| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geng-Lin Li, Jozsef Vigh, Henrique von Gersdorf. Short-term depression at the reciprocal synapses between a retinal bipolar cell terminal and amacrine cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 28. 2007-08-07. PMID:17626198. |
we find that this release of gaba undergoes paired-pulse depression (ppd) that recovers in <1 min (single exponential time constant, tau approximately = 12 s). |
2007-08-07 |
2023-08-12 |
human |
| Nicolas Wanaverbecq, Alexey Semyanov, Ivan Pavlov, Matthew C Walker, Dimitri M Kullman. Cholinergic axons modulate GABAergic signaling among hippocampal interneurons via postsynaptic alpha 7 nicotinic receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 21. 2007-06-22. PMID:17522313. |
this depression is accompanied by a small increase in gaba release. |
2007-06-22 |
2023-08-12 |
Not clear |
| Gerard Sanacora, Aybala Saricice. GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action. CNS & neurological disorders drug targets. vol 6. issue 2. 2007-05-29. PMID:17430150. |
this review outlines the existing literature investigating the possible involvement of gaba in the neurobiology of depression and briefly highlights how this information may afford new targets for antidepressant drug development. |
2007-05-29 |
2023-08-12 |
human |
| D Merlo, C Mollinari, Y Inaba, A Cardinale, A M Rinaldi, M D'Antuono, G D'Arcangelo, V Tancredi, D Ragsdale, M Avol. Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17207629. |
intracellular recordings from neocortical cells in an in vitro slice preparation demonstrated reduced paired-pulse depression of pharmacologically isolated excitatory and inhibitory responses in epileptic wag/rij rats as compared with necs; moreover, paired-pulse depression in nec slices was diminished by a gaba(b) receptor antagonist to a greater extent than in wag/rij rats further suggesting gaba(b) receptor dysfunction. |
2007-05-17 |
2023-08-12 |
rat |
| D Merlo, C Mollinari, Y Inaba, A Cardinale, A M Rinaldi, M D'Antuono, G D'Arcangelo, V Tancredi, D Ragsdale, M Avol. Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17207629. |
in conclusion, our data identify changes in gaba(b) receptor subunit expression and distribution along with decreased paired-pulse depression in epileptic wag/rij rat neocortex. |
2007-05-17 |
2023-08-12 |
rat |
| Daniela Eser, Cornelius Schüle, Thomas C Baghai, Elena Romeo, Rainer Rupprech. Neuroactive steroids in depression and anxiety disorders: clinical studies. Neuroendocrinology. vol 84. issue 4. 2007-05-01. PMID:17159334. |
the modulation of gaba(a) receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds. |
2007-05-01 |
2023-08-12 |
Not clear |
| Gregor Hasler, Jan Willem van der Veen, Toni Tumonis, Noah Meyers, Jun Shen, Wayne C Drevet. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Archives of general psychiatry. vol 64. issue 2. 2007-04-16. PMID:17283286. |
reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. |
2007-04-16 |
2023-08-12 |
Not clear |
| Grazyna Rajkowska, Gillian O'Dwyer, Zsofia Teleki, Craig A Stockmeier, Jose Javier Miguel-Hidalg. GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 2. 2007-03-02. PMID:17063153. |
these cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of gaba in depression. |
2007-03-02 |
2023-08-12 |
human |
| Axel Neu, Csaba Földy, Ivan Soltes. Postsynaptic origin of CB1-dependent tonic inhibition of GABA release at cholecystokinin-positive basket cell to pyramidal cell synapses in the CA1 region of the rat hippocampus. The Journal of physiology. vol 578. issue Pt 1. 2007-02-26. PMID:17053036. |
these interneurons express high levels of presynaptic cannabinoid type 1 (cb1) receptors that mediate short-term depression of gaba release following depolarization of postsynaptic cells. |
2007-02-26 |
2023-08-12 |
human |
| He Zhu, Beata Karolewicz, Emily Nail, Craig A Stockmeier, Katalin Szebeni, Gregory A Ordwa. Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide. Brain research. vol 1125. issue 1. 2007-02-20. PMID:17118347. |
numerous studies demonstrating low levels of gaba in the csf and plasma of subjects with major depressive disorder (mdd) raise the possibility that lc overactivity in depression may be secondary to reduced gabaergic input to the lc. |
2007-02-20 |
2023-08-12 |
human |
| He Zhu, Beata Karolewicz, Emily Nail, Craig A Stockmeier, Katalin Szebeni, Gregory A Ordwa. Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide. Brain research. vol 1125. issue 1. 2007-02-20. PMID:17118347. |
here, gabaergic input to the lc in depression was evaluated by studying the binding of [(3)h]flunitrazepam to gaba(a) receptors at three anatomically defined levels of the human postmortem lc. |
2007-02-20 |
2023-08-12 |
human |
| Una Cheung, Mehrnoush Moghaddasi, Hannah L Hall, J J B Smith, Leslie T Buck, Melanie A Woodi. Excitatory actions of GABA mediate severe-hypoxia-induced depression of neuronal activity in the pond snail (Lymnaea stagnalis). The Journal of experimental biology. vol 209. issue Pt 22. 2007-02-08. PMID:17079713. |
excitatory actions of gaba mediate severe-hypoxia-induced depression of neuronal activity in the pond snail (lymnaea stagnalis). |
2007-02-08 |
2023-08-12 |
Not clear |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Ivan O Edafiogh. Enaminones and norepinephrine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. The European journal of neuroscience. vol 24. issue 10. 2007-01-30. PMID:17156204. |
similar to the e139-induced epsc depression, the ne-induced epsc depression was also blocked by the gaba(b) receptor antagonist, cgp55845. |
2007-01-30 |
2023-08-12 |
rat |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Ivan O Edafiogh. Enaminones and norepinephrine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. The European journal of neuroscience. vol 24. issue 10. 2007-01-30. PMID:17156204. |
these results suggest that ne and e139, but not da, employ a similar mechanism to depress epscs in the nac, and support the hypothesis that e139, like ne, may act on alpha(2)-adrenoceptors to cause the release of gaba, which then mediates synaptic depression via gaba(b) receptors. |
2007-01-30 |
2023-08-12 |
rat |
| Thomas Bessaïh, Laurence Bourgeais, Carmen I Badiu, David A Carter, Tibor I Toth, Diego Ruano, Bertrand Lambolez, Vincenzo Crunelli, Nathalie Leresch. Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures. Journal of neurophysiology. vol 96. issue 6. 2007-01-17. PMID:16971676. |
paired-pulse depression was 45% smaller in gaers nrt, but not in vb, and was insensitive to gaba(b) antagonists. |
2007-01-17 |
2023-08-12 |
human |
| Tyson B Brust, Francisco S Cayabyab, Ning Zhou, Brian A MacVica. p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 48. 2006-12-21. PMID:17135404. |
in contrast, the p38 mapk inhibitors did not inhibit gaba(b)-mediated synaptic depression. |
2006-12-21 |
2023-08-12 |
rat |
| Monica Garcia-Alloza, Shirley W Tsang, Francisco J Gil-Bea, Paul T Francis, Mitchell K Lai, Beatriz Marcos, Christopher P Chen, María J Ramire. Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. Neurobiology of aging. vol 27. issue 8. 2006-12-20. PMID:15996794. |
both gaba levels and the glutamate/gaba ratio showed significant correlations with depression in ad. |
2006-12-20 |
2023-08-12 |
Not clear |
| Monica Garcia-Alloza, Shirley W Tsang, Francisco J Gil-Bea, Paul T Francis, Mitchell K Lai, Beatriz Marcos, Christopher P Chen, María J Ramire. Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. Neurobiology of aging. vol 27. issue 8. 2006-12-20. PMID:15996794. |
in the temporal cortex, higher densities of gaba(a)/benzodiazepine receptors also correlated with more severe depression. |
2006-12-20 |
2023-08-12 |
Not clear |
| Yasunobu Igarashi, Yuichi Sakumura, Shin Ishi. The role of short-term depression in sustained neural activity in the prefrontal cortex: a simulation study. Neural networks : the official journal of the International Neural Network Society. vol 19. issue 8. 2006-12-12. PMID:16949792. |
our model shows that short-term depression (std) enables the network to sustain its activity despite the presence of long-term inhibition by gaba(b) receptors and that the sustained firing rates have a bell-shaped dependence on the degree of std. |
2006-12-12 |
2023-08-12 |
Not clear |
| Annika B Malmberg, William T O'Connor, Jeffery C Glennon, Rose Ceseña, Nigel A Calcut. Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats. Brain research. vol 1115. issue 1. 2006-12-04. PMID:16920081. |
these findings indicate that the selective depression of basal and stimulus-evoked glutamate levels in the spinal cord of diabetic rats occurs in parallel with elevated spinal gaba levels. |
2006-12-04 |
2023-08-12 |
rat |