Divergent Whole Brain Projections from the Ventral Midbrain in Macaques. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 6. 2021-10-11. PMID:33558867. |
thus, the dopaminergic ventral midbrain sends heterogeneous projections throughout the brain. |
2021-10-11 |
2023-08-13 |
monkey |
| Yong Ren, Houbo Jiang, Jiali Pu, Li Li, Jianbo Wu, Yaping Yan, Guohua Zhao, Thomas J Guttuso, Baorong Zhang, Jian Fen. Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society. 2021-10-08. PMID:34564901. |
molecular features of parkinson's disease in patient-derived midbrain dopaminergic neurons. |
2021-10-08 |
2023-08-13 |
Not clear |
| Alexandre Iarkov, Cristhian Mendoza, Valentina Echeverri. Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-10-08. PMID:34616271. |
parkinson's disease (pd) is a neurodegenerative condition characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) in the midbrain resulting in progressive impairment in cognitive and motor abilities. |
2021-10-08 |
2023-08-13 |
Not clear |
| Jayanth Anantha, Susan R Goulding, Eszter Tuboly, Adam G O'Mahony, Gerard M Moloney, Gareth Lomansey, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease. Molecular neurobiology. 2021-10-08. PMID:34623600. |
parkinson's disease (pd) is a neurodegenerative disease characterised by the progressive degeneration of midbrain dopaminergic neurons, coupled with the intracellular accumulation of α-synuclein. |
2021-10-08 |
2023-08-13 |
human |
| Daniel J Rees, Luke Roberts, M Carla Carisi, Alwena H Morgan, M Rowan Brown, Jeffrey S Davie. Automated Quantification of Mitochondrial Fragmentation in an In Vitro Parkinson's Disease Model. Current protocols in neuroscience. vol 94. issue 1. 2021-10-06. PMID:33147381. |
basic protocol 1: sn4741 neuron culture and treatment in a rotenone-based model of parkinson's disease basic protocol 2: identification of cell nuclei, measurement of mitochondrial membrane potential, and measurement of mitochondrial fragmentation in mouse-derived midbrain dopaminergic neurons. |
2021-10-06 |
2023-08-13 |
Not clear |
| Magdalena Guerra-Crespo, Omar Collazo-Navarrete, Rodrigo Ramos-Acevedo, Carmen Alejandra Morato-Torres, Birgitt Schül. Embryoid Body Formation from Mouse and Human Pluripotent Stem Cells for Transplantation to Study Brain Microenvironment and Cellular Differentiation. Methods in molecular biology (Clifton, N.J.). 2021-10-06. PMID:34611820. |
our approach focuses on studying the midbrain dopaminergic phenotype and transplanting eb into the substantia nigra pars compacta (snpc) in a parkinson's disease rodent model. |
2021-10-06 |
2023-08-13 |
mouse |
| Sunila G Nair, Denis S Smirnov, Melissa M Estabrook, Ashlee D Chisholm, Phillip R Silva, John F Neumaie. Effect of chemogenetic inhibition of lateral habenula neuronal activity on cocaine- and food-seeking behaviors in the rat. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31994279. |
the lateral habenula (lhb), an epithalamic nucleus, regulates midbrain dopaminergic systems that are known to be involved in cocaine taking and seeking behaviors. |
2021-10-05 |
2023-08-13 |
rat |
| Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang, Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi L. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell death & disease. vol 12. issue 1. 2021-10-05. PMID:33441545. |
iron deposition is present in main lesion areas in the brains of patients with parkinson's disease (pd) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. |
2021-10-05 |
2023-08-13 |
human |
| Mohammad Farhadi, Mahdi Eskandarian Boroujeni, Seyed Kamran Kamrava, Zohreh Bagher, Ava Modirzadeh Tehrani, Fakhroddin Aghajanpour, Samira Ezi, Reza Soltani, Aysan Khatmi, Rafieh Alizade. Implantation of human olfactory ecto-mesenchymal stem cells restores locomotion in a rat model of Parkinson's disease. Journal of chemical neuroanatomy. vol 114. 2021-10-05. PMID:33933574. |
pd is mainly caused by dopaminergic (daergic) neuron degeneration in the midbrain. |
2021-10-05 |
2023-08-13 |
human |