| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Graziano Pinna, Roberto Carlos Agis-Balboa, Fabio Pibiri, Marianela Nelson, Alessandro Guidotti, Erminio Cost. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochemical research. vol 33. issue 10. 2008-12-08. PMID:18473173. |
by selectively targeting allopregnanolone downregulation in glutamatergic cortico-limbic neurons, i.e., by improving the response of gaba(a) receptors to gaba, new therapeutics would offer appropriate and safe management of psychiatric conditions, including impulsive aggression, irritability, irrational fear, anxiety, posttraumatic stress disorders, and depression. |
2008-12-08 |
2023-08-12 |
mouse |
| Martin D Haustein, Thomas Reinert, Annika Warnatsch, Bernhard Englitz, Beatrice Dietz, Andrea Robitzki, Rudolf Rübsamen, Ivan Milenkovi. Synaptic transmission and short-term plasticity at the calyx of Held synapse revealed by multielectrode array recordings. Journal of neuroscience methods. vol 174. issue 2. 2008-11-18. PMID:18703090. |
moreover, meas enable convenient analysis of activity-dependent depression and modulation of neuronal activity by glycine and gaba at later developmental stages not accessible to patch recordings. |
2008-11-18 |
2023-08-12 |
Not clear |
| Zeng-You Ye, Ke-Qing Zhou, Tian-Le Xu, Jiang-Ning Zho. Fluoxetine potentiates GABAergic IPSCs in rat hippocampal neurons. Neuroscience letters. vol 442. issue 1. 2008-10-14. PMID:18606211. |
this potentiation by fluoxetine may normalize the hippocampal gaba deficit during depression and in part exert its antidepressant activity. |
2008-10-14 |
2023-08-12 |
rat |
| Masato Matsumoto, Tsuyoshi Ichikawa, Wise Young, Namio Kodam. Glutamine synthetase protects the spinal cord against hypoxia-induced and GABA(A) receptor-activated axonal depressions. Surgical neurology. vol 70. issue 2. 2008-09-19. PMID:18262603. |
we investigated the effects of exogenous gs on hypoxia- and gaba(a) receptor-induced axonal depression in neonatal rats. |
2008-09-19 |
2023-08-12 |
rat |
| Małgorzata Frankowska, Małgorzata Filip, Edmund Przegalińsk. Effects of GABAB receptor ligands in animal tests of depression and anxiety. Pharmacological reports : PR. vol 59. issue 6. 2008-09-17. PMID:18195453. |
preclinical evidence strongly implicates gaba(b) receptors in the pathophysiology of several psychiatric disorders including anxiety and depression. |
2008-09-17 |
2023-08-12 |
Not clear |
| Małgorzata Frankowska, Małgorzata Filip, Edmund Przegalińsk. Effects of GABAB receptor ligands in animal tests of depression and anxiety. Pharmacological reports : PR. vol 59. issue 6. 2008-09-17. PMID:18195453. |
our results indicate that differential manipulation of gaba(b) receptors can modify behaviors relevant to depression and anxiety. |
2008-09-17 |
2023-08-12 |
Not clear |
| Sietske M Schotanus, Karima Chergu. NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18540994. |
synaptic depression was not dependent on gaba release because the gaba(a) receptor antagonist bicuculline did not affect nmda-induced decrease of the fepsp/ps. |
2008-09-12 |
2023-08-12 |
mouse |
| Charles B Nemerof. Understanding the pathophysiology of postpartum depression: implications for the development of novel treatments. Neuron. vol 59. issue 2. 2008-08-26. PMID:18667144. |
in this issue of neuron, maguire and mody provide evidence for a role for aberrant neurosteroid regulation of the gaba(a) receptor subunit in the etiology of postpartum depression, presaging elucidation of the pathophysiology and development of treatments of this depression endophenotype. |
2008-08-26 |
2023-08-12 |
Not clear |
| Jamie Maguire, Istvan Mod. GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron. vol 59. issue 2. 2008-08-26. PMID:18667149. |
gaba(a)r plasticity during pregnancy: relevance to postpartum depression. |
2008-08-26 |
2023-08-12 |
mouse |
| Itsaso Buesa, Andrés Urrutia, Juan Bilbao, Luciano Aguilera, Manfred Zimmermann, Jon Jatsu Azku. Morphine-induced depression of spinal excitation is not altered following acute disruption of GABA(A) or GABA(B) receptor activity. European journal of pain (London, England). vol 12. issue 6. 2008-08-20. PMID:18551744. |
morphine-induced depression of spinal excitation is not altered following acute disruption of gaba(a) or gaba(b) receptor activity. |
2008-08-20 |
2023-08-12 |
rat |
| Astrid C E Linthorst, Johannes M Reu. Stress and the brain: solving the puzzle using microdialysis. Pharmacology, biochemistry, and behavior. vol 90. issue 2. 2008-08-12. PMID:18028991. |
the therapeutical efficacy of selective serotonin re-uptake inhibitors and benzodiazepines points to a key role of serotonin and gamma-aminobutyric acid (gaba) in depression and anxiety. |
2008-08-12 |
2023-08-12 |
human |
| Fan Jia, Dev Chandra, Gregg E Homanics, Neil L Harriso. Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18477766. |
ethanol had no effect on the paired-pulse depression ratio, suggesting that the release of gaba from presynaptic terminals is insensitive to ethanol. |
2008-08-12 |
2023-08-12 |
mouse |
| Junya Kuribayashi, Shigeki Sakuraba, Masanori Kashiwagi, Eiki Hatori, Miki Tsujita, Yuki Hosokawa, Junzo Takeda, Shun-Ichi Kuwan. Neural mechanisms of sevoflurane-induced respiratory depression in newborn rats. Anesthesiology. vol 109. issue 2. 2008-08-07. PMID:18648232. |
furthermore, they clarified the role of gamma-aminobutyric acid type a receptors in sevoflurane-induced respiratory depression. |
2008-08-07 |
2023-08-12 |
rat |
| Juha Huttunen, Eero Pekkonen, Reetta Kivisaari, Taina Autti, Seppo Kähköne. Modulation of somatosensory evoked fields from SI and SII by acute GABA A-agonism and paired-pulse stimulation. NeuroImage. vol 40. issue 2. 2008-07-15. PMID:18234513. |
the lack of ppd modulation of n20m by lorazepam suggests that paired-pulse depression of the first cortical excitatory response (n20m) may be caused by mechanisms other than gaba a receptor-mediated inhibition. |
2008-07-15 |
2023-08-12 |
Not clear |
| Patrizia Longone, Rainer Rupprecht, Gaia A Manieri, Giorgio Bernardi, Elena Romeo, Augusto Pasin. The complex roles of neurosteroids in depression and anxiety disorders. Neurochemistry international. vol 52. issue 4-5. 2008-06-20. PMID:17996986. |
in this review, we will focus mainly on the steroids active on the gaba(a) receptors studied in anxiety and depression. |
2008-06-20 |
2023-08-12 |
Not clear |
| Zubin Bhagwagar, Marzena Wylezinska, Peter Jezzard, John Evans, Erie Boorman, Paul M Matthews, Philip J Cowe. Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. The international journal of neuropsychopharmacology. vol 11. issue 2. 2008-05-08. PMID:17625025. |
the aim of this study was to use 1h-mrs to determine if changes in occipital and frontal cortical gaba levels were present in patients with a history of depression who had recovered and were no longer taking medication. |
2008-05-08 |
2023-08-12 |
human |
| Zubin Bhagwagar, Marzena Wylezinska, Peter Jezzard, John Evans, Erie Boorman, Paul M Matthews, Philip J Cowe. Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. The international journal of neuropsychopharmacology. vol 11. issue 2. 2008-05-08. PMID:17625025. |
we used 1h-mrs to measure levels of gaba in both occipital cortex and anterior cingulate cortex/prefrontal cortex in medication-free, fully recovered subjects with a history of recurrent unipolar depression. |
2008-05-08 |
2023-08-12 |
human |
| Zubin Bhagwagar, Marzena Wylezinska, Peter Jezzard, John Evans, Erie Boorman, Paul M Matthews, Philip J Cowe. Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. The international journal of neuropsychopharmacology. vol 11. issue 2. 2008-05-08. PMID:17625025. |
our data provide preliminary evidence that a history of recurrent depression is associated with decreased gaba levels in anterior cingulate cortex and occipital cortex. |
2008-05-08 |
2023-08-12 |
human |
| Tohru Kurotani, Kazumasa Yamada, Yumiko Yoshimura, Michael C Crair, Yukio Komats. State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. Neuron. vol 57. issue 6. 2008-04-28. PMID:18367091. |
the depression is mediated by l-type ca2+ channels and gaba(a) receptor endocytosis, whereas potentiation is mediated by r-type ca2+ channels and receptor exocytosis. |
2008-04-28 |
2023-08-12 |
rat |
| Tyson B Brust, Francisco S Cayabyab, Brian A MacVica. C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:17967469. |
in contrast, the jnk inhibitor sp600125 did not inhibit gaba(b)-mediated synaptic depression. |
2008-03-21 |
2023-08-12 |
rat |