| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Huang, Zhiting Wan, Shaogang Q. Targeting the RUNX3-miR-186-3p-DAT-IGF1R axis as a therapeutic strategy in a Parkinson's disease model. Journal of translational medicine. vol 22. issue 1. 2024-08-06. PMID:39103832. |
furthermore, the high mir-186-3p expression in pd can be targeted to inhibit the dat expression, resulting in a decrease in the dopamine content of dopaminergic neurons. |
2024-08-06 |
2024-08-08 |
mouse |
| María Fernanda Urmeneta-Ortíz, Aldo Rafael Tejeda-Martínez, Orfil González-Reynoso, Mario Eduardo Flores-Sot. Potential Neuroprotective Effect of the Endocannabinoid System on Parkinson's Disease. Parkinson's disease. vol 2024. 2024-08-06. PMID:39104613. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by alterations in motor capacity resulting from a decrease in the neurotransmitter dopamine due to the selective death of dopaminergic neurons of the nigrostriatal pathway. |
2024-08-06 |
2024-08-08 |
Not clear |
| Lining Yin, Fang Han, Qingyun Wan. A biophysical model for dopamine modulating working memory through reward system in obsessive-compulsive disorder. Cognitive neurodynamics. vol 18. issue 4. 2024-08-06. PMID:39104680. |
in addition, we elucidate the potential mechanisms of dopamine antagonists in ocd, indicating that dopaminergic drugs might be available for treatment, even if the abnormality is a consequence of glutamate hypermetabolism rather than dopamine. |
2024-08-06 |
2024-08-08 |
Not clear |
| Lars Janerås, Harald Breivik, Bård Lundeland, Geir Andre Ringstad, Audun Stubhau. Long-term intrathecal infusion of low-dose morphine effectively relieves symptoms of severe restless legs syndrome/Willis-Ekbom disease without inducing opioid tolerance. Pain. 2024-08-06. PMID:39106456. |
we report 7 patients suffering from severe rls/wed, who had no relief from oral dopaminergic, gabapentinoid, or opioid drugs; they all had excellent relief during ongoing spinal intrathecal infusion of morphine at only 1 to 5 μg/h, ongoing for 1 to 21 years without need of higher doses of morphine.. we suggest that morphine may be transported with the cerebrospinal fluid reaching and readjusting malfunctioning dopamine neuronal systems in the brain and spinal cord. |
2024-08-06 |
2024-08-09 |
Not clear |
| Ryo Tsukaguchi, Masashi Hasebe, Kimitaka Shibue, Akihiro Hamasak. Diabetic striatopathy: Hyperglycemic chorea/ballism successfully treated with L-dopa. Journal of diabetes investigation. 2024-08-02. PMID:39090828. |
dopamine transporter single photon emission computed tomography revealed diminished bilateral striatal uptake, suggesting presynaptic dopaminergic dysfunction. |
2024-08-02 |
2024-08-05 |
Not clear |
| Emilio J Romano, Dao-Qi Zhan. Dopaminergic amacrine cells express HCN channels in the developing and adult mouse retina. bioRxiv : the preprint server for biology. 2024-08-02. PMID:39091772. |
to determine the molecular and functional expression of hyperpolarization-activated cyclic nucleotide-gated (hcn) channels in developing and mature dopaminergic amacrine cells (dacs), the sole source of ocular dopamine that plays a vital role in visual function and eye development. |
2024-08-02 |
2024-08-05 |
mouse |
| Qi Zhang, Jingfei Xue, Jiahui Tang, Siting Wu, Zhe Liu, Caiqing Wu, Canying Liu, Yidan Liu, Jicheng Lin, Jiaxu Han, Liyan Liu, Yuze Chen, Jinpeng Yang, Zhidong Li, Ling Zhao, Yantao Wei, Yiqing Li, Yehong Zhu. Modulating amacrine cell-derived dopamine signaling promotes optic nerve regeneration and preserves visual function. Science advances. vol 10. issue 31. 2024-08-02. PMID:39093964. |
here, we identified a unique ac subtype, dopaminergic acs (dacs), that responded early after optic nerve crush by down-regulating neuronal activity and reducing retinal dopamine (da) release. |
2024-08-02 |
2024-08-06 |
Not clear |
| Zhehong Li, Lifei Zheng, Jing Wang, Liang Wang, Yao Qi, Buhe Amin, Jinxia Zhu, Nengwei Zhan. Dopamine in the regulation of glucose and lipid metabolism: a narrative review. Obesity (Silver Spring, Md.). 2024-07-31. PMID:39081007. |
the dopaminergic system, including dopamine, dopamine receptors, dopamine transporters, and other components, is involved in numerous physiological and pathological processes. |
2024-07-31 |
2024-08-02 |
Not clear |
| Shalini Gupta, Nancy Ahuja, Sumit Kumar, Rashmi Arora, Saumyata Kumawat, Vipashu Kaushal, Pawan Gupt. Rev-erbα regulate neurogenesis through suppression of Sox2 in neuronal cells to regenerate dopaminergic neurons and abates MPP Free radical biology & medicine. 2024-07-31. PMID:39084577. |
the dearth of therapeutic interventions in parkinson's disease has driven attention in the search for targets that may augment dopamine secretion, promote differentiation towards dopaminergic neuronal lineage, or aid in neuroprotection from neuronal stress and inflammation, and prevent parkinson's disease associated motor impairment and behavioural chaos. |
2024-07-31 |
2024-08-03 |
mouse |
| Natalie Schroyens, Laura Vercammen, Burcu Özcan, Victoria Aurora Ossorio Salazar, Jonas Zaman, Dimitri De Bundel, Tom Beckers, Laura Luyte. No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats. Journal of psychopharmacology (Oxford, England). 2024-07-28. PMID:39068641. |
the neurotransmitter dopamine plays an important role in the processing of emotional memories, and prior research suggests that dopaminergic manipulations immediately after fear learning can affect the retention and generalization of acquired fear. |
2024-07-28 |
2024-08-02 |
rat |
| Ann-Kathrin Weishaupt, Lysann Ruecker, Torben Meiners, Tanja Schwerdtle, Daiana Silva Avila, Michael Aschner, Julia Bornhors. Copper-mediated neurotoxicity and genetic vulnerability in the background of neurodegenerative diseases in C. elegans. Toxicological sciences : an official journal of the Society of Toxicology. 2024-07-27. PMID:39067045. |
furthermore, our study provides insight into the mechanisms underlying cu-induced neurotoxicity in pd models, including disruptions in dopamine levels, altered dopamine-dependent behavior and degraded dopaminergic neurons. |
2024-07-27 |
2024-08-02 |
caenorhabditis_elegans |
| Roger A Barker, Anders Björklund, Malin Parma. The history and status of dopamine cell therapies for Parkinson's disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-07-26. PMID:39058892. |
this data has shown that developing dopamine cells when transplanted in the brain of a pwp can survive long term with clinical benefits lasting decades and with restoration of normal dopaminergic innervation in the grafted striatum. |
2024-07-26 |
2024-07-29 |
human |
| Samuel J Gershman, John A Assad, Sandeep Robert Datta, Scott W Linderman, Bernardo L Sabatini, Naoshige Uchida, Linda Wilbrech. Explaining dopamine through prediction errors and beyond. Nature neuroscience. 2024-07-25. PMID:39054370. |
therefore, looking forward, we discuss the prospects for a unifying theory that respects the diversity of dopamine signaling and function as well as the complex circuitry that both underlies and responds to dopaminergic transmission. |
2024-07-25 |
2024-07-28 |
Not clear |
| He Cui, Chang Shu, Yuxuan Peng, Ziyun Wei, Xiao Ni, Linlin Zheng, Jianing Shang, Fu Liu, Jieyu Li. Long-life triclosan exposure induces ADHD-like behavior in rats via prefrontal cortex dopaminergic deficiency. Ecotoxicology and environmental safety. vol 282. 2024-07-24. PMID:39047361. |
mechanistically, tcs reduced dopamine (da) synthesis, release, and transmission, and increased reuptake in pfc, thereby reducing synaptic gap da levels and causing dopaminergic deficits. |
2024-07-24 |
2024-07-28 |
rat |
| Ming Li, Xue-Ke Yang, Jian Yang, Tong-Xia Li, Chi Cui, Xiang Peng, Jie Lei, Kun Ren, Jie Ming, Pei Zhang, Bo Tia. Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells. Neuron. 2024-07-20. PMID:39032491. |
furthermore, activation or inhibition of dopaminergic projections from the ventral tegmental area to the bla effectively mimics or blocks the therapeutic effect of re-exposure with ketamine and is dopamine d2 receptor dependent. |
2024-07-20 |
2024-07-24 |
mouse |
| Cintia Klaudia Finszter, Róbert Kemecsei, Gergely Zachar, Ágota Ádám, András Csilla. Gestational VPA exposure reduces the density of juxtapositions between TH+ axons and calretinin or calbindin expressing cells in the ventrobasal forebrain of neonatal mice. Frontiers in neuroanatomy. vol 18. 2024-07-19. PMID:39026519. |
previous quantitative morphometric studies from our laboratory showed a marked reduction and defasciculation of the mesotelencephalic dopaminergic pathway of vpa treated mice, along with a decrease in tissue dopamine in the nucleus accumbens (nac), but not in the caudatoputamen (cpu). |
2024-07-19 |
2024-07-21 |
mouse |
| Katarzyna Czarzasta, Dorota Sztechman, Tymoteusz Zera, Malgorzata Wojciechowska, Agnieszka Segiet-Swiecicka, Liana Puchalska, Karol Momot, Ilona Joniec-Maciejak, Ewa Machaj, Elizabeth M Sajdel-Sulkowsk. Age- and sex-dependent cardiovascular impact of maternal perinatal stress and altered dopaminergic metabolism in the medulla oblongata of the offspring. American journal of physiology. Heart and circulatory physiology. 2024-07-19. PMID:39028279. |
a significant decrease in homovanillic acid, a dopamine metabolite and indicator of dopaminergic activity, was observed in adult stress-exposed female offspring. |
2024-07-19 |
2024-07-21 |
rat |
| Katarina Tomović Pavlović, Budimir S Ilić, Luisa Leitzbach, Kameliya K Anichina, Denitsa Yancheva, Aleksandra Živković, Anelia Ts Mavrova, Holger Stark, Andrija Smelcerovi. Bis(benzimidazol-2-yl)amine-based DPP-4 Inhibitors Potentially Suitable for Combating Diabetes and Associated Nervous System Alterations. Chemistry & biodiversity. 2024-07-13. PMID:39001610. |
the potential beneficial effects on dopamine synthesis and the survival of dopaminergic neurons could be mediated by dpp-4 inhibition. |
2024-07-13 |
2024-07-15 |
human |
| Ian Cone, Claudia Clopath, Harel Z Shouva. Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time. Nature communications. vol 15. issue 1. 2024-07-12. PMID:38997276. |
the td algorithm has been traditionally mapped onto the dopaminergic system, as firing properties of dopamine neurons can resemble rpes. |
2024-07-12 |
2024-07-15 |
Not clear |
| Vrinda Jain, Phillip J M Liang, Sushmitha Raja, Meena Mikhael, Morven A Camero. Light activation of the dopaminergic system occurs after eye-opening in the mouse retina. Frontiers in ophthalmology. vol 3. 2024-07-10. PMID:38983102. |
dopaminergic amacrine cells in the adult retina release dopamine in response to light stimulation, however, the light-induced activity of these cells in during postnatal development is not known. |
2024-07-10 |
2024-07-12 |
mouse |