| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linda L Carpenter, Jordan M Schecter, Audrey R Tyrka, Andrea F Mello, Marcelo F Mello, Ryan Haggarty, Lawrence H Pric. Open-label tiagabine monotherapy for major depressive disorder with anxiety. The Journal of clinical psychiatry. vol 67. issue 1. 2006-03-28. PMID:16426090. |
tiagabine, a selective gaba reuptake inhibitor (sgri) that enhances normal gaba tone, was evaluated for its efficacy and safety in the treatment of depression comorbid with significant anxiety. |
2006-03-28 |
2023-08-12 |
Not clear |
| John M Bissonnette, Sharon J Knop. Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65). Respiratory research. vol 5. 2006-03-14. PMID:15134589. |
we hypothesized that this developmental pattern would be present in the mouse which is also less mature at birth and that gaba mediates this relative respiratory depression. |
2006-03-14 |
2023-08-12 |
mouse |
| Anja Zeller, Margarete Arras, Anelise Lazaris, Rachel Jurd, Uwe Rudolp. Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 12. 2006-03-07. PMID:16046472. |
taken together with previous findings, our results show that both immobilization and respiratory depression are mediated by beta3-containing gaba(a) receptors, hypnosis by both beta3- and beta2-containing gaba(a) receptors, while the hypothermic, cardiac depressant, and sedative actions are largely independent of beta3-containing gaba(a) receptors. |
2006-03-07 |
2023-08-12 |
mouse |
| Christopher J Price, Bruno Cauli, Endre R Kovacs, Akos Kulik, Bertrand Lambolez, Ryuichi Shigemoto, Marco Capogn. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 29. 2006-02-15. PMID:16033887. |
unitary ipscs recorded from neurogliaform pairs readily fatigued, had a slow decay, and had a strong depression of the synaptic response at a 5 hz stimulation frequency that was antagonized by the gaba(b) antagonist (2s)-3-[[(1s)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl) phosphinic acid (cgp55845). |
2006-02-15 |
2023-08-12 |
Not clear |
| P Tosetti, N Ferrand, I Colin-Le Brun, J L Gaïars. Epileptiform activity triggers long-term plasticity of GABA(B) receptor signalling in the developing rat hippocampus. The Journal of physiology. vol 568. issue Pt 3. 2006-01-31. PMID:16096337. |
paired-pulse depression of gaba release (ppd) and heterosynaptic depression of glutamate release were used to monitor the efficacy of presynaptic gaba(b)r-mediated inhibition in slices. |
2006-01-31 |
2023-08-12 |
rat |
| Gregor Hasler, Alexander Neumeister, Jan Willem van der Veen, Toni Tumonis, Earle E Bain, Jun Shen, Wayne C Drevets, Dennis S Charne. Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biological psychiatry. vol 58. issue 12. 2006-01-20. PMID:16043137. |
there is growing evidence that the brain gamma-aminobutyric acid (gaba) system is involved in depression. |
2006-01-20 |
2023-08-12 |
human |
| Gregor Hasler, Alexander Neumeister, Jan Willem van der Veen, Toni Tumonis, Earle E Bain, Jun Shen, Wayne C Drevets, Dennis S Charne. Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biological psychiatry. vol 58. issue 12. 2006-01-20. PMID:16043137. |
lowered plasma gaba levels were identified as a traitlike abnormality found in patients with remitted unipolar depression and in healthy first-degree relatives of patients with unipolar depression. |
2006-01-20 |
2023-08-12 |
human |
| Mario Manto, Marie-Aline Laute, Massimo Pandolf. Depression of extra-cellular GABA and increase of NMDA-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat. Cerebellum (London, England). vol 4. issue 4. 2006-01-18. PMID:16321878. |
depression of extra-cellular gaba and increase of nmda-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat. |
2006-01-18 |
2023-08-12 |
rat |
| Samuel B Kombian, Ivan O Edafiogho, Kethireddy V V Ananthalakshm. Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels. British journal of pharmacology. vol 145. issue 7. 2006-01-17. PMID:15912138. |
the excitatory postsynaptic current (epsc) depression caused by 10 microm e139 (-27.7+/-3.8%) was blocked by 1 microm cgp55845 (6.3+/-8.1%), a potent gaba(b) receptor antagonist. |
2006-01-17 |
2023-08-12 |
rat |
| Samuel B Kombian, Ivan O Edafiogho, Kethireddy V V Ananthalakshm. Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels. British journal of pharmacology. vol 145. issue 7. 2006-01-17. PMID:15912138. |
pretreatment of slices with gamma-vinylgaba and 1-(2-(((diphenylmethylene)imino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridine-carboxylic acid (no-711), an irreversible gaba transaminase (gaba-t) inhibitor and a gaba reuptake blocker, respectively, like the anticonvulsant enaminones, also caused a depression of the evoked epsc (-38.1+/-14.1 and -24.1+/-8.9%, respectively). |
2006-01-17 |
2023-08-12 |
rat |
| Samuel B Kombian, Ivan O Edafiogho, Kethireddy V V Ananthalakshm. Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels. British journal of pharmacology. vol 145. issue 7. 2006-01-17. PMID:15912138. |
our data suggest that anticonvulsant enaminones cause epsc depression by enhancing extracellular gaba levels possibly through the inhibition of either gaba reuptake or gaba-t enzyme, or both. |
2006-01-17 |
2023-08-12 |
rat |
| M Rav-Acha, N Sagiv, I Segev, H Bergman, Y Yaro. Dynamic and spatial features of the inhibitory pallidal GABAergic synapses. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16154280. |
furthermore, we showed that gaba can promote globus pallidus synchronization by affecting the timing of globus pallidus spiking, and that the globus pallidus gabaergic synapse undergoes rapid frequency-dependent depression. |
2005-12-22 |
2023-08-12 |
rat |
| S Hayley, M O Poulter, Z Merali, H Anisma. The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16154288. |
corticotropin releasing hormone, and corticoids) and central neurotransmitters (serotonin and gaba), alterations of neuronal plasticity or even neuronal survival may play a role in depression. |
2005-12-22 |
2023-08-12 |
Not clear |
| François Maingret, Sari E Lauri, Tomi Taira, John T R Isaa. Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations. The Journal of physiology. vol 567. issue Pt 1. 2005-11-01. PMID:15946969. |
the up-regulation of spontaneous transmission was due to activation of somatodendritic and axonal receptors while the depression of evoked transmission could be fully accounted for by a direct regulation of gaba release by kainate receptors located at the terminals. |
2005-11-01 |
2023-08-12 |
rat |
| Yoshihiko Yamazaki, Yousheng Jia, Naoya Hamaue, Katumi Sumikaw. Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115208. |
furthermore, nicotine increased the frequency of spontaneous inhibitory postsynaptic currents (ipscs) in pyramidal cells, and concomitantly caused a reduction in the size of responses to focal gaba application onto the dendrites of pyramidal cells, suggesting that the nicotine-induced increase in interneuronal activity leads ultimately to a use-dependent depression of evoked ipscs in pyramidal cells. |
2005-10-18 |
2023-08-12 |
Not clear |
| Ying Chen, Keith Phillips, Gareth Minton, Emanuele She. GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. British journal of pharmacology. vol 144. issue 7. 2005-09-29. PMID:15711597. |
gaba(b) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. |
2005-09-29 |
2023-08-12 |
rat |
| Ying Chen, Keith Phillips, Gareth Minton, Emanuele She. GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. British journal of pharmacology. vol 144. issue 7. 2005-09-29. PMID:15711597. |
in this study, we assessed the ability of cgp7930 to modulate the baclofen-induced depression of dopamine (da) neuron activity via the activation of gaba(b) receptors in the ventral tegmental area in rat midbrain slices. |
2005-09-29 |
2023-08-12 |
rat |
| Ying Chen, Keith Phillips, Gareth Minton, Emanuele She. GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. British journal of pharmacology. vol 144. issue 7. 2005-09-29. PMID:15711597. |
it is therefore concluded that the recently reported gaba(b) receptor modulators, cgp7930 and fendiline, can enhance gaba(b) receptor-mediated depression of da neuronal activity. |
2005-09-29 |
2023-08-12 |
rat |
| Pirjo Saransaari, Simo S Oj. GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions. Neurochemical research. vol 30. issue 4. 2005-08-24. PMID:16076017. |
the demonstrated depression of gaba release by adenosine in the hippocampus could be deleterious to neurons and contribute to excitotoxicity. |
2005-08-24 |
2023-08-12 |
mouse |
| Laura H Jacobson, John F Crya. Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. Psychopharmacology. vol 179. issue 3. 2005-08-18. PMID:15668819. |
recent evidence has demonstrated the importance of gaba b receptors in anxiety and depression. |
2005-08-18 |
2023-08-12 |
mouse |