| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung Yoon Choi, Hee Jae Jang, Sharon Ornelas, Weston T Fleming, Daniel Fürth, Jennifer Au, Akhil Bandi, Esteban A Engel, Ilana B Witte. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory. Cell reports. vol 33. issue 11. 2021-05-13. PMID:33326775. |
a comparison of dopaminergic and cholinergic populations reveals unique contributions of vta dopamine neurons to short-term memory. |
2021-05-13 |
2023-08-13 |
rat |
| Mustafa Makav, Hüseyin Avni Eroğl. Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats. Environmental science and pollution research international. vol 28. issue 17. 2021-05-12. PMID:33410082. |
histopathological examination indicated a significant difference in tyrosine hydroxylase-stained cells (dopaminergic neurons and dopamine) between the parkinson's + estrogen group and the parkinson's group. |
2021-05-12 |
2023-08-13 |
rat |
| Andrea Fabbrini, Andrea Guerr. Pathophysiological Mechanisms and Experimental Pharmacotherapy for L-Dopa-Induced Dyskinesia. Journal of experimental pharmacology. vol 13. 2021-05-08. PMID:33953618. |
recent advances in the understanding of the pathophysiological mechanisms underlying lid suggest that abnormalities in multiple neurotransmitter systems, in addition to dopaminergic nigrostriatal denervation and altered dopamine release and reuptake dynamics at the synaptic level, are involved in lid development. |
2021-05-08 |
2023-08-13 |
Not clear |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
given that dopaminergic nigral neurons are selectively vulnerable to neurodegeneration in pd, we now investigated if dopamine can promote the neurodegenerative potential of β-syn. |
2021-05-04 |
2023-08-13 |
human |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
we show that in cultured rodent and human neurons a dopaminergic neurotransmitter phenotype substantially enhanced β-syn-induced neurodegeneration, irrespective if dopamine is synthesized within neurons or up-taken from extracellular space. |
2021-05-04 |
2023-08-13 |
human |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
in conclusion, our results suggest that β-syn can play a significant pathophysiological role in etiology of pd through its interaction with dopamine metabolites and thus should be re-considered as a disease-relevant factor, at least for those symptoms of pd that depend on degeneration of nigral dopaminergic neurons. |
2021-05-04 |
2023-08-13 |
human |
| Samuel Floren, Nicholas King, Allonso Carrasco, Nachum Dafn. Glutamate and dopamine in the VTA participate differently in the acute and chronic effect of methylphenidate. Behavioural brain research. vol 380. 2021-05-03. PMID:31783089. |
psychostimulants such as mpd are indirect dopamine antagonists and are known to act on the dopaminergic system of the brain to produce their effects. |
2021-05-03 |
2023-08-13 |
rat |
| Kadri Kõiv, Kai Tiitsaar, Karita Laugus, Jaanus Harr. Extracellular Dopamine Levels in Nucleus Accumbens after Chronic Stress in Rats with Persistently High vs. Low 50-kHz Ultrasonic Vocalization Response. Brain sciences. vol 11. issue 4. 2021-05-02. PMID:33917789. |
to examine whether these differential responses are associated with dopaminergic neurotransmission in the nucleus accumbens (nac), juvenile male wistar rats were categorized as of high or low positive affectivity (hc and lc, respectively), and after reaching adulthood, extracellular dopamine (da) levels in the nac shell were measured using in vivo microdialysis after three weeks of cvs. |
2021-05-02 |
2023-08-13 |
rat |
| Brooke J Olson, Mohan S Dhariwa. Neuroleptic Malignant Syndrome: A Case of Unknown Causation and Unique Clinical Course. Cureus. vol 13. issue 3. 2021-05-02. PMID:33927924. |
neuroleptic malignant syndrome (nms) is a rare, potentially lethal syndrome known to be related to the initiation of dopamine antagonist medications or rapid withdrawal of dopaminergic medications. it is a diagnosis of exclusion with a known sequela of symptoms, but not all patients experience these characteristic symptoms making it difficult at times to diagnose and treat. |
2021-05-02 |
2023-08-13 |
Not clear |
| Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Ho-Won Lee, Dong-Kug Cho. Lipid-based nanodelivery approaches for dopamine-replacement therapies in Parkinson's disease: From preclinical to translational studies. Biomaterials. vol 232. 2021-04-30. PMID:31901690. |
pd is primarily characterized by the progressive loss of dopaminergic (daergic) neurons and/or associated neuronal networks and the subsequent depletion of dopamine (da) levels in the brain. |
2021-04-30 |
2023-08-13 |
Not clear |
| Siddhartha Sahai, Emaan T Effendi, Emily C Mahoney, Heidi R Tucker, Benjamin J Moolick, Gianna Mamone, Saisree Mikkilineni, Megan Gupta, Alycia Nicholson, Fu Yee Chua, Kainat Akhtar, Zall Hirschstein, Eric S Molho, Julie G Pilitsis, Damian S Shi. Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson's disease. Neuroscience letters. vol 739. 2021-04-30. PMID:33141067. |
the underlying mechanisms contributing to this reduction remain unclear, but studies posit that stn-dbs may increase striatal dopamine levels by exciting remaining dopaminergic cells in the substantia nigra pars compacta (snc). |
2021-04-30 |
2023-08-13 |
rat |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Shameema Bano, Shubha Shukl. Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease. Behavioural brain research. vol 378. 2021-04-29. PMID:31626851. |
dopamine d1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of parkinson's disease. |
2021-04-29 |
2023-08-13 |
rat |
| Lukas Meyerolbersleben, Christine Winter, Nadine Bernhard. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. Behavioural brain research. vol 378. 2021-04-28. PMID:31629834. |
the predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. |
2021-04-28 |
2023-08-13 |
rat |
| Alexandra Perebikovsky, Alexander T Hwu, Andrew R Yale, Maziar Ghazinejad, Marc Mado. Nanofibrous Carbon Multifunctional Smart Scaffolds for Simultaneous Cell Differentiation and Dopamine Detection. ACS biomaterials science & engineering. vol 6. issue 1. 2021-04-28. PMID:33463198. |
carbon mss is used to (1) enhance the morphology and differentiation of mouse neural stem/progenitor cells (mnspcs) derived from different regions of the developing brain and (2) simultaneously detect a neurotransmitter, dopamine, from a model dopaminergic cell line growing on the electrode. |
2021-04-28 |
2023-08-13 |
mouse |
| Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarr. A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-04-28. PMID:33808343. |
at present, anti-pd drugs acting on dopamine receptors are mainly symptomatic and have only very limited neuroprotective effects, whereas drugs slowing down neurodegeneration of dopaminergic neurons and deterioration of clinical symptoms are not yet available. |
2021-04-28 |
2023-08-13 |
human |
| Mariana H G Monje, Javier Blesa, Miguel Ángel García-Cabezas, José A Obeso, Carmen Cavad. Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 3. 2021-04-27. PMID:31800134. |
the primate thalamus is densely and heterogeneously innervated with dopaminergic axons, most of which express the dopamine transporter, as does the nigrostriatal system. |
2021-04-27 |
2023-08-13 |
monkey |
| Zahra Jafari, Bryan E Kolb, Majid H Mohajeran. Auditory Dysfunction in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 4. 2021-04-27. PMID:32052894. |
improvement in auditory responses following dopaminergic therapies also indicates the presence of similar neurotransmitters (i.e., glutamate and dopamine) in the auditory system and basal ganglia. |
2021-04-27 |
2023-08-13 |
Not clear |
| Jodi R Godfrey, Melanie Pincus, Zsofia Kovacs-Balint, Eric Feczko, Eric Earl, Oscar Miranda-Dominguez, Damien A Fair, Sara R Jones, Jason Locke, Mar M Sanchez, Mark E Wilson, Vasiliki Michopoulo. Obesogenic diet-associated C-reactive protein predicts reduced central dopamine and corticostriatal functional connectivity in female rhesus monkeys. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32240763. |
alterations in dopamine (da) signaling and reductions in functional connectivity (fc; a measure of temporal correlations of activity between different brain regions) within dopaminergic reward pathways are implicated in the etiology of psychopathology and have been associated with increased concentrations of inflammatory markers, including c-reactive protein. |
2021-04-27 |
2023-08-13 |
monkey |
| Jian-Fu Liao, Yun-Fang Cheng, Shu-Ting You, Wen-Chun Kuo, Chi-Wei Huang, Jen-Jie Chiou, Chih-Chieh Hsu, Hsiu-Mei Hsieh-Li, Sabrina Wang, Ying-Chieh Tsa. Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32739365. |
here, we report that orally administering ps128 for 4 weeks significantly alleviated the motor deficits, elevation in corticosterone, nigrostriatal dopaminergic neuronal death, and striatal dopamine reduction in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (mptp)-induced pd mouse models. |
2021-04-27 |
2023-08-13 |
mouse |
| Rowan Saloner, Mariana Cherner, David J Grelotti, Emily W Paolillo, David J Moore, Robert K Heaton, Scott L Letendre, Adarsh Kumar, Igor Grant, Ronald J Elli. Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32966871. |
abnormalities in dopaminergic neurotransmission and depression are common in people with hiv (pwh), however the link between dopamine (da) and depression in pwh is poorly characterized. |
2021-04-27 |
2023-08-13 |
Not clear |