| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark C Bieda, M Bruce MacIve. Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability. Journal of neurophysiology. vol 92. issue 3. 2004-11-04. PMID:15140905. |
gabazine (20 microm) completely blocked both evoked and spontaneous ipscs but failed to block the propofol-induced depression of intrinsic excitability, implicating tonic, but not phasic, gaba(a) inhibition. |
2004-11-04 |
2023-08-12 |
rat |
| Peter L Lutz, Göran E Nilsso. Vertebrate brains at the pilot light. Respiratory physiology & neurobiology. vol 141. issue 3. 2004-10-25. PMID:15288600. |
the crucian carp displays a more modest depression of atp use, probably achieved through a moderated release of gaba and adenosine, allowing the animal to maintain physical activity in anoxia. |
2004-10-25 |
2023-08-12 |
Not clear |
| Dong-Ho Youn, Mirjana Randi. Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit. The Journal of physiology. vol 555. issue Pt 3. 2004-10-21. PMID:14724198. |
in the absence of synaptic inhibition mediated by gaba(a) and glycine receptors, a biphasic effect of kainate is characteristic with facilitation apparent at a low concentration (30 nm) and depression at a higher concentration (3 microm). |
2004-10-21 |
2023-08-12 |
mouse |
| Geoffrey M Drew, Philip J Siddall, Arthur W Dugga. Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. Pain. vol 109. issue 3. 2004-09-30. PMID:15157699. |
by contrast, in allodynic sci animals, bicuculline ejection had little or no effect on dorsal horn neurone responses to mechanical skin stimuli and paired-pulse depression despite reliably blocking the inhibition of cell firing produced by similarly applied gaba. |
2004-09-30 |
2023-08-12 |
rat |
| V Fenik, R O Davies, L Kubi. Combined antagonism of aminergic excitatory and amino acid inhibitory receptors in the XII nucleus abolishes REM sleep-like depression of hypoglossal motoneuronal activity. Archives italiennes de biologie. vol 142. issue 3. 2004-09-24. PMID:15260378. |
we used this model to determine whether microinjections of a combination of antagonists of serotonergic, adrenergic, gaba(a) and glycinergic receptors (methysergide, prazosin, bicuculline and strychnine) into the xii nucleus can abolish the carbachol-induced depression of xii motoneuronal activity. |
2004-09-24 |
2023-08-12 |
rat |
| V Fenik, R O Davies, L Kubi. Combined antagonism of aminergic excitatory and amino acid inhibitory receptors in the XII nucleus abolishes REM sleep-like depression of hypoglossal motoneuronal activity. Archives italiennes de biologie. vol 142. issue 3. 2004-09-24. PMID:15260378. |
we conclude that the rem sleep-like depression of xii motoneuronal activity can be fully accounted for by all or some of the following mechanisms: a withdrawal of motoneuronal excitation mediated by norepinephrine and serotonin and increased inhibition mediated by gaba and glycine. |
2004-09-24 |
2023-08-12 |
rat |
| M M Hoskison, J A Connor, C W Shuttlewort. GABA(B)-receptor modulation of short-term synaptic depression at an excitatory input to murine hippocampal CA3 pyramidal neurons. Neuroscience letters. vol 365. issue 1. 2004-09-14. PMID:15234471. |
gaba(b)-receptor modulation of short-term synaptic depression at an excitatory input to murine hippocampal ca3 pyramidal neurons. |
2004-09-14 |
2023-08-12 |
Not clear |
| Masanori Kashiwagi, Yasumasa Okada, Shun-Ichi Kuwana, Shigeki Sakuraba, Ryoichi Ochiai, Junzo Taked. A neuronal mechanism of propofol-induced central respiratory depression in newborn rats. Anesthesia and analgesia. vol 99. issue 1. 2004-08-26. PMID:15281502. |
in the present study, we studied these mechanisms and the involvement of gamma-aminobutyric acid (gaba)a receptors in propofol-induced central respiratory depression. |
2004-08-26 |
2023-08-12 |
rat |
| I G Sil'ki. [Potential mechanisms of effects of endogenous neuromodulators on the interdependent activity of neurons in various nuclei of the basal ganglia]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 3. 2004-08-23. PMID:15152564. |
according to modulation rules, an activation of postsynaptic gs- or gq/11-(gi/0-) protein coupled receptors promotes induction of long-term potentiation (depression) of excitatory inputs to different neurons and augmentation (lowering) of their activity; an activation of presynaptic gs- or gq/11-(gi/0-) protein coupled receptors promotes a rise (decrease) of release of gaba and co-peptides from striatal terminals and glutamate release from subthalamic terminals in the globus pallidus and output nuclei. |
2004-08-23 |
2023-08-12 |
Not clear |
| Shu Hui Wu, Chun Lei Ma, Jack B Kell. Contribution of AMPA, NMDA, and GABA(A) receptors to temporal pattern of postsynaptic responses in the inferior colliculus of the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140934. |
gaba(a) ipscs could also follow stimulus pulses over this frequency range but showed depression at low rates and facilitation at higher rates. |
2004-08-13 |
2023-08-12 |
rat |
| Shu Hui Wu, Chun Lei Ma, Jack B Kell. Contribution of AMPA, NMDA, and GABA(A) receptors to temporal pattern of postsynaptic responses in the inferior colliculus of the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140934. |
gaba(a) inhibition suppressed activation of nmda receptors and reduced both the degree of ampa epsc depression and the extent of temporal summation of nmda epscs. |
2004-08-13 |
2023-08-12 |
rat |
| Archana Jha, Shripad B Deshpand. Aglycemia and ischemia depress spinal synaptic transmission via inhibitory systems involving NMDA receptors. European journal of pharmacology. vol 481. issue 2-3. 2004-08-03. PMID:14642785. |
strychnine (glycine(a) receptor antagonist) or bicuculline (gaba(a) receptor antagonist) blocked the aglycemia-induced depression of the reflexes. |
2004-08-03 |
2023-08-12 |
rat |
| Jaakko Lappalainen, Gerard Sanacora, Henry R Kranzler, Robert Malison, Ellen S Hibbard, Lawrence H Price, John Krystal, Joel Gelernte. Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 124B. issue 1. 2004-07-28. PMID:14681921. |
abnormally low concentrations of brain gamma-aminobutyric acid (gaba) have been reported in unipolar depression. |
2004-07-28 |
2023-08-12 |
human |
| Gerard Sanacora, Ralitza Gueorguieva, C Neill Epperson, Yu-Te Wu, Michael Appel, Douglas L Rothman, John H Krystal, Graeme F Maso. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of general psychiatry. vol 61. issue 7. 2004-07-23. PMID:15237082. |
subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. |
2004-07-23 |
2023-08-12 |
human |
| Kerstin Wirkner, Zoltan Gerevich, Thomas Krause, Albrecht Günther, Laszlo Köles, Dietmar Schneider, Wolfgang Nörenberg, Peter Ille. Adenosine A2A receptor-induced inhibition of NMDA and GABAA receptor-mediated synaptic currents in a subpopulation of rat striatal neurons. Neuropharmacology. vol 46. issue 7. 2004-06-29. PMID:15081796. |
however, in the presence of external mg(2+), the inhibition by cgs 21680 of the gaba(a) receptor-mediated ipscs led to a depression of the epsc/ipsc complexes. |
2004-06-29 |
2023-08-12 |
rat |
| Hong Jia, Yu-Feng Xie, Dan-Qin Xiao, Jing-Shi Tan. Involvement of GABAergic modulation of the nucleus submedius (Sm) morphine-induced antinociception. Pain. vol 108. issue 1-2. 2004-06-03. PMID:15109504. |
these results suggest that locally released gaba acting at gaba(a) receptors is involved in the modulation of sm morphine-induced antinociception, and support the hypothesis that a disinhibitory effect elicited by morphine on gabaergic terminals in sm may lead to activation of the sm-ventrolateral orbital cortex (vlo)-perioqueductal gray (pag) brainstem descending inhibitory system and depression of the nociceptive inputs at the spinal cord level. |
2004-06-03 |
2023-08-12 |
rat |
| Markus Kosel, Uwe Rudolph, Peter Wielepp, Martin Luginbühl, Wolfgang Schmitt, Hans U Fisch, Thomas E Schlaepfe. Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14628001. |
diminished gaba(a) receptor-binding capacity and a dna base substitution in a patient with treatment-resistant depression and anxiety. |
2004-04-27 |
2023-08-12 |
Not clear |
| Zul Merali, Lisheng Du, Pavel Hrdina, Miklos Palkovits, Gabor Faludi, Michael O Poulter, Hymie Anisma. Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 6. 2004-04-26. PMID:14960621. |
these findings raise the possibility that the crh and gaba(a) receptor subunit changes, or the disturbed coordination between these gaba(a) receptor subunits, contribute to depression and/or suicidality or are secondary to the illness/distress associated with it. |
2004-04-26 |
2023-08-12 |
Not clear |
| Tawnya L Cary, G Thomas Chandler, David C Volz, Spencer S Walse, John L Ferr. Phenylpyrazole insecticide fipronil induces male infertility in the estuarine meiobenthic crustacean Amphiascus tenuiremis. Environmental science & technology. vol 38. issue 2. 2004-04-22. PMID:14750729. |
the new gaba (gamma-aminobutyric acid)-disrupting insecticide fipronil (fp) induces unique sex-specific reproductive dysfunction in male meiobenthic copepods, leading to trans-generational population depression at environmentally realistic concentrations (0.63 microg/l). |
2004-04-22 |
2023-08-12 |
Not clear |
| Tetsuro Shirasaka, Yasuhiro Yoshimura, De-Lai Qiu, Mayumi Takasak. The effects of propofol on hypothalamic paraventricular nucleus neurons in the rat. Anesthesia and analgesia. vol 98. issue 4. 2004-04-19. PMID:15041591. |
taken together, these results suggest that propofol enhancement of gaba(a)-receptor mediated currents and inhibition of voltage-gated ca(2+) currents at the central level, which is involved in the control of cardiovascular and sympathetic functions may be, at least in part, involved in general anesthetic-induced cardiovascular and sympathetic depression. |
2004-04-19 |
2023-08-12 |
rat |