| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone Mesman, Marten P Smid. Acquisition of the Midbrain Dopaminergic Neuronal Identity. International journal of molecular sciences. vol 21. issue 13. 2021-02-16. PMID:32629812. |
acquisition of the midbrain dopaminergic neuronal identity. |
2021-02-16 |
2023-08-13 |
Not clear |
| Anna Tejchman, Agnieszka Znój, Paula Chlebanowska, Aneta Frączek-Szczypta, Marcin Majk. Carbon Fibers as a New Type of Scaffold for Midbrain Organoid Development. International journal of molecular sciences. vol 21. issue 17. 2021-02-16. PMID:32825046. |
the use of ips cells in organoid cultures enables the differentiation of cells into dopaminergic neurons, also found in the human midbrain. |
2021-02-16 |
2023-08-13 |
human |
| Sheng Zhang, Simon Zhornitsky, Gustavo A Angarita, Chiang-Shan R L. Hypothalamic response to cocaine cues and cocaine addiction severity. Addiction biology. vol 25. issue 1. 2021-02-10. PMID:30295396. |
abundant research has examined the roles of the dopaminergic midbrain and ventral striatum (vs) in cue-induced craving and habitual drug consumption. |
2021-02-10 |
2023-08-13 |
Not clear |
| Akio Mori, Yuzuru Imai, Nobutaka Hattor. Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease. International journal of molecular sciences. vol 21. issue 9. 2021-02-10. PMID:32392751. |
parkinson's disease (pd) is the second most common neurodegenerative disease; it is characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of neuronal inclusions, mainly consisting of α-synuclein (α-syn) fibrils in the affected regions. |
2021-02-10 |
2023-08-13 |
Not clear |
| Suet Lee Hor, Seong Lin Teoh, Wei Ling Li. Plant Polyphenols as Neuroprotective Agents in Parkinson's Disease Targeting Oxidative Stress. Current drug targets. vol 21. issue 5. 2021-02-08. PMID:31625473. |
parkinson's disease (pd) is the second most prevalent progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the human midbrain. |
2021-02-08 |
2023-08-13 |
human |
| Enaam Chleilat, Abhishek Pethe, Dietmar Pfeifer, Kerstin Krieglstein, Eleni Rouss. TGF-β Signaling Regulates SLC8A3 Expression and Prevents Oxidative Stress in Developing Midbrain Dopaminergic and Dorsal Raphe Serotonergic Neurons. International journal of molecular sciences. vol 21. issue 8. 2021-02-08. PMID:32326436. |
tgf-β signaling regulates slc8a3 expression and prevents oxidative stress in developing midbrain dopaminergic and dorsal raphe serotonergic neurons. |
2021-02-08 |
2023-08-13 |
Not clear |
| Alessandro Fiorenzano, Marcella Birtele, Jenny Nelander Wahlestedt, Malin Parma. Evaluation of Heliyon. vol 7. issue 1. 2021-02-06. PMID:33532642. |
evaluation of the focal and progressive degeneration of dopaminergic (da) neurons in ventral midbrain has made parkinson's disease (pd) a particularly interesting target of cell-based therapies. |
2021-02-06 |
2023-08-13 |
human |
| Claudia I Aghaie, Kathryn A Hausknecht, Ruixiang Wang, Parisa Halaji Dezfuli, Samir Haj-Dahmane, Cynthia J M Kane, Wade J Sigurdson, Roh-Yu She. Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood. Alcoholism, clinical and experimental research. vol 44. issue 2. 2021-02-04. PMID:31872887. |
prenatal ethanol exposure (pe) impairs midbrain dopaminergic (da) neuron function, which might contribute to various cognitive and behavioral deficits, including attention deficits and increased addiction risk, often observed in individuals with fetal alcohol spectrum disorders. |
2021-02-04 |
2023-08-13 |
Not clear |
| Priyankar Sanphui, Anoy Kumar Das, Subhas C Biswa. Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson's disease. Journal of neurochemistry. vol 154. issue 5. 2021-02-04. PMID:31971251. |
parkinson's disease (pd) results from the selective loss of dopaminergic neurons of substantia nigra pars compacta region of the midbrain. |
2021-02-04 |
2023-08-13 |
rat |
| R N Lippert, S Hess, P Klemm, L M Burgeno, T Jahans-Price, M E Walton, P Kloppenburg, J C Brünin. Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. The Journal of clinical investigation. vol 130. issue 7. 2021-02-02. PMID:32510473. |
this translated into silencing of dopaminergic midbrain neurons, reduced connectivity to their downstream targets, and reduced stimulus-evoked dopamine (da) release in the striatum. |
2021-02-02 |
2023-08-13 |
mouse |
| Soo Min Kim, Soo Young Cho, Min Woong Kim, Seung Ryul Roh, Hee Sun Shin, Young Ho Suh, Dongho Geum, Myung Ae Le. Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells. Molecules and cells. vol 43. issue 6. 2021-01-25. PMID:32522891. |
nuclear receptor-related 1 (nurr1) protein has been identified as an obligatory transcription factor in midbrain dopaminergic neurogenesis, but the global set of human nurr1 target genes remains unexplored. |
2021-01-25 |
2023-08-13 |
mouse |
| Soo Min Kim, Soo Young Cho, Min Woong Kim, Seung Ryul Roh, Hee Sun Shin, Young Ho Suh, Dongho Geum, Myung Ae Le. Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells. Molecules and cells. vol 43. issue 6. 2021-01-25. PMID:32522891. |
specifically, expression of genes related to synapse formation and neuronal cell migration correlated tightly with nurr1 expression, whereas cell cycle progression correlated negatively with it, precisely recapitulating midbrain dopaminergic development. |
2021-01-25 |
2023-08-13 |
mouse |
| Wenjun Xie, Jieying Gao, Rong Jiang, Xinrong Liu, Feng Lai, Yong Tang, Hong Xiao, Yan Jia, Qunhua Ba. Twice subacute MPTP administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in PD mice. Neurotoxicology. vol 76. 2021-01-20. PMID:31790727. |
twice subacute mptp administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in pd mice. |
2021-01-20 |
2023-08-13 |
mouse |
| Wenjun Xie, Jieying Gao, Rong Jiang, Xinrong Liu, Feng Lai, Yong Tang, Hong Xiao, Yan Jia, Qunhua Ba. Twice subacute MPTP administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in PD mice. Neurotoxicology. vol 76. 2021-01-20. PMID:31790727. |
our study found that two subacute administrations of mptp induced dopaminergic (daergic) neuron injury and inflammation in the midbrain and ileum, impaired intestinal barrier function and gm disorders closely related to administration. |
2021-01-20 |
2023-08-13 |
mouse |
| Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizaw. Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32847967. |
to investigate how dopamine signaling modulates stress-coping behavior, we measured the subsecond fluctuation of extracellular dopamine concentration and ph using fast scanning cyclic voltammetry (fscv) in the nac, a postsynaptic target of midbrain dopaminergic neurons, in male mice engaged in a tail suspension test (tst). |
2021-01-15 |
2023-08-13 |
mouse |
| M I Airapetov, S O Eresco, A A Lebedev, E R Bychkov, P D Shabano. [Ethanol induced increase of fibroblast growth factor 2 mRNA content in emotiogenic brain structures of rats]. Biomeditsinskaia khimiia. vol 66. issue 5. 2021-01-13. PMID:33140737. |
results suggest a possible role of fgf2 in the functioning of dopaminergic neurons in the midbrain. |
2021-01-13 |
2023-08-13 |
rat |
| Fabio Massimo Corsi, Carmela Gerace, Monica Ricc. Rotigotine effect in prolonged disturbance of consciousness. Brief report of two cases. Acta bio-medica : Atenei Parmensis. vol 91. issue 1. 2021-01-12. PMID:32191667. |
in particular, dysfunction of dopaminergic pathways from the mesencephalon to the frontal cortical areas may be responsible for clinical pictures characterized by preserved alertness and total loss of interactions with the surrounding environment; the so called "waking coma" cases. |
2021-01-12 |
2023-08-13 |
Not clear |
| Jayanth Anantha, Susan R Goulding, Sean L Wyatt, Ruth M Concannon, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5. iScience. vol 23. issue 9. 2021-01-10. PMID:32853992. |
loss of midbrain dopaminergic (mda) neurons and their axons is central to parkinson's disease (pd). |
2021-01-10 |
2023-08-13 |
rat |
| Oeystein Roed Brekk, Jonathan R Honey, Seungil Lee, Penelope J Hallett, Ole Isacso. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 44. 2021-01-07. PMID:33060302. |
histological localization of neutral lipids using a fluorescent probe (bodipy) revealed that dopaminergic neurons and midbrain microglia significantly accumulated intracellular lipids in pd sn, while adjacent astrocytes had a reduced lipid load overall. |
2021-01-07 |
2023-08-13 |
mouse |
| Ioannis Mantas, Yunting Yang, Clotilde Mannoury-la-Cour, Mark J Millan, Xiaoqun Zhang, Per Svenningsso. Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. Neuropharmacology. vol 162. 2021-01-06. PMID:31666199. |
parkinson's disease (pd) is characterized by progressive loss of midbrain dopaminergic neurons and treated with the dopamine precursor, 3,4-dihydroxy-l-phenylalanine (l-dopa). |
2021-01-06 |
2023-08-13 |
mouse |