| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard A DeFazio, John J Hablit. Horizontal spread of activity in neocortical inhibitory networks. Brain research. Developmental brain research. vol 157. issue 1. 2005-08-12. PMID:15939088. |
gaba responses propagated at a speed of 2.7 +/- 0.2 mm/s, a rate intermediate to fast synaptic transmission and spreading depression. |
2005-08-12 |
2023-08-12 |
Not clear |
| John F Cryan, Klemens Kaupman. Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends in pharmacological sciences. vol 26. issue 1. 2005-08-08. PMID:15629203. |
: a role for gaba(b) receptors in anxiety and depression. |
2005-08-08 |
2023-08-12 |
mouse |
| John F Cryan, Klemens Kaupman. Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends in pharmacological sciences. vol 26. issue 1. 2005-08-08. PMID:15629203. |
in this review, we discuss evidence that points to a role of gaba(b) receptors in anxiety and depression. |
2005-08-08 |
2023-08-12 |
mouse |
| Ying Li, Anthony N van den Po. Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 1. 2005-07-20. PMID:15634779. |
ne therefore inhibits hypocretin neurons directly through two mechanisms: activation of a girk current, depression of calcium currents, and indirectly through increased inhibitory gaba input. |
2005-07-20 |
2023-08-12 |
mouse |
| Sam Medhat Salah, Anna Katharina Jäge. Screening of traditionally used Lebanese herbs for neurological activities. Journal of ethnopharmacology. vol 97. issue 1. 2005-05-26. PMID:15652288. |
aqueous, ethanol and ethyl acetate extracts of seven lebanese plants that are used traditionally for neurological disorders as alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the gaba(a)-benzodiazepine site and to the serotonin transporter. |
2005-05-26 |
2023-08-12 |
Not clear |
| Alon Korngreen, Katharina M M Kaiser, Yuri Zilberte. Subthreshold inactivation of voltage-gated K+ channels modulates action potentials in neocortical bitufted interneurones from rats. The Journal of physiology. vol 562. issue Pt 2. 2005-05-16. PMID:15539396. |
we speculate that this signal may modulate retrograde gaba release and consequently depression of synaptic efficacy of excitatory input from neighbouring pyramidal neurones. |
2005-05-16 |
2023-08-12 |
rat |
| Gregory O Hjelmsta. Dopamine excites nucleus accumbens neurons through the differential modulation of glutamate and GABA release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 39. 2005-04-14. PMID:15456835. |
this differential modulation may be explained by a calcium-dependent change in the recovery from depression at the gaba synapses, where da acts by decreasing ca2+ entry. |
2005-04-14 |
2023-08-12 |
rat |
| David A Slattery, Sandrine Desrayaud, John F Crya. GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. The Journal of pharmacology and experimental therapeutics. vol 312. issue 1. 2005-04-13. PMID:15333677. |
however, the role of metabotropic gaba(b) receptors in depression is not well defined. |
2005-04-13 |
2023-08-12 |
rat |
| David A Slattery, Sandrine Desrayaud, John F Crya. GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. The Journal of pharmacology and experimental therapeutics. vol 312. issue 1. 2005-04-13. PMID:15333677. |
together, these data demonstrate that gaba(b) receptor antagonists via an interaction with the serotonergic system display antidepressant-like properties and therefore represent a novel approach for the treatment of depression. |
2005-04-13 |
2023-08-12 |
rat |
| Christiaan P J de Kock, Nail Burnashev, Johannes C Lodder, Huibert D Mansvelder, Arjen B Brussaar. NMDA receptors induce somatodendritic secretion in hypothalamic neurones of lactating female rats. The Journal of physiology. vol 561. issue Pt 1. 2005-04-06. PMID:15459239. |
this implies that glutamatergic synaptic input in itself is sufficient to elicit the release of oxytocin, which in turn acts as a retrograde messenger leading to the depression of nearby gaba synapses. |
2005-04-06 |
2023-08-12 |
rat |
| A V Kaluev, D J Nut. [On the role of GABA in anxiety and depression]. Eksperimental'naia i klinicheskaia farmakologiia. vol 67. issue 4. 2005-03-31. PMID:15500054. |
[on the role of gaba in anxiety and depression]. |
2005-03-31 |
2023-08-12 |
Not clear |
| A V Kaluev, D J Nut. [On the role of GABA in anxiety and depression]. Eksperimental'naia i klinicheskaia farmakologiia. vol 67. issue 4. 2005-03-31. PMID:15500054. |
data on the role of gamma-aminobutyric acid (gaba) in pathogenesis of anxiety and depression are critically assessed. |
2005-03-31 |
2023-08-12 |
Not clear |
| Scott A Sands, Scott A Reisman, S J Enn. Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus. Biochemical pharmacology. vol 68. issue 8. 2005-02-22. PMID:15451391. |
the results indicate that an enhancement in the production of hippocampal gaba(b(1a)) subunits may be a component of the response to antidepressants, supporting a possible role for this receptor in the symptoms of depression and the treatment of this condition. |
2005-02-22 |
2023-08-12 |
rat |
| H-S Kim, X Wan, D A Mathers, E Pui. Selective GABA-receptor actions of amobarbital on thalamic neurons. British journal of pharmacology. vol 143. issue 4. 2005-02-01. PMID:15381635. |
depression was reversed by gaba(a) antagonists, and surmountable by increasing current injection, implicating a receptor-mediated shunt mechanism. |
2005-02-01 |
2023-08-12 |
rat |
| Thomas R Kosten, Therese A Koste. New medication strategies for comorbid substance use and bipolar affective disorders. Biological psychiatry. vol 56. issue 10. 2005-01-11. PMID:15556122. |
adding atypical antipsychotic agents might not improve valproate's efficacy, but combining gaba medications with selective serotonin reuptake inhibitors holds promise for sud with depression. |
2005-01-11 |
2023-08-12 |
Not clear |
| Karaturan Nermin Yelme. The role of gamma-aminobutyric acid and glutamate for hypoxic ventilatory response in anesthetized rabbits. The Tohoku journal of experimental medicine. vol 203. issue 3. 2005-01-06. PMID:15240932. |
after icv injection of gaba (0.48 mg/kg), air breathing in both groups caused a depression of respiratory activity. |
2005-01-06 |
2023-08-12 |
Not clear |
| Karaturan Nermin Yelme. The role of gamma-aminobutyric acid and glutamate for hypoxic ventilatory response in anesthetized rabbits. The Tohoku journal of experimental medicine. vol 203. issue 3. 2005-01-06. PMID:15240932. |
our findings suggest that icv injection of gaba causes respiratory depression in normoxic conditions, and that it increases ventilation in hypoxic conditions with or without peripheral chemoreceptor impulses by increasing glutamate. |
2005-01-06 |
2023-08-12 |
Not clear |
| J Martin Verkuyl, Scott E Hemby, Marian Joël. Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355334. |
however, expression of the extra-synaptic gaba(a)alpha5 subunit, earlier linked to depression in humans, and of the delta receptor subunit were found to be significantly changed. |
2004-12-20 |
2023-08-12 |
rat |
| Linda L Carpenter, Francisco A Moreno, Mitchel A Kling, George M Anderson, William T Regenold, David M Labiner, Lawrence H Pric. Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients. Biological psychiatry. vol 56. issue 6. 2004-11-08. PMID:15364040. |
cerebrospinal fluid (csf) studies in epilepsy patients show that vns alters concentrations of monamines and gamma-aminobutyric acid (gaba), neurotransmitter systems possibly involved in the pathogenesis of depression. |
2004-11-08 |
2023-08-12 |
Not clear |
| Mark C Bieda, M Bruce MacIve. Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability. Journal of neurophysiology. vol 92. issue 3. 2004-11-04. PMID:15140905. |
propofol-induced depression of intrinsic excitability was completely reversed by bicuculline and picrotoxin but was strychnine-insensitive, implicating gaba(a) but not glycine receptors. |
2004-11-04 |
2023-08-12 |
rat |