| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
despite postmortem analyses from patients with parkinson's disease that demonstrate decreased vesicular sequestration of dopamine with a corresponding increase in dopamine metabolism, dopamine's contribution to nigrostriatal dopaminergic degeneration in parkinson's disease has been debated. |
2021-06-30 |
2023-08-13 |
rat |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
here, we present a new in vivo model demonstrating the induction of parkinson's disease-associated pathogenic mechanisms of degeneration resulting from acquired dysregulation of dopamine sequestration in nigrostriatal dopaminergic neurons in adult rats. |
2021-06-30 |
2023-08-13 |
rat |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
the loss of vmat2 resulted in an accumulation of cytosolic dopamine and subsequent increased dopamine metabolism, deficits in dopamine-mediated behaviors, and degeneration of nigrostriatal dopaminergic neurons that was rescued through reintroduction of exogenous vmat2, demonstrating that the toxicity was specific to the loss of vmat2. |
2021-06-30 |
2023-08-13 |
rat |
| Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Cour. The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell death and differentiation. vol 27. issue 4. 2021-06-29. PMID:31591470. |
parkinson's disease (pd) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum. |
2021-06-29 |
2023-08-13 |
mouse |
| Robert Lindroos, Jeanette Hellgren Kotalesk. Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32609903. |
the two systems are tightly connected, for example, synchronized activity of cholinergic interneurons, leading to increased acetylcholine release, has been shown to directly trigger dopamine release from dopaminergic terminals in striatum. |
2021-06-29 |
2023-08-13 |
Not clear |
| Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim, In Joo Ki. The association of DAT gene methylation with striatal DAT availability in healthy subjects. EJNMMI research. vol 11. issue 1. 2021-06-29. PMID:34120227. |
functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (dat), and genetic variations in the gene encoding dat contribute to differences in reward processing. |
2021-06-29 |
2023-08-13 |
human |
| Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W Logan, Claes B Wollheim, Massimo Trucco, Vijay K Yechoor, David R Sibley, Rita Bottino, Zachary Freyber. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33589583. |
dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. |
2021-06-28 |
2023-08-13 |
mouse |
| Hidekazu Sotoyama, Hisaaki Namba, Yutaro Kobayashi, Taku Hasegawa, Dai Watanabe, Ena Nakatsukasa, Kenji Sakimura, Tomoyuki Furuyashiki, Hiroyuki Naw. Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33888687. |
in vivo single-unit recording and microdialysis revealed that the baseline firing frequency of and dopamine release from vta dopaminergic neurons were chronically increased in egf model rats, and their social interaction was concomitantly reduced. |
2021-06-28 |
2023-08-13 |
rat |
| Aditi Mishra, Patrick Cronley, Mathangi Ganesan, David J Schulz, Troy Zar. Dopaminergic neurons can influence heat-box place learning in Journal of neurogenetics. vol 34. issue 1. 2021-06-25. PMID:31997669. |
dopaminergic neurons can influence heat-box place learning in dopamine provides crucial neuromodulatory functions in several insect and rodent learning and memory paradigms. |
2021-06-25 |
2023-08-13 |
Not clear |
| Lilian R F Faro, Lorenzo A Justo, Miguel Alfonso, Rafael Durá. Possible synergies between isatin, an endogenous MAO inhibitor, and antiparkinsonian agents on the dopamine release from striatum of freely moving rats. Neuropharmacology. vol 171. 2021-06-25. PMID:32304702. |
for this, we co-administered isatin with the mao inhibitors selegiline and clorgyline, l-dopa, the catechol-o-methyl-transferase (comt) inhibitors tropolone and dinitrocatechol, with the dopaminergic agonist ropinirole, and with the psychostimulant caffeine, in order to evaluate possible synergies between these substances to increase the dopamine extracellular levels in freely moving rats. |
2021-06-25 |
2023-08-13 |
rat |
| Marilena Mangiardi, Guido Alfan. A clinical improvement of a idiopathic cervical dystonia in a patient treated with transdermal Rotigotine: a case-report. Acta bio-medica : Atenei Parmensis. vol 91. issue 3. 2021-06-25. PMID:32921774. |
we report a case of focal cervical dystonia successful treated with a dopamine agonist (d3>d2>d1) rotigotine, a transdermal drug that induces a continuous dopaminergic stimulation. |
2021-06-25 |
2023-08-13 |
mouse |
| Emilia Pascale, Giuseppina Divisato, Renata Palladino, Margherita Auriemma, Edward Faustine Ngalya, Massimiliano Caiazz. Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease. Biomolecules. vol 10. issue 9. 2021-06-24. PMID:32899172. |
the identification of noncoding rna networks underlying all stages of dopamine neuron development and plasticity is an essential step to deeply understand their physiological role and also their involvement in the etiology of dopaminergic diseases. |
2021-06-24 |
2023-08-13 |
Not clear |
| Chenyang Han, Heping Shen, Yi Yang, Yongjia Sheng, Jin Wang, Wenyan Li, Xiaohong Zhou, Li Guo, Liping Zhai, Qiaobing Gua. Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation. Brain and behavior. vol 10. issue 11. 2021-06-24. PMID:32902155. |
the main pathological change is the apoptosis of dopaminergic neurons in the substantia nigra pars compacta (snpc), thereby leading to dopamine reduction in nigral striatum. |
2021-06-24 |
2023-08-13 |
mouse |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nicotine is transferred through milk and alters the dopaminergic reward system of adult male rats, reducing dopamine action in the nucleus accumbens (nac) and hypothalamic arcuate nucleus. |
2021-06-24 |
2023-08-13 |
rat |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Maria Grazia Zizzo, Annalisa Bellanca, Antonella Amato, Rosa Seri. Opposite effects of dopamine on the mechanical activity of circular and longitudinal muscle of human colon. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 32. issue 6. 2021-06-23. PMID:32012410. |
because dopamine (da) has gained increasing evidence as modulator of gut motility, we aimed to characterize dopaminergic response in human colon, evaluating function and distribution of dopamine receptors in circular vs longitudinal muscle strips. |
2021-06-23 |
2023-08-13 |
human |
| Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignan. Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32473593. |
here, we focus on methylphenidate (mph), which binds to the dopamine transporter (dat) and the norepinephrine transporter (net), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. |
2021-06-23 |
2023-08-13 |
Not clear |
| Sara Schiavi, Francesca Melancia, Emilia Carbone, Valeria Buzzelli, Antonia Manduca, Patricia Jiménez Peinado, Clemens Zwergel, Antonello Mai, Patrizia Campolongo, Louk J M J Vanderschuren, Viviana Trezz. Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 12. 2021-06-23. PMID:32506112. |
as the behavioral effects of mdpv have been ascribed to dopaminergic and noradrenergic neurotransmission, and given the role of these neurotransmitters in social play, we investigated the involvement of dopamine and noradrenaline in the play-suppressant effects of mdpv. |
2021-06-23 |
2023-08-13 |
human |
| Alberto F Cintrón-Colón, Gabriel Almeida-Alves, Alicia M Boynton, John M Spitsberge. GDNF synthesis, signaling, and retrograde transport in motor neurons. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32897420. |
gdnf was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons. |
2021-06-23 |
2023-08-13 |
rat |
| F Y Wong, A Gogos, N Hale, S A Ingelse, N Brew, K L Shepherd, M van den Buuse, D W Walke. Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain. Journal of applied physiology (Bethesda, Md. : 1985). vol 129. issue 6. 2021-06-23. PMID:33054660. |
however, the effects of exogenous dopamine and cerebral hi on dopaminergic signaling in the immature brain are unknown. |
2021-06-23 |
2023-08-13 |
Not clear |