| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen-Meng Qiao, Meng-Fei Sun, Xue-Bing Jia, Yang Li, Bo-Ping Zhang, Li-Ping Zhao, Yun Shi, Zhi-Lan Zhou, Ying-Li Zhu, Chun Cui, Yan-Qin She. Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32556930. |
interestingly, nab significantly aggravated mptp-induced motor dysfunction (p < 0.01), decreased dopamine (p < 0.05) and 5-ht (p < 0.05) levels, exacerbated declines of dopaminergic neurons (34%, p < 0.05) and downregulated expression of tyrosine hydroxylase (th, 47%, p < 0.05), potentiated glia-mediated neuroinflammation by increasing the number of microglia (17%, p < 0.05) and activating astrocytes (28%, p < 0.01). |
2021-06-08 |
2023-08-13 |
mouse |
| Siqi Luo, Libo Du, Yan Cu. Potential Therapeutic Applications and Developments of Exosomes in Parkinson's Disease. Molecular pharmaceutics. vol 17. issue 5. 2021-06-07. PMID:32227966. |
current treatments alleviate the symptoms through the administration of drugs, including dopamine precursors, dopamine metabolism inhibitors, and activated dopamine agonists, but they cannot prevent the ongoing dopaminergic damage. |
2021-06-07 |
2023-08-13 |
Not clear |
| Lorena Jiménez-Sánchez, Javier Blesa, Natalia L Del Rey, Mariana H G Monje, José A Obeso, Carmen Cavad. Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease. Neuropharmacology. vol 170. 2021-06-03. PMID:31589886. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra and dopamine depletion in the striatum. |
2021-06-03 |
2023-08-13 |
monkey |
| Lorena Oliveira de Matos, Ana Luiza de Araujo Lima Reis, Lorena Terene Lopes Guerra, Leonardo de Oliveira Guarnieri, Muiara Aparecida Moraes, Laila Blanc Arabe, Renan Pedra de Souza, Grace Schenatto Pereira, Bruno Rezende Souz. Early postnatal l-Dopa treatment causes behavioral alterations in female vs. male young adult Swiss mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32325324. |
knockout mice for dopamine transporters (dat) as well as site-specific knockout mice lacking dopaminergic d2 autoreceptors in dopaminergic neurons (da-d2rko) display behavioral alterations such as hyperlocomotion and abnormal prepulse inhibition. |
2021-06-03 |
2023-08-13 |
mouse |
| Della Grace Thomas Parambi, Uzma Saleem, Muhammad Ajmal Shah, Fareeha Anwar, Bashir Ahmad, Amna Manzar, Aqsa Itzaz, Seetha Harilal, Md Sahab Uddin, Hoon Kim, Bijo Mathe. Exploring the Therapeutic Potentials of Highly Selective Oxygenated Chalcone Based MAO-B Inhibitors in a Haloperidol-Induced Murine Model of Parkinson's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32939670. |
parkinson's disease (pd) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visual hallucinations. |
2021-06-02 |
2023-08-13 |
Not clear |
| Liesbeth Reneman, Marieke van der Pluijm, Anouk Schrantee, Elsmarieke van de Giesse. Imaging of the dopamine system with focus on pharmacological MRI and neuromelanin imaging. European journal of radiology. vol 140. 2021-06-02. PMID:34004428. |
neuromelanin is located in the cell bodies of dopaminergic neurons of the nigrostriatal pathway and can be used as a proxy measure for long term dopamine function or degeneration of dopaminergic neurons. |
2021-06-02 |
2023-08-13 |
Not clear |
| Pia M Vidal, Rodrigo Pachec. Targeting the Dopaminergic System in Autoimmunity. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 1. 2021-05-27. PMID:30661214. |
thus, impaired dopaminergic signalling through different dopamine receptors may result in altered behaviour of immunity, contributing to the development and progression of autoimmune pathologies. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mikhail Melnikov, Vladimir Rogovskii, Alexey Boykо, Mikhail Pashenko. Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 1. 2021-05-27. PMID:31011885. |
recent studies have shown that dopamine can enhance or inhibit the functions of innate and adaptive immune system, depending on the activation of different dopaminergic receptors, and can therefore influence the course of experimental autoimmune encephalomyelitis (eae) and ms. |
2021-05-27 |
2023-08-13 |
Not clear |
| Silvia Capellin. Dopaminergic Agents in Rheumatoid Arthritis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 1. 2021-05-27. PMID:31016462. |
while more research is necessary to accurately determine the effect of dopamine in ra, these results are encouraging and support a possible use of dopaminergic drugs for the treatment of arthritis in the future. |
2021-05-27 |
2023-08-13 |
Not clear |
| S M Matt, P J Gaskil. Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 1. 2021-05-27. PMID:31077015. |
many immune cells express dopamine receptors and other dopamine related proteins, enabling them to actively respond to dopamine and suggesting that dopaminergic immunoregulation is an important part of proper immune function. |
2021-05-27 |
2023-08-13 |
human |
| Firoz Anwar, Salma Naqvi, Fahad A Al-Abbasi, Nauroz Neelofar, Vikas Kumar, Ankit Sahoo, Mohammad Amjad Kama. Targeting COVID-19 in Parkinson's Patients: Drugs Repurposed. Current medicinal chemistry. vol 28. issue 12. 2021-05-27. PMID:32881656. |
alteration in dopaminergic neurons and deficiency of dopamine in pd patients are the most common symptoms affecting 1% population above the age of 60 years. |
2021-05-27 |
2023-08-13 |
Not clear |
| Anna Schildt, Erik F J de Vries, Antoon T M Willemsen, Bruno Lima Giacobbo, Rodrigo Moraga-Amaro, Jürgen W A Sijbesma, Aren van Waarde, Vesna Sossi, Rudi A J O Dierckx, Janine Doordui. Effect of Dopamine D Molecular pharmaceutics. vol 17. issue 3. 2021-05-26. PMID:32011892. |
effect of dopamine d the interaction of dopaminergic and cholinergic neurotransmission in, e.g., parkinson's disease has been well established. |
2021-05-26 |
2023-08-13 |
Not clear |
| Hongyang Li, Jingya Wei, Fengtao Ma, Qiang Shan, Duo Gao, Yuhang Jin, Peng Su. Melatonin Modulates Lactation by Regulating Prolactin Secretion Via Tuberoinfundibular Dopaminergic Neurons in the Hypothalamus- Pituitary System. Current protein & peptide science. vol 21. issue 8. 2021-05-26. PMID:32392109. |
the hypothalamus-pituitary system, the most important endocrine system in the body, regulates prolactin secretion mainly through dopamine released from tuberoinfundibular dopaminergic neurons. |
2021-05-26 |
2023-08-13 |
Not clear |
| Manvi Goel, Stuart C Mange. Dopamine-Mediated Circadian and Light/Dark-Adaptive Modulation of Chemical and Electrical Synapses in the Outer Retina. Frontiers in cellular neuroscience. vol 15. 2021-05-26. PMID:34025356. |
dopamine is released by dopaminergic cells, interneurons whose cell bodies are located in the second synaptic layer of the retina. |
2021-05-26 |
2023-08-13 |
Not clear |
| Naeem Asad, Duncan E McLain, Alec F Condon, Sangram Gore, Shahienaz E Hampton, Sauparnika Vijay, John T Williams, Timothy M Dor. Photoactivatable Dopamine and Sulpiride to Explore the Function of Dopaminergic Neurons and Circuits. ACS chemical neuroscience. vol 11. issue 6. 2021-05-24. PMID:32077679. |
photoactivatable dopamine and sulpiride to explore the function of dopaminergic neurons and circuits. |
2021-05-24 |
2023-08-13 |
Not clear |
| Julian L Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W L Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K Luthra, William D Shingleton, Steve K W Oh, Li Zeng, Edward G Robin. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease. Stem cell research & therapy. vol 11. issue 1. 2021-05-24. PMID:32771055. |
the current study examines the utility of neuroimaging to characterise the in vivo maturation, innervation and functional dopamine release of transplanted human embryonic stem cell-derived midbrain dopaminergic neurons (hesc-mdas) in a preclinical model of pd. |
2021-05-24 |
2023-08-13 |
human |
| Alyssa G Yocky, Dan P Cove. Evolution of in vivo dopamine monitoring techniques. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33278398. |
current understanding of how dopamine neurotransmission contributes to behavior and its dysfunction has been driven by technological advancements that permit spatiotemporally-defined measurements of dopaminergic signaling in behaving animals. |
2021-05-24 |
2023-08-13 |
Not clear |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
the results confirm that the unilateral injection of fipronil into the substantia nigra caused the degeneration of nigrostriatal dopaminergic neurons, which leads to a decrease around 50 % in striatal dopamine content and substantia nigra th imunoreactivity. |
2021-05-20 |
2023-08-13 |
rat |
| Michelle S Antunes, Leandro Cattelan Souza, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Vandreza Cardoso Bortolotto, Márcia Rósula Poetini Silva, Stífani Machado Araújo, Marina Prigol, Cristina Wayne Nogueira, Silvana Peterini Boeir. Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice. Molecular neurobiology. vol 57. issue 7. 2021-05-19. PMID:32458386. |
hesperidin treatment was also capable to increase striatal levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid and protects against the impairment of dopaminergic neurons in the substantia nigra pars compacta (snpc) (p < 0.05). |
2021-05-19 |
2023-08-13 |
mouse |
| Patricia García-Sanz, Johannes M F G Aerts, Rosario Moratall. The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 5. 2021-05-19. PMID:33219714. |
parkinson's disease (pd) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. |
2021-05-19 |
2023-08-13 |
Not clear |