| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lusi Zhang, Jie Deng, Qian Pan, Yan Zhan, Jian-Bing Fan, Kun Zhang, Zhuohua Zhan. Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease. Journal of genetics and genomics = Yi chuan xue bao. vol 43. issue 10. 2017-10-16. PMID:27692691. |
consistent with the dna methylation changes, marked reduction of protein expression was observed for four wnt and neurogenesis related genes (foxc1, neurg2, spry1, and ctnnb1) in midbrain dopaminergic (da) neurons of pd. |
2017-10-16 |
2023-08-13 |
human |
| A James Melrose, Ursula Bailer, Christina E Wierenga, Amanda Bischoff-Grethe, Martin P Paulus, Walter H Kay. Amphetamine alters neural response to sucrose in healthy women. Psychiatry research. Neuroimaging. vol 252. 2017-10-10. PMID:27179312. |
amphetamine, likely via action on the brain's dopaminergic systems, induces anorectic eating behavior and blunts dopaminergic midbrain activation to rewards. |
2017-10-10 |
2023-08-13 |
Not clear |
| Joanna A Korecka, Elizabeth B Moloney, Ruben Eggers, Barbara Hobo, Sanny Scheffer, Nienke Ras-Verloop, R Jeroen Pasterkamp, Dick F Swaab, August B Smit, Ronald E van Kesteren, Koen Bossers, Joost Verhaage. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 39. 2017-10-10. PMID:28842419. |
here we demonstrate the expression of rgma in midbrain human dopaminergic (da) neurons. |
2017-10-10 |
2023-08-13 |
mouse |
| Joanna A Korecka, Elizabeth B Moloney, Ruben Eggers, Barbara Hobo, Sanny Scheffer, Nienke Ras-Verloop, R Jeroen Pasterkamp, Dick F Swaab, August B Smit, Ronald E van Kesteren, Koen Bossers, Joost Verhaage. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 39. 2017-10-10. PMID:28842419. |
to investigate whether rgma might model aspects of the neuropathology of parkinson's disease in mouse, we targeted rgma to adult midbrain dopaminergic neurons using adeno-associated viral vectors. |
2017-10-10 |
2023-08-13 |
mouse |
| Willemieke M Kouwenhoven, Lars von Oerthel, Marten P Smid. Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool. PloS one. vol 12. issue 8. 2017-10-09. PMID:28800615. |
mesodiencephalic dopaminergic (mdda) neurons are located in the ventral midbrain. |
2017-10-09 |
2023-08-13 |
Not clear |
| Marika Doucet, Aadil El-Turabi, Franziska Zabel, Benjamin H M Hunn, Nora Bengoa-Vergniory, Milena Cioroch, Mauricio Ramm, Amy M Smith, Ariane Cruz Gomes, Gustavo Cabral de Miranda, Richard Wade-Martins, Martin F Bachman. Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles. PloS one. vol 12. issue 8. 2017-10-06. PMID:28797124. |
parkinson's disease (pd) is a progressive and currently incurable neurological disorder characterised by the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha-synuclein (a-syn). |
2017-10-06 |
2023-08-13 |
mouse |
| Susan E Maloney, Eakta Khangura, Joseph D Doughert. The RNA-binding protein Celf6 is highly expressed in diencephalic nuclei and neuromodulatory cell populations of the mouse brain. Brain structure & function. vol 221. issue 4. 2017-10-03. PMID:25682262. |
the greatest protein expression was observed in distinct nuclei of the diencephalon and neuromodulatory cell populations of the midbrain and hindbrain, with clear expression in dopaminergic, noradrenergic, histaminergic, serotonergic and cholinergic populations, and a variety of presumptive peptidergic cells of the hypothalamus. |
2017-10-03 |
2023-08-13 |
mouse |
| Zi-Ying Wang, Jing-Yi Liu, Chuan-Bin Yang, Sandeep Malampati, Ying-Yu Huang, Mei-Xiang Li, Min Li, Ju-Xian Son. Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review. Phytotherapy research : PTR. vol 31. issue 8. 2017-10-03. PMID:28504367. |
impairment of the alp has been found to be linked to the pathogenesis of parkinson's disease (pd), a chronic neurodegenerative disorder characterized by the accumulation of protein aggregates and loss of dopaminergic neurons in the midbrain. |
2017-10-03 |
2023-08-13 |
Not clear |
| Pei-Chun Wu, Lung-Sen Ka. Calcium regulation in mouse mesencephalic neurons-Differential roles of Na(+)/Ca(2+) exchanger, mitochondria and endoplasmic reticulum. Cell calcium. vol 59. issue 6. 2017-09-29. PMID:27020658. |
midbrain dopaminergic (da) neurons are the key to finely tune the voluntary movement, habit and motivation. |
2017-09-29 |
2023-08-13 |
mouse |
| Simon McArthur, Ilse S Pienaar, Sindhu M Siddiqi, Glenda E Gillie. Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Brain structure & function. vol 221. issue 5. 2017-09-20. PMID:25944572. |
sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal gc treatment. |
2017-09-20 |
2023-08-13 |
mouse |
| Simon McArthur, Ilse S Pienaar, Sindhu M Siddiqi, Glenda E Gillie. Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Brain structure & function. vol 221. issue 5. 2017-09-20. PMID:25944572. |
the mammalian midbrain dopaminergic systems arising in the substantia nigra pars compacta (snc) and ventral tegmental area (vta) are critical for coping behaviours and are implicated in neuropsychiatric disorders where early life challenges comprise significant risk factors. |
2017-09-20 |
2023-08-13 |
mouse |
| Lin Lin, Jonathan Göke, Engin Cukuroglu, Mark R Dranias, Antonius M J VanDongen, Lawrence W Stanto. Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. Cell reports. vol 15. issue 11. 2017-09-18. PMID:27264186. |
we observed signs of degeneration in midbrain dopaminergic neurons, reflecting the cardinal feature of pd. gene expression signatures of pd neurons provided molecular insights into disease phenotypes observed in vitro, including oxidative stress vulnerability and altered neuronal activity. |
2017-09-18 |
2023-08-13 |
Not clear |
| Soojin Kim, Yangu Zhao, Ja-Myong Lee, Woon Ryoung Kim, Marat Gorivodsky, Heiner Westphal, Dongho Geu. Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons. Stem cells and development. vol 25. issue 13. 2017-09-11. PMID:27171818. |
ldb1 is essential for the development of isthmic organizer and midbrain dopaminergic neurons. |
2017-09-11 |
2023-08-13 |
mouse |
| Soojin Kim, Yangu Zhao, Ja-Myong Lee, Woon Ryoung Kim, Marat Gorivodsky, Heiner Westphal, Dongho Geu. Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons. Stem cells and development. vol 25. issue 13. 2017-09-11. PMID:27171818. |
the midbrain and the cerebellum were severely reduced in size, and the midbrain dopaminergic (mda) neurons were missing in the mutant. |
2017-09-11 |
2023-08-13 |
mouse |
| Sara Nolbrant, Andreas Heuer, Malin Parmar, Agnete Kirkeb. Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation. Nature protocols. vol 12. issue 9. 2017-09-11. PMID:28858290. |
generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation. |
2017-09-11 |
2023-08-13 |
human |
| Simon R W Stott, Shaista Hayat, Tom Carnwath, Shaady Garas, Jonathan P Sleeman, Roger A Barke. CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease. PloS one. vol 12. issue 2. 2017-09-07. PMID:28182766. |
our results indicate that in the absence of cd24, there is a reduction in the protective effects of gdnf on the dopaminergic fibres in the striatum, but no difference in the survival of the cell bodies in the midbrain. |
2017-09-07 |
2023-08-13 |
mouse |
| Cristina Deflorio, Stéphane Blanchard, Maria Carla Carisì, Delphine Bohl, Uwe Masko. Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 2. 2017-09-01. PMID:27856558. |
we have differentiated human induced pluripotent stem (ips) cells into midbrain dopaminergic (da) neurons and obtained a comprehensive characterization of these neurons by quantitative rt-pcr. |
2017-09-01 |
2023-08-13 |
human |
| Olga A Sergeeva, Roberto De Luca, Karolina Mazur, Aissa N Chepkova, Helmut L Haas, Andreas Baue. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Neuropharmacology. vol 119. 2017-08-31. PMID:28400256. |
n-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. |
2017-08-31 |
2023-08-13 |
mouse |
| Olga A Sergeeva, Roberto De Luca, Karolina Mazur, Aissa N Chepkova, Helmut L Haas, Andreas Baue. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Neuropharmacology. vol 119. 2017-08-31. PMID:28400256. |
the present study investigates olda targets in midbrain dopaminergic (da) neurons. |
2017-08-31 |
2023-08-13 |
mouse |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
altered antioxidant homeostasis and mitochondrial functions are the key mechanisms in loss of dopaminergic neurons in the substantia nigra (sn) region of the midbrain in pd. |
2017-08-25 |
2023-08-13 |
mouse |