| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Hui Nies, Nor Haliza Mohamad Najib, Wei Ling Lim, Mohd Amir Kamaruzzaman, Mohamad Fairuz Yahaya, Seong Lin Teo. MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994934. |
the severe loss of dopaminergic neurons in the substantia nigra pars compacta causes striatal dopamine deficiency and the presence of lewy bodies indicates a pathological hallmark of pd. |
2021-05-18 |
2023-08-13 |
Not clear |
| Yong Hui Nies, Nor Haliza Mohamad Najib, Wei Ling Lim, Mohd Amir Kamaruzzaman, Mohamad Fairuz Yahaya, Seong Lin Teo. MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994934. |
although the current treatment of pd aims to preserve dopaminergic neurons or to replace dopamine depletion in the brain, it is notable that complete recovery from the disease is yet to be achieved. |
2021-05-18 |
2023-08-13 |
Not clear |
| Davide Amato, Fabio Canneva, Paul Cumming, Simone Maschauer, Dominik Groos, Jana Katharina Dahlmanns, Teja W Grömer, Lisa Chiofalo, Marc Dahlmanns, Fang Zheng, Johannes Kornhuber, Olaf Prante, Christian Alzheimer, Stephan von Hörsten, Christian P Mülle. A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter. Molecular psychiatry. vol 25. issue 9. 2021-05-14. PMID:30038229. |
a dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter. |
2021-05-14 |
2023-08-13 |
rat |
| Miguel Perez de la Mora, Carlos Hernandez-Mondragon, Minerva Crespo-Ramirez, José Rejon-Orantes, Dasiel O Borroto-Escuela, Kjell Fux. Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson's Disease and Schizophrenia. Neuroscience. vol 439. 2021-05-14. PMID:31349007. |
dopamine released from these neurons operates mainly via the short distance extrasynaptic volume transmission and activates five different dopaminergic receptor subtypes modulating synaptic gaba and glutamate transmission. |
2021-05-14 |
2023-08-13 |
Not clear |
| Enrico D'Ambrosio, Sameer Jauhar, Seoyoung Kim, Mattia Veronese, Maria Rogdaki, Fiona Pepper, Ilaria Bonoldi, Vasileia Kotoula, Matthew J Kempton, Federico Turkheimer, Jun Soo Kwon, Euitae Kim, Oliver D Howe. The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31690805. |
the relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal a leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. |
2021-05-14 |
2023-08-13 |
Not clear |
| Enrico D'Ambrosio, Sameer Jauhar, Seoyoung Kim, Mattia Veronese, Maria Rogdaki, Fiona Pepper, Ilaria Bonoldi, Vasileia Kotoula, Matthew J Kempton, Federico Turkheimer, Jun Soo Kwon, Euitae Kim, Oliver D Howe. The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31690805. |
we therefore investigated the in vivo relationship between striatal dopamine synthesis capacity and prefrontal grey matter volume in treatment-responsive patients with psychosis, and compared them to treatment non-responsive patients, where dopaminergic mechanisms are not thought to be central. |
2021-05-14 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Anupom Borah, Shuvasish Choudhur. Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities. Medical hypotheses. vol 137. 2021-05-14. PMID:31954292. |
parkinson's disease (pd), a progressive neurodegenerative motor disorder, is caused due to the loss of dopaminergic neurons in the substantia nigra pars compacta region of mid-brain and the resultant depletion of the levels of the neurotransmitter dopamine. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jincheol Seo, Junghyung Park, Keonwoo Kim, Jinyoung Won, Hyeon-Gu Yeo, Yeung Bae Jin, Bon-Sang Koo, Kyung Seob Lim, Kang-Jin Jeong, Philyong Kang, Hwal-Yong Lee, Won Seok Choi, Seung Ho Baek, Chang-Yeop Jeon, Jung-Joo Hong, Jae-Won Huh, Young-Hyun Kim, Sang Je Park, Sun-Uk Kim, Dong-Seok Lee, Sang-Rae Lee, Youngjeon Le. Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson's Disease. Neuroscience. vol 431. 2021-05-14. PMID:32036014. |
we found selective and local chronic infiltration of cd4+ and cd8+ t lymphocytes, loss of dopaminergic neurons, dopamine transporter expression, chronic normalization of rantes in the peripheral blood, and altered microglial morphology at 48 weeks after mptp injection. |
2021-05-14 |
2023-08-13 |
Not clear |
| Zhourui Wu, Yiyuan Xia, Zhihao Wang, Seong Su Kang, Kecheng Lei, Xia Liu, Lingjing Jin, Xiaochuan Wang, Liming Cheng, Keqiang Y. C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:32086435. |
maob, a crucial monoamine oxidase for dopamine metabolism, triggers oxidative stress in dopaminergic neurons and α-syn aggregation. |
2021-05-14 |
2023-08-13 |
mouse |
| Kenneth Blum, David Baron, Thomas McLaughlin, Mark S Gol. Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS). Journal of the neurological sciences. vol 411. 2021-05-14. PMID:32088516. |
the role of dopamine in terms of alcohol withdrawal symptomology, cocaine craving behavior, dopamine -condensation products (tiqs), and more recently, the genetic aspects of drug-seeking and pro-dopamine regulation, provide compelling evidence of the relevant molecular neurological correlates of dopaminergic /endorphinergic mechanisms in reward circuitry due to genetic polymorphisms and epigenetic insults. |
2021-05-14 |
2023-08-13 |
Not clear |
| Claire E Meyer, Juan Liu, Ioana Craciun, Dalin Wu, Hui Wang, Mingqi Xie, Martin Fussenegger, Cornelia G Paliva. Segregated Nanocompartments Containing Therapeutic Enzymes and Imaging Compounds within DNA-Zipped Polymersome Clusters for Advanced Nanotheranostic Platform. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 27. 2021-05-14. PMID:32130785. |
the therapeutic compartment, loaded with active ddc, triggers the cellular expression of a secreted reporter enzyme via production of dopamine and activation of dopaminergic receptors implicated in atherosclerosis. |
2021-05-14 |
2023-08-13 |
human |
| Yuanjing Feng, Wenxuan Yan, Jingqiang Wang, Jiahao Song, Qingrun Zeng, Changchen Zha. Local White Matter Fiber Clustering Differentiates Parkinson's Disease Diagnoses. Neuroscience. vol 435. 2021-05-14. PMID:32272152. |
scans without evidence of dopaminergic deficit (swedd) patients are often misdiagnosed with parkinson's disease (pd) but have normal dopamine transporter scans. |
2021-05-14 |
2023-08-13 |
Not clear |
| Nae Saito, Kazuki Tainaka, Tom Macpherson, Takatoshi Hikida, Shun Yamaguchi, Toshikuni Sasaok. Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex. Neuroscience research. vol 156. 2021-05-14. PMID:32380131. |
here, we investigated the role of dopaminergic neurotransmission via dopamine d1 receptors (d1rs) in aversive memory formation in a passive avoidance test using d1r knockdown (kd) mice, in which the expression of d1rs can conditionally and reversibly be controlled by doxycycline (dox) treatment. |
2021-05-14 |
2023-08-13 |
mouse |
| Nian-Ting Yao, Qian Zheng, Zi-Qian Xu, Jian-Hong Yin, Lin-Guang Lu, Qi Zuo, Su Yang, Chun-Lin Zhang, Ling Jia. Positron emission computed tomography/single photon emission computed tomography in Parkinson disease. Chinese medical journal. vol 133. issue 12. 2021-05-14. PMID:32404694. |
its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a lewy body, leading to a decreased dopamine level. |
2021-05-14 |
2023-08-13 |
Not clear |
| Gregor Leicht, Christina Andreou, Till Nafe, Felix Nägele, Jonas Rauh, Stjepan Curic, Paul Schauer, Daniel Schöttle, Saskia Steinmann, Christoph Muler. Alterations of oscillatory neuronal activity during reward processing in schizophrenia. Journal of psychiatric research. vol 129. 2021-05-14. PMID:32619750. |
remarkably, midbrain dopaminergic signalling also includes theta and high-beta frequency modes, which have been assumed to reflect tonic and phasic dopamine responses, respectively. |
2021-05-14 |
2023-08-13 |
Not clear |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
both compounds significantly attenuated dopamine depletion, cytokine production, microglial activation, dopaminergic neuronal loss, oxidative/nitrative stress indices, and behavioral abnormality in a parkinson disease rat model. |
2021-05-14 |
2023-08-13 |
mouse |
| Ryuichi Takahashi, Kazunari Ishii, Kaoru Sousa, Kohei Marumoto, Tetsuo Kashibayashi, Jun Fujita, Kazumasa Yokoyam. Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms. Journal of the neurological sciences. vol 423. 2021-05-14. PMID:33640580. |
this study aimed to identify regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms, using dopamine transporter single-photon emission computed tomography images. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lang Li, Yang Lu, Ziting Qian, Zhaoyan Yang, Kuo Yang, Shenfei Zong, Zhuyuan Wang, Yiping Cu. Ultra-sensitive surface enhanced Raman spectroscopy sensor for in-situ monitoring of dopamine release using zipper-like ortho-nanodimers. Biosensors & bioelectronics. vol 180. 2021-05-14. PMID:33677355. |
accurate quantitative detection of dopamine (da) in blood is essential for the early diagnosis and the pathogenesis analysis of dopaminergic dysfunction, which still remains a great challenge because of the extremely low concentration in patients. |
2021-05-14 |
2023-08-13 |
human |
| Agnès Benvenutto, Eric Guedj, Olivier Felician, Alexandre Eusebio, Jean-Philippe Azulay, Mathieu Ceccaldi, Lejla Kori. Clinical Phenotypes in Corticobasal Syndrome with or without Amyloidosis Biomarkers. Journal of Alzheimer's disease : JAD. vol 74. issue 1. 2021-05-13. PMID:32039846. |
interestingly, dopamine transporter spect imaging showed similar levels of dopaminergic degeneration in both groups. |
2021-05-13 |
2023-08-13 |
Not clear |