| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fouad Lemtiri-Chlieh, Eric S Levin. Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs. Journal of neurophysiology. vol 98. issue 5. 2008-02-25. PMID:17881480. |
in layer 2/3 of neocortex, brief trains of action potentials in pyramidal neurons (pns) induce the mobilization of endogenous cannabinoids (ecbs), resulting in a depression of gaba release from the terminals of inhibitory interneurons (ins). |
2008-02-25 |
2023-08-12 |
mouse |
| Tomohiko Irie, Harunori Ohmor. Presynaptic GABA(B) receptors modulate synaptic facilitation and depression at distinct synapses in fusiform cells of mouse dorsal cochlear nucleus. Biochemical and biophysical research communications. vol 367. issue 2. 2008-02-15. PMID:18190780. |
presynaptic gaba(b) receptors modulate synaptic facilitation and depression at distinct synapses in fusiform cells of mouse dorsal cochlear nucleus. |
2008-02-15 |
2023-08-12 |
mouse |
| Shigeyuki Chaki, Taketoshi Okubo, Yoshinori Sekiguch. Non-monoamine-based approach for the treatment of depression and anxiety disorders. Recent patents on CNS drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221188. |
in particular, receptors within the glutamate, gamma-aminobutyric acid and neuropeptide systems provide a diversity of drug targets, and molecular biological and behavioral studies of these receptors have revealed the important roles they play in depression and anxiety. |
2008-02-15 |
2023-08-12 |
Not clear |
| Dorothy A Hehre, Carlos J Devia, Eduardo Bancalari, Cleide Suguihar. Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets. Pediatric research. vol 63. issue 1. 2008-02-07. PMID:18043517. |
these data suggest that the larger depression in the ventilatory response to hypoxia observed in younger piglets is mediated by predominance of the inhibitory aa neurotransmitters, gaba, glycine, and taurine, in the nts. |
2008-02-07 |
2023-08-12 |
Not clear |
| Kristina S Vikman, Arthur W Duggan, Philip J Siddal. Interferon-gamma induced disruption of GABAergic inhibition in the spinal dorsal horn in vivo. Pain. vol 133. issue 1-3. 2008-01-31. PMID:17407800. |
seventy-four percent of cells from ifn-gamma treated animals showed a reduction in the response to noxious stimulation and 47% of the cells showed increased rather than reduced paired-pulse depression in the presence of bicuculline, thus suggesting ifn-gamma-induced excitatory actions by gaba. |
2008-01-31 |
2023-08-12 |
rat |
| T I Tóth, T Bessaïh, N Leresche, V Crunell. The properties of reticular thalamic neuron GABA(A) IPSCs of absence epilepsy rats lead to enhanced network excitability. The European journal of neuroscience. vol 26. issue 7. 2008-01-29. PMID:17883416. |
recently we showed that, prior to seizure onset, gaba(a) ipscs in thalamic reticular (nrt) neurons of genetic absence epilepsy rats from strasbourg (gaers) had a 25% larger amplitude, a 40% faster decay and a 45% smaller paired-pulse depression than those of nonepileptic control (nec) rats. |
2008-01-29 |
2023-08-12 |
human |
| Yuji Kamikubo, Toshihide Tabata, Sho Kakizawa, Daisuke Kawakami, Masahiko Watanabe, Akihiko Ogura, Masamitsu Iino, Masanobu Kan. Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells. The Journal of physiology. vol 585. issue Pt 2. 2008-01-29. PMID:17947316. |
around the postsynaptic membrane of these synapses, b-type gamma-aminobutyric acid receptor (gababr), a gi/o protein-coupled receptor for the inhibitory transmitter gaba is concentrated and closely associated with type-1 metabotropic glutamate receptors (mglur1) whose signalling is a key factor for inducing ltd. we found that in cultured purkinje cells, gababr activation enhanced ltd of a glutamate-evoked current (ltdglu), increasing the magnitude of depression. |
2008-01-29 |
2023-08-12 |
mouse |
| Allan V Kalueff, David J Nut. Role of GABA in anxiety and depression. Depression and anxiety. vol 24. issue 7. 2008-01-14. PMID:17117412. |
role of gaba in anxiety and depression. |
2008-01-14 |
2023-08-12 |
human |
| Allan V Kalueff, David J Nut. Role of GABA in anxiety and depression. Depression and anxiety. vol 24. issue 7. 2008-01-14. PMID:17117412. |
this review assesses the parallel data on the role of gamma-aminobutyric acid (gaba) in depression and anxiety. |
2008-01-14 |
2023-08-12 |
human |
| Alexander Sartorius, Magdalena M Mahlstedt, Barbara Vollmayr, Fritz A Henn, Gabriele End. Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness. Neuroreport. vol 18. issue 14. 2007-12-06. PMID:17712276. |
the theory of depression is dominated by the monoamine hypothesis but there is increasing evidence that beyond monoamines, glutamate (glu) and gamma-aminobutyric acid (gaba) play an essential role in the pathogenesis of depression. |
2007-12-06 |
2023-08-12 |
rat |
| Alberto Castro, Justo Aguilar, David Elias, Ricardo Felix, Rodolfo Delgado-Lezam. G-protein-coupled GABAB receptors inhibit Ca2+ channels and modulate transmitter release in descending turtle spinal cord terminal synapsing motoneurons. The Journal of comparative neurology. vol 503. issue 5. 2007-10-12. PMID:17559099. |
our data show that epsp depression caused by baclofen was prevented by nem, suggesting that gaba(b)rs inhibit n-type channels via g-protein activation. |
2007-10-12 |
2023-08-12 |
Not clear |
| JongBun Kim, Richard Atherley, David F Werner, Gregg E Homanics, Earl Carstens, Joseph F Antognin. Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant gamma-aminobutyric acid type-A receptors. Neuroscience letters. vol 420. issue 3. 2007-09-26. PMID:17543455. |
isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant gamma-aminobutyric acid type-a receptors. |
2007-09-26 |
2023-08-12 |
mouse |
| Silvarosa Grassi, Adele Frondaroli, Cristina Dieni, Mayank B Dutia, Vito E Pettoross. Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei. The European journal of neuroscience. vol 26. issue 1. 2007-09-19. PMID:17596193. |
the depressions depended on gaba(a) receptors, as they were abolished by bicuculline, while early potentiation involved glutamate ampa/kainate receptors, as nbqx markedly reduced the incidence of early firing rate enhancement and, in the case of allo, even provoked depression. |
2007-09-19 |
2023-08-12 |
rat |
| Sarah E Thompson, Goher Ayman, Gavin L Woodhall, Roland S G Jone. Depression of glutamate and GABA release by presynaptic GABAB receptors in the entorhinal cortex in normal and chronically epileptic rats. Neuro-Signals. vol 15. issue 4. 2007-08-24. PMID:17215590. |
depression of glutamate and gaba release by presynaptic gabab receptors in the entorhinal cortex in normal and chronically epileptic rats. |
2007-08-24 |
2023-08-12 |
rat |
| Sarah E Thompson, Goher Ayman, Gavin L Woodhall, Roland S G Jone. Depression of glutamate and GABA release by presynaptic GABAB receptors in the entorhinal cortex in normal and chronically epileptic rats. Neuro-Signals. vol 15. issue 4. 2007-08-24. PMID:17215590. |
quantitatively, the depression of gaba release in layer ii and layer v, and of glutamate release in layer v was similar, but glutamate release in layer ii was depressed to a greater extent. |
2007-08-24 |
2023-08-12 |
rat |
| Janne Grønli, Eldbjørg Fiske, Robert Murison, Bjørn Bjorvatn, Eli Sørensen, Reidun Ursin, Chiara M Porta. Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study in an animal model of depression. Behavioural brain research. vol 181. issue 1. 2007-08-24. PMID:17477980. |
recent evidence suggests that serotonergic involvement in depression may be modulated by the action of gamma-hydroxybutyric acid (gaba). |
2007-08-24 |
2023-08-12 |
rat |
| Janne Grønli, Eldbjørg Fiske, Robert Murison, Bjørn Bjorvatn, Eli Sørensen, Reidun Ursin, Chiara M Porta. Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study in an animal model of depression. Behavioural brain research. vol 181. issue 1. 2007-08-24. PMID:17477980. |
hence, the present paper reports a study on simultaneously measurement of hippocampal levels of serotonin and gaba during waking and sleep in the chronic mild stress (cms) animal model of depression. |
2007-08-24 |
2023-08-12 |
rat |
| Ann E Fink, Joshua Sariñana, Erin E Gray, Thomas J O'del. Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus. Journal of neurophysiology. vol 97. issue 6. 2007-08-15. PMID:17409173. |
blocking gaba(b) receptors abolished paired-pulse depression but had little effect on low-frequency stimulation (lfs)-induced depression. |
2007-08-15 |
2023-08-12 |
mouse |
| Ann E Fink, Joshua Sariñana, Erin E Gray, Thomas J O'del. Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus. Journal of neurophysiology. vol 97. issue 6. 2007-08-15. PMID:17409173. |
blocking the postsynaptic effects of gaba(b) and a1 receptor activation on ca1 pyramidal cell excitability with an inhibitor of g-protein-activated inwardly rectifying potassium channels had no effect on either paired-pulse depression or lfs-induced depression. |
2007-08-15 |
2023-08-12 |
mouse |
| Ann E Fink, Joshua Sariñana, Erin E Gray, Thomas J O'del. Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus. Journal of neurophysiology. vol 97. issue 6. 2007-08-15. PMID:17409173. |
thus activation of presynaptic gaba(b) and adenosine receptors appears to have an important role in activity-dependent depression at recurrent synapses. |
2007-08-15 |
2023-08-12 |
mouse |