| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charleen Salesse, Julien Charest, Hélène Doucet-Beaupré, Anne-Marie Castonguay, Simon Labrecque, Paul De Koninck, Martin Lévesqu. Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior. Cell reports. vol 30. issue 7. 2021-03-09. PMID:32075770. |
here, transcription factors lmx1a and lmx1b are shown to be essential for midbrain dopaminergic (mda) neuron excitatory synaptic inputs and dendritic development. |
2021-03-09 |
2023-08-13 |
Not clear |
| Giulia Gaggi, Andrea Di Credico, Pascal Izzicupo, Francesco Alviano, Michele Di Mauro, Angela Di Baldassarre, Barbara Ghinass. Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage. International journal of molecular sciences. vol 21. issue 18. 2021-03-05. PMID:32916865. |
we finally obtained a homogeneous population of cells resembling the morphology of primary midbrain dopaminergic neurons that expressed the functional dopaminergic markers th, dat, and nurr1. |
2021-03-05 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
enduring, sexually dimorphic impact of in utero exposure to elevated levels of glucocorticoids on midbrain dopaminergic populations. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
in order to understand the underlying neural processes, particular interest has focused on the midbrain dopaminergic systems, which are critical regulators of normal adaptive behaviours, cognitive and sensorimotor functions. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
although such substantial neurobiological changes might presage marked behavioural effects, in utero gc exposure had only a modest or no effect, depending on sex, on a range of conditioned and unconditioned behaviours known to depend on midbrain dopaminergic transmission. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
collectively, these findings suggest that apparent behavioural normality in certain tests, but not others, arises from agt-induced adaptations or compensatory mechanisms within the midbrain dopaminergic systems, which preserve some, but not all functions. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
behavioural "normality" is thus achieved by the midbrain dopaminergic network operating outside its normal limits (in a state of allostasis), rendering it at greater risk to malfunction when challenged in later life. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
sex-specific neurobiological programming of midbrain dopaminergic systems may, therefore, have psychopathological relevance for the sex bias commonly found in brain disorders associated with these systems, and which have a neurodevelopmental component, including schizophrenia, adhd (attention/deficit hyperactivity disorders), autism, depression and substance abuse. |
2021-03-04 |
2023-08-13 |
human |
| Yi-Chun Chang, Wai-Yu Li, Lukas Jyuhn-Hsiarn Lee, Li-Jen Le. Interplay of Prenatal and Postnatal Risk Factors in the Behavioral and Histological Features of a "Two-Hit" Non-Genetic Mouse Model of Schizophrenia. International journal of molecular sciences. vol 21. issue 22. 2021-03-03. PMID:33198225. |
prenatal infection increased the number of dopaminergic neurons in midbrain, whereas postweaning isolation decreased the gabaergic neurons in cortex. |
2021-03-03 |
2023-08-13 |
mouse |
| Suzanne O Nolan, Jennifer E Zachry, Amy R Johnson, Lillian J Brady, Cody A Siciliano, Erin S Calipar. Direct dopamine terminal regulation by local striatal microcircuitry. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32356315. |
here we review how these mechanisms work in concert to influence the timing and magnitude of striatal dopamine signaling, independent of action potential activity at the level of dopaminergic cell bodies in the midbrain, thereby providing a parallel pathway by which dopamine can be modulated. |
2021-03-02 |
2023-08-13 |
Not clear |
| Jenesis D Gayden, Zachary Freyber. Commentary: Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the Wnt/β-catenin pathway. Frontiers in cellular neuroscience. vol 14. 2021-03-01. PMID:32973452. |
commentary: ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the wnt/β-catenin pathway. |
2021-03-01 |
2023-08-13 |
Not clear |
| Sandra Iglesias, Lars Kasper, Samuel J Harrison, Robert Manka, Christoph Mathys, Klaas E Stepha. Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning. NeuroImage. vol 226. 2021-03-01. PMID:33285332. |
in a previous fmri study we found that low-level precision-weighted pes about visual outcomes (that update beliefs about associations) activated the putative dopaminergic midbrain; by contrast, precision-weighted pes about cue-outcome associations (that update beliefs about volatility) activated the cholinergic basal forebrain. |
2021-03-01 |
2023-08-13 |
human |
| Sandra Iglesias, Lars Kasper, Samuel J Harrison, Robert Manka, Christoph Mathys, Klaas E Stepha. Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning. NeuroImage. vol 226. 2021-03-01. PMID:33285332. |
additionally, in the putative dopaminergic midbrain, galantamine compared to placebo enhanced low-level pe responses (in a body-weight dependent manner) and amisulpride enhanced high-level precision activity. |
2021-03-01 |
2023-08-13 |
human |
| Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhan. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 Aging. vol 12. issue 9. 2021-02-25. PMID:32396526. |
hotair drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of parkinson's disease by elevating nptx2 parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive cell loss, largely confined to mesencephalic dopamine neurons of the substantia nigra. |
2021-02-25 |
2023-08-13 |
mouse |
| I-Jung Lee, Che-Yi Chao, Ying-Chen Yang, Jing-Jy Cheng, Chuen-Lin Huang, Chun-Tang Chiou, Hung-Tse Huang, Yao-Haur Kuo, Nai-Kuei Huan. Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-02-24. PMID:33383311. |
besides, paraquat (pq) as an herbicide has been known to impair midbrain dopaminergic neurons, resemblance to the pathology of pd. |
2021-02-24 |
2023-08-13 |
human |
| Paula Chlebanowska, Maciej Sułkowski, Klaudia Skrzypek, Anna Tejchman, Agata Muszyńska, Rezvan Noroozi, Marcin Majk. Origin of the Induced Pluripotent Stem Cells Affects Their Differentiation into Dopaminergic Neurons. International journal of molecular sciences. vol 21. issue 16. 2021-02-22. PMID:32784894. |
to conclude, the origin of ips cells may significantly affect ips differentiation abilities in teratomas, as well as exerting effects on 2d differentiation into dopaminergic neurons and the early stages of 3d midbrain organoid formation. |
2021-02-22 |
2023-08-13 |
human |
| Ronghui Li, Xuxia Wang, Fuchun Lin, Tao Song, Xutao Zhu, Hao Le. Mapping accumulative whole-brain activities during environmental enrichment with manganese-enhanced magnetic resonance imaging. NeuroImage. vol 210. 2021-02-19. PMID:32004718. |
relative to the mice residing in a standard environment (se), the mice subjected to ee treatment had significantly enhanced regional memri signal intensities in the prefrontal cortex, somatosensory cortices, basal ganglia, amygdala, motor thalamus, lateral hypothalamus, ventral hippocampus and midbrain dopaminergic areas at the end of the 7-day exposure, likely attributing to enhanced mn |
2021-02-19 |
2023-08-13 |
mouse |
| Sarah Ben Youssef, Guillaume Brisson, Hélène Doucet-Beaupré, Anne-Marie Castonguay, Charles Gora, Mohamed Amri, Martin Lévesqu. Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease. Nutritional neuroscience. vol 24. issue 3. 2021-02-17. PMID:31131731. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta, and it involves oxidative stress. |
2021-02-17 |
2023-08-13 |
mouse |
| Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo Horg. Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses. NeuroImage. vol 208. 2021-02-17. PMID:31841683. |
furthermore, a voxelwise-analysis approach has been validated to resolve substructures, such as the ventral tegmental area (vta), within midbrain dopaminergic nuclei thought to have distinct anatomical targets and functional roles. |
2021-02-17 |
2023-08-13 |
Not clear |
| Yuzuru Ima. Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders". International journal of molecular sciences. vol 21. issue 12. 2021-02-17. PMID:32549241. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by age-dependent motor dysfunction and degeneration of the midbrain dopaminergic neurons [...]. |
2021-02-17 |
2023-08-13 |
Not clear |