| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
however, the impact of hypercholesterolemia on the midbrain dopaminergic neurons in animal models of pd remains elusive. |
2017-08-25 |
2023-08-13 |
mouse |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
in conclusion, our findings provide evidence of increased vulnerability of the midbrain dopaminergic neurons in pd with hypercholesterolemia. |
2017-08-25 |
2023-08-13 |
mouse |
| Giuseppe P Cortese, Mei Zhu, Damian Williams, Sarah Heath, Clarissa L Waite. Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 48. 2017-08-18. PMID:27903732. |
mutations in the gene encoding parkin, an e3 ubiquitin ligase, lead to juvenile-onset parkinson's disease by inducing the selective death of midbrain dopaminergic neurons. |
2017-08-18 |
2023-08-13 |
rat |
| Shabana Khan, Simon R W Stott, Audrey Chabrat, Anna M Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque, Siew-Lan An. Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 9. 2017-08-18. PMID:28130357. |
survival of a novel subset of midbrain dopaminergic neurons projecting to the lateral septum is dependent on neurod proteins. |
2017-08-18 |
2023-08-13 |
Not clear |
| Shabana Khan, Simon R W Stott, Audrey Chabrat, Anna M Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque, Siew-Lan An. Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 9. 2017-08-18. PMID:28130357. |
midbrain dopaminergic neurons are highly heterogeneous. |
2017-08-18 |
2023-08-13 |
Not clear |
| Shabana Khan, Simon R W Stott, Audrey Chabrat, Anna M Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque, Siew-Lan An. Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 9. 2017-08-18. PMID:28130357. |
in this paper, we report the identification and characterization of a novel subset of midbrain dopaminergic neurons located in the ventral tegmental area that expresses the basic helix-loop-helix transcription factor, neurogenic differentiation factor-6 (neurod6). |
2017-08-18 |
2023-08-13 |
Not clear |
| Kelly M J Diederen, Hisham Ziauddeen, Martin D Vestergaard, Tom Spencer, Wolfram Schultz, Paul C Fletche. Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28202786. |
such adaptive coding has been linked to midbrain dopamine neurons in nonhuman primates, and evidence in support for a similar role of the dopaminergic system in humans is emerging from fmri data. |
2017-08-18 |
2023-08-13 |
human |
| Mengyuan Gong, Ke Jia, Sheng L. Perceptual Competition Promotes Suppression of Reward Salience in Behavioral Selection and Neural Representation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 26. 2017-08-18. PMID:28539425. |
by analyzing the fmri data in primary visual cortex, we found that the behavioral pattern of results could be predicted by the suppressed channel responses tuned to the reward-associated orientation in the distractor location, accompanied by increased responses in the midbrain dopaminergic region. |
2017-08-18 |
2023-08-13 |
human |
| Rebecca M Marton, Sergiu P Paşc. Neural Differentiation in the Third Dimension: Generating a Human Midbrain. Cell stem cell. vol 19. issue 2. 2017-08-08. PMID:27494668. |
(2016) describe a 3d culture model of the human midbrain containing dopaminergic neurons and neuromelanin. |
2017-08-08 |
2023-08-13 |
human |
| Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Free. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-08-07. PMID:27512998. |
in the 1990s, we used the sv40 large t antigen to immortalize dopaminergic neurons derived from embryonic day 14 rat mesencephalon. |
2017-08-07 |
2023-08-13 |
rat |
| Martin Engel, Dzung Do-Ha, Sonia Sanz Muñoz, Lezanne Oo. Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research. Cellular and molecular life sciences : CMLS. vol 73. issue 19. 2017-08-04. PMID:27154043. |
we have analyzed the literature that describes differentiation of human pluripotent stem cells into three neural cell types that are commonly used to study diseases, including forebrain cholinergic neurons for alzheimer's disease, midbrain dopaminergic neurons for parkinson's disease and cortical astrocytes for neurodegenerative and psychiatric disorders. |
2017-08-04 |
2023-08-13 |
human |
| Nathan F Parker, Courtney M Cameron, Joshua P Taliaferro, Junuk Lee, Jung Yoon Choi, Thomas J Davidson, Nathaniel D Daw, Ilana B Witte. Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target. Nature neuroscience. vol 19. issue 6. 2017-08-02. PMID:27110917. |
dopaminergic (da) neurons in the midbrain provide rich topographic innervation of the striatum and are central to learning and to generating actions. |
2017-08-02 |
2023-08-13 |
Not clear |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
thus, the objective of this study was to evaluate (1) the validity of mre to detect viscoelastic changes in small and specific brain regions: the substantia nigra (sn), midbrain and hippocampus in a mouse model of pd, and (2) if the induced dopaminergic neurodegeneration and inflammation in the sn is reflected by local changes in viscoelasticity. |
2017-07-31 |
2023-08-13 |
mouse |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
therefore, mre measurements of the sn, midbrain and hippocampus were performed in adult female mice before and at five time points after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin hydrochloride (mptp) treatment specifically lesioning dopaminergic neurons in the sn. |
2017-07-31 |
2023-08-13 |
mouse |
| Ina Tesseur, Andy Nguyen, Betty Chang, Lulin Li, Nathaniel S Woodling, Tony Wyss-Coray, Jian Lu. Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 17. 2017-07-31. PMID:28363982. |
transforming growth factor-β (tgf-β) plays an important role in the development and maintenance of embryonic dopaminergic (da) neurons in the midbrain. |
2017-07-31 |
2023-08-13 |
mouse |
| Alexandru-Ştefan Niculae, Denis Pavă. From molecules to behavior: An integrative theory of autism spectrum disorder. Medical hypotheses. vol 97. 2017-07-27. PMID:27876135. |
in turn, this molecular syndrome generates an altered brain connectivity between the cerebellum, the midbrain dopaminergic areas, and the prefrontal cortex. |
2017-07-27 |
2023-08-13 |
Not clear |
| Thorsten Kahnt, Philippe N Toble. Dopamine Modulates the Functional Organization of the Orbitofrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 6. 2017-07-27. PMID:28069917. |
the primate orbitofrontal cortex (ofc) receives dopaminergic input from midbrain nuclei, but the role of dopamine in the ofc is still unclear. |
2017-07-27 |
2023-08-13 |
Not clear |
| Tim D Aumann, Mai Raabus, Doris Tomas, Agustinus Prijanto, Leonid Churilov, Nicholas C Spitzer, Malcolm K Horn. Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans. PloS one. vol 11. issue 7. 2017-07-26. PMID:27428306. |
recent evidence indicates the number of dopaminergic neurons in the adult rodent hypothalamus and midbrain is regulated by environmental cues, including photoperiod, and that this occurs via up- or down-regulation of expression of genes and proteins that are important for dopamine (da) synthesis in extant neurons ('da neurotransmitter switching'). |
2017-07-26 |
2023-08-13 |
Not clear |
| Teresia Osborn, Penelope J Hallet. Seq-ing Markers of Midbrain Dopamine Neurons. Cell stem cell. vol 20. issue 1. 2017-07-26. PMID:28061349. |
(2017) identify specific markers of midbrain dopaminergic progenitors to improve their derivation and predict dopamine neuron content after engraftment. |
2017-07-26 |
2023-08-13 |
human |
| Yuejun Chen, Man Xiong, Yi Dong, Alexander Haberman, Jingyuan Cao, Huisheng Liu, Wenhao Zhou, Su-Chun Zhan. Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell stem cell. vol 18. issue 6. 2017-07-19. PMID:27133795. |
here, we show tunable rescue of motor function in a mouse model of pd, following transplantation of human midbrain dopaminergic (mda) neurons differentiated from hpscs engineered to express dreadds (designer receptors exclusively activated by designer drug). |
2017-07-19 |
2023-08-13 |
mouse |