| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elissavet Akrioti, Timokratis Karamitros, Panagiotis Gkaravelas, Georgia Kouroupi, Rebecca Matsas, Era Taoufi. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883433. |
neurodegeneration of dopamine neurons leads to a prominent dopaminergic deficiency in the basal ganglia, responsible for motor disturbances. |
2022-07-27 |
2023-08-14 |
Not clear |
| Maria Rosaria Melis, Fabrizio Sanna, Antonio Argiola. Dopamine, Erectile Function and Male Sexual Behavior from the Past to the Present: A Review. Brain sciences. vol 12. issue 7. 2022-07-27. PMID:35884633. |
these studies show that (i) the mesolimbic/mesocortical dopaminergic system plays a key role in the preparatory phase of sexual behavior, e.g., in sexual arousal, motivation and reward, whereas the nigrostriatal system controls the sensory-motor coordination necessary for copulation, (ii) the incertohypothalamic system is involved in the consummatory aspects of sexual behavior (penile erection and copulation), but evidence for its role in sexual motivation is also available, (iii) the pro-sexual effects of dopamine occur in concert with neural systems interconnecting the hypothalamus and preoptic area with the spinal cord, ventral tegmental area and other limbic brain areas and (iv) d |
2022-07-27 |
2023-08-14 |
Not clear |
| Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Strońska-Pluta, Aleksandra Suchanecka, Kinga Humińska-Lisowska, Milena Lachowicz, Marta Niewczas, Monika Białecka, Małgorzata Śmiarowska, Anna Grzywac. Methylation in the Promoter Region of the Dopamine Transporter International journal of environmental research and public health. vol 19. issue 14. 2022-07-27. PMID:35886451. |
methylation in the promoter region of the dopamine transporter the dopaminergic system is a crucial element of the addiction processes. |
2022-07-27 |
2023-08-14 |
Not clear |
| Sevag Hamamah, Andras Hajnal, Mihai Covas. Impact of Nutrition, Microbiota Transplant and Weight Loss Surgery on Dopaminergic Alterations in Parkinson's Disease and Obesity. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35886849. |
overall, understanding the role of nutrition on dopamine bioavailability and gut microbiota in dopamine-related pathologies such as pd will help develop more precise therapeutic targets to rescue dopaminergic deficits in neurologic and metabolic disorders. |
2022-07-27 |
2023-08-14 |
Not clear |
| Xiaojie Liu, Hao Yu, Bixuan Chen, Vladislav Friedman, Lianwei Mu, Thomas J Kelly, Gonzalo Ruiz-Pérez, Li Zhao, Xiaowen Bai, Cecilia J Hillard, Qing-Song Li. CB2 Agonist GW842166x Protected against 6-OHDA-Induced Anxiogenic- and Depressive-Related Behaviors in Mice. Biomedicines. vol 10. issue 8. 2022-07-27. PMID:35892676. |
here, we report that the selective cb2 agonist gw842166x exerted neuroprotective effects against 6-hydroxydopamine (6-ohda)-induced loss of dopaminergic terminals and dopamine release in the striatum, which were blocked by the cb2 antagonist am630. |
2022-07-27 |
2023-08-14 |
mouse |
| Jun Yu, Susan R Sesack, Yanhua Huang, Oliver M Schlüter, Anthony A Grace, Yan Don. Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-to-Accumbens Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-15. PMID:35840324. |
furthermore, this ltp is more prominent in dopamine d1 receptor-expressing (d1) msns than d2 msns and can be prevented by inhibition of either d1 receptors or dopaminergic terminals in nacsh. |
2022-07-15 |
2023-08-14 |
mouse |
| Rosa Mastrogiacomo, Gabriella Trigilio, Céline Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Managò, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry. 2022-07-13. PMID:35821415. |
in agreement, dys1a disruption only in astrocytes resulted in decreased motivation and sensorimotor gating deficits, increased astrocytic dopamine d2 receptors and decreased dopaminergic tone within basal ganglia. |
2022-07-13 |
2023-08-14 |
mouse |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
these processes cause dopamine levels released in structures innervated by midbrain dopaminergic neurons (e.g., the striatum) to oscillate in a circadian fashion. |
2022-07-11 |
2023-08-14 |
human |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
thus, circadian changes in the activity of the dopaminergic system and concomitant dopamine release observed on a daily scale are likely to be generated both intrinsically and entrained by the master clock. |
2022-07-11 |
2023-08-14 |
human |
| Kevin Yen, Amanda Yaworski, Miguel Bussiere, Fang B. Pearls & Oy-sters: A Case Report of Holmes Tremor Due to Nigrostriatal Dopamine Disruption that Responded to Dopamine Replacement Therapy. Neurology. 2022-07-08. PMID:35803716. |
dopamine transport imaging demonstrated significant dopaminergic denervation in the right caudate and putamen. |
2022-07-08 |
2023-08-14 |
Not clear |
| Kevin Yen, Amanda Yaworski, Miguel Bussiere, Fang B. Pearls & Oy-sters: A Case Report of Holmes Tremor Due to Nigrostriatal Dopamine Disruption that Responded to Dopamine Replacement Therapy. Neurology. 2022-07-08. PMID:35803716. |
the striatal dopaminergic function imaging may have a role in assessing pre-synaptic dopamine dysfunction and guiding treatment. |
2022-07-08 |
2023-08-14 |
Not clear |
| Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Sing. Role of Platelet in Parkinson's Disease: Insights into Pathophysiology & Theranostic Solutions. Ageing research reviews. 2022-07-07. PMID:35798236. |
gradual death and progressive loss of dopaminergic neurons in the pars compacta region of substantia nigra results in striatal dopamine deficiency in pd. |
2022-07-07 |
2023-08-14 |
Not clear |
| Ryunosuke Amo, Sara Matias, Akihiro Yamanaka, Kenji F Tanaka, Naoshige Uchida, Mitsuko Watabe-Uchid. A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning. Nature neuroscience. 2022-07-07. PMID:35798979. |
here we demonstrate that such a gradual shift occurs both at the level of dopaminergic cellular activity and dopamine release in the ventral striatum in mice. |
2022-07-07 |
2023-08-14 |
mouse |
| Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Higor A Iha, Yukihiro Ohn. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784764. |
since nicotine is known to enhance dopamine release by stimulating α4β2 and/or α6 nach receptors, we examined the effects of various dopamine receptor ligands on nicotine-induced tremor to clarify the role of the dopaminergic system in modulating nicotine tremor. |
2022-07-05 |
2023-08-14 |
Not clear |
| Jing Deng, Ting Zhang, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754103. |
dysregulation of dopamine transporters (dat) within the dopaminergic system is an important biomarker of cocaine exposure. |
2022-06-27 |
2023-08-14 |
rat |
| Michael V Ugrumov, Ekaterina N Pavlova, Anna A Kolacheva, Liliya K Dil'mukhametova, Vsevolod V Bogdanov, Victor Blokhin, Tatiana S Pronin. The Periventricular Nucleus as a Brain Center Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743179. |
the periventricular nucleus as a brain center containing dopaminergic neurons and neurons expressing individual enzymes of dopamine synthesis. |
2022-06-24 |
2023-08-14 |
rat |
| Michael V Ugrumov, Ekaterina N Pavlova, Anna A Kolacheva, Liliya K Dil'mukhametova, Vsevolod V Bogdanov, Victor Blokhin, Tatiana S Pronin. The Periventricular Nucleus as a Brain Center Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743179. |
it has been shown that, in addition to dopaminergic neurons, most of these centers contain neurons expressing one of the enzymes of dopamine synthesis: tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2022-06-24 |
2023-08-14 |
rat |
| Angélica Pilar Escobar, Rodrigo C Meza, Marcela Gonzalez, Pablo Henny, María Estela André. Immunolocalization of kappa opioid receptors in the axon initial segment of a group of embryonic mesencephalic dopamine neurons. IBRO neuroscience reports. vol 12. 2022-06-24. PMID:35746971. |
interestingly, kor immunolabelling was observed in the first part of the axon, colocalizing with ankyrin in 20% of cultured dopamine neurons, indicative that kor is present in the axon initial segment (ais) of a group of dopaminergic neurons. |
2022-06-24 |
2023-08-14 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |
| Shuai Wang, Ming Li, Linlan Su, Yu Wang, Dongliang Ma, Hongyan Wang, Jie Zhu, Teng Che. Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice. Frontiers in cellular neuroscience. vol 16. 2022-06-17. PMID:35711471. |
knockout of dopamine d3 receptor gene blocked methamphetamine-induced distinct changes of dopaminergic and glutamatergic synapse in the nucleus accumbens shell of mice. |
2022-06-17 |
2023-08-14 |
mouse |