| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahash. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model. Nature. vol 548. issue 7669. 2018-01-25. PMID:28858313. |
induced pluripotent stem cells (ips cells) are a promising source for a cell-based therapy to treat parkinson's disease (pd), in which midbrain dopaminergic neurons progressively degenerate. |
2018-01-25 |
2023-08-13 |
human |
| Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahash. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model. Nature. vol 548. issue 7669. 2018-01-25. PMID:28858313. |
here we show that human ips cell-derived dopaminergic progenitor cells survived and functioned as midbrain dopaminergic neurons in a primate model of pd (macaca fascicularis) treated with the neurotoxin mptp. |
2018-01-25 |
2023-08-13 |
human |
| Pamela Mahe. Protective effects of fisetin and other berry flavonoids in Parkinson's disease. Food & function. vol 8. issue 9. 2018-01-24. PMID:28714503. |
parkinson's disease (pd) is an age-associated degenerative disease of the midbrain that results from the loss of dopaminergic neurons in the substantia nigra. |
2018-01-24 |
2023-08-13 |
human |
| Karl-Jürgen Bär, Feliberto de la Cruz, Andy Schumann, Stefanie Koehler, Heinrich Sauer, Hugo Critchley, Gerd Wagne. Functional connectivity and network analysis of midbrain and brainstem nuclei. NeuroImage. vol 134. 2018-01-23. PMID:27046112. |
by means of univariate functional connectivity and graph-based analysis, we show that dopaminergic midbrain centers and the serotonergic dorsal raphe nucleus (drn) are functionally integrated with the default mode network (dmn), whereas the remaining serotonergic raphe nuclei and the noradrenergic locus coeruleus are functionally integrated with the executive-control network (ecn). |
2018-01-23 |
2023-08-13 |
human |
| Francesco Rigoli, Benjamin Chew, Peter Dayan, Raymond J Dola. Multiple value signals in dopaminergic midbrain and their role in avoidance contexts. NeuroImage. vol 135. 2018-01-23. PMID:27132047. |
multiple value signals in dopaminergic midbrain and their role in avoidance contexts. |
2018-01-23 |
2023-08-13 |
Not clear |
| Martin Ulrich, Felix Endres, Markus Kölle, Oliver Adolph, Katharina Widenhorn-Müller, Georg Grö. Glucose modulates food-related salience coding of midbrain neurons in humans. Human brain mapping. vol 37. issue 12. 2018-01-18. PMID:27411574. |
although early rat studies demonstrated that administration of glucose diminishes dopaminergic midbrain activity, evidence in humans has been lacking so far. |
2018-01-18 |
2023-08-13 |
human |
| Stefanie Köhler, Karl-Jürgen Bär, Gerd Wagne. Differential involvement of brainstem noradrenergic and midbrain dopaminergic nuclei in cognitive control. Human brain mapping. vol 37. issue 6. 2018-01-16. PMID:26970351. |
differential involvement of brainstem noradrenergic and midbrain dopaminergic nuclei in cognitive control. |
2018-01-16 |
2023-08-13 |
human |
| Zong-Bo Wei, Ye-Feng Yuan, Florence Jaouen, Mei-Sheng Ma, Chan-Juan Hao, Zhe Zhang, Quan Chen, Zengqiang Yuan, Li Yu, Corinne Beurrier, Wei L. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. vol 12. issue 7. 2018-01-16. PMID:27171858. |
slc35d3 increases autophagic activity in midbrain dopaminergic neurons by enhancing becn1-atg14-pik3c3 complex formation. |
2018-01-16 |
2023-08-13 |
mouse |
| Nivedita Bhattacharjee, Anupom Bora. Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease. Neurochemistry international. vol 101. 2018-01-12. PMID:27732886. |
unilateral intranigral infusion of hcy (1.0 μmol in 2 μl) caused inhibition of mitochondrial complex-i activity, decrease in the level of striatal dopamine, loss of midbrain dopaminergic neurons, and motor abnormalities. |
2018-01-12 |
2023-08-13 |
rat |
| Dawei Zhang, Shanzheng Yang, Enrique M Toledo, Daniel Gyllborg, Carmen Saltó, J Carlos Villaescusa, Ernest Arena. Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP. Science signaling. vol 10. issue 493. 2018-01-10. PMID:28831020. |
parkinson's disease (pd) is a neurodegenerative disorder in which the loss of dopaminergic neurons in the midbrain (mda neurons) causes progressive loss of motor control and function. |
2018-01-10 |
2023-08-13 |
mouse |
| Dagmar Zeithamova, Christine Manthuruthil, Alison R Presto. Repetition suppression in the medial temporal lobe and midbrain is altered by event overlap. Hippocampus. vol 26. issue 11. 2018-01-08. PMID:27479864. |
repeated encounters with the same event typically lead to decreased activation in the medial temporal lobe (mtl) and dopaminergic midbrain, a phenomenon known as repetition suppression. |
2018-01-08 |
2023-08-13 |
human |
| Diogo S Castr. One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons. The EMBO journal. vol 35. issue 18. 2018-01-08. PMID:27534772. |
one more factor joins the plot: pbx1 regulates differentiation and survival of midbrain dopaminergic neurons. |
2018-01-08 |
2023-08-13 |
Not clear |
| Beverley M Henley, Bruce N Cohen, Charlene H Kim, Heather D Gold, Rahul Srinivasan, Sheri McKinney, Purnima Deshpande, Henry A Leste. Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression. Journal of visualized experiments : JoVE. issue 120. 2018-01-08. PMID:28287593. |
reliable identification of living dopaminergic neurons in midbrain cultures using rna sequencing and th-promoter-driven egfp expression. |
2018-01-08 |
2023-08-13 |
mouse |
| Louise M Collins, Giorgia Dal Bo, Mariangela Calcagno, Jimena Monzón-Sandoval, Aideen M Sullivan, Humberto Gutierrez, Michele Morari, Gerard W O'Keeff. Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687234. |
nociceptin/orphanin fq inhibits the survival and axon growth of midbrain dopaminergic neurons through a p38-mapk dependent mechanism. |
2017-12-25 |
2023-08-13 |
rat |
| Louise M Collins, Giorgia Dal Bo, Mariangela Calcagno, Jimena Monzón-Sandoval, Aideen M Sullivan, Humberto Gutierrez, Michele Morari, Gerard W O'Keeff. Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687234. |
genetic removal of the n/ofq precursor partially protects midbrain dopaminergic neurons from 1-methyl-4-phenylpyridine-induced toxicity, suggesting that endogenous n/ofq may be detrimental to dopaminergic neurons. |
2017-12-25 |
2023-08-13 |
rat |
| Louise M Collins, Giorgia Dal Bo, Mariangela Calcagno, Jimena Monzón-Sandoval, Aideen M Sullivan, Humberto Gutierrez, Michele Morari, Gerard W O'Keeff. Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687234. |
here, we show that n/ofq has a detrimental effect on the survival of dopaminergic neurons and the growth of their axons in primary cultures of the e14 rat ventral mesencephalon. |
2017-12-25 |
2023-08-13 |
rat |
| Louise M Collins, Giorgia Dal Bo, Mariangela Calcagno, Jimena Monzón-Sandoval, Aideen M Sullivan, Humberto Gutierrez, Michele Morari, Gerard W O'Keeff. Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687234. |
these results demonstrate for the first time that n/ofq is detrimental to the survival and growth of dopaminergic neurons and that its expression is altered in the midbrain of patients with parkinson's disease. |
2017-12-25 |
2023-08-13 |
rat |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth. Neuroscience letters. vol 643. 2017-12-19. PMID:28188849. |
bone morphogenetic protein 2 (bmp2) is a neurotrophic factor which induces the growth of midbrain dopaminergic (da) neurons in vitro and in vivo, and its neurotrophic effects have been shown to be dependent on activation of bmp receptors (bmprs) and smad 1/5/8 signalling. |
2017-12-19 |
2023-08-13 |
human |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth. Neuroscience letters. vol 643. 2017-12-19. PMID:28188849. |
this study demonstrates that bmp2-induced smad signalling and neurite growth is regulated by dynamin-dependent endocytosis in a model of human midbrain dopaminergic neurons. |
2017-12-19 |
2023-08-13 |
human |
| Pablo Ripollés, Josep Marco-Pallarés, Helena Alicart, Claus Tempelmann, Antoni Rodríguez-Fornells, Toemme Noessel. Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop. eLife. vol 5. 2017-12-11. PMID:27644419. |
here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fmri-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the sn/vta-hippocampal loop) when successfully grasping the meaning of new-words. |
2017-12-11 |
2023-08-13 |
human |