| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhu Zhu, Wu Yichen, Zhang Ziheng, Ge Dinghao, Lu Ming, Liu Wei, Shan Enfang, Hu Gang, Hiroaki Honda, Yang Jia. The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling. Aging. vol 11. issue 24. 2020-11-10. PMID:31884423. |
here we study the effects of differentiated embryonic chondrocyte gene 1(dec1) deficiency on midbrain dopaminergic(da) neurons in the substantia nigra pars compacta(snpc) through behavioral, histological and molecular analysis. |
2020-11-10 |
2023-08-13 |
mouse |
| Jose A Morales-Garcia, Sandra Alonso-Gil, Ángel Santos, Ana Perez-Castill. Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31473904. |
parkinson's disease is characterized by a loss of dopaminergic neurons in the ventral midbrain. |
2020-11-05 |
2023-08-13 |
mouse |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |
| Tae-Yoon Park, Yongwoo Jang, Woori Kim, Joon Shin, Hui Ting Toh, Chun-Hyung Kim, Ho Sup Yoon, Pierre Leblanc, Kwang-Soo Ki. Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31664129. |
the orphan nuclear receptor nurr1 (also known as nr4a2) is an essential transcription factor affecting the development and maintenance of midbrain dopaminergic neurons. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
synchronized pauses in the activity of striatal cholinergic interneurons (chins) are correlated with elevated activity of midbrain dopaminergic neurons, whereas synchronous firing of chins induces local release of dopamine. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
inhibition between chins is attenuated by dopaminergic midbrain afferents acting presynaptically on d2 receptors. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matías Cavelli, Giselle Prunell, Gustavo Costa, Noelia Velásquez, Joaquín Gonzalez, Santiago Castro-Zaballa, Marcelo M S Lima, Pablo Torterol. Electrocortical high frequency activity and respiratory entrainment in 6-hydroxydopamine model of Parkinson's disease. Brain research. vol 1724. 2020-10-29. PMID:31499018. |
), which are associated with the degeneration of the dopaminergic neurons of the midbrain. |
2020-10-29 |
2023-08-13 |
rat |
| Matías Cavelli, Giselle Prunell, Gustavo Costa, Noelia Velásquez, Joaquín Gonzalez, Santiago Castro-Zaballa, Marcelo M S Lima, Pablo Torterol. Electrocortical high frequency activity and respiratory entrainment in 6-hydroxydopamine model of Parkinson's disease. Brain research. vol 1724. 2020-10-29. PMID:31499018. |
in the present study, we evaluate the role of midbrain dopaminergic neurons, in the modulation of the electrocorticogram activity and its respiratory entrainment during wakefulness and sleep. |
2020-10-29 |
2023-08-13 |
rat |
| Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Paris. An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions. STAR protocols. vol 1. issue 2. 2020-10-29. PMID:33111103. |
here, we describe a xeno-free, feeder-free, and chemically defined protocol for the generation of ventral midbrain dopaminergic (vmda) progenitors from human pluripotent stem cells (hpscs). |
2020-10-29 |
2023-08-13 |
human |
| Mary-Frances E Hall, Frank C Churc. Exercise for Older Adults Improves the Quality of Life in Parkinson's Disease and Potentially Enhances the Immune Response to COVID-19. Brain sciences. vol 10. issue 9. 2020-10-28. PMID:32899958. |
parkinson's disease (pd) is a progressive neurodegenerative disorder brought about due to dopaminergic neuronal cell loss in the midbrain substantia nigra pars compacta region. |
2020-10-28 |
2023-08-13 |
Not clear |
| J A Hosp, K L Greiner, L Martinez Arellano, F Roth, F Löffler, J Reis, B Fritsc. Progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. Experimental neurology. vol 327. 2020-10-27. PMID:31987834. |
progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. |
2020-10-27 |
2023-08-13 |
rat |
| J A Hosp, K L Greiner, L Martinez Arellano, F Roth, F Löffler, J Reis, B Fritsc. Progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. Experimental neurology. vol 327. 2020-10-27. PMID:31987834. |
in the case of middle cerebral artery occlusion (mcao), in which striato-nigral connections are affected, the hypothesis of inflammation-induced remote neurodegeneration is based on the temporal dynamics of an early appearance of inflammatory markers in midbrain followed by dopaminergic neuronal loss. |
2020-10-27 |
2023-08-13 |
rat |
| J A Hosp, K L Greiner, L Martinez Arellano, F Roth, F Löffler, J Reis, B Fritsc. Progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. Experimental neurology. vol 327. 2020-10-27. PMID:31987834. |
to test the hypothesis of a direct transsynaptic mediation of secondary exo-focal post-ischemic neurodegeneration, we used a photochemical induction of a stroke (pts) in sprague-dawley rats restricted to motor cortex (mc), thereby sparing the striatal connections to dopaminergic midbrain nuclei. |
2020-10-27 |
2023-08-13 |
rat |
| Teresia M Osborn, Penelope J Hallett, James M Schumacher, Ole Isacso. Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients. Frontiers in cellular neuroscience. vol 14. 2020-10-27. PMID:32317934. |
restoration of dopaminergic synapses using neuronal cell replacement therapy has shown benefit in clinical studies using cells from fetal ventral midbrain. |
2020-10-27 |
2023-08-13 |
Not clear |
| Jeffrey Kim, Marcel M Daad. Non-cell autonomous mechanism of Parkinson's disease pathology caused by G2019S LRRK2 mutation in Ashkenazi Jewish patient: Single cell analysis. Brain research. vol 1722. 2020-10-21. PMID:31330122. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease, characterized by the loss of the midbrain dopaminergic neurons, which leads to impaired motor and cognitive functions. |
2020-10-21 |
2023-08-13 |
Not clear |
| Ashraf Mahmud, Petio Petrov, Guillem R Esber, Mihaela D Iordanov. The serial blocking effect: a testbed for the neural mechanisms of temporal-difference learning. Scientific reports. vol 9. issue 1. 2020-10-16. PMID:30979910. |
the application of these models to understanding the role of phasic midbrain dopaminergic responses in reward prediction learning constitutes one of the greatest success stories in behavioural and cognitive neuroscience. |
2020-10-16 |
2023-08-13 |
Not clear |
| Carles Calatayud, Giulia Carola, Irene Fernández-Carasa, Marco Valtorta, Senda Jiménez-Delgado, Mònica Díaz, Jordi Soriano-Fradera, Graziella Cappelletti, Javier García-Sancho, Ángel Raya, Antonella Consigli. CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons. Scientific reports. vol 9. issue 1. 2020-10-16. PMID:31048719. |
we also employed calcium imaging techniques to determine the intrinsic functional differences between dopaminergic and non-dopaminergic ventral midbrain neurons. |
2020-10-16 |
2023-08-13 |
human |
| Anupam Raina, Sameehan Mahajani, Mathias Bähr, Sebastian Kügle. Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31317490. |
intriguingly, gabaergic neurons isolated from embryonal midbrain could not be trans-differentiated into dopaminergic neurons by ascl1 and nurr1. |
2020-10-07 |
2023-08-13 |
rat |
| Liting Hang, John Thundyil, Geraldine W Y Goh, Kah-Leong Li. AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression. Neuromolecular medicine. vol 21. issue 1. 2020-10-02. PMID:30411223. |
parkinson's disease (pd) is a prevalent neurodegenerative movement disorder that is characterized pathologically by the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) of the midbrain. |
2020-10-02 |
2023-08-13 |
mouse |
| Mary Gazea, Evangelia Tasouri, Tobias Heigl, Viktoria Bosch, Kerry L Tucker, Sandra Blaes. Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis. Neurogenesis (Austin, Tex.). vol 3. issue 1. 2020-10-01. PMID:28090543. |
definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis. |
2020-10-01 |
2023-08-13 |
Not clear |