| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E L Bartlett, P H Smit. Effects of paired-pulse and repetitive stimulation on neurons in the rat medial geniculate body. Neuroscience. vol 113. issue 4. 2002-11-27. PMID:12182900. |
depression was not blocked by ionotropic glutamate, gaba(a) or gaba(b) receptor antagonists. |
2002-11-27 |
2023-08-12 |
rat |
| Tim F Oberlander, Ruth Eckstein Grunau, Colleen Fitzgerald, Ann-Louise Ellwood, Shaila Misri, Dan Rurak, Kenneth Wayne Rigg. Prolonged prenatal psychotropic medication exposure alters neonatal acute pain response. Pediatric research. vol 51. issue 4. 2002-11-26. PMID:11919328. |
selective serotonin reuptake inhibitors (ssris) and benzodiazepines are frequently used to treat maternal depression during pregnancy, however the effect of increased serotonin (5ht) and gamma-amino-butyric acid (gaba) agonists in the fetal human brain remains unknown. |
2002-11-26 |
2023-08-12 |
human |
| David W Volk, Joseph N Pierri, Jean-Marc Fritschy, Sungyoung Auh, Allan R Sampson, David A Lewi. Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 10. 2002-11-15. PMID:12217970. |
because the alpha(2) subunit of the gaba(a) receptor is preferentially localized at pyramidal neuron ais, we quantified alpha(2) subunit immunoreactive ais in tissue sections containing prefrontal cortex area 46 from 14 matched triads of subjects with schizophrenia, subjects with major depression and control subjects. |
2002-11-15 |
2023-08-12 |
human |
| Abdulmonem Al-Hayani, Stephen N Davie. Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020681. |
we have previously reported that the synthetic cannabinoid r-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (win55,212-2) causes a selective inhibition of paired pulse depression of population spikes recorded from the ca1 region of rat hippocampal slices maintained at 28-30 degrees c. we now show that this effect is highly temperature-dependent and that win55,212-2 actually increases paired pulse depression of population spikes recorded from slices maintained at 35 degrees c. this temperature dependence was found to correlate with the effects of the known gamma-amino butyric acid (gaba)-uptake inhibitors, nipecotic acid and guvacine, which were without effect at 28-30 degrees c, but increased paired pulse depression at 35 degrees c. the results show that the effects of cannabinoids on synaptic transmission in the hippocampal slice are highly temperature-dependent and it is suggested that this is due to the presence of increased gaba uptake at higher temperatures. |
2002-10-08 |
2023-08-12 |
rat |
| Ingrid Sundman-Eriksson, Per Allar. [(3)H]Tiagabine binding to GABA transporter-1 (GAT-1) in suicidal depression. Journal of affective disorders. vol 71. issue 1-3. 2002-10-08. PMID:12167498. |
[(3)h]tiagabine binding to gaba transporter-1 (gat-1) in suicidal depression. |
2002-10-08 |
2023-08-12 |
Not clear |
| Mauro Federici, Silvia Natoli, Giorgio Bernardi, Nicola B Mercur. Dopamine selectively reduces GABA(B) transmission onto dopaminergic neurones by an unconventional presynaptic action. The Journal of physiology. vol 540. issue Pt 1. 2002-09-23. PMID:11927674. |
the da-induced depression of the gaba(b) ipsp occluded the depression produced by serotonin and was not antagonized by serotonin antagonists. |
2002-09-23 |
2023-08-12 |
Not clear |
| Mauro Federici, Silvia Natoli, Giorgio Bernardi, Nicola B Mercur. Dopamine selectively reduces GABA(B) transmission onto dopaminergic neurones by an unconventional presynaptic action. The Journal of physiology. vol 540. issue Pt 1. 2002-09-23. PMID:11927674. |
the da- and 5-ht-induced depression of the gaba(b) ipsp persisted when calcium and potassium currents were reduced in to the presynaptic terminals. |
2002-09-23 |
2023-08-12 |
Not clear |
| Masanori Yamauchi, Hiroshi Sekiyama, Steven G Shimada, J G Collin. Halothane suppression of spinal sensory neuronal responses to noxious peripheral stimuli is mediated, in part, by both GABA(A) and glycine receptor systems. Anesthesiology. vol 97. issue 2. 2002-09-10. PMID:12151932. |
the authors tested the hypothesis that gamma-aminobutyric acid receptor type a (gaba(a)) and strychnine-sensitive glycine receptor systems mediate halothane depression of spinal sensory neuronal responses to noxious stimuli. |
2002-09-10 |
2023-08-12 |
Not clear |
| J H Krystal, G Sanacora, H Blumberg, A Anand, D S Charney, G Marek, C N Epperson, A Goddard, G F Maso. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular psychiatry. vol 7 Suppl 1. 2002-09-04. PMID:11986998. |
recent studies employing magnetic resonance spectroscopy also suggest that unipolar, but not bipolar, depression is associated with reductions in cortical gaba levels. |
2002-09-04 |
2023-08-12 |
Not clear |
| F Wendling, F Bartolomei, J J Bellanger, P Chauve. Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028360. |
it starts with recent hypotheses about: (i) the behaviour of inhibitory interneurons in hippocampal or neocortical networks in the generation of gamma frequency oscillations; (ii) the nonuniform alteration of gabaergic inhibition in experimental epilepsy (reduced dendritic inhibition and increased somatic inhibition); and (iii) the possible depression of gaba(a,fast) circuit activity by gaba(a,slow) inhibitory postsynaptic currents. |
2002-07-26 |
2023-08-12 |
human |
| Jan C Behrends, John C Lambert, Kimmo Jense. Repetitive activation of postsynaptic GABA(A )receptors by rapid, focal agonist application onto intact rat striatal neurones in vitro. Pflugers Archiv : European journal of physiology. vol 443. issue 5-6. 2002-07-24. PMID:11889567. |
responses to paired-pulse application of gaba at inter-pulse intervals (ipis) of 30, 100 and 300 ms showed no depression of the second response (r2) relative to the first (r1). |
2002-07-24 |
2023-08-12 |
rat |
| Jan C Behrends, John C Lambert, Kimmo Jense. Repetitive activation of postsynaptic GABA(A )receptors by rapid, focal agonist application onto intact rat striatal neurones in vitro. Pflugers Archiv : European journal of physiology. vol 443. issue 5-6. 2002-07-24. PMID:11889567. |
in conclusion, rapid focal iontophoresis of exogenous gaba onto gaba(a) receptors does not result in activity-dependent depression of the postsynaptic response. |
2002-07-24 |
2023-08-12 |
rat |
| Brian H Harvey, Lucy P Jonker, Linda Brand, Marietha Heenop, Dan J Stei. NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus. Life sciences. vol 71. issue 1. 2002-07-22. PMID:12020747. |
prolonged depression involves the stress-related release of glucocorticoids and glutamate, while response to antidepressants involves gamma-amino butyric acid (gaba) and the glutamate n-methyl-d-aspartate (nmda) receptor. |
2002-07-22 |
2023-08-12 |
rat |
| Bradley J Molyneaux, Michael E Hasselm. GABA(B) presynaptic inhibition has an in vivo time constant sufficiently rapid to allow modulation at theta frequency. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877493. |
the experiments described here analyzed the time course of gaba(b) modulation using a heterosynaptic depression paradigm in anesthetized rats at physiological temperatures. |
2002-05-20 |
2023-08-12 |
rat |
| Bradley J Molyneaux, Michael E Hasselm. GABA(B) presynaptic inhibition has an in vivo time constant sufficiently rapid to allow modulation at theta frequency. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877493. |
this heterosynaptic depression was significantly reduced by local infusion of the gaba(b) receptor antagonist cgp55845a. |
2002-05-20 |
2023-08-12 |
rat |
| Stefan Hefft, Udo Kraushaar, Jörg R P Geiger, Peter Jona. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. The Journal of physiology. vol 539. issue Pt 1. 2002-05-06. PMID:11850513. |
to examine possible interactions between fast depression and modulation of inhibitory synaptic transmission in the hippocampus, we recorded from pairs of synaptically connected basket cells (bcs) and granule cells (gcs) in the dentate gyrus of rat brain slices at 34 degrees c. multiple-pulse depression (mpd) was examined in trains of 5 or 10 inhibitory postsynaptic currents (ipscs) evoked at frequencies of 10-100 hz under several conditions that inhibit transmitter release: block of voltage-dependent ca2+ channels by cd2+ (10 microm), activation of gamma-amino-butyric acid type b receptors (gaba(b)rs) by baclofen (10 microm) and activation of muscarinic acetylcholine receptors (machrs) by carbachol (2 microm). |
2002-05-06 |
2023-08-12 |
rat |
| L E Buckby, M G Lace. Depression of excitatory cortico-nucleus accumbens synaptic transmission in rat brain slices by dopamine, but not adenosine, depends upon intracortical mechanisms. Experimental brain research. vol 141. issue 4. 2002-04-18. PMID:11810149. |
the gaba(a) receptor antagonists picrotoxin (10, 30 microm), or bicuculline methiodide (bmi, 20 microm), significantly reduced the pec depression caused by dopamine (100 microm) to 9+/-3% ( n=20), 12+/-7% ( n=8) and 13+/-3% ( n=4) of control respectively, which, in the case of bmi, was reversible on washout of bmi. |
2002-04-18 |
2023-08-12 |
rat |
| Gerard Sanacora, Graeme F Mason, Douglas L Rothman, John H Krysta. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. The American journal of psychiatry. vol 159. issue 4. 2002-04-18. PMID:11925309. |
the goal of this study was to determine whether these occipital cortex gaba concentrations are altered after administration of selective serotonin reuptake inhibitors (ssris) in the treatment of depression. |
2002-04-18 |
2023-08-12 |
human |
| Miriam Melis, Rosana Camarini, Mark A Ungless, Antonello Bonc. Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 6. 2002-03-27. PMID:11896147. |
we observed that evoked gaba(a) ipscs in da neurons of ethanol-treated animals exhibited paired-pulse depression (ppd) compared with saline-treated animals, which exhibited paired-pulse facilitation (ppf). |
2002-03-27 |
2023-08-12 |
mouse |
| J Kim, B E Alge. Random response fluctuations lead to spurious paired-pulse facilitation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739571. |
we studied paired-pulse depression (ppd) of gaba(a)ergic ipscs under conditions of reduced transmitter release (caused by cd(2+), baclofen, or reduced stimulus intensity) with whole-cell voltage clamp in ca1 pyramidal cells in vitro. |
2002-01-23 |
2023-08-12 |
Not clear |