| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Grasshoff, Berthold Drexler, Uwe Rudolph, Bernd Antkowia. Anaesthetic drugs: linking molecular actions to clinical effects. Current pharmaceutical design. vol 12. issue 28. 2006-11-30. PMID:17073666. |
respiratory depression involves beta3 containing gaba(a) receptors whereas hypothermia is largely mediated by gaba(a) receptors containing beta2 subunits. |
2006-11-30 |
2023-08-12 |
mouse |
| Fulvia Bongianni, Donatella Mutolo, Furio Nardone, Tito Pantale. GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16630584. |
depression of both the frequency and amplitude of respiratory bursts was induced by blockades of gaba and glycine uptake using, respectively, nipecotic acid and sarcosine. |
2006-09-25 |
2023-08-12 |
Not clear |
| D S S Vieira, M G Naffah-Mazacoratti, E Zukerman, C A Senne Soares, E O Alonso, M H W Faulhaber, E A Cavalheiro, M F P Pere. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16638608. |
cerebrospinal fluid gaba levels in chronic migraine with and without depression. |
2006-09-25 |
2023-08-12 |
Not clear |
| D S S Vieira, M G Naffah-Mazacoratti, E Zukerman, C A Senne Soares, E O Alonso, M H W Faulhaber, E A Cavalheiro, M F P Pere. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16638608. |
preclinical studies have suggested that gamma-aminobutyric acid (gaba) levels may be decreased in animal models of depression. |
2006-09-25 |
2023-08-12 |
Not clear |
| D S S Vieira, M G Naffah-Mazacoratti, E Zukerman, C A Senne Soares, E O Alonso, M H W Faulhaber, E A Cavalheiro, M F P Pere. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16638608. |
we hypothesized that low gaba levels in the brain might be related to the depression associated with cm. |
2006-09-25 |
2023-08-12 |
Not clear |
| D S S Vieira, M G Naffah-Mazacoratti, E Zukerman, C A Senne Soares, E O Alonso, M H W Faulhaber, E A Cavalheiro, M F P Pere. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16638608. |
csf gaba levels showed significant lower levels in depressed patients than those without depression. |
2006-09-25 |
2023-08-12 |
Not clear |
| D S S Vieira, M G Naffah-Mazacoratti, E Zukerman, C A Senne Soares, E O Alonso, M H W Faulhaber, E A Cavalheiro, M F P Pere. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16638608. |
a gaba deficiency may be the underlying mechanism of depression in cm. |
2006-09-25 |
2023-08-12 |
Not clear |
| D S S Vieira, M G Naffah-Mazacoratti, E Zukerman, C A Senne Soares, E O Alonso, M H W Faulhaber, E A Cavalheiro, M F P Pere. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research. vol 1090. issue 1. 2006-09-25. PMID:16638608. |
hence, preventive therapies modulating gaba neurotransmission could be used in cm associated with depression. |
2006-09-25 |
2023-08-12 |
Not clear |
| Jun Ren, John J Gree. Neurosteroid modulation of respiratory rhythm in rats during the perinatal period. The Journal of physiology. vol 574. issue Pt 2. 2006-09-18. PMID:16690709. |
perinatal respiration is strongly modulated by gabaergic synaptic drive, and gaba release is increased during hypoxia to contribute to hypoxia-induced depression of neonatal ventilation. |
2006-09-18 |
2023-08-12 |
rat |
| Lénaïc Monconduit, Alberto Lopez-Avila, Jean-Louis Molat, Maryse Chalus, Luis Villanuev. Corticofugal output from the primary somatosensory cortex selectively modulates innocuous and noxious inputs in the rat spinothalamic system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914669. |
gaba(a)-mediated depression of corticofugal output concomitantly depressed noxious and enhanced innocuous-evoked responses of vpl neurons. |
2006-09-12 |
2023-08-12 |
rat |
| Shu-Ling Liang, Gregory C Carlson, Douglas A Coulte. Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914680. |
we found that, in meaib-containing medium, moderate stimulation induced depression in potency of meipscs but no change in release probability, consistent with reduced vesicular gaba content. |
2006-09-12 |
2023-08-12 |
Not clear |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Subramanian S Parvathy, Wandikayi C Matow. Cholecystokinin-2 receptors couple to cAMP-protein kinase A to depress excitatory synaptic currents in rat nucleus accumbens in vitro. Canadian journal of physiology and pharmacology. vol 84. issue 2. 2006-08-25. PMID:16900946. |
however, depression of the evoked epsc by baclofen, a gaba(b) receptor agonist, was not blocked by h89 or forskolin. |
2006-08-25 |
2023-08-12 |
rat |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Subramanian S Parvathy, Wandikayi C Matow. Cholecystokinin-2 receptors couple to cAMP-protein kinase A to depress excitatory synaptic currents in rat nucleus accumbens in vitro. Canadian journal of physiology and pharmacology. vol 84. issue 2. 2006-08-25. PMID:16900946. |
these findings indicate that cholecystokinin-2, but not gaba(b), receptors are coupled to the adenylyl cyclase-camp-protein kinase a signaling pathway in the nac to induce inward currents and cause synaptic depression. |
2006-08-25 |
2023-08-12 |
rat |
| H S Engelman, R L Anderson, C Daniele, A B Macdermot. Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience. vol 139. issue 2. 2006-07-31. PMID:16472927. |
in addition, we have observed ampa-induced depression of evoked release of gaba and glycine onto lamina i nk1r+ neurons. |
2006-07-31 |
2023-08-12 |
rat |
| Chao-Ling Qu, Jing-Shi Tang, Hong Ji. Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex. Brain research. vol 1073-1074. 2006-07-19. PMID:16448630. |
these results suggest that the gaba(a) receptor is involved in the modulation of vlo morphine-induced antinociception, and provide a behavioral support for the hypothesis that morphine may directly inhibit the gabaergic inhibitory interneurons leading to indirect activation of the descending antinociceptive pathway through a disinhibitory effect on the vlo output neurons and depression of the nociceptive inputs at the spinal cord level. |
2006-07-19 |
2023-08-12 |
rat |
| Steven F Kendell, John H Krystal, Gerrard Sanacor. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert opinion on therapeutic targets. vol 9. issue 1. 2006-06-01. PMID:15757488. |
gaba and glutamate systems as therapeutic targets in depression and mood disorders. |
2006-06-01 |
2023-08-12 |
Not clear |
| D Eser, E Romeo, T C Baghai, F di Michele, C Schüle, A Pasini, P Zwanzger, F Padberg, R Rupprech. Neuroactive steroids as modulators of depression and anxiety. Neuroscience. vol 138. issue 3. 2006-05-18. PMID:16310959. |
the modulation of gaba type a-receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds. |
2006-05-18 |
2023-08-12 |
Not clear |
| Malek Bajbouj, Sarah H Lisanby, Undine E Lang, Heidi Danker-Hopfe, Isabella Heuser, Peter Ne. Evidence for impaired cortical inhibition in patients with unipolar major depression. Biological psychiatry. vol 59. issue 5. 2006-05-11. PMID:16197927. |
several lines of evidence suggest that central cortical inhibitory mechanisms, especially associated with gamma-aminobutyric acid (gaba) neurotransmission, may play a role in the pathophysiology of major depression. |
2006-05-11 |
2023-08-12 |
Not clear |
| Gerard Sanacora, Lisa R Fenton, Madonna K Fasula, Douglas L Rothman, Yael Levin, John H Krystal, Graeme F Maso. Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biological psychiatry. vol 59. issue 3. 2006-04-13. PMID:16139814. |
the purpose of this study was to determine whether treatment of major depression with cognitive behavioral therapy (cbt) produces similar changes in cortical gaba concentrations. |
2006-04-13 |
2023-08-12 |
human |
| Linda L Carpenter, Jordan M Schecter, Audrey R Tyrka, Andrea F Mello, Marcelo F Mello, Ryan Haggarty, Lawrence H Pric. Open-label tiagabine monotherapy for major depressive disorder with anxiety. The Journal of clinical psychiatry. vol 67. issue 1. 2006-03-28. PMID:16426090. |
gamma-aminobutyric acid (gaba) plays a key role in the pathophysiology and treatment of depression and anxiety. |
2006-03-28 |
2023-08-12 |
Not clear |