| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Will Collins, Nicolas Rouleau, Mattia Bonzanni, Kevin Kapner, Alex Jeremiah, Chuang Du, Emmanuel N Pothos, David L Kapla. Functional Effects of a Neuromelanin Analogue on Dopaminergic Neurons in 3D Cell Culture. ACS biomaterials science & engineering. vol 5. issue 1. 2021-01-06. PMID:33405867. |
to address this limitation, we modified our established silk 3d brain tissue model to emulate key characteristics of the snpc by using a structural analogue of nm to examine the effects of the material on dopaminergic neurons using lund's human mesencephalon (luhmes) cells. |
2021-01-06 |
2023-08-13 |
human |
| Yuko Nakamura, Naohiro Okada, Daisuke Koshiyama, Kouhei Kamiya, Osamu Abe, Akira Kunimatsu, Kazuo Okanoya, Kiyoto Kasai, Shinsuke Koik. Differences in Functional Connectivity Networks Related to the Midbrain Dopaminergic System-Related Area in Various Psychiatric Disorders. Schizophrenia bulletin. 2021-01-05. PMID:31901932. |
differences in functional connectivity networks related to the midbrain dopaminergic system-related area in various psychiatric disorders. |
2021-01-05 |
2023-08-13 |
Not clear |
| Qi-Wen Han, Yu-He Yuan, Nai-Hong Che. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31442553. |
parkinson's disease (pd) is a neurodegenerative disease and its characteristic is the progressive degeneration of dopaminergic neurons within the substantia nigra (sn) of the midbrain. |
2021-01-04 |
2023-08-13 |
Not clear |
| Pascaline Aimé, Saravanan S Karuppagounder, Apeksha Rao, Yingxin Chen, Robert E Burke, Rajiv R Ratan, Lloyd A Green. The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiology of disease. vol 136. 2021-01-04. PMID:31911115. |
neuronal pc12 cells and ventral midbrain dopaminergic neurons were assessed in vitro for survival, transcription factor levels and trib3 or parkin expression after exposure to 6-hydroxydopamine or 1-methyl-4-phenylpyridinium with or without adaptaquin co-treatment. |
2021-01-04 |
2023-08-13 |
mouse |
| Sergio Espeso-Gil, Tobias Halene, Jaroslav Bendl, Bibi Kassim, Gabriella Ben Hutta, Marina Iskhakova, Neda Shokrian, Pavan Auluck, Behnam Javidfar, Prashanth Rajarajan, Sandhya Chandrasekaran, Cyril J Peter, Alanna Cote, Rebecca Birnbaum, Will Liao, Tyler Borrman, Jennifer Wiseman, Aaron Bell, Michael J Bannon, Panagiotis Roussos, John F Crary, Zhiping Weng, Stefano Marenco, Barbara Lipska, Nadejda M Tsankova, Laura Huckins, Yan Jiang, Schahram Akbaria. A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons. Genome medicine. vol 12. issue 1. 2021-01-04. PMID:32075678. |
midbrain dopaminergic neurons (mdn) represent 0.0005% of the brain's neuronal population and mediate cognition, food intake, and metabolism. |
2021-01-04 |
2023-08-13 |
Not clear |
| Georgia Minakaki, Dimitri Krainc, Lena F Burbull. The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease. Frontiers in cell and developmental biology. vol 8. 2021-01-01. PMID:33381501. |
the convergence of alpha-synuclein, mitochondrial, and lysosomal pathways in vulnerability of midbrain dopaminergic neurons in parkinson's disease. |
2021-01-01 |
2023-08-13 |
Not clear |
| Laura Bordoni, Irene Petracci, Jean Calleja-Agius, Joan G Lalor, Rosita Gabbianell. NURR1 Alterations in Perinatal Stress: A First Step towards Late-Onset Diseases? A Narrative Review. Biomedicines. vol 8. issue 12. 2020-12-29. PMID:33302583. |
nuclear receptor related 1 protein (nurr1), a transcription factor with a critical role in the development of the dopaminergic neurons in the midbrain, mediates the response to stressful environmental stimuli in the perinatal period. |
2020-12-29 |
2023-08-13 |
human |
| Surya Narayan Rath, Lingaraja Jena, Manorama Patr. Understanding ligands driven mechanism of wild and mutant aryl hydrocarbon receptor in presence of phytochemicals combating Parkinson's disease: an Journal of biomolecular structure & dynamics. vol 38. issue 3. 2020-12-28. PMID:30836878. |
b[a] p induces oxidative stress and causes degeneration of dopaminergic neurons in the midbrain, may leads to parkinson's disease (pd). |
2020-12-28 |
2023-08-13 |
Not clear |
| Justin K Siemann, Piper Williams, Turnee N Malik, Chad R Jackson, Noah H Green, Ronald B Emeson, Pat Levitt, Douglas G McMaho. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963273. |
hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (th) and serotonergic (tph2, sert, and pet-1) genes, and midbrain monoamine content in mice raised under control equinox (ld 12:12), short winter-like (ld 8:16), or long summer-like (ld 16:8) photoperiods. |
2020-12-15 |
2023-08-13 |
mouse |
| Michael Freedberg, Andrew C Toader, Eric M Wassermann, Joel L Vos. Competitive and cooperative interactions between medial temporal and striatal learning systems. Neuropsychologia. vol 136. 2020-12-11. PMID:31733236. |
the involvement of other regions, such as midbrain dopaminergic nuclei and the prefrontal cortex, may promote and mediate cooperation between the striatum and the mtl during learning. |
2020-12-11 |
2023-08-13 |
Not clear |
| Tingting Di, Ya Wang, Yajie Zhang, Sha Sha, Yanying Zeng, Ling Che. Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin-releasing hormone in paraventricular nucleus. Journal of neurochemistry. vol 154. issue 2. 2020-12-10. PMID:32096869. |
dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin-releasing hormone in paraventricular nucleus. |
2020-12-10 |
2023-08-13 |
mouse |
| Tingting Di, Ya Wang, Yajie Zhang, Sha Sha, Yanying Zeng, Ling Che. Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin-releasing hormone in paraventricular nucleus. Journal of neurochemistry. vol 154. issue 2. 2020-12-10. PMID:32096869. |
dopaminergic (daergic) neurons of the midbrain ventral tegmental area (vta) are known to regulate the hypothalamic-pituitary-adrenal (hpa) axis but have no direct projections to the paraventricular nucleus (pvn) of the hypothalamus. |
2020-12-10 |
2023-08-13 |
mouse |
| Jan Grohn, Urs Schüffelgen, Franz-Xaver Neubert, Alessandro Bongioanni, Lennart Verhagen, Jerome Sallet, Nils Kolling, Matthew F S Rushwort. Multiple systems in macaques for tracking prediction errors and other types of surprise. PLoS biology. vol 18. issue 10. 2020-12-09. PMID:33125367. |
activity in the vicinity of the dopaminergic midbrain only reflected surprise about the amount of reward. |
2020-12-09 |
2023-08-13 |
Not clear |
| N V Katolikova, A B Malashicheva, R R Gainetdino. [Cell Replacement Therapy in Parkinson's Disease-History of Development and Prospects for Use in Clinical Practice]. Molekuliarnaia biologiia. vol 54. issue 6. 2020-12-09. PMID:33276357. |
parkinson's disease is a widespread neurodegenerative disease, which is characterized by the death of dopaminergic neurons in the substantia nigra of the midbrain. |
2020-12-09 |
2023-08-13 |
Not clear |
| Raniki Kumari, Roshan Kumar, Sanjay Kumar, Abhishek Kumar Singh, Pranita Hanpude, Deepak Jangir, Tushar Kanti Mait. Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease. The Journal of biological chemistry. vol 295. issue 11. 2020-12-07. PMID:32005664. |
parkinson's disease (pd) is a multifactorial malady and the second most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in the midbrain. |
2020-12-07 |
2023-08-13 |
mouse |
| Sreekanth Rajan, Yongwoo Jang, Chun-Hyung Kim, Woori Kim, Hui Ting Toh, Jeha Jeon, Bin Song, Aida Serra, Julien Lescar, Jun Yeob Yoo, Serap Beldar, Hong Ye, Congbao Kang, Xue-Wei Liu, Melissa Feitosa, Yeahan Kim, Dabin Hwang, Geraldine Goh, Kah-Leong Lim, Hye Min Park, Choong Hwan Lee, Sungwhan F Oh, Gregory A Petsko, Ho Sup Yoon, Kwang-Soo Ki. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature chemical biology. vol 16. issue 8. 2020-11-23. PMID:32451509. |
the orphan nuclear receptor nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mda) neurons. |
2020-11-23 |
2023-08-13 |
mouse |
| Ashutosh Dhingra, Joachim Täger, Elisangela Bressan, Salvador Rodriguez-Nieto, Manmeet-Sakshi Bedi, Stefanie Bröer, Eldem Sadikoglou, Noémia Fernandes, Melissa Castillo-Lizardo, Patrizia Rizzu, Peter Heutin. Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring. Journal of visualized experiments : JoVE. issue 162. 2020-11-20. PMID:32831313. |
we describe the automation of a short-term differentiation protocol using neurogenin-2 (ngn2) over-expression to produce hipsc-derived cortical neurons within 6‒8 days, and the implementation of a long-term differentiation protocol to generate hipsc-derived midbrain dopaminergic (mda) neurons within 65 days. |
2020-11-20 |
2023-08-13 |
human |
| b' Slobodan Kapor, Milan Aksi\\xc4\\x87, Laslo Pu\\xc5\\xa1ka\\xc5\\xa1, Marin Juki\\xc4\\x87, Joko Poleksi\\xc4\\x87, Filip Milosavljevi\\xc4\\x87, Suncica Bjelica, Branislav Filipovi\\xc4\\x8. Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats. Frontiers in neuroanatomy. vol 14. 2020-11-17. PMID:33192342.' |
maternally deprived and control wistar rats were sacrificed on postnatal day 35 or 60, and the dopaminergic neurons were stained in coronal histological sections of ventral midbrain with the tyrosine hydroxylase antibody. |
2020-11-17 |
2023-08-13 |
rat |
| Yujuan Gui, Mélanie H Thomas, Pierre Garcia, Mona Karout, Rashi Halder, Alessandro Michelucci, Heike Kollmus, Cuiqi Zhou, Shlomo Melmed, Klaus Schughart, Rudi Balling, Michel Mittelbronn, Joseph H Nadeau, Robert W Williams, Thomas Sauter, Manuel Buttini, Lasse Sinkkone. Frontiers in genetics. vol 11. 2020-11-13. PMID:33173537. |
dopaminergic neurons in the midbrain are of particular interest due to their role in diseases such as parkinson's disease and schizophrenia. |
2020-11-13 |
2023-08-13 |
mouse |
| Yujuan Gui, Mélanie H Thomas, Pierre Garcia, Mona Karout, Rashi Halder, Alessandro Michelucci, Heike Kollmus, Cuiqi Zhou, Shlomo Melmed, Klaus Schughart, Rudi Balling, Michel Mittelbronn, Joseph H Nadeau, Robert W Williams, Thomas Sauter, Manuel Buttini, Lasse Sinkkone. Frontiers in genetics. vol 11. 2020-11-13. PMID:33173537. |
genetic variation between individuals can affect the integrity and function of dopaminergic neurons but the dna variants and molecular cascades modulating dopaminergic neurons and other cells types of ventral midbrain remain poorly defined. |
2020-11-13 |
2023-08-13 |
mouse |